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Since 1997, EVS has worked with many partners to build shared content and services, so that information can be effectively exchanged, interpreted and analyzed while minimizing overall effort and cost. Much of this content has been created and published using NCI Thesaurus and NCI Metathesaurus, as outlined in the following sections and described in more detail in the individual user profiles later, where other shared development efforts are also described.

NCI Thesaurus (NCIt)

NCI Thesaurus (NCIt) is NCI's core reference terminology. Over the last 16 years, it has also been adopted by FDA, CDISC, NCPDP and other partners as a shared standards development and coding environment, allowing participants to compare and harmonize with each other's content while taking advantage of full-text definitions, codes, and other features.

About 117,000 out of the 154,946 current NCIt concepts have terms from both EVS and from one or more of these other sources. The chart below gives a detailed breakdown of the main areas of overlapping tagged content. Note that some partners have used NCI terms rather than tagging their own, so these figures understate the true extent of cross-source sharing.

NCIt concepts with terms from tagged outside sources (21.05a: May 2021)

NCIt concepts with tagged synonyms from each outside source (21.05a: May 2021)

NCIt Concepts

Source

3ACC
716ACC/AHA
2017

BRIDG

408CareLex
55CBDD
267

CCPS

21894CDISC
769CDISC-GLOSS
2067Cellosaurus
3661CPTAC
406CRCH
8924CTCAE
280CTDC
426CTEP
24562CTRP
1030EDQM-HC
26210FDA
239GAIA
5684GDC
127HL7
602ICDC
216ICH
215INC
1281MedDRA
23NAACCR
243NCCN
510NCPDP
6NDC
4784NICHD
1196PCDC
40PI-RADS
377SEER
298SeroNet
284UCUM

NCI Metathesaurus (NCIm)

NCI Metathesaurus (NCIm) was started in the late 1990s to gather up, translate between, and publish the many terminologies used by NCI, including some created in part or whole within NCI. Development of NCI Thesaurus started within NCIm as NewPDQ, an effort to extend and restructure the PDQ Terminology long used to code cancer clinical trial, research and public information resources. NCIm continues to provide a vital environment for EVS collaboration with NCI and other partners to develop, map and publish terminologies of shared interest, and responds to the requirements of a broad range of stakeholders within the cancer research and biomedical community.

NCIt tagged content from outside sources is imported into NCIm with separate source tags. NCIt-derived sources are grouped separately below. The NCIm tags are mostly identical or very similar to those in NCIt; exceptions are CADSR, converted to NCI; HL7, converted to NCI-HL7; and CTRM, which is not imported.

NCIm sources and the number of concepts to which each contributes (201908: August 2019)

NCIm concepts

Source Label - NCIt-derived

Source Name

713ACC-AHAAmerican College of Cardiology/American Heart Association Clinical Data Terminology, 2021_01D
334BioCBioCarta online maps of molecular pathways, adapted for NCI use, 2021_01D
27BRIDGBiomedical Research Integrated Domain Group Model, 2021_01D
1148BRIDG_3_0_3Biomedical Research Integrated Domain Group Model, 3.0.3, 2021_01D
1658BRIDG_5_3Biomedical Research Integrated Domain Group Model, 5.3, 2021_01D
17254caDSRCancer Data Standards Registry and Repository, 2021_01D
407CARELEXContent Archive Resource Exchange Lexicon, 2021_01D
49CBDDChemical Biology and Drug Development Vocabulary, 2021_01D
923CDCU.S. Centers for Disease Control and Prevention, 2021_01D
23324CDISCClinical Data Interchange Standards Consortium, 2021_01D
770CDISC-GLOSSClinical Data Interchange Standards Consortium Glossary Terms, 2021_01D
2000CELLOSAURUSCellosaurus, 2021_01D
3688CPTACClinical Proteomic Tumor Analysis Consortium, 2021_01D
406CRCHCancer Research Center of Hawaii Nutrition Terminology, 2021_01D
775CTCAECommon Terminology Criteria for Adverse Events, 2021_01D
5599CTCAE_3Common Terminology Criteria for Adverse Events 3.0, 2021_01D
4022CTCAE_5Common Terminology Criteria for Adverse Events 5.0, 2021_01D
276CTDCClinical Trial Data Commons, 2021_01D
318CTEPCancer Therapy Evaluation Program, 2004
373CTEP-SDCCancer Therapy Evaluation Program - Simple Disease Classification, 2021_01D
23675CTRPClinical Trials Reporting Program, 2021_01D
903DCPNCI Division of Cancer Prevention Program, 2021_01D
114DICOMDigital Imaging Communications in Medicine, 2021_01D
694DTPNCI Developmental Therapeutics Program, 2021_01D
1026EDQM-HCEuropean Directorate for the Quality of Medicines & Healthcare, 2021_01D
24499FDAU.S. Food and Drug Administration, 2021_01D
207GAIAGlobal Alignment of Immunization Safety Assessment in pregnancy, 2021_01D
5055GDCNCI Genomic Data Commons, 2021_01D
281GENCGeopolitical Entities, Names, and Codes Standard, 2021_01D
632ICDCNCI Integrated Canine Data Commons, 2021_01D
215ICHInternational Conference on Harmonization, 2021_01D
215INCInternational Neonatal Consortium, 2021_01D
156JAXJackson Laboratories Mouse Terminology, adapted for NCI use, 2021_01D
244KEGGKEGG Pathway Database, 2021_01D
158661NCINational Cancer Institute Thesaurus, 2021_01D
5077NCI-GLOSSNCI Dictionary of Cancer Terms, 2021_01D
5158NCI-HGNCNCI HUGO Gene Nomenclature Committee, 2021_01D
129NCI-HL7NCI Health Level 7, 2021_01D
509NCPDPNational Council for Prescription Drug Programs, 2021_01D
5NDCNational Drug Code, 2021_01D
4781NICHDNational Institute of Child Health and Human Development, 2021_01D
879PCDCPediatric Cancer Data Commons, 2021_01D
39PI-RADSProstate Imaging Reporting and Data System, 2021_01D
169PIDNational Cancer Institute Nature Pathway Interaction Database, 2021_01D
310RENIRegistry Nomenclature Information System, 2021_01D
1437UCUMUnified Code for Units of Measure, 2021_01D
25ZFINZebrafish Model Organism Database, 2021_01D

