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The Study File will vary depending on whether the study performed is a physico-chemical characterization, in vitro characterization, or in vivo characterization. Provided below are examples of Study Files for created from studies performed by the Nanotechnology Characterization Laboratory (NCL).
Physico-Chemical Characterization Studies
Size Study
Size by Dynamic Light Scattering (DLS) Study
Dynamic Light Scattering (DLS) is a type of spectroscopy that uses a laser beam to irradiate a sample containing particles in suspension resulting in light scattering. Rapid fluctuations in scattering intensity around a mean value at a certain angle occur because of particle diffusion and are dependent upon on particle size. The calculated correlation function yields a diffusion coefficient, for a given temperature and viscosity, that can be used to calculate particle size.
For physico-chemical characterization studies, the primary study sample is the nanopartlcle or other small moledule.
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In Vitro Characterization Studies
For in vitro characterization studies, the primary study sample is the biospecimen. Nanoparticles or other small molecules administered to the biospecimen are considered factors in the study.
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