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Proteomics Data Management has three subprojects; Proteomics Data Commons (PDC), Clinical Proteomics Tumor Analysis Consortium (CPTAC) Data Assay Portal and CPTAC DCC (Data Coordinating Center). PDC starts on April 1, 2020 while the other two projects will start August 31^st 2021. All three projects are already underway with ESAC, Inc. The PDC is part of NCI’s CRDC. Reports are provided to Division of Cancer Biology (DCB) and through the BIDS monthly reporting system. Anticipated period of performance is 4 years, with severable funding. EPLC is needed and an ATO is already in place (held with ESAC).

Project Details:

YT20-068 (FCAS ID is NCI-CSSI-20-YT0057)

Task Order Title and Number: NCI Operational Task Order: 75N91019F00129

Contract type: Severable

Base period of performance: Date of Award - August 30, 2020

PIDS:

600.129.27.01.014.002.0001 – Proteomic Data Mgmt
600.129.27.01.014.002.0001.001 – Proteomic Data Mgmt;Gen
600.129.27.01.014.002.0001.007 – Proteomic Data Mgmt;TPM
600.129.27.01.014.002.0001.003 – Proteomic Data Mgmt;DEV

Scope:

The vision for a Cancer Research Data Commons (CRDC) is a virtual, expandable infrastructure that will eventually support collaboration among researchers, computational scientists, and tool developers. It will house multiple cloud-based Commons Nodes for multiple data types, initially including genomic, imaging, and proteomics data. In the future, additional nodes will support other data types. Genomics data in the CRDC is supported by the Genomic Data Commons (GDC), which provides a means of data submission, user interfaces, and search & visualization tools. The proteomics data node, as described below, will incorporate data from the Clinical Proteomics Tumor Analysis Consortium (CPTAC) and other sources. The Office of Cancer Clinical Proteomics Research works closely with CBIIT to integrate the PDC with CRDC.

The Proteomic Data Commons (PDC) is a node of the CRDC that collects, harmonizes, and hosts proteomic data across a variety of sample types. It incorporates data from various programs including CPTAC and ICPC where the majority of data are generated from quantitative mass spectrometry-based proteomic targeted assays. The PDC is open access and provides a space to query, visualize, and download available datasets. PDC has migrated to production and can be viewed here: https://pdc.esacinc.com/pdc/ .

Anticipated PDC benefits:

Enhance access to NCI and research community-generated cancer proteomic data and tools
Take advantage of increases in compute efficiency and scalability
Accelerate bioinformatics tool development
Serve the individual researcher who has limited or no access to high-performance computing
Make proteomic data and analysis tools readily accessible to the broad cancer research community
Support collaboration across research institutes and scientific disciplines
Reduce data storage redundancies

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