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This page provides an example of the ISA-TAB-Nano Study file, leveraging data from The Study File will vary depending on whether the study performed is a physico-chemical characterization, in vitro characterization, or in vivo characterization. Provided below are examples of Study Files for created from studies performed by the Nanotechnology Characterization Laboratory (NCL) Investigation (NCL200612A).
TABLE 1: Example Study File
Physico-Chemical Characterization Studies
Size Study
Size by Dynamic Light Scattering (DLS) Study
Dynamic Light Scattering (DLS) is a type of spectroscopy that uses a laser beam to irradiate a sample containing particles in suspension resulting in light scattering. Rapid fluctuations in scattering intensity around a mean value at a certain angle occur because of particle diffusion and are dependent upon on particle size. The calculated correlation function yields a diffusion coefficient, for a given temperature and viscosity, that can be used to calculate particle size.
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| Source Name | Protocol REF | Sample Name | Performer | Parameter Value[pH] | Parameter Value[particle concentration] | Unit | Term Accession Number | Term Source Ref | ParameterValue[NaCl concentration] | Unit | Term Accession Number | Term Source Ref | Material Type | Term Accession Number | Term Source Ref | Material File | Provider |
| NCL-20 | Measuring the size of nanoparticles in aqueous media using batch-mode dynamic light scattering | NCL-20-1 | Anil Patri | 7.4 | 1 | mg/mL | UO_0000176 | UO | 154 | mM | UO_0000063 | UO | nanoparticle sample | NPO_1404 | NPO | m_NCL-20.xls | Dendritic Nanotechnologies, Inc. |
| NCL-22 | Measuring the size of nanoparticles in aqueous media using batch-mode dynamic light scattering | NCL-22-1 | Anil Patri | 7.4 | 1 | mg/mL | UO_0000176 | UO | 154 | mM | UO_0000063 | UO | nanoparticle sample | NPO_1404 | NPO | m_NCL-22.xls | Dendritic Nanotechnologies, Inc. |
| NCL-23 | Measuring the size of nanoparticles in aqueous media using batch-mode dynamic light scattering | NCL-23-1 | Anil Patri | 7.4 | 1 | mg/mL | UO_0000176 | UO | 154 | mM | UO_0000063 | UO | nanoparticle sample | NPO_1404 | NPO | m_NCL-23.xls | Dendritic Nanotechnologies, Inc. |
