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Committee MemberPresentAbsent
Kuffel, Gina (NIH/NCI) [C]
X
Pihl, Todd (NIH/NCI) [C]

X
Unknown User (leblancak)


Otridge, John (NIH/NCI) [C]

X
Kim, Erika (NIH/NCI) [E]
X

Sommers, Connie (NIH/NCI) [E]

X
Debbie KnappX
Toby HechtX

Unknown User (parchmentr)



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ItemWhoTalking Points
DGAB Updates

Kuffel, Gina (NIH/NCI) [C]

  • UBC02 - Basal and Luminal Molecular Subtypes in Naturally-Occurring Canine Urothelial Carcinoma Are Associated With Tumor Immune Signatures and Dog Breed - Released to production on 1/11/22, adds 122 files (349.5 GB)
  • UBC01 - A clinical for Vemurafenib treatment in canine bladder cancer - targeting release to production next week
  • PanCancer data is being copied into an ICDC bucket (~120 hours remain)
    • Folder containing all submission artifacts for this study can be found here
  • Communications with authors of first candidate publication test case from Candidate Publication List
    • Data Submission Request was completed on their behalf
    • Email was sent by Warren Kibbe on behalf of DGAB on 11/24/21
    • Acknowledgment email sent by Gina 12/2/21
    • Follow-up email sent by Gina 1/6/22
    • Follow-up email sent by Gina 1/24/22
    • Folder containing all submission artifacts for this test case can be found here
ICDC Next Phase Focus Groups

Unknown User (hechtt)

  • 2 focus groups - 1 happened last Wed, next one is next Tues. 
    • Discussions so far have been about the types of projects we would be interested in:

Data Use Guidelines

Kuffel, Gina (NIH/NCI) [C] 

  • Received feedback from Office of Communications
  • Sent to Jason Cristofaro for final review of proposed revisions
  • Link to draft document can be found here
Refresh and revisit of Canine Grantees Master List

Kuffel, Gina (NIH/NCI) [C] Sommers, Connie (NIH/NCI) [E] 

  • Link to updated master list
User Research for ICDC by the Office of Communications and Public Liaison (OCPL)Kuffel, Gina (NIH/NCI) [C] 
  • Usability sessions with volunteers are in progress
ICDC Site Updates

Kuffel, Gina (NIH/NCI) [C]

  • Work now in progress to integrate JBrowse a genomic file viewer
  • Next software release targets the end of March
Steering Committee Meeting Updates from 1/26Unknown User (parchmentr)
  • Minutes to be posted
  • Next meeting is Wed 2/23

Minutes (Not Verbatim)

Toby - Regarding the Focus Group Discussions so far, parallel data between canine and humans from the same treatment, cell sub-types before and after treatment, environmental insults in canines vs. humans (exposures for humans cause cancer, canines subjected to same exposures), urothelial cancers in human vs. canine (Knapp lab has studied this), looking for data beyond genomics data.

Debbie - Lots of groups showing interest, proteomic data coming, others will mine the data we are generating.

Toby - Adverse events in canines in clinical trials, important for comparison to human. Warren brought up flea and tick medications and this can be absorbed by their human companions and be linked to cancer. Connie suggested looking at raw flow cytometry data, this data can be used to make predictions. The NanoString data will be coming and will introduce data model expansions. Potential to involve pharma.

Connie - Possibly the aging study, involves all breeds.

Toby - Waiting to hear from Dan Promislow and to determine if he has had communications with the Aging Institute will co-fund with the NCI looking at canine tumors and conducting sequencing. Need to secure this before the end of the fiscal year in order to use the funding.

Toby - Genomics Working group and the Imaging Working group is part of the BPSC, Data Governance Advisory Board is separate led by Warren Kibbe.

Previous ICDC Use Cases from Steering Committee

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