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SYNOPSIS:At Windber Research Institute, Dr. Hu and his colleagues have developed a biomedical informatics infrastructure to support multiple translational research programs, including the Clinical Breast Care Project and the Gynecological Disease Program. The system is composed of a data tracking system, a set of QA programs, and a data warehouse system. The data tracking system, named the Clinical Laboratory Workflow System, is used for managing daily activities including subject enrollment, clinicopathologic data collection, and

tissue banking. The QA programs focus on clinical data, including a QA issue tracking system and a QAMetrics. In addition, a Data Warehouse for Translational Research was developed to integrate the clinicopathologic data and molecular dataThe use of genome-wide profiling technologies in basic and translational  research is on the rise in the clinical setting.  However, several potent informatics barriers must be overcome before clinical sequencing can become routine.  Good Laboratory Practice-based quality-assurance metrics must be established to guarantee the accuracy required to make medical decisions.  Genetic variants identified by sequencing must be systematically annotated and interpreted so that a clinical genomicist can decide which are medically actionable.  Software applications and technologies are required to facilitate reporting of genomic results and to transmit these data to electronic health records. To address these issues, we have developed the Clinical Genomicist Workstation, which provides a “soup-to-nuts” solution for processing clinical sequencing orders.

BIO:

Dr. Hai Hu is Senior Director of Biomedical Informatics and Deputy Chief Scientific Officer for the Windber Research Institute in Pennsylvania. He also serves as Adjunct Professor for the Shanghai Center for Bioinformation Technology in Shanghai, and for the Department of Surgery at the USUHS School of Medicine in Bethesda, MD. Dr Hu received his Ph.D. in Biophysics from the State University of New York at BuffaloRakesh Nagarajan is an Assistant Professor in the Department of Pathology and Immunology at Washington University School of Medicine in St. Louis, Director of the Institute of Clinical and Translational Sciences, and Director of the Alvin J. Siteman Cancer Center for Biomedical Informatics.  As Director of the Center for Biomedical Informatics, he and his group have developed and support broad biomedical informatics infrastructure to facilitate clinical and translational research as well as collaborate on clinical and genomic projects by providing in silico analyses and expertise.  Trained as a physician-scientist, Dr. Nagarajan received his M.D. and Ph.D. degrees from Washington University in St. Louis in 2002.

SUMMARY:

Topic: Biomedical Informatics Infrastructure to Support Translational Research

Speaker: Dr. Hai Hu. Rakesh Nagarajan, M.D., Ph.D.

Date: Wednesday, September 519, 2012

Time: 11 AM – 12 PM

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