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The Reference Image Database to Evaluate Therapy Response (RIDER) database is a targeted data collection for the purpose of generating an initial consensus on how to harmonize data collection and analysis for quantitative imaging methods as applied to measure the response to drug or radiation therapy. The long term goal is to provide a resource to permit harmonized methods for data collection and analysis across different commercial imaging platforms, as required to support multi-site clinical trials, using imaging as a biomarker for therapy response. Thus the database should permit an objective comparison of methods for data collection and analysis as a national and international resource as described in the first RIDER white paper report (2006):

• RIDER White Paper: Executive Summary PDF
• RIDER White Paper: Editorial in Nature.com

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1. Develop a consensus on requirements for quantity assurance methods for longitudinal studies using phantom data as applied to each modality above,
2. Develop a consensus on the stability of imaging platforms using repeat and longitudinal phantom measurements over the time period that therapy would be exercised,
3. Develop a consensus on methods to measure the minimum change that can be measured using repeat and longitudinal patient or volunteer studies
4. Provide access to results of measurements performed on these databases by each academic site to encourage a comparison on methodologies,
5. Provide consensus-based juried publications to encourage a broad acceptance of the methods described above.
6. Provide a resource for NCI research networks that address quantitative imaging such as the Quantitative Imaging Network QIN):     http://grants.nih.gov/grants/guide/pa-files/PAR-11.150.html

The databases are being provided with a timely goal of 18 months time frame, namely from the time the contract was initiated and the published results within less than 2 years. The methods for data collection and analysis including results are described in the new Combined RIDER white Paper Report (Sept 2008): RIDER White Paper: Combined contracts report ( Sept 2008)

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The RIDER project will be replaced when the QIN initiative is fully implemented as this research network will be tasked to create database resources collected from phase 1-3 clinical trials, where clinical outcomes will be included in the meta data: http://grants.nih.gov/grants/guide/pa-files/PAR-11-150.html

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• Images contained in "RIDER Lung CT" Collection
• Repeat CT Measurements: Human subjects: Lung
• Download the related lesion notes: MSKCC RepeatCT Lesion notes for RIDER.xls
• Download the related publication: Zhaob-RepeatCT Radiology2009.pdf

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• Images contained in "RIDER Phantom MRI" Collection
• Repeat measurement: Phantom studies
• DCE MRI

• RIDER_MR_Phantom_Data_Summary

  .pdf

  provides a summary of the images in this collection.

• RIDER_PhantomMR_Key

  .pdf

  provides a key for understanding their presentation in NBIA.

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