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MultiExcerptNameSharedTerminologyDevelopment

Since 1997, EVS has worked with many partners to build shared content and services, so that information can be effectively exchanged, interpreted and analyzed while minimizing overall effort and cost. Much of this content has been created and published using NCI Thesaurus and NCI Metathesaurus, as outlined in the following sections and described in more detail in the individual user profiles later, where other shared development efforts are also described.

Table of Contents
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NCI Thesaurus (NCIt)

NCI Thesaurus (NCIt) is NCI's core reference terminology. Over the last 16 years, it has also been adopted by FDA, CDISC, NCPDP and other partners as a shared standards development and coding environment, allowing participants to compare and harmonize with each other's content while taking advantage of full-text definitions, codes, and other features.

About 117,000 out of the 154,946 current NCIt concepts have terms from both EVS and from one or more of these other sources. The chart below gives a detailed breakdown of the main areas of overlapping tagged content. Note that some partners have used NCI terms rather than tagging their own, so these figures understate the true extent of cross-source sharing.

NCIt concepts with terms from tagged outside sources (1922.12e09d: December 2019September 2022)

Image RemovedImage Added

NCIt concepts with tagged synonyms from each outside source (1922.12e09d: December 2019September 2022)

3357463690ZFin

NCIt Concepts

Source

3BIOCARTAACC
1,149

BRIDG

1148BRIDG 3.0.3
1658BRIDG 5.3
28

CADSR

46CBDD
923

CDC

22,234

CDISC

716ACC/AHA
2016

BRIDG

408CareLex
56CBDD
268

CCPS

25456CDISC
787CDISC-GLOSS
2249Cellosaurus
3660CPTAC425
406CRCH772
8924CTCAE
5,599CTCAE 3.0
4,022CTCAE 5.0
373CTEP
2,114

CTRM

22,109CTRP
407CareLex
1,816Cellosaurus
903

DCP

114

DICOM

698

DTP

22,628

FDA

207GAIA
4,194GDC
281GENC
5,058HGNC
129

HL7

215

ICH

156

JAX

255

KEGG

154,946NCI
4

NCICB

5,158

NCI-GLOSS

509

NCPDP

4,785

NICHD

39PI-RADS
169

PID

312

RENI

63

SEER

1,546

UCUM

25
280CTDC
426CTEP
26579CTRP
636DIPG/DMG
1047EDQM-HC
27494FDA
239GAIA
5996GDC
127HL7
106ICD-10
663ICDC
216ICH
215INC
1281MedDRA
23NAACCR
243NCCN
510NCPDP
6NDC
4785NICHD
38ORCHESTRA
1862PCDC
40PI-RADS
377SEER
660SeroNet
284UCUM

NCI Metathesaurus (NCIm)

NCI Metathesaurus (NCIm) was started in the late 1990s to gather up, translate between, and publish the many terminologies used by NCI, including some created in part or whole within NCI. Development of NCI Thesaurus started within NCIm as NewPDQ, an effort to extend and restructure the PDQ Terminology long used to code cancer clinical trial, research and public information resources. NCIm continues to provide a vital environment for EVS collaboration with NCI and other partners to develop, map and publish terminologies of shared interest, and responds to the requirements of a broad range of stakeholders within the cancer research and biomedical community.

NCIt tagged content from outside sources is imported into NCIm with separate source tags. NCIt-derived sources are grouped separately below. The NCIm tags are mostly identical or very similar to those in NCIt; exceptions are CADSR, converted to NCI; HL7, converted to NCI-HL7; and CTRM, which is not imported.

NCIm sources and the number of concepts to which each contributes (201908202105:  August 2019May 2021)

1149    201907E20    201907E201 International Neonatal 201907E156 Jackson Laboratories 201907E244  Pathway Database, 2019_07E5077  of Cancer 201907E5001  201907E129  201907E Council for 201907E   201907E4782    , 2019_07E39    201907E169    201907E310    , 2019_07E1361    2019_07E 25   201907E

NCIm concepts

Source Label - NCIt-derived

Source Name

713ACC-AHAAmerican College of Cardiology/American Heart Association Clinical Data Terminology, 2021_01D
334BioCBioCarta online maps of molecular pathways, adapted for NCI use, 2021_01D
27BRIDGBiomedical Research Integrated Domain Group Model, 2021_01D
1148BRIDG_3_0_3Biomedical Research Integrated Domain Group Model, 3.0.3, 2021_01D
1658BRIDG_5_3Biomedical Research Integrated Domain Group Model, 5.3, 2021_01D334
17974