NCIm concepts

Source Label - Other

Source Name

15,873

AOD

Alcohol and Other Drug Thesaurus, 2000

276

AOT

Authorized Osteopathic Thesaurus, 2003

13,255

CBO

Clinical Bioinformatics Ontology, 2011_02

622

CCS

Clinical Classifications Software, 2005

3,080

COSTAR

COSTAR, 1989-1995

16,501

CSP

CRISP Thesaurus, 2006

3,843

CST

COSTART, 1995

318

CTEP

Cancer Therapy Evaluation Program, 2004

435

CVX

Vaccines   Administered, 2018_10_18, 2019_03_04
7,711

DRUGBANK

DrugBank,   5.0_2016_06_22, 5.0_2019_01_31
7,293

DXP

DXplain, 1994
102,404

FMA

Foundational Model   of Anatomy Ontology, 4_10
7,503

GARD

Genetic and Rare   Diseases Information Center, 2015_04
70,289

GO

Gene Ontology,   2018_05_20
6,655

HCPCS

Healthcare Common   Procedure Coding System, 2019
41,301

HGNC

HUGO Gene   Nomenclature Committee, 2018_03
9,789
HL7V3.0HL7 Vocabulary   Version 3.0, 2018_08
15,301

HPO

Human Phenotype   Ontology, 2018_11_08
102,167ICD10CMInternational   Classification of Diseases, 10th Edition, Clinical Modification, 2019
190,389ICD10PCSICD-10-PCS, 2019
17,425ICD10ICD10, 2016
20,941ICD9CMInternational   Classification of Diseases, Ninth Revision, Clinical Modification, 2014
2,588

ICDO

International   Classification of Disease for Oncology, 3_1
748

ICPC

International   Classification of Primary Care, 1993
5,057
ISO3166-2International   Organization for Standardization 3166-2, 2012
146,331

LNC

LOINC, 265
41

MCM

McMaster University   Epidemiology Terms, 1992
332
MDBCACMitelman Database   of Chromosome Aberrations in Cancer, 2005_12
56,014

MDR

Medical Dictionary   for Regulatory Activities Terminology (MedDRA), 22.0
3,315
MED-RTMedication   Reference Terminology, 2019_03_04
2,119
MEDLINEPLUSMedlinePlus Health   Topics, 20181108
900

MGED

MGED Ontology, 131
373,575  MSHMedical Subject Headings, 2019_2019_01_07
9

MTHCMSFRF

Metathesaurus CMS Formulary Reference File, MTHCMSFRF_2014

521

MTHHH

Metathesaurus HCPCS Hierarchical Terms, 2019

19,021

MTHICD9

International Classification of Diseases, Ninth Revision, Clinical Modification, Metathesaurus additional entry terms, 2014

1,633

MTHMST

Metathesaurus Version of Minimal Standard Terminology Digestive Endoscopy, 2001

58,600

MTHSPL

Metathesaurus FDA Structured Product Labels, 2019_02_22

194,860

MTH

UMLS Metathesaurus, 2019AA

76

MVX

Manufacturers of Vaccines, 2018_08_31

 1,409,501 NCBINCBI Taxonomy,   2018_04_19
 5,749NCIMTHNCIMTH
NCISEERNCI SEER ICD   Neoplasm Code Mappings, 1999
NDFRT_FDASPLNational Drug File   - FDASPL, 2018_02_05
NDFRT_FMTSMENational Drug File   - FMTSME, 2018_02_05
39,434 NDFRTNational Drug File,   2018_02_05
1,887  NPONPO: NanoParticle   Ontology for Cancer Nanotechnology Research, 2011_12_08
106,313

OMIM

Online Mendelian   Inheritance in Man, 2019_02_04
12,399

PDQ

Physician Data   Query, 2016_07_31
2,039

PMA

Portfolio   Management Application, 2010
260

PNDS

Perioperative   Nursing Data Set, 4_2018
940

QMR

Quick Medical   Reference (QMR), 1996
45,733

RADLEX

RadLex, 3_15
201,450
RXNORMRxNorm Vocabulary,   18AB_190304F
347030SNOMEDCT_USUS Edition of   SNOMED CT, 2019_03_01
162

SOP

Source of Payment   Typology, 8
4,810

SPN

Standard Product   Nomenclature, 2003
200

SRC

Metathesaurus   Source Terminology Names
27,283

UMD

UMDNS: product   category thesaurus, 2019
 1,693 USPMGUSP Medicare Model   Guidelines, 2017
 4,352 USPUSP Compendial   Nomenclature, 2018_12_10
61,112

UWDA

University of   Washington Digital Anatomist, 1.7.3
34,194

VANDF

Veterans Health   Administration National Drug File, 2019_02_01

Overall Counts (August 2019)

ConceptsRelationships Attributes Total Number of Terms
3,265,686

22,852,144

 25,184,657 7,508,907



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