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The National Cancer Institute (NCI) National Cancer Informatics Program (NCIP) Nanotechnology Working Group was established in 2008 for researchers with a specific interest in informatics and computational approaches to nanotechnology, with a particular emphasis on nanomedicine. The goal of this working group is to demonstrate the scientific potential of federating nanotechnology databases through pilot projects aimed at integrated semantic search and retrieval of nanomedicine and nanotoxicology datasets that are applicable across nanoscience. The NCIP Nanotechnology Working Group (NCIP Nano WG) comprises over 20 active participants from academia, government and industry with diverse interests.
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Goals
Long-term
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goals
This Working Group is motivated by two high-priority nanomedicine informatics applications:
- The rational design of nanomaterials customized for use in nanomedicine, including therapeutic, diagnostic, and preventive applications.
- The development of robust and validated structure-activity relationships to predict nanomaterial toxicity the biological effects associated with nanomaterials and to tailor utilize this toxicity insight for therapeutic medical applications and/or to reduce hazards, exposures, and resulting risks to health, safety and the environment.
These applications will be enabled by broad computational capability applied to nanotechnology research. The development of such capability has led to the following long-term objectives for the NCIP Nano WG:the Nano WG:
- To enable nanomedicine data search, sharing, and analysis through ontology development.
- One project directly related to this goal is the NanoParticle Ontology: http://nano-ontology.org
- To establish a common framework for describing and accessing the physiochemical and biological properties of nanotechnology using common data elements and data sharing formats.
- One project directly derived from this goal is the ISA-TAB-Nano standard for data submission: http://is.gd/foSKV
- To develop a framework for uniform and comprehensive data curation and annotation while ensuring that data reliability and reproducibility is evaluated by those users most familiar with both the data and the methods used to produce it.To establish a common framework for describing and accessing nanotechnology data using common data elements.
- To encourage the development of effective data mining standards and tools that are particularly suited for nanomaterial safety assessment, safe-by-design approaches, establishing nanotoxicology structure-activity relationships and nanomaterials characterization databases used for accompanying these objectives.
To enable nanomedicine data search, sharing, and analysis through ontology development. One project directly related to this goal is the NanoParticle Ontology: http://nano-ontology.org
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To facilitate nanomedicine and nanotoxicology data sharing and database interoperability through the development of standardized spreadsheet-based formats for nanotechnology datasets. One project directly derived from this goal is the ISA-TAB-Nano standard for data submission: http://is.gd/foSKV
.Wiki Markup {multi-excerpt-include:wikicontent:Exit Disclaimer to Include|name=ExitDisclaimer|nopanel=true}- To encourage adoption and use of a shared informatics infrastructure by the nanotechnology and broader communities.
.Short-term goals
To realize the long-term objectives outlined above, the NCIP Nano WG has established several short-term goals with 6-12 month timeframes.
Defining basic nanomaterial characterizations. Careful physical, structural, and chemical characterizations are essential ingredients for nanomedicine informatics applications. While the fields of structural biology, genome sequencing, chemical synthesis, microarray analysis, etc. have defined basic assays for their respective technologies, the field of nanomedicine lacks a set of well-defined and "minimal" characterization methods for nanomaterials. There is an urgent need in the field to:
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