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Some

significant

examples

of

collaborations

and

use

of

EVS

resources

and

services

are

briefly

outlined

in

this

section

covering

NCI,

and

in

later

sections

covering

NIH,

government

and

standards

organizations,

and

other

organizations

in

the

cancer

research

and

biomedical

community.

This

NCI

section

includes

the

following

NCI profiles:

{

Table of Contents

:

minLevel

=2} h2. NCI Division of Cancer Biology

2

NCI Division of Cancer Biology (DCB)

EVS

has

supported

DCB

research

on

mouse

and

other

animal

models

of

cancer

for

more

than

10

years.

EVS

has

helped

develop

and

maintain

accurate

coding

and

classification

terminology

for

animal

models,

and

has

worked

with

NCI

and

community

partners

to

develop

accurate

mappings

between

terminologies

currently

in

use.

Key

NCI

components

of

this

effort

are

described

here,

while

community

partners

are

described

later

[EVS:

14

-

User

Profiles

-

Broader

Community

]

.

*

Mouse

Models

of

Human

Cancer

Consortium

(MMHCC)

*

was

established

by

NCI

in

1999

to

accelerate

the

development

and

validation

of

mouse

models

by

the

scientific

community.

When

the

MMHCC

was

initiated,

one

of

the

early

projects

was

to

create

a

repository

of

curated

information

about

animal

models

that

have

been

employed

in

cancer

studies,

called

the

*Cancer

Cancer Models

Database

*

(now

*

caMOD

*

).

EVS

staff

participated

in

developing

the

classifications

of

mouse

diagnoses

used

for

annotating

the

mouse

models,

and

provided

support

for

additional

terminology

such

as

strains

and

anatomy.

All

of

this

terminology

has

been

incorporated

into

NCI

Thesaurus

(NCIt),

used

by

caMOD

and

other

users

through

both

browser

and

programming

interfaces.

caMOD

caMOD annotates

information

with

NCIt

terminology,

and

uses

the

LexEVS

API

directly

to

generate

anatomy

and

diagnosis

tree

hierarchies.

400

concepts

were

added

or

updated

for

caMOD

in

the

last-recorded

six

month

period.

EVS

has

supported

periodic

updates

to

this

animal

model

terminology,

and

has

extended

terminology

support

to

cover

rats

and

zebrafish,

using

existing

community

standards

where

available:

* *

  • International
  • Harmonization
  • of
  • Rat
  • Nomenclature
  • (RENI)
*
  • was
  • used
  • as
  • the
  • foundation
  • for
  • the
  • Terminology
  • of
  • Rat
  • Pathologic
  • Diagnoses
  • in
  • NCI
  • Thesaurus
  • (NCIt).
* *
  • Zebrafish
  • Information
  • Network
  • (ZFIN)
*
  • zebrafish
  • anatomy
  • is
  • provided
  • as
  • a
  • standalone
  • terminology
  • in
  • EVS
  • systems
  • including
  • the
[ |http://nciterms.nci.nih.gov/ncitbrowser/pages/vocabulary.jsf?dictionary=Zebrafish]. MMHCC has merged with the *Mouse Repository at Frederick National Research Laboratories*, which provides mouse cancer models and associated strains, live and cryopreserved. Additional future support for updating the diagnosis terminology to reflect new models is anticipated. For more information, visit the NCI *eMICE* website: [http://emice.nci.nih.gov/]. +EVS Related References+ # Bodenreider O, Hayamizu TF, Ringwald M, De Coronado S, Zhang S. *Of mice and men: aligning mouse and human anatomies.* ??AMIA Annu Symp Proc.??
  • .

MMHCC has merged with the Mouse Repository at Frederick National Research Laboratories, which provides mouse cancer models and associated strains, live and cryopreserved. Additional future support for updating the diagnosis terminology to reflect new models is anticipated.

For more information, visit the NCI eMICE website.

