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Some |
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significant |
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examples |
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of |
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collaborations |
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and |
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use |
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of |
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EVS |
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resources |
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and |
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services |
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are |
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briefly |
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outlined |
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in |
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this |
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section |
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covering |
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NCI, |
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and |
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in |
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later |
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sections |
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covering |
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NIH, |
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government |
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and |
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standards |
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organizations, |
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and |
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other |
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organizations |
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in |
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the |
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cancer |
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research |
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and |
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biomedical |
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community. |
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section |
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includes |
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the |
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following |
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NCI profiles: |
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NCI Division of Cancer Biology (DCB) |
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EVS |
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has |
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supported |
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DCB |
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research |
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on |
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mouse |
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and |
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other |
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animal |
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models |
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of |
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cancer |
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for |
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more |
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than |
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10 |
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years. |
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EVS |
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has |
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helped |
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develop |
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and |
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maintain |
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accurate |
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coding |
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and |
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classification |
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terminology |
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for |
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animal |
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models, |
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and |
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has |
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worked |
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with |
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NCI |
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and |
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community |
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partners |
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to |
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develop |
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accurate |
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mappings |
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between |
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terminologies |
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currently |
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in |
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use. |
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Key |
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NCI |
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components |
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of |
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this |
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effort |
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are |
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described |
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here, |
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while |
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community |
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partners |
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are |
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described |
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later |
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. |
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Mouse |
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Models |
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of |
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Human |
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Cancer |
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Consortium |
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(MMHCC) |
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was |
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established |
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by |
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NCI |
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in |
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1999 |
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to |
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accelerate |
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the |
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development |
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and |
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validation |
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of |
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mouse |
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models |
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by |
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the |
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scientific |
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community. |
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When |
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the |
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MMHCC |
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was |
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initiated, |
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one |
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of |
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the |
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early |
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projects |
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was |
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to |
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create |
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a |
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repository |
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of |
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curated |
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information |
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about |
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animal |
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models |
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that |
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have |
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been |
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employed |
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in |
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cancer |
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studies, |
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called |
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the |
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Cancer Models |
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Database |
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(now |
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caMOD |
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). |
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EVS |
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staff |
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participated |
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in |
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developing |
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the |
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classifications |
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of |
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mouse |
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diagnoses |
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used |
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for |
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annotating |
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the |
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mouse |
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models, |
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and |
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provided |
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support |
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for |
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additional |
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terminology |
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such |
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as |
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strains |
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and |
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anatomy. |
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All |
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of |
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this |
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terminology |
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has |
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been |
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incorporated |
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into |
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NCI |
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Thesaurus |
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(NCIt), |
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used |
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by |
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caMOD |
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and |
