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Multiexcerpt
MultiExcerptNameSharedTerminologyDevelopment

Since 1997, EVS has worked with many partners to build shared content and services, so that information can be effectively exchanged, interpreted and analyzed while minimizing overall effort and cost. Much of this content has been created and published using NCI Thesaurus and NCI Metathesaurus, as outlined in the following sections and described in more detail in the individual user profiles later, where other shared development efforts are also described.

Table of Contents
minLevel2

NCI Thesaurus (NCIt)

NCI Thesaurus (NCIt) is NCI's core reference terminology. Over the last 10 years, it It has also been adopted by FDA, CDISC, NCPDP and other partners as a shared standards development and coding environment, allowing participants to compare and harmonize with each other's content while taking advantage of full-text definitions, codes, and other features.

About 45125,000 out of the 100178,000 080 current NCIt concepts have terms from both EVS and from one or more of these other sources. The chart below gives a detailed breakdown of the main areas of overlapping tagged content. Note that some partners have used NCI terms rather than tagging their own, so these figures understate the true extent of cross-source sharing.

NCIt concepts with terms from tagged outside sources (1124.09d07E: September 2011July 2024) chart showing NCIt concepts with terms from tagged outside sourcesImage Removed

Image Added

NCIt concepts with tagged synonyms from each outside source (1324.03d07E: March 2013July 2024)

NCIt Concepts

Source

335

BIOCARTA

1,149

BRIDG

27

CADSR

921

CDC

9,003

CDISC

425

CRCH

6,368

CTCAE

4,421

CTRM

903

DCP

114

DICOM

695

DTP

16,334

FDA

126

HL7

215

ICH

156

JAX

255

KEGG

4

NCICB

5,154

NCI-GLOSS

517

NCPDP

1731

NICHD

169

PID

311

RENI

62

SEER

288

UCUM

25
3ACC
1182ACC/AHA
2016

BRIDG

408CareLex
56CBDD
268

CCPS

28113CDISC
799CDISC-GLOSS
2470Cellosaurus
3654CPTAC
406CRCH
8924CTCAE
280CTDC
428CTEP
28606CTRP
636DIPG/DMG
1076EDQM-HC
28882FDA
239GAIA
12505GDC
1649HemOnc
127HL7
106ICD-10
664ICDC
216ICH
215INC
5660mCode
1281MedDRA
150MRCT-Ctr
23NAACCR
246NCCN
510NCPDP
6NDC
4783NICHD
826OORO
71ORCHESTRA
1862PCDC
40PI-RADS
211PRO-CTCAE
377SEER
662SeroNet
344UBERON
284UCUM

NCI Metathesaurus (NCIm)

NCI Metathesaurus (NCIm) was started in the late 1990s to gather up, translate between, and publish the many terminologies used by NCI, including some created in part or whole within NCI. Development of NCI Thesaurus started within NCIm as NewPDQ, an effort to extend and restructure the PDQ Terminology long used to code cancer clinical trial, research and public information resources. NCIm continues to provide a vital environment for EVS collaboration with NCI and other partners to develop, map and publish terminologies of shared interest, and responds to the requirements of a broad range of stakeholders within the cancer research and biomedical community.

NCIt tagged content from outside sources is imported into NCIm with separate source tags. NCIt-derived sources are grouped separately below. The NCIm tags are mostly identical or very similar to those in NCIt; exceptions are CADSR, converted to NCI; HL7, converted to NCI-HL7; and CTRM, which is not imported. 

NCIm sources and the number of concepts to which each contributes (201105202408: May 2011August 2024)

NCIm concepts

Source Label - NCIt-derived

Source Name

1177ACC-AHAAmerican College of Cardiology/American Heart Association Clinical Data Terminology, 2024_06D
334BioCBioCarta online maps of molecular pathways, adapted for NCI use,
1105E
1,139
2024_06D
27BRIDGBiomedical Research Integrated Domain Group Model, 2024_06D
1148BRIDG_3_0_3Biomedical Research Integrated Domain Group Model, 3.0.3, 2024_06D
1658BRIDG_5_3
BRIDG
Biomedical Research Integrated Domain Group Model
, 1105E921
, 5.3, 2024_06D
20456caDSRCancer Data Standards Registry and Repository, 2024_06D
407CARELEXContent Archive Resource Exchange Lexicon, 2024_06D
53CBDDChemical Biology and Drug Development Vocabulary, 2024_06D
265CCPSChildhood Cancer Predisposition Study, 2024_06D
922CDCU.S. Centers for Disease Control and Prevention,
1105E
5,636
2024_06D
29309CDISCClinical Data Interchange Standards Consortium, 2024_06D
800CDISC-GLOSS
CDISC
Clinical Data Interchange Standards
Consortium, 1105E
Consortium Glossary Terms, 2024_06D