EVS Related References

  1. Bodenreider O, Hayamizu TF, Ringwald M, De Coronado S, Zhang S.
    Of mice and men: aligning mouse and human anatomies.
    AMIA Annu Symp Proc. 2005:61-5.
  1. PubMed
  1. PMID:
  1. 16779002;
  1. PubMed
  1. Central
  1. PMCID:
  1. PMC1560846.
\[
  1. [PubMed
|http://www.ncbi.nlm.nih.gov/pubmed/16779002]\] # Hayamizu TF, de Coronado S, Fragoso G, Sioutos N, Kadin JA, Ringwald M. *The mouse-human anatomy ontology mapping project.* ??Database (Oxford)??. 2012 Mar
  1. ]
  2. Hayamizu TF, de Coronado S, Fragoso G, Sioutos N, Kadin JA, Ringwald M.
    The mouse-human anatomy ontology mapping project.
    Database (Oxford). 2012 Mar 20;2012:bar066.
  1. Print
  1. 2012.
  1. PubMed
  1. PMID:
  1. 22434834.
\[
  1. [PubMed
|http://www.ncbi.nlm.nih.gov/pubmed/22434834]\
  1. ]
\[
  1. [Full
  1. Text
|http://database.oxfordjournals.org/content/2012/bar066.full]\] # Kogan SC, Ward JM, Anver MR, Berman JJ, Brayton C, Cardiff RD, Carter JS, de Coronado S, Downing JR, Fredrickson TN, Haines DC, Harris AW, Harris NL, Hiai H, Jaffe ES, MacLennan IC, Pandolfi PP, Pattengale PK, Perkins AS, Simpson RM, Tuttle MS, Wong JF, Morse HC 3rd; Hematopathology subcommittee of the Mouse Models of Human Cancers Consortium. *Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice.* ??Blood??. 2002 Jul
  1. ]
  2. Kogan SC, Ward JM, Anver MR, Berman JJ, Brayton C, Cardiff RD, Carter JS, de Coronado S, Downing JR, Fredrickson TN, Haines DC, Harris AW, Harris NL, Hiai H, Jaffe ES, MacLennan IC, Pandolfi PP, Pattengale PK, Perkins AS, Simpson RM, Tuttle MS, Wong JF, Morse HC 3rd; Hematopathology subcommittee of the Mouse Models of Human Cancers Consortium.
    Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice.
    Blood. 2002 Jul 1;100(1):238-45.
  1. PubMed
  1. PMID:
  1. 12070033.
\[
  1. [PubMed
|http://www.ncbi.nlm.nih.gov/pubmed/12070033]\] h2. NCI Division of Cancer Control and Population Sciences (DCCPS) DCCPS collaboration includes several terminology projects related to cancer classification, drugs, chemotherapy regimens, and statistics. DCCPS is currently launching a new initiative on standardized terminology for population health data collection. *Portfolio Management Application
  1. ]

NCI Division of Cancer Control and Population Sciences (DCCPS)

DCCPS collaboration includes several terminology projects related to cancer classification, drugs, chemotherapy regimens, and statistics. DCCPS is currently launching a new initiative on standardized terminology for population health data collection.

Portfolio Management Application (PMA-DCCPS)

*

:

EVS

has

worked

with

DCCPS

for

a

number

of

years

to

integrate

PMA-DCCPS

grant

coding

terminology

with

other

EVS

resources.

NCIt

now

includes

more

than

1,500

concepts

for

PMA

grant

coding.

PMA

terms

are

also

inserted

and

appear

in

the

NCI

Metathesaurus

as

a

separate

terminology.

h2.

NCI

Division

of

Cancer

Prevention

(DCP)

DCP

has

used

EVS,

and

worked

consistently

with

EVS,

since

2002,

including

the

following

collaborations

and

uses:

*

  • Use
  • of
  • NCIt
  • agent
  • information
  • in
  • DCP
  • systems.
*
  • Joint
  • work
  • on
  • improved
  • coverage
  • of
  • nutritional
  • and
  • other
  • preventive
  • agents.
*
  • Joint
  • work
  • in
  • wider
  • working
  • groups
  • and
  • other
  • initiatives
  • to
  • harmonize
  • broader
  • NCI
  • agent
  • and adverse event coding
  • practices.
h2. NCI DCP and DCTD EVS staff provides terminology support for the Community Clinical Oncology Program (CCOP), including concepts for use in coding four (4) major clinical trials involving 85,000 patients. An estimated total of 500 studies use NCI Thesaurus terminology. h2. NCI Division of Cancer Treatment and Diagnosis (DCTD) h3. Cancer Therapy Evaluation Program (CTEP) The Cancer Therapy Evaluation Program (CTEP) has had many and sustained collaborations with EVS from 1999 onwards, including: * Use of NCI Thesaurus (NCIt) terminology for protocol abstraction. * Harmonization and use of NCIt drug and molecular target information in CTEP systems. * Harmonization and integration of CTEP disease classification with NCIt, PDQ and MedDRA, involving several detailed comparative mappings and analyses as well as concept based mappings in the NCI Metathesaurus (NCIm). * Joint development, together with other partners, of the redesigned Common Terminology Criteria for Adverse Events (CTCAE) v.4, which has been widely adopted since its release in 2010 (see the detailed description below). h3. Common Terminology Criteria for Adverse Events (CTCAE) CTCAE, created by CTEP in 1983, is used throughout the entire oncology community as the standard classification and severity grading scale for adverse events in cancer therapy clinical trials and other oncology settings. It is also used in a number of non-oncology trials and settings. Version 4, released in May 2009, is a major update based on extensive international participation by stakeholders and experts. It is harmonized with MedDRA at the Adverse Event (AE) level, includes revised AE terms and severity indicators to reflect clinical effects identified with current oncology interventions, and was selected as a caBIG® vocabulary standard. This version is used by more than 50 academic and research organizations, as well as many commercial and non-profit organizations. Five different Apple applications utilize the NCI Thesaurus version of the CTCAE data, and cite NCIt as the source. CTCAE is designed to integrate into information networks for safety data exchange, and plays a major role in data management for AE data collection, analysis, and patient outcomes associated with cancer research and care. EVS played a central role in designing and managing this effort, working closely with CTEP, DCP, caBIG®, the FDA, and many participants from the broader community. The revision was developed and deployed using various EVS tools including the BiomedGT Wiki, Protégé editing tools, LexEVS terminology server, NCI Term Browser, and the [EVS ftp site http://evs.nci.nih.gov/ftp1/CTCAE/About.html|http://evs.nci.nih.gov/ftp1/CTCAE/About.html] . h3. Cancer Diagnosis Program (CDP) - Diagnostics Evaluation Branch * EVS is supporting gene nomenclature used in a new CDP Biomarker project, including updating Human Genome Organisation (HUGO) Gene Nomenclature Committee (HGNC) terminology in the EVS servers so it is accessible to CDP curators. See [HGNC on NCI Term Browser|http://nciterms.nci.nih.gov/ncitbrowser/pages/vocabulary.jsf?dictionary=HGNC]. * In an extension to this project, EVS will be creating gene and protein sequence variations in the NCIt, according to HGVS guidelines, for genes/proteins of therapeutic interest as requested by CDP. The initial request is 150 genes (in progress), with about 180 protein variants, 300 gene variants, 300 fusion genes, and 300 fusion proteins. * This work is to support creation of an application to retrieve content from the NIH Clinical Trial Database into the NCI Clinical Trials Reporting Program (CTRP), and is being done jointly with DCTD, NCI/OCE, NCI/CCR and NIH/NLM. +EVS Related References+ # Cimino JJ, Hayamizu TF, Bodenreider O, Davis B, Stafford GA, Ringwald M. *The caBIG terminology review process.* ??J Biomed Inform.?? 2009

EVS Related References

  1. Kaefer CM, Milner JA.
    The role of herbs and spices in cancer prevention.
    J Nutr Biochem. 2008 Jun;19(6):347-61. Review. PubMed PMID: 18499033; PubMed Central PMCID: PMC2771684. [PubMed] [PubMed Central]

NCI DCP and DCTD

EVS staff provides terminology support for the Community Clinical Oncology Program (CCOP), including concepts for use in coding four (4) major clinical trials involving 85,000 patients. An estimated total of 500 studies use NCI Thesaurus terminology.

NCI Division of Cancer Treatment and Diagnosis (DCTD)

Cancer Therapy Evaluation Program (CTEP)

The Cancer Therapy Evaluation Program (CTEP) has had many and sustained collaborations with EVS from 1999 onwards, including:

  • Use of NCI Thesaurus (NCIt) terminology for protocol abstraction.
  • Harmonization and use of NCIt drug and molecular target information in CTEP systems.
  • Harmonization and integration of CTEP disease classification with NCIt, PDQ and MedDRA, involving several detailed comparative mappings and analyses as well as concept based mappings in the NCI Metathesaurus (NCIm).
  • Joint development, together with other partners, of the redesigned Common Terminology Criteria for Adverse Events (CTCAE) v.4, which has been widely adopted since its release in 2010 (see the detailed description below).

Common Terminology Criteria for Adverse Events (CTCAE)

CTCAE, created by CTEP in 1983, is used throughout the entire oncology community as the standard classification and severity grading scale for adverse events in cancer therapy clinical trials and other oncology settings. It is also used in a number of non-oncology trials and settings.

Version 4, released in May 2009, is a major update based on extensive international participation by stakeholders and experts. It is harmonized with MedDRA at the Adverse Event (AE) level, includes revised AE terms and severity indicators to reflect clinical effects identified with current oncology interventions, and was selected as a caBIG® vocabulary standard. This version is used by more than 50 academic and research organizations, as well as many commercial and non-profit organizations. Five different Apple applications utilize the NCI Thesaurus version of the CTCAE data, and cite NCIt as the source.

CTCAE is designed to integrate into information networks for safety data exchange, and plays a major role in data management for AE data collection, analysis, and patient outcomes associated with cancer research and care. EVS played a central role in designing and managing this effort, working closely with CTEP, DCP, caBIG®, the FDA, and many participants from the broader community. The revision was developed and deployed using various EVS tools including the BiomedGT Wiki, Protégé editing tools, LexEVS terminology server, NCI Term Browser, and the EVS ftp site .

Cancer Diagnosis Program (CDP) - Diagnostics Evaluation Branch

  • EVS is supporting gene nomenclature used in a new CDP Biomarker project, including updating Human Genome Organisation (HUGO) Gene Nomenclature Committee (HGNC) terminology in the EVS servers so it is accessible to CDP curators. See HGNC on NCI Term Browser.
  • In an extension to this project, EVS will be creating gene and protein sequence variations in the NCIt, according to HGVS guidelines, for genes/proteins of therapeutic interest as requested by CDP. The initial request is 150 genes (in progress), with about 180 protein variants, 300 gene variants, 300 fusion genes, and 300 fusion proteins.
  • This work is to support creation of an application to retrieve content from the NIH Clinical Trial Database into the NCI Clinical Trials Reporting Program (CTRP), and is being done jointly with DCTD, NCI/OCPL, NCI/CCR and NIH/NLM.

EVS Related References

  1. Chen AP, Setser A, Anadkat MJ, Cotliar J, Olsen EA, Garden BC, Lacouture ME.
    Grading dermatologic adverse events of cancer treatments: the Common Terminology Criteria for Adverse Events Version 4.0.
    J Am Acad Dermatol. 2012 Nov;67(5):1025-39. doi: 10.1016/j.jaad.2012.02.010. Epub 2012 Apr 11. PubMed PMID: 22502948. [PubMed]
  2. Cimino JJ, Hayamizu TF, Bodenreider O, Davis B, Stafford GA, Ringwald M.
    The caBIG terminology review process.
    J Biomed Inform. 2009 Jun;42(3):571-80.
  1. Epub
  1. 2008
  1. Dec
  1. 25.
  1. PubMed
  1. PMID:
  1. 19154797;
  1. PubMed
  1. Central
  1. PMCID:
  1. PMC2729758.
\[
  1. [PubMed
|http://www.ncbi.nlm.nih.gov/pubmed/19154797]\] h2. NCI Division of Extramural Activities (DEA) DEA is supported by EVS, which helps collect, develop and map grant-related terminology, including representing NCI in the NIH Research, Condition and Disease Categorization (RCDC) effort. h2. NCI Office of Communications and Education (OCE) OCE co-managed EVS with CBIIT until late 2007, and has continued as an important partner since that time. Some key areas of ongoing collaboration are: * *PDQ Terminology* has been used for decades to code cancer clinical trials and other NCI scientific and public information resources, including NCI's [Clinical Trials Reporting Program (CTRP)|http://www.cancer.gov/clinicaltrials/conducting/ncictrp/main] initiative. EVS has used PDQ terminology as a core component of its NCI Thesaurus (NCIt) reference terminology, and has worked to harmonize with and add to PDQ terminology even as NCIt was extended in many ways not required for PDQ itself. EVS took over and carries on efforts to harmonize and cross-link both PDQ terminology and NCIt with other NCI coding terminologies including CTEP disease and adverse event terminologies, NCI Developmental Therapeutics Program drug terms, and terminology from DCCCPS and DCP. EVS continues to work with OCE on strengthening PDQ terminology as a coding and information retrieval resource. See [PDQ on NCI Term Browser|http://nciterms.nci.nih.gov/ncitbrowser/pages/vocabulary.jsf?dictionary=PDQ] and the [PDQ to NCIt Mapping|http://ncit.nci.nih.gov/ncitbrowser/pages/vocabulary.jsf?dictionary=PDQ2010_08_06_TO_NCI2011_12E]. * [*NCI Drug Dictionary*|http://www.cancer.gov/drugdictionary] provides technical definitions, alternate names, and links to related information for more than 3,000 agents that are being used in the treatment of patients with cancer or cancer-related conditions. Each entry includes a link to a more detailed entry in NCIt, which provides the information presented, as well as links to lists of open and closed cancer clinical trials on NCI's Web site, Cancer.gov. Each month, the NCI Drug Dictionary is used by over 30,000 unique visitors who view more than 65,000 pages. * [*Cancer.gov Database of Cancer Clinical Trials*|http://www.cancer.gov/clinicaltrials/search] is updated daily and covers over 11,000 clinical trials now accepting participants, plus more than 25,000 others that are no longer recruiting. NCIt drug terminology is used to index PDQ trials, and EVS has contributed to the development of PDQ Terminology used to code cancers and related conditions, procedures, and chemotherapy regimens. * [*NCI Dictionary of Cancer Terms*|http://www.cancer.gov/dictionary] defines more than 7,000 cancer and biomedical terms in non-technical language. Terms and definitions are reviewed by a multidisciplinary panel of reviewers, and approximately 50 new and 50 revised terms are included each month. The dictionary is available as a stand-alone resource on every Cancer.gov Web page, and is widely used by other institutions and Web sites. Its contents are integrated into both NCI Thesaurus and NCI Metathesaurus, providing an important resource especially for non-technical users. +EVS Related References+ # De Coronado S, Haber MW, Sioutos N, Tuttle MS, Wright LW. *NCI Thesaurus: Using Science-Based Terminology to Integrate Cancer Research Results.* ??Proceedings of the 11th World Congress on Medical Informatics (Medinfo 2004)?? Amsterdam: IOS Press 2004, pp. 33-37. Also cited as: ??Stud Health Technol Inform.?? 2004;107(Pt 1):33-7. \[[PubMed|http://www.ncbi.nlm.nih.gov/pubmed/15360769]\] # Hubbard SL. *Information systems in oncology.* ??Cancer: Principles & Practice of Oncology, 6th ed.?? Devita VT, Hellman S, Rosenberg SA, eds. Philadelphia: Lippincott Williams & Wilkins; 2001. pp. 3135–46. # Hubbard SM, Setser A. *The Cancer Informatics Infrastructure: a new initiative of the National Cancer Institute.* ??Semin Oncol Nurs.?? 2001
  1. ]

NCI Division of Extramural Activities (DEA)

DEA is supported by EVS, which helps collect, develop and map grant-related terminology, including representing NCI in the NIH Research, Condition and Disease Categorization (RCDC) effort.

NCI Office of Communications and Public Liaison (OCPL)

OCPL co-managed EVS with CBIIT until late 2007, and has continued as an important partner since that time. Some key areas of ongoing collaboration are:

  • PDQ Terminology has been used for decades to code cancer clinical trials and other NCI scientific and public information resources, including NCI's Clinical Trials Reporting Program (CTRP) initiative. EVS has used PDQ terminology as a core component of its NCI Thesaurus (NCIt) reference terminology, and has worked to harmonize with and add to PDQ terminology even as NCIt was extended in many ways not required for PDQ itself. EVS took over and carries on efforts to harmonize and cross-link both PDQ terminology and NCIt with other NCI coding terminologies including CTEP disease and adverse event terminologies, NCI Developmental Therapeutics Program drug terms, and terminology from DCCPS and DCP. EVS continues to work with OCPL on strengthening PDQ terminology as a coding and information retrieval resource. See PDQ on NCI Term Browser and the PDQ to NCIt Mapping.
  • NCI Drug Dictionary provides technical definitions, alternate names, and links to related information for more than 3,000 agents that are being used in the treatment of patients with cancer or cancer-related conditions. Each entry includes a link to a more detailed entry in NCIt, which provides the information presented, as well as links to lists of open and closed cancer clinical trials on NCI's Web site, Cancer.gov. Each month, the NCI Drug Dictionary is used by over 30,000 unique visitors who view more than 65,000 pages.
  • Cancer.gov Database of Cancer Clinical Trials is updated daily and covers over 11,000 clinical trials now accepting participants, plus more than 25,000 others that are no longer recruiting. NCIt drug terminology is used to index PDQ trials, and EVS has contributed to the development of PDQ Terminology used to code cancers and related conditions, procedures, and chemotherapy regimens.
  • NCI Dictionary of Cancer Terms defines more than 7,000 cancer and biomedical terms in non-technical language. Terms and definitions are reviewed by a multidisciplinary panel of reviewers, and approximately 50 new and 50 revised terms are included each month. The dictionary is available as a stand-alone resource on every Cancer.gov Web page, and is widely used by other institutions and Web sites. Its contents are integrated into both NCI Thesaurus and NCI Metathesaurus, providing an important resource especially for non-technical users.

EVS Related References

  1. De Coronado S, Haber MW, Sioutos N, Tuttle MS, Wright LW.
    NCI Thesaurus: Using Science-Based Terminology to Integrate Cancer Research Results.
    Proceedings of the 11th World Congress on Medical Informatics (Medinfo 2004) Amsterdam: IOS Press 2004, pp. 33-37. Also cited as: Stud Health Technol Inform. 2004;107(Pt 1):33-7. [PubMed]
  2. Hubbard SL.
    Information systems in oncology.
    Cancer: Principles & Practice of Oncology, 6th ed. Devita VT, Hellman S, Rosenberg SA, eds. Philadelphia: Lippincott Williams & Wilkins; 2001. pp. 3135–46.
  3. Hubbard SM, Setser A.
    The Cancer Informatics Infrastructure: a new initiative of the National Cancer Institute.
    Semin Oncol Nurs. 2001 Feb;17(1):55-61.
  1. Review.
  1. PubMed
  1. PMID:
  1. 11236366.
\[
  1. [PubMed
|http://www.ncbi.nlm.nih.gov/pubmed/11236366]\
  1. ]
\[
  1. [Full
  1. Text
|http://www.sciencedirect.com/science/article/pii/S0749208101800322]\] # Sioutos N, De Coronado S, Haber MW, Hartel FW, Shaiu WL, Wright LW. *NCI Thesaurus: A Semantic Model Integrating Cancer-Related Clinical and Molecular Information.* ??Journal of Biomedical Informatics?? 2007
  1. ]
  2. Sioutos N, De Coronado S, Haber MW, Hartel FW, Shaiu WL, Wright LW.
    NCI Thesaurus: A Semantic Model Integrating Cancer-Related Clinical and Molecular Information.
    Journal of Biomedical Informatics 2007 Feb;40(1):30
-43. Epub 2006 Mar 15. \[[PubMed|http://www.ncbi.nlm.nih.gov/pubmed/16697710]\] h2. Other NCI *Cooperative Human Tissue Bank (CHTB)*:  EVS has supported terminology creation and editing for this network of research institutions, established by the NCI Cancer Diagnosis Program in 1987 and now including six divisions located at Vanderbilt, U. Penn, UAB School of Medicine, Nationwide Children's Hospital, Ohio State, University of Virginia. CHTB hosts NCI funded tissue facilities and services providing remnant human tissue and fluids from routine procedures to investigators. There is active use by 14 academic and research organizations and eight (8) commercial organizations. EVS staff assisted with matching up terminology used by these groups to NCIt terminology, creating new NCIt concepts and definitions as needed. *Cancer Central Clinical Database (C3D)*: EVS provides support for C3D, largely through providing the new and updated terminology and definitions for case report forms. C3D currently supports electronic submission of clinical trials data to the NCI Clinical Data System (CDS) and the Clinical Trials Monitoring Service (CTMS/Theradex). *OPEN (Oncology Patient Enrollment Network)*: This web-based registration system for patient enrollments onto NCI-sponsored Cooperative Group clinical trials is a highly active project; most terminology supplied for this is standard demographic terminology.{multi-excerpt}
Wiki Markup
{scrollbar:icons=false}
  1. -43. Epub 2006 Mar 15. [PubMed]

Other NCI User Profiles

Cooperative Human Tissue Bank (CHTB):  EVS has supported terminology creation and editing for this network of research institutions, established by the NCI Cancer Diagnosis Program in 1987 and now including six divisions located at Vanderbilt, U. Penn, UAB School of Medicine, Nationwide Children's Hospital, Ohio State, University of Virginia. CHTB hosts NCI funded tissue facilities and services providing remnant human tissue and fluids from routine procedures to investigators. There is active use by 14 academic and research organizations and eight (8) commercial organizations. EVS staff assisted with matching up terminology used by these groups to NCIt terminology, creating new NCIt concepts and definitions as needed.

Cancer Central Clinical Database (C3D): EVS provides support for C3D, largely through providing the new and updated terminology and definitions for case report forms. C3D currently supports electronic submission of clinical trials data to the NCI Clinical Data System (CDS) and the Clinical Trials Monitoring Service (CTMS/Theradex).

OPEN (Oncology Patient Enrollment Network): This web-based registration system for patient enrollments onto NCI-sponsored Cooperative Group clinical trials is a highly active project; most terminology supplied for this is standard demographic terminology.