BioC

BioCarta online maps of molecular pathways, adapted for NCI use, 2019_07EcaDSRCancer Data Standards Registry and Repository, 2021_01D
407CARELEXContent Archive   Resource Exchange Lexicon, 20192021_07E01D40
53CBDDChemical Biology and Biology and Drug Development Vocabulary, 2019_07E2021_01D
265CCPSChildhood Cancer Predisposition Study, 2022_01E
923CDCU.S. Centers for   Disease Control and Prevention, 20192021_07E01D714
26120CDISC-GLOSSClinical Data   Interchange Standards Consortium Glossary Terms, 20192021_07E01D21313
788CDISC-GLOSSClinical Data   Interchange Standards Consortium , 2019_07E3657Glossary Terms, 2021_01D

2167

CELLOSAURUSCellosaurus, 2021_01D
3688CPTACClinical Proteomic   Tumor Analysis Consortium, 20192021_07E01D
406CRCHCancer Research   Center of Hawaii Nutrition Terminology, 2019_07E2021_01D
775CTCAECommon Terminology Criteria for Adverse Events, 2021_01D
5599CTCAE_3Common Terminology   Criteria for Adverse Events 3.0, 20192021_07E01D
4022CTCAE_5Common Terminology   Criteria for Adverse Events 5.0, 20192021_07E01D
770276CTCAECommon Terminology   Criteria for Adverse Events, 2019_07ECTDCClinical Trial Data Commons, 2021_01D
318CTEPCancer Therapy Evaluation Program, 2004
373CTEP-SDCCancer Therapy   Evaluation Program - Simple Disease Classification, 20192021_07E01D
2134325582CTRPClinical Trials   Reporting Program, 20192021_07E01D
903DCPNCI Division of   Cancer Prevention Program, 20192021_07E01D
114DICOMDigital Imaging   Communications in Medicine, 2019_07E, 2021_01D
627DIPG_DMGDiffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma Terminology, 2022_01E
694DTPNCI Developmental   Therapeutics Program, 20192021_07E01D
10091041EDQM-HCEuropean   Directorate for the Quality of Medicines & Healthcare, 20192021_07E01D
2185725994FDAU.S. Food and Drug   Administration, 20192021_07E01D
207GAIAGlobal Alignment of   Immunization Safety Assessment in pregnancy, 2019_07E2021_01D
5472GDCNCI Genomic Data Commons, 2021_01D
281GENCGeopolitical   Entities, Names, and Codes Standard, 2019_07E, 2021_01D
106ICD-10International Classification of Diseases, 10th Edition, 2022_01E
671ICDCNCI Integrated Canine Data Commons, 2021_01D
215ICHInternational   Conference on Harmonization, 20192021_07E01D
215INCInternational Neonatal Consortium, 2021_01D
156JAXJackson Laboratories Mouse Terminology, adapted for NCI use, 2021_01D
244KEGGKEGG Pathway Database, 2021_01D
166401NCINational Cancer Institute Thesaurus, 2021_01D
5078NCI-GLOSSNCI Dictionary of Cancer Terms, 2021_01D
5392NCI-HGNCNCI HUGO Gene Nomenclature Committee, 2021_01D
129NCI-HL7NCI Health Level 7, 2021_01D
146328NCINational Cancer Institute Thesaurus, 2019_07E
540 509NCPDPNational Council for Prescription Drug Programs, 2021_01D
5NDCNational Drug Code, 2021_01D
4782NICHDNational Institute of Child Health and Human Development, 2021_01D
1200PCDCPediatric Cancer Data Commons, 2021_01D
39PI-RADSProstate Imaging Reporting and Data System, 2021_01D
169PIDNational Cancer Institute Nature Pathway Interaction Database, 2021_01D
310RENIRegistry Nomenclature Information System, 2021_01D
296SeroNetSerological Sciences Network Terminology, 2022_01E
1456UCUMUnified Code for Units of Measure, 2021_01D
20WHOWorld Health Organization (WHO) Terminology, 2022_01E
25ZFINZebrafish Model Organism Database, 2021_01D
15,873102167373,575  MSH 2019201901_07 NCBI   20180419 5,749      1,693 Medicare Model   Guidelines, 2017 USP   201812_10

