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- To enable nanomedicine data search, sharing, and analysis through ontology development.
- One project directly related to this goal is the NanoParticle Ontology: http://nano-ontology.org
Multiexcerpt include MultiExcerptName ExitDisclaimer nopanel true PageWithExcerpt wikicontent:Exit Disclaimer to Include - To establish a common framework for describing and accessing the physiochemical and biological properties of nanotechnology using common data elements and data sharing formats.
- One project directly derived from this goal is the ISA-TAB-Nano standard for data submission: http://is.gd/foSKV
Multiexcerpt include MultiExcerptName ExitDisclaimer nopanel true PageWithExcerpt wikicontent:Exit Disclaimer to Include - To develop a framework for uniform and comprehensive data curation and annotation ensuring that data reliability and reproducibility is evaluated by users most familiar with both the data and the methods used to produce it.
- To encourage the development of effective data mining standards and tools that are particularly suited for nanomaterial safety assessment, safe-by-design approaches, establishing nanotoxicology structure-activity relationships and nanomaterials characterization databases used for accompanying these objectives.
- To encourage adoption and use of a shared informatics infrastructure by the nanotechnology and broader communities.
Short-term aims
To realize the long-term objectives outlined above, the NCIP Nano WG has established several short-term goals with 6-12 month timeframes.
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Data generated from nanotechnology research are so diverse and large in volume that it is difficult to share and efficiently use them without informatics tools. In particular, ontologies that provide a unifying knowledge framework for annotating the data are required to facilitate the semantic integration, knowledge-based searching, unambiguous interpretation, mining and inferencing of the data using informatics methods. The Nano WG supports the continuing development and application of the NanoParticle Ontology (NPO), which is developed within the framework of the Basic Formal Ontology (BFO), and implemented in the Ontology Web Language (OWL) using well-defined ontology design principles. Nano WG will work closely with data repositories and data curation efforts to capture requirements and incorporate new terminology in NPO. See http://nano-ontology.org
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- Identify NPO requirements through regular interactions or collaborations with the Nanomaterial Registry, the US-EU Community of Research on Databases and Ontology, UC CEIN, CEINT, the National Nanomanufacturing Network, and other interested parties.
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- Grow the NPO through identification and definition of additional concepts in Task A and incorporate those concepts into the NPO.
Aim 3. Continued data sharing standard development
ISA-TAB-Nano was developed to facilitate the import and export of data on nanomaterials and their characterizations among nanotechnology resources. Nano WG will continue to update the specification based on the feedback from the community. Nano WG will also continue to work with the ISA-team
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- Nano WG will continue to reach out to the community to increase awareness of the resources developed by the Nano WG, and to encourage community participation in the WG activities.
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- In particular, the following activities will be leveraged to increase participation: invitations to program officers with nanotechnology portfolios, announcements and invitations via the nano.gov portal, society presentations (e.g. Society of Toxicology Nanotoxicology Specialty Section, Society for Environmental Toxicology and Chemistry); and present posters on WG activities at conferences and meetings.
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- Additional templates and examples will be developed based on community needs and feedback to improve overall usability and to facilitate adoption of the ISA-Tools.
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- The ISA-TAB-Nano standard will continue to be developed/modified based on user feedback and interaction with the ISA-Tools community.
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- Time permitting, we will explore the extension of ISA-TAB formats to the sharing of nanotechnology models in addition to the current data sharing activities.
In the course of these activities, we also plan to survey and identify issues in nanotechnology data curation and search that should be standardized across data resources.
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See Nanocharacterization Library
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Standardizing nanomaterial characterization protocols. Several Working Group members have noted that standard characterizations discussed above are only useful if the protocols for these characterizations are themselves standardized and reproducible. Furthermore, evidence from inter-laboratory studies by ASTM and IANH suggests that there is significant variability in results from existing "standard" protocols, suggesting that current mechanisms for protocol communication are ineffective. This nanotechnology problem is currently under investigation by ASTM and ISO groups. The Working Group assists in this effort by:
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More information can be found athttpat http://nano-ontology.org
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