NIH | National Cancer Institute | NCI Wiki  

WIKI MAINTENANCE NOTICE

Please be advised that NCI Wiki will be undergoing maintenance on Thursday, May 23rd between 1200 ET and 1300 ET.
Wiki will remain available, but users may experience screen refreshes or HTTP 502 errors during the maintenance period. If you encounter these errors, wait 1-2 minutes, then refresh your page.

If you have any questions or concerns, please contact the CBIIT Atlassian Management Team.

Versions Compared

Old Version 2

changes.mady.by.user Kuffel, Gina (NIH/NCI) [C]

Saved on

compared with

New Version Current

changes.mady.by.user Kuffel, Gina (NIH/NCI) [C]

Saved on

Key

  • This line was added.
  • This line was removed.
  • Formatting was changed.

...

Committee MemberPresentAbsent
Kuffel, Gina (NIH/NCI) [C]
X
Pihl, Todd (NIH/NCI) [C]
X
Unknown User (leblancak)

X

Otridge, John (NIH/NCI) [C]

X
Kim, Erika (NIH/NCI) [E]
X

Sommers, Connie (NIH/NCI) [E]

X
Debbie Knapp

Toby HechtX

Unknown User (parchmentr)



...

ItemWhoTalking Points
DGAB Updates

Kuffel, Gina (NIH/NCI) [C]

  • 33 TB of data are now available in ICDC (five-fold increase since January)
  • UBC01 - Antitumor Activity and Molecular Effects of Vemurafenib in Dogs with BRAF-mutant Bladder Cancer
    • Adds 170 files (320 GB)
    • Released 2-28-22
    • Activated multi-study matching
  • OSA01 - A Multi-Platform Sequencing Analysis of Canine Appendicular Osteosarcoma
    • Adds 278 files (6.98 TB)
    • Released 4-22-22
  • PanCancer data has been copied into an ICDC bucket 
    • Folder containing all submission artifacts for this study can be found here
  • Candidate publication test case from Candidate Publication List
  • CCL01 - A multi-omics analysis of canine cancer cell lines
    • Data has been received and is being curated for submission
BPSC Updates

Kuffel, Gina (NIH/NCI) [C] 

April Steering Committee Updates

Unknown User (parchmentr)

  • Minutes to be posted
  • Next meeting is Wed May 18th
ICDC Site Updates

Kuffel, Gina (NIH/NCI) [C]

  • Presented ICDC at CRDC All Hands Meeting CRDC-Spring2022-All-Hands.pptx
  • ICDC version 3.21.3 was released on April 1st
    • Interactive Home Page Demo
    • JBrowse Demo
ICDC Next Phase 

Unknown User (hechtt)

Minutes (Not Verbatim)

Toby - Can canine bladder cancer be a good model for invasive human bladder cancer? Maybe running differential expression in dogs at various stages vs. human data at different stages of disease obtained from the GDC and then comparing expression patterns and gene signatures. Real focus is comparative genomics.

Ralph - Possibly raise as a discussion point to the SC. Does this cancer in both species survive therapy to resist disease using same pathways? Is there biological convergence?

Toby - Look at dogs in ICDC and see what the genes are in dogs that are more resistant to glioma vs. dogs that are not and see if those up or down regulated genes have human homologs.

Toby - Real data in ICDC can now be used to answer real biological questions.

Ralph - Will put use case into SC meeting agenda.

Previous ICDC Use Cases from Steering Committee

...