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The Study File will vary depending on whether the study performed is a physico-chemical characterization, in vitro characterization, or in vivo characterization.   Provided below are The following sections provide examples of Study Files for created from studies performed by the Nanotechnology Characterization Laboratory (NCL).

Physico-Chemical Characterization Studies

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Size Study

Size by Dynamic Light Scattering (DLS) Study

Dynamic Light Scattering (DLS) is a type of spectroscopy that uses a laser beam to irradiate a sample containing particles in suspension resulting in light scattering. Rapid fluctuations in scattering intensity around a mean value at a certain angle occur because of particle diffusion and are dependent upon on particle size. The calculated correlation function yields a diffusion coefficient, for a given temperature and viscosity, that can be used to calculate particle size.

For physico-chemical characterization studies, the primary study sample is the nanopartlcle or other small moledule.

Study File	Study Sample	Study Parameters	Supporting Information
s_size-DLS	Nanoparticle Sample Multiexcerpt include MultiExcerptName ExitDisclaimer nopanel true PageWithExcerpt wikicontent:Exit Disclaimer to Include	pH Multiexcerpt include MultiExcerptName ExitDisclaimer nopanel true PageWithExcerpt wikicontent:Exit Disclaimer to Include Concentration Multiexcerpt include MultiExcerptName ExitDisclaimer nopanel true PageWithExcerpt wikicontent:Exit Disclaimer to Include	Measuring the Size of Nanoparticles in Aqueous Solution using DLS Characterization of Nanoparticles for Therapeutics Dendrimer-Based MRI Contrast Agents

In Vitro Characterization Studies

For in vitro characterization studies, the primary study sample is the biospecimen.  Nanoparticles or other small molecules administered to the biospecimen are considered factors in the study.

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Size_by_DLS

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• Nanoparticle Sample

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• pH
• Concentration

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