NCIm concepts

Source Label - Other

Source Name

15882AODAlcohol and Other Drug Thesaurus, 2000
276AOTAuthorized Osteopathic Thesaurus, 200313,255
13257CBOClinical Bioinformatics Ontology, 2011_02
622
CCS
541CCSR_ICD10CMClinical Classifications Software Refined for ICD-10-CM, 2021
356CCSR_ICD10PCSClinical Classifications Software , 20053,080Refined for ICD-10-PCS, 2021
962CDCRECRace & Ethnicity - CDC, 1.2
3078COSTARCOSTAR, 1989-199516,501
16494CSPCRISP Thesaurus, 20063,843
3843CSTCOSTART, 1995
318CTEPCancer Therapy Evaluation Program, 2004435
529CVXVaccines   Administered, 20182017_1002_1808, 20192020_0307_04287,711
9620DRUGBANKDrugBank,   5.0_2016_06_22, 5.0_20192020_0107_31307,293
7289DXPDXplain, 1994102,404
102562FMAFoundational Model   of Anatomy Ontology, 4_10157,503
7495GARDGenetic and Rare   Diseases Information Center, 2015_0470,289
71208GOGene Ontology,   20182020_05_20026,655
7591HCPCSHealthcare Common   Procedure Coding System, 2019202041,301
42505HGNCHUGO Gene   Nomenclature Committee, 20182020_03059,789
9061HL7V3.0HL7 Vocabulary   Version 3.0, 20182019_081215,301
17747HPOHuman Phenotype   Ontology, 20182020_1106_08
17424ICD10ICD10, 2016
103391ICD10CMInternational   Classification of Diseases, 10th Edition, Clinical Modification, 20192021
190,389190986ICD10PCSICD-10-PCS, 2019
17,425ICD10ICD10, 2016
20,9412021
20937ICD9CMInternational   Classification of Diseases, Ninth Revision, Clinical Modification, 20142,588
2874ICDOInternational   Classification of Disease for Oncology, 3_12
748ICPCInternational   Classification of Primary Care, 19935,057
5055ISO3166-2International   Organization for Standardization 3166-2, 2012146,331
167298LNCLOINC, 265268
41MCMMcMaster University   Epidemiology Terms, 1992
332MDBCACMitelman Database   of Chromosome Aberrations in Cancer, 2005_1256,014
59238MDRMedical Dictionary   for Regulatory Activities Terminology (MedDRA), 22.03,31523_1
3431MED-RTMedication   Reference Terminology, 20192020_0309_04082,119
2109MEDLINEPLUSMedlinePlus Health   Topics, 2018110820191029
900MGEDMGED Ontology, 131
449367MSHMedical Subject Headings, 2021_2020_907_16
212203MTHUMLS Metathesaurus, 2020AB
11MTHCMSFRFMetathesaurus CMS Formulary Reference File, MTHCMSFRF_2014
521

MTHHH

Metathesaurus HCPCS Hierarchical Terms, 2019

19,021
19009MTHICD9International Classification of Diseases, Ninth Revision, Clinical Modification, Metathesaurus additional entry terms, 20141,633
1633MTHMSTMetathesaurus Version of Minimal Standard Terminology Digestive Endoscopy, 2001
58,60069394MTHSPLMetathesaurus FDA Structured Product Labels, 20192020_0208_2228
194,860

MTH

UMLS Metathesaurus, 2019AA

7684MVXManufacturers of Vaccines, 20182020_0809_31 1,409,50104
1983453NCBINCBI Taxonomy, 2020_05_21
7984NCIMTHNCIMTH
0NCISEERNCI SEER ICD Neoplasm Code Mappings, 1999
NDFRT_FDASPLNational Drug File   - FDASPL, 2018_02_05
NDFRT_FMTSMENational Drug File   - FMTSME, 2018_02_05
39,434 NDFRTNational Drug File,   2018_02_05
1,887  NPO1887NPONPO: NanoParticle Ontology for Cancer Nanotechnology Research, 2011_12_08106,313
97276OMIMOnline Mendelian   Inheritance in Man, 20192020_0207_042712,399
12398PDQPhysician Data   Query, 2016_07_312,039
2039PMAPortfolio   Management Application, 2010
260PNDSPerioperative   Nursing Data Set, 4_2018
940QMRQuick Medical   Reference (QMR), 199645,733
45834RADLEXRadLex, 34_151201,450
198630RXNORMRxNorm Vocabulary,   18AB20AA_190304F200908F
347030349474SNOMEDCT_USUS Edition of   SNOMED CT, 20192020_0309_01162
167SOPSource of Payment   Typology, 894,810
4810SPNStandard Product   Nomenclature, 2003200
222SRCMetathesaurus   Source Terminology Names27,283
28738UMDUMDNS: product   category thesaurus, 20192020
4978 USPMGUSP 4,352USP Compendial Nomenclature, 2020_61,11202_06
1605USPMGUSP Medicare Model Guidelines, 2020
61112UWDAUniversity of   Washington Digital Anatomist, 1.7.334,194
35585VANDFVeterans Health   Administration National Drug File, 20192020_0208_0103

Overall Counts (August 2019May 2021)

ConceptsRelationships Attributes Total Number of Terms
3,265894,686448

2225,852315,144538

 25 28,184523,657670 7 8,508643,907581