{multi-excerpt:name=NBIA}The National Biomedical Imaging Archive (NBIA) is a free and open source service and software application that enables users to securely store, search, and download diagnostic medical images, providing a searchable national repository integrating in vivo cancer images with clinical and genomic data. Using role-based security, NBIA provides web-based access to de-identified DICOM images, image markup, annotations, and rich meta data. The NBIA download package is a ZIP package that includes the NBIA application, supporting libraries, the RSNA MIRC application (with NBIA modifications), documentation, and a sample NBIA database. A web-based visualization and annotation tool, I-Response, is available to users of the NCI NBIA instance.{multi-excerpt}