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BioCarta online maps of molecular pathways, adapted for NCI use, 2019_07E
Multiexcerpt
MultiExcerptNameSharedTerminologyDevelopment

Since 1997, EVS has worked with many partners to build shared content and services, so that information can be effectively exchanged, interpreted and analyzed while minimizing overall effort and cost. Much of this content has been created and published using NCI Thesaurus and NCI Metathesaurus, as outlined in the following sections and described in more detail in the individual user profiles later, where other shared development efforts are also described.

Table of Contents
minLevel2

NCI Thesaurus (NCIt)

NCI Thesaurus (NCIt) is NCI's core reference terminology. Over the last 10 16 years, it has also been adopted by FDA, CDISC, NCPDP and other partners as a shared standards development and coding environment, allowing participants to compare and harmonize with each other's content while taking advantage of full-text definitions, codes, and other features.

About 50117,000 out of the 120154,000 946 current NCIt concepts have terms from both EVS and from one or more of these other sources. The chart below gives a detailed breakdown of the main areas of overlapping tagged content. Note that some partners have used NCI terms rather than tagging their own, so these figures understate the true extent of cross-source sharing.

NCIt concepts with terms from tagged outside sources (1122.09d: September 20112022) chart showing NCIt concepts with terms from tagged outside sourcesImage Removed

Image Added

NCIt concepts with tagged synonyms from each outside source (1322.03d09d: March 2013September 2022)

NCIt Concepts

Source

3ACC335
716

BIOCARTA

1,149

BRIDG

27

CADSR

921

CDC

9,003

CDISC

425

CRCH

6,368

CTCAE

4,421

CTRM

903

DCP

114

DICOM

695

DTP

16,334

FDA

126

HL7

215

ICH

156

JAX

255

KEGG

4

NCICB

5,154

NCI-GLOSS

517

NCPDP

1731

NICHD

169

PID

311

RENI

62

SEER

288

UCUM

25
ZFinACC/AHA
2016

BRIDG

408CareLex
56CBDD
268

CCPS

25456CDISC
787CDISC-GLOSS
2249Cellosaurus
3660CPTAC
406CRCH
8924CTCAE
280CTDC
426CTEP
26579CTRP
636DIPG/DMG
1047EDQM-HC
27494FDA
239GAIA
5996GDC
127HL7
106ICD-10
663ICDC
216ICH
215INC
1281MedDRA
23NAACCR
243NCCN
510NCPDP
6NDC
4785NICHD
38ORCHESTRA
1862PCDC
40PI-RADS
377SEER
660SeroNet
284UCUM

NCI Metathesaurus (NCIm)

NCI Metathesaurus (NCIm) was started in the late 1990s to gather up, translate between, and publish the many terminologies used by NCI, including some created in part or whole within NCI. Development of NCI Thesaurus started within NCIm as NewPDQ, an effort to extend and restructure the PDQ Terminology long used to code cancer clinical trial, research and public information resources. NCIm continues to provide a vital environment for EVS collaboration with NCI and other partners to develop, map and publish terminologies of shared interest, and responds to the requirements of a broad range of stakeholders within the cancer research and biomedical community.

NCIt tagged content from outside sources is imported into NCIm with separate source tags. NCIt-derived sources are grouped separately below. The NCIm tags are mostly identical or very similar to those in NCIt; exceptions are CADSR, converted to NCI; HL7, converted to NCI-HL7; and CTRM, which is not imported.

NCIm sources and the number of concepts to which each contributes (201908202105:  August 2019May 2021)

NCIm concepts

Source Label - NCIt-derived

Source Name

1149 

713ACC-AHAAmerican College of Cardiology/American Heart Association Clinical Data Terminology, 2021_01D
334BioCBioCarta online maps of molecular pathways, adapted for NCI use, 2021_01D
27BRIDGBiomedical Research Integrated Domain Group Model, 2021_01D
1148BRIDG_3_0_3Biomedical Research
 
Integrated Domain Group Model, 3.0.3,
2019
2021_
07E
01D
20 
1658BRIDG_5_3Biomedical Research
 
Integrated Domain Group Model, 5.3,
2019
2021_
07E
01D
334
17974

BioC

caDSRCancer Data Standards Registry and Repository, 2021_01D
407CARELEXContent Archive
 
Resource Exchange Lexicon,
2019
2021_
07E
01D
40
53CBDDChemical
Biology and
Biology and Drug Development Vocabulary,
2019_07E
2021_01D
265CCPSChildhood Cancer Predisposition Study, 2022_01E
923CDCU.S. Centers for
 
Disease Control and Prevention,
2019
2021_
07E
01D
714
26120CDISC
-GLOSS
Clinical Data
 
Interchange Standards Consortium
Glossary Terms
,
2019
2021_
07E
01D
21313
788CDISC-GLOSSClinical Data
 