2485

CELLOSAURUSCellosaurus, 2024_06D
3678CPTACClinical Proteomic Tumor Analysis Consortium, 2024_06D
406CRCHCancer Research Center of Hawaii Nutrition Terminology, 2024_06D
775CTCAECommon Terminology
, 1105E
6,368
Criteria for Adverse Events, 2024_06D
5599CTCAE_3Common Terminology Criteria for Adverse Events 3.0, 2024_06D
4022CTCAE_5
CTCAE
Common Terminology Criteria for Adverse Events
, 1105E903
5.0, 2024_06D
276CTDCClinical Trial Data Commons, 2024_06D
373CTEP-SDCCancer Therapy Evaluation Program - Simple Disease Classification, 2024_06D
28536CTRPClinical Trials Reporting Program, 2024_06D
904DCPNCI Division of Cancer Prevention Program,
1105E
2024_06D
114DICOMDigital Imaging Communications in Medicine,
1105E
2024_06D
627DIPG_DMGDiffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma Terminology, 2024_06D
694
693
DTPNCI Developmental Therapeutics Program,
1105E15,471
2024_06D
1076EDQM-HCEuropean Directorate for the Quality of Medicines & Healthcare, 2024_06D
27764FDAU.S. Food and Drug Administration
, 1105E
, 2024_06D
207GAIAGlobal Alignment of Immunization Safety Assessment in pregnancy, 2024_06D
6092GDCNCI Genomic Data Commons, 2024_06D
281GENCGeopolitical Entities, Names, and Codes Standard, 2024_06D
1648HemOncHematology-Oncology (HemOnc) Chemotherapy Regimen Vocabulary, 2024_06D
106ICD-10International Classification of Diseases, 10th Edition, 2024_06D
693ICDCNCI Integrated Canine Data Commons, 2024_06D
215ICHInternational Conference on Harmonization,
1105E
2024_06D
215INCInternational Neonatal Consortium, 2024_06D
156JAXJackson Laboratories Mouse Terminology, adapted for NCI use,
1105E
2024_06D
244KEGGKEGG Pathway Database,
1105E85,314
2024_06D
5661mCodeMinimal Common Oncology Data Elements, 2024_06D
187216NCINational Cancer Institute Thesaurus,
2011_05E5,084
2024_06D
150MRCT-CtrMRCT Center Clinical Research Plain Language Glossary, 2024_06D
5079NCI-GLOSSNCI Dictionary of Cancer Terms
, 1105E125
, 2024_06D
6004NCI-HGNCNCI HUGO Gene Nomenclature Committee, 2024_06D
129NCI-HL7NCI Health Level 7,
1105E
2024_06D
514
509NCPDPNational Council for Prescription Drug Programs
, 1105E715
, 2024_06D
5NDCNational Drug Code, 2024_06D
4779NICHDNational Institute of Child Health and Human Development
, 1105E
, 2024_06D
825OOROOperational Ontology for Radiation Oncology, 2024_06D
70ORCHESTRAORCHESTRA, 2024_06D
1831PCDCPediatric Cancer Data Commons, 2024_06D
39PI-RADSProstate Imaging Reporting and Data System, 2024_06D
169PIDNational Cancer Institute Nature Pathway Interaction Database
, 1105E
, 2024_06D
210PRO-CTCAEPatient Reported Outcomes version of Common Terminology Criteria for Adverse Events, 2024_06D
310RENIRegistry Nomenclature Information System
, 1105E287
, 2024_06D
659SeroNetSerological Sciences Network Terminology, 2024_06D
236UBERONUBERON Ontology, 2024_06D
1557UCUMUnified Code for Units of Measure,
1105E
2024_06D
78WHOWorld Health Organization (WHO) Terminology, 2024_06D
25ZFINZebrafish Model Organism Database,
1105E
2024_06D

NCIm concepts

Source Label - Other

Source Name

15,870
15885AODAlcohol and Other Drug Thesaurus, 2000
278
276AOTAuthorized Osteopathic Thesaurus, 2003
13,255
13257CBOClinical Bioinformatics Ontology, 2011_02
1,104
CCS
544CCSR_ICD10CMClinical Classifications Software Refined for ICD-10-CM, 2024
357CCSR_ICD10PCSClinical Classifications Software
, 20053,073
Refined for ICD-10-PCS, 2024
962CDCRECRace & Ethnicity - CDC, 1.2
3081COSTARCOSTAR, 1989-1995
16,572
16483CSPCRISP Thesaurus, 2006
3,836
3839CSTCOSTART, 1995
345
318CTEPCancer Therapy Evaluation Program, 2004
7,278
642CVXVaccines Administered, 2024_02_15
12392DRUGBANKDrugBank, 5.0_2024_02_09
7289DXPDXplain, 1994
77,923
102550FMAFoundational Model of Anatomy Ontology,
2_054,439
4_15
7480GARDGenetic and Rare Diseases Information Center, 2015_04
71878GOGene Ontology,
2010
2023_
04
05_
01
10
5,602
8457HCPCSHealthcare Common Procedure Coding System,
20107,483
2024
43627HGNCHUGO Gene Nomenclature Committee, 2023_04
9077HL7V3.0HL7 Vocabulary Version 3.0,
2006
2023_
05
11
29,335
19432

