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Table of Contents

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This page provides an examples of an example of the ISA-TAB-Nano Investigation File leveraging data from an Nanotechnology Characterization Laboratory (NCL) Investigation (NCL200612A).

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The ISA-TAB-Nano Investigation File consists of the following sections:

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Ontology Source Reference

TABLE 21: Example Investigation File Ontology Source Reference Section

ONTOLOGY SOURCE REFERENCE
Term Source Name	MO	NPO	UO	ChEBI	PATO	NCIt
Term Source File	http://purl.bioontology.org/ontology/MO	http://purl.bioontology.org/ontology/npo	http://purl.bioontology.org/ontology/UO	http://purl.bioontology.org/ontology/CHEBI	http://purl.bioontology.org/ontology/PATO	http://ncit.nci.nih.gov/
Term Source Version	v.1.3.1.1	v.2011-02-12		v.80		v.11.11d
Term Source Description	MGED Ontology	NanoParticle Ontology	Unit Ontology	Chemical Entities of Biological Interest	Phenotype Ontology	NCI Thesaurus

Investigation

TABLE 32: Example Investigation File Investigation Section

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Investigation Contacts

TABLE 43: Example Investigation File Investigation Contacts Section

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Investigation Publication

TABLE 54. Example Investigation Publication Section

INVESTIGATION PUBLICATIONS
Investigation PubMed ID	18095846
Investigation Publication DOI	10.2217/17435889.2.6.789
Investigation Publication Author list	Hall JB; Dobrovolskaia MA; Patri AK; McNeil SE
Investigation Publication Title	Characterization of nanoparticles for therapeutics
Investigation Publication Status	published
Investigation Publication Status Term Accession Number
Investigation Publication Status Term Source REF

Study

TABLE 65. Example Investigation File Study Section

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Study Design Descriptors

TABLE 76. Example Investigation File Study Design Descriptors Section

STUDY DESIGN DESCRIPTORS
Study Design Type	comparison
Study Design Type Term Accession Number
Study Design Type Term Source REF

Study Contacts

TABLE 87. Example Investigation File Study Contacts Section

STUDY CONTACTS
Study Person Last Name	Dobrovolskaia
Study Person First Name	Marina
Study Person Mid Initials	A
Study Person Email	marina@mail.nih.gov
Study Person Phone	3018466352
Study Person Fax
Study Person Address	MSC 1050 Boyles Street, Frederick, MD 21702
Study Person Affiliation	Nanotechnology Characterization Laboratory
Study Person Roles	investigator
Study Person Roles Term Accession Number
Study Person Roles Term Source REF	MO

Study Publications

TABLE 98. Example Investigation File Study Publications Section

STUDY PUBLICATIONS
Study PubMed ID	18095846
Study Publication DOI	10.2217/17435889.2.6.789
Study Publication Author list	Hall JB; Dobrovolskaia MA; Patri AK; McNeil SE
Study Publication Title	Characterization of nanoparticles for therapeutics
Study Publication Status	published
Study Publication Status Term Accession Number
Study Publication Status Term Source REF

Study Assays

TABLE 109. Example Investigation File Study Assays Section

STUDY ASSAYS
Study Assay Measurement Type	MTT Assay	LDH Release Assay
Study Assay Measurement Type Term Accession Number		NPO_1709
Study Assay Measurement Type Term Source REF		NPO
Study Assay Technology Type
Study Assay Technology Type Term Accession Number
Study Assay Technology Type Term Source REF
Study Assay Technology Platform
Study Assay Measurement Name	cell viability	LDH release
Study Assay Measurement Name Term Accession Number	NPO_1343
Study Assay Measurement Name Term Source REF	NPO
Study Assay File Name	a_MTT-LLCPK1.xls	a_LDH-LLCPK1.xls

Study Factors

TABLE 1110. Example Investigation File Study Factors Section

STUDY FACTORS
Study Factor Name	nanoparticle sample	particle concentration	time of exposure
Study Factor Name Term Accession Number	NPO_1404	NPO_1830	NPO_1819
Study Factor Name Term Source REF	NPO	NPO	NPO
Study Factor Type
Study Factor Type Term Accession Number
Study Factor Type Term Source REF

Study Protocols

TABLE 1211. Example Investigation File Study Protocols Section

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