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other |
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users |
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through |
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both |
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browser |
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and |
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programming |
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interfaces. |
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caMOD annotates |
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information |
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with |
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NCIt |
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terminology, |
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and |
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uses |
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the |
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LexEVS |
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API |
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directly |
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to |
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generate |
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anatomy |
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and |
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diagnosis |
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tree |
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hierarchies. |
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400 |
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concepts |
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were |
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added |
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or |
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updated |
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for |
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caMOD |
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in |
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the |
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last-recorded |
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six |
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month |
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period. |
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EVS |
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has |
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supported |
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periodic |
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updates |
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to |
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this |
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animal |
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model |
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terminology, |
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and |
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has |
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extended |
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terminology |
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support |
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to |
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cover |
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rats |
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and |
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zebrafish, |
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using |
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existing |
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community |
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standards |
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where |
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available: |
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MMHCC has merged with the Mouse Repository at Frederick National Research Laboratories, which provides mouse cancer models and associated strains, live and cryopreserved. Additional future support for updating the diagnosis terminology to reflect new models is anticipated. For more information, visit the NCI eMICE website. EVS Related References
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NCI Division of Cancer Control and Population Sciences (DCCPS)DCCPS collaboration includes several terminology projects related to cancer classification, drugs, chemotherapy regimens, and statistics. DCCPS is currently launching a new initiative on standardized terminology for population health data collection. Portfolio Management Application (PMA-DCCPS) |
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: |
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EVS |
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has |
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worked |
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with |
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DCCPS |
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for |
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a |
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number |
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of |
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years |
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to |
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integrate |
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PMA-DCCPS |
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grant |
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coding |
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terminology |
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with |
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other |
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EVS |
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resources. |
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NCIt |
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now |
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includes |
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more |
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than |
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1,500 |
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concepts |
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for |
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PMA |
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grant |
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coding. |
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PMA |
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terms |
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are |
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also |
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inserted |
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and |
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appear |
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in |
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the |
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NCI |
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Metathesaurus |
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as |
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a |
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separate |
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terminology. |
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NCI |
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Division |
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of |
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Cancer |
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Prevention |
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(DCP) |
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DCP |
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has |
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used |
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EVS, |
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and |
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worked |
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consistently |
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with |
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EVS, |
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since |
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2002, |
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including |
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the |
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following |
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collaborations |
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and |
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uses: |
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EVS Related References
NCI DCP and DCTDEVS staff provides terminology support for the Community Clinical Oncology Program (CCOP), including concepts for use in coding four (4) major clinical trials involving 85,000 patients. An estimated total of 500 studies use NCI Thesaurus terminology. NCI Division of Cancer Treatment and Diagnosis (DCTD)Cancer Therapy Evaluation Program (CTEP)The Cancer Therapy Evaluation Program (CTEP) has had many and sustained collaborations with EVS from 1999 onwards, including:
Common Terminology Criteria for Adverse Events (CTCAE)CTCAE, created by CTEP in 1983, is used throughout the entire oncology community as the standard classification and severity grading scale for adverse events in cancer therapy clinical trials and other oncology settings. It is also used in a number of non-oncology trials and settings. Version 4, released in May 2009, is a major update based on extensive international participation by stakeholders and experts. It is harmonized with MedDRA at the Adverse Event (AE) level, includes revised AE terms and severity indicators to reflect clinical effects identified with current oncology interventions, and was selected as a caBIG® vocabulary standard. This version is used by more than 50 academic and research organizations, as well as many commercial and non-profit organizations. Five different Apple applications utilize the NCI Thesaurus version of the CTCAE data, and cite NCIt as the source. CTCAE is designed to integrate into information networks for safety data exchange, and plays a major role in data management for AE data collection, analysis, and patient outcomes associated with cancer research and care. EVS played a central role in designing and managing this effort, working closely with CTEP, DCP, caBIG®, the FDA, and many participants from the broader community. The revision was developed and deployed using various EVS tools including the BiomedGT Wiki, Protégé editing tools, LexEVS terminology server, NCI Term Browser, and the EVS ftp site . Cancer Diagnosis Program (CDP) - Diagnostics Evaluation Branch
EVS Related References
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NCI Division of Extramural Activities (DEA)DEA is supported by EVS, which helps collect, develop and map grant-related terminology, including representing NCI in the NIH Research, Condition and Disease Categorization (RCDC) effort. NCI Office of Communications and Public Liaison (OCPL)OCPL co-managed EVS with CBIIT until late 2007, and has continued as an important partner since that time. Some key areas of ongoing collaboration are:
EVS Related References
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Other NCI User ProfilesCooperative Human Tissue Bank (CHTB): EVS has supported terminology creation and editing for this network of research institutions, established by the NCI Cancer Diagnosis Program in 1987 and now including six divisions located at Vanderbilt, U. Penn, UAB School of Medicine, Nationwide Children's Hospital, Ohio State, University of Virginia. CHTB hosts NCI funded tissue facilities and services providing remnant human tissue and fluids from routine procedures to investigators. There is active use by 14 academic and research organizations and eight (8) commercial organizations. EVS staff assisted with matching up terminology used by these groups to NCIt terminology, creating new NCIt concepts and definitions as needed. Cancer Central Clinical Database (C3D): EVS provides support for C3D, largely through providing the new and updated terminology and definitions for case report forms. C3D currently supports electronic submission of clinical trials data to the NCI Clinical Data System (CDS) and the Clinical Trials Monitoring Service (CTMS/Theradex). OPEN (Oncology Patient Enrollment Network): This web-based registration system for patient enrollments onto NCI-sponsored Cooperative Group clinical trials is a highly active project; most terminology supplied for this is standard demographic terminology. |