HUGO

HUGO Gene Nomenclature, 2010_05

HPOHuman Phenotype Ontology, 2023_10_09
17415
11,532
ICD10ICD10,
1998
1,004

ICD10AE

ICD10, American English Equivalents, 1998

97,631
2016
105371ICD10CMInternational Classification of Diseases, 10th Edition, Clinical Modification,
2010_03181,116
2024
191545ICD10PCSICD-10-PCS,
2009
2024
20,779
20887ICD9CMInternational Classification of Diseases, Ninth Revision, Clinical Modification,
2011
2014
2,466
2861ICDOInternational Classification of
Diseases
Disease for Oncology,
3rd Edition, 2000
3_2
748ICPCInternational Classification of Primary Care, 1993
37,923

ICPC2ICD10ENG

ICPC2 - ICD10 Thesaurus, 200412

80,206

LNC

Logical Observation Identifier Names and Codes, 232
5055ISO3166-2International Organization for Standardization 3166-2, 2012
177072LNCLOINC, 277
41MCMMcMaster University Epidemiology Terms, 1992
331
332MDBCACMitelman Database of Chromosome Aberrations in Cancer, 2005_12
47,210
62725MDRMedical Dictionary for Regulatory Activities Terminology
, 14.01,897
(MedDRA), 27_0
3559MED-RTMedication Reference Terminology, 2024_03_04
2120MEDLINEPLUSMedlinePlus Health Topics,
20080614
20221101
900
901MGEDMGED Ontology, 131
310,485
457042MSHMedical Subject Headings,
2011
2024_
2010
2024_
08
02_
30
01
85,138
21941MTHUMLS Metathesaurus,
2010AB
2024AA
19,880
11
MTHFDA
MTHCMSFRFMetathesaurus
FDA National Drug Code Directory, 2010_08_02
CMS Formulary Reference File, MTHCMSFRF_2020
19008
337

MTHHH

Metathesaurus HCPCS Hierarchical Terms, 2010

16,081
MTHICD9International Classification of Diseases, Ninth Revision, Clinical Modification, Metathesaurus additional entry terms,
2011
94

MTHICPC2ICD107B

ICPC2 - ICD10 Thesaurus, 7-bit Equivalents, 0412

76

MTHICPC2ICD10AE

ICPC2 - ICD10 Thesaurus, American English Equivalents, 0412

1,633
2014
1633MTHMSTMetathesaurus Version of Minimal Standard Terminology Digestive Endoscopy, 2001
12,969
57707MTHSPLMetathesaurus FDA Structured Product Labels,
2010
2024_
08_27478,187
02_24
88MVXManufacturers of Vaccines, 2024_02_12
722235NCBINCBI Taxonomy,
2010
2023_
04
11_
29
01
135
38,863

NDFRT

National Drug File, 2010_09_07

1,781
10188NCIMTH

NCI Metathesaurus

NCIMTH
1887
NPONPO: NanoParticle Ontology for Cancer Nanotechnology Research,
2010
2011_
10
12_
31
08
63,924
105235OMIMOnline Mendelian Inheritance in Man,
2010
2024_
04
02_
08
12
9,869
12396PDQPhysician Data Query,
2010
2016_
08
07_
06
31
2,041
2039PMAPortfolio Management Application, 2010
268
279PNDSPerioperative Nursing Data Set,
2nd edition, 2002
2024
940QMRQuick Medical Reference (QMR), 1996
30,033
45821RADLEXRadLex,
3
4_
33
1
227,498
219001RXNORMRxNorm Vocabulary,
10AA
20AA_
100907F
240304F
281,843
363404SNOMEDCT_US

SNOMED Clinical Terms

4,808
US Edition of SNOMED CT, 2024_03_01
167SOPSource of Payment Typology, 9.2
4811SPNStandard Product Nomenclature, 2003
156
234SRCMetathesaurus Source Terminology Names
13,788
29105UMDUMDNS: product category thesaurus,
20101,765
2023
5009USPUSP Compendial Nomenclature, 2024_01_08
1688USPMGUSP Medicare Model Guidelines,
2004
2023
61,191
61107UWDAUniversity of Washington Digital Anatomist, 1.7.3
26,546
38761VANDFVeterans Health Administration National Drug File,
2010
2024_
07_26
Wiki Markup
01_31

Overall Counts (August 2024)

ConceptsRelationships Attributes Total Number of Terms
2,696,773

23,619,364

 26,334,4837,164,803
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