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Data generated from nanotechnology research are so diverse and large in volume that it is difficult to share and efficiently use them without informatics tools.  In particular, ontologies that provide a unifying knowledge framework for annotating the data are required to facilitate the semantic integration, knowledge-based searching, unambiguous interpretation, mining and inferencing of the data using informatics methods.  The Nano WG supports the continuing development and application of the NanoParticle Ontology (NPO), which is developed within the framework of the Basic Formal Ontology (BFO), and implemented in the Ontology Web Language (OWL) using well-defined ontology design principles. Nano WG will work closely with data repositories and data curation efforts to capture requirements and incorporate new terminology in NPO.  See http://nano-ontology.org for more information.  Work on this aim will consist of the following tasks:

a)      Identify  Identify NPO requirements through regular interactions or collaborations with the Nanomaterial Registry, the US-EU Community of Research on Databases and Ontology, UC CEIN, CEINT, the National Nanomanufacturing Network, and other interested parties.

b)       Grow the NPO through identification and definition of additional concepts in Task A and incorporate those concepts into the NPO.

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ISA-TAB-Nano was developed to facilitate the import and export of data on nanomaterials and their characterizations among nanotechnology resources. Nano WG will continue to update the specification based on the feedback from the community. Nano WG will also continue to work with the ISA-team to extend the ISA-TAB validator to support ISA-TAB-Nano extensions, and to explore the use of ISA OntoMaton that allows users to search for ontology terms while annotating their experiments. The ISA-TAB-Nano project is under development as an ASTM standard (WK28974 at http://is.gd/foSKV).  See the ISA-TAB-Nano Specification for more information.  Work on this Aim will be focused on the following tasks:

a)      Nano  Nano WG will continue to reach out to the community to increase awareness of the resources developed by the Nano WG, and to encourage community participation in the WG activities.  In particular, the following activities will be leveraged to increase participation:  invitations to program officers with nanotechnology portfolios, announcements and invitations via the nano.gov portal, society presentations (e.g. Society of Toxicology Nanotoxicology Specialty Section, Society for Environmental Toxicology and Chemistry); and present posters on WG activities at conferences and meetings.

b)      Additional  Additional templates and examples will be developed based on community needs and feedback to improve overall usability and to facilitate adoption of the ISA-Tools.

c)       The  The ISA-TAB-Nano standard will continue to be developed/modified based on user feedback and interaction with the ISA-Tools community.

d)      Time  Time permitting, we will explore the extension of ISA-TAB formats to the sharing of nanotechnology models in addition to the current data sharing activities.

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Defining standards for nanomedicine data sharing and exchange. Currently, access to relevant data is a major barrier to the realization of the nanomedical goals of rational nanomaterial design and toxicity prediction. While a few detailed datasets exist for nanomaterial toxicity (ONAMI), and nanomaterial-cellular interactions (Shaw and others) most of the necessary data is dispersed across a wide array of nanotechnology data resources. Therefore, it is essential to implement an infrastructure to ensure that these data can be shared among researchers and data resources. To develop this (federated) data sharing infrastructure, the Working Group has undertaken development of the ISA-TAB-Nano spreadsheet form, based on the ISA-TAB framework, to facilitate submission of data by experimental researchers. The ISA-TAB-Nano effort is translating the great success of MAGE-TAB microarray and similar formats for enabling data sharing in other communities. The ISA-TAB-Nano project is actively growing and under development as an ASTM standard (WK28974 at http://is.gd/foSKV)

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Completed

Ongoing development based on community requirements and feedack: See ISA-TAB-Nano Specification

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