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Since 1997, EVS has worked with many partners to build shared content and services, so that information can be effectively exchanged, interpreted and analyzed while minimizing overall effort and cost. Much of this content has been created and published using NCI Thesaurus and NCI Metathesaurus, as outlined in the following sections and described in more detail in the individual user profiles later, where other shared development efforts are also described.

NCI Thesaurus (NCIt)

NCI Thesaurus (NCIt) is NCI's core reference terminology. Over the last 16 years, it has also been adopted by FDA, CDISC, NCPDP and other partners as a shared standards development and coding environment, allowing participants to compare and harmonize with each other's content while taking advantage of full-text definitions, codes, and other features.

About 117,000 out of the 154,946 current NCIt concepts have terms from both EVS and from one or more of these other sources. The chart below gives a detailed breakdown of the main areas of overlapping tagged content. Note that some partners have used NCI terms rather than tagging their own, so these figures understate the true extent of cross-source sharing.

NCIt concepts with terms from tagged outside sources (22.02d: February 2022)

NCIt concepts with tagged synonyms from each outside source (21.11e: November 2021)

NCIt Concepts







NCI Metathesaurus (NCIm)

NCI Metathesaurus (NCIm) was started in the late 1990s to gather up, translate between, and publish the many terminologies used by NCI, including some created in part or whole within NCI. Development of NCI Thesaurus started within NCIm as NewPDQ, an effort to extend and restructure the PDQ Terminology long used to code cancer clinical trial, research and public information resources. NCIm continues to provide a vital environment for EVS collaboration with NCI and other partners to develop, map and publish terminologies of shared interest, and responds to the requirements of a broad range of stakeholders within the cancer research and biomedical community.

NCIt tagged content from outside sources is imported into NCIm with separate source tags. NCIt-derived sources are grouped separately below. The NCIm tags are