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Abstract

The field of nanomedicine faces many challenges in the development of standards to support meaningful data submission and information exchange.  Numerous physico-chemical, in vitro, and in vivo assays must be addressed, with measurements currently dependent on non-standardized protocols and diverse technology types.  Representing Structure-Activity-Relationships (SARs) in nanomedicine, in particular, is critical to understanding the effects of nanomaterial structure on biological activity.  Unfortunately, information describing the nanomaterial including functionalizing entities and 3D structure is often represented in an undisciplined fashion.  This lack of standardization has been a significant deterrent to meaningful data sharing across the nanotechnology community; few publications contain sufficient information to enable adequate interpretation of results and successful achievement of experimental reproducibility.

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