Interchange Standards Consortium
, 2019_07E3657
Glossary Terms, 2021_01D

2167

CELLOSAURUSCellosaurus, 2021_01D
3688CPTACClinical Proteomic
 
Tumor Analysis Consortium,
2019
2021_
07E
01D
406CRCHCancer Research
 
Center of Hawaii Nutrition Terminology,
2019_07E
2021_01D
775CTCAECommon Terminology Criteria for Adverse Events, 2021_01D
5599CTCAE_3Common Terminology
 
Criteria for Adverse Events 3.0,
2019
2021_
07E
01D
4022CTCAE_5Common Terminology
 
Criteria for Adverse Events 5.0,
2019
2021_
07E
01D
770Common Terminology   Criteria for Adverse Events, 2019_07E
276
CTCAE
CTDCClinical Trial Data Commons, 2021_01D
318CTEPCancer Therapy Evaluation Program, 2004
373CTEP-SDCCancer Therapy
 
Evaluation Program - Simple Disease Classification,
2019
2021_
07E
01D
21343
25582CTRPClinical Trials
 
Reporting Program,
2019
2021_
07E
01D
903DCPNCI Division of
 
Cancer Prevention Program,
2019
2021_
07E
01D
114DICOMDigital Imaging
 
Communications in Medicine
, 2019_07E
, 2021_01D
627DIPG_DMGDiffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma Terminology, 2022_01E
694DTPNCI Developmental
 
Therapeutics Program,
2019
2021_
07E
01D
1009
1041EDQM-HCEuropean
 
Directorate for the Quality of Medicines & Healthcare,
2019
2021_
07E
01D
21857
25994FDAU.S. Food and Drug
 
Administration,
2019
2021_
07E
01D
207GAIAGlobal Alignment of
 
Immunization Safety Assessment in pregnancy
, 2019_07E
, 2021_01D
5472GDCNCI Genomic Data Commons, 2021_01D
281GENCGeopolitical
 
Entities, Names, and Codes Standard,
2019_07E
2021_01D
106ICD-10International Classification of Diseases, 10th Edition, 2022_01E
671ICDCNCI Integrated Canine Data Commons, 2021_01D
215ICHInternational
 
Conference on Harmonization,
2019
2021_
07E
01D
201 
215INC
International Neonatal
International Neonatal Consortium,
2019
2021_
07E
01D
156 
156JAX
Jackson Laboratories
Jackson Laboratories Mouse Terminology, adapted for NCI use,
2019
2021_
07E
01D
244 
244KEGGKEGG
Pathway Database, 2019_07E5077 
Pathway Database, 2021_01D
166401NCINational Cancer Institute Thesaurus, 2021_01D
5078NCI-GLOSSNCI Dictionary
of Cancer
of Cancer Terms,
2019
2021_
07E
01D
5001 
5392NCI-HGNCNCI HUGO Gene Nomenclature Committee,
2019
2021_
07E
01D
129 
129NCI-HL7NCI Health Level 7,
 2019
2021_
07E146328NCINational Cancer Institute Thesaurus, 2019_07E540 
01D
509NCPDPNational
Council for
Council for Prescription Drug Programs,
2019
2021_
07E
01D
5NDCNational Drug Code,
  2019
2021_
07E
01D
4782 
4782NICHDNational Institute
 
of Child Health and Human Development,
2019_07E39 
2021_01D
1200PCDCPediatric Cancer Data Commons, 2021_01D
39PI-RADSProstate Imaging
 
Reporting and Data System,
2019
2021_
07E
01D
169 
169PIDNational Cancer
 
Institute Nature Pathway Interaction Database,
2019
2021_
07E
01D
310 
310RENIRegistry
 
Nomenclature Information System
, 2019_07E1361 
, 2021_01D
296SeroNetSerological Sciences Network Terminology, 2022_01E
1456UCUMUnified Code for
 
Units of Measure
, 2019_07E 25
, 2021_01D
20WHOWorld Health Organization (WHO) Terminology, 2022_01E
25ZFINZebrafish Model
 
Organism Database,
2019
2021_
07E
01D

NCIm concepts

Source Label - Other

Source Name

15,870
15882AODAlcohol and Other Drug Thesaurus, 2000
278
276AOTAuthorized Osteopathic Thesaurus, 2003
13,255
13257CBOClinical Bioinformatics Ontology, 2011_02
1,104
CCS
541CCSR_ICD10CMClinical Classifications Software Refined for ICD-10-CM, 2021
356CCSR_ICD10PCSClinical Classifications Software
, 20053,073
Refined for ICD-10-PCS, 2021
962CDCRECRace & Ethnicity - CDC, 1.2
3078COSTARCOSTAR, 1989-1995
16,572
16494CSPCRISP Thesaurus, 2006
3,836
3843CSTCOSTART, 1995
345
318CTEPCancer Therapy Evaluation Program, 2004
7,278
529CVXVaccines Administered, 2017_02_08, 2020_07_28
9620DRUGBANKDrugBank, 5.0_2016_06_22, 5.0_2020_07_30
7289DXPDXplain, 1994
77,923
102562FMAFoundational Model of Anatomy Ontology,
2_054,439
4_15
7495GARDGenetic and Rare Diseases Information Center, 2015_04
71208GOGene Ontology,
2010
2020_
04
05_
01
02
5,602
7591HCPCSHealthcare Common Procedure Coding System,
20107,483
2020
42505HGNCHUGO Gene Nomenclature Committee, 2020_05
9061HL7V3.0HL7 Vocabulary Version 3.0,
2006
2019_
05
12
29,33511,532
17747

HUGO

HUGO Gene Nomenclature, 2010_05

HPOHuman Phenotype Ontology, 2020_06_08
17424ICD10ICD10,
1998
1,004

ICD10AE

ICD10, American English Equivalents, 1998

97,631
2016
103391ICD10CMInternational Classification of Diseases, 10th Edition, Clinical Modification,
2010_03181,116
2021
190986ICD10PCSICD-10-PCS,
2009
2021
20,779
20937ICD9CMInternational Classification of Diseases, Ninth Revision, Clinical Modification,
2011
2014
2,466
2874ICDOInternational Classification of
Diseases
Disease for Oncology,
3rd Edition, 2000
3_2
748ICPCInternational Classification of Primary Care, 1993
37,923

ICPC2ICD10ENG

ICPC2 - ICD10 Thesaurus, 200412

80,206

LNC

Logical Observation Identifier Names and Codes, 232
5055ISO3166-2International Organization for Standardization 3166-2, 2012
167298LNCLOINC, 268
41MCMMcMaster University Epidemiology Terms, 1992
331
332MDBCACMitelman Database of Chromosome Aberrations in Cancer, 2005_12
47,210
59238MDRMedical Dictionary for Regulatory Activities Terminology
, 14.01,897
(MedDRA), 23_1
3431MED-RTMedication Reference Terminology, 2020_09_08
2109MEDLINEPLUSMedlinePlus Health Topics,
20080614
20191029
900MGEDMGED Ontology, 131
310,485
449367MSHMedical Subject Headings,
2011
2021_
2010
2020_
08
07_
30
16
85,138
212203MTHUMLS Metathesaurus,
2010AB
2020AB
19,880
11
MTHFDA
MTHCMSFRFMetathesaurus
FDA National Drug Code Directory, 2010_08_02
337

MTHHH

Metathesaurus HCPCS Hierarchical Terms, 2010

16,081
CMS Formulary Reference File, MTHCMSFRF_2014
19009MTHICD9International Classification of Diseases, Ninth Revision, Clinical Modification, Metathesaurus additional entry terms,
2011
94

MTHICPC2ICD107B

ICPC2 - ICD10 Thesaurus, 7-bit Equivalents, 0412

76

MTHICPC2ICD10AE

ICPC2 - ICD10 Thesaurus, American English Equivalents, 0412

1,633
2014
1633MTHMSTMetathesaurus Version of Minimal Standard Terminology Digestive Endoscopy, 2001
12,969
69394MTHSPLMetathesaurus FDA Structured Product Labels,
2010
2020_08_
27478,187
28
84MVXManufacturers of Vaccines, 2020_09_04
1983453NCBINCBI Taxonomy,
2010
2020_
04
05_
29
21
135
7984NCIMTH

NCI Metathesaurus

38,863

NDFRT

National Drug File, 2010_09_07

1,781
NCIMTH
0NCISEERNCI SEER ICD Neoplasm Code Mappings, 1999
1887NPONPO: NanoParticle Ontology for Cancer Nanotechnology Research,
2010
2011_
10
12_
31
08
63,924
97276OMIMOnline Mendelian Inheritance in Man,
2010
2020_
04
07_
08
27
9,869
12398PDQPhysician Data Query,
2010
2016_
08
07_
06
31
2,041
2039PMAPortfolio Management Application, 2010
268
260PNDSPerioperative Nursing Data Set,
2nd edition, 2002
4_2018
940QMRQuick Medical Reference (QMR), 1996
30,033
45834RADLEXRadLex,
3
4_
33
1
227,498
198630RXNORMRxNorm Vocabulary,
10AA
20AA_
100907F
200908F
281,843
349474SNOMEDCT_US

SNOMED Clinical Terms

4,808
US Edition of SNOMED CT, 2020_09_01
167SOPSource of Payment Typology, 9
4810SPNStandard Product Nomenclature, 2003
156
222SRCMetathesaurus Source Terminology Names
13,788
28738UMDUMDNS: product category thesaurus,
20101,765
2020
4978USPUSP Compendial Nomenclature, 2020_02_06
1605USPMGUSP Medicare Model Guidelines,
2004
2020
61,191
61112UWDAUniversity of Washington Digital Anatomist, 1.7.3
26,546
35585VANDFVeterans Health Administration National Drug File,
2010
2020_
07_26
08_03

Overall Counts (May 2021)

ConceptsRelationships Attributes Total Number of Terms
3,894,448

25,315,538

 28,523,670 8,643,581