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As described in NCL200612A, the objective of the Dendritic Nanotechnologies, Inc.-NCL collaboration is to characterize a PAMAM dendrimer with an associated gadolinium chelate MRI contrast agent. The nanomaterials submitted for testing at the NCL were:

  • (NCL20) G4 tris (hydroxyl) terminated PAMAM

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  • dendrimer 
  • (NCL21) G4 pyrrolidinone terminated PAMAM

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  • dendrimer 
  • (NCL22) G4.5 COONa terminated PAMAM

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  • dendrimer 
  • (NCL23) G4.5 COONa terminated PAMAM dendrimer-Magnevist®

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  • complex 
  • (NCL25) G4 tris (hydroxyl) terminated PAMAM dendrimer-Magnevist®

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  • complex 
  • (NCL26) G4 pyrrolidinone terminated PAMAM dendrimer-Magnevist®

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  • complex 

Commercially available Magnevist® (NCL24) was used as a control. NCL studies addressed in this report can be divided into three main The NCL example files encompass three categories: physicochemical characterization, immunotoxicology, and in-vitro toxicology.

Optional Files

Structure File

The structure file describes the 3D composition of the material and is not included in the ISA-TAB specification. The structure file is an optional file and typically developed for modeling and simulation activities in support of structure-Investigating structure-activity-relationships (SAR) . The ability to develop this file requires a detailed understanding of is important to nanotechnology modeling and simulation but the ISA-TAB specification does not support files describing the 3D composition of the particles and the ability to represent each atom of the nanomaterial and relationships to other atoms. The structure file is referenced from the material experimental material. The ISA-TAB-Nano extension allows for the optional inclusion of a structure file. Structure files are referenced in the Material file.

Since there are no standard structure files for nanotechnology, investigators can include structure files of any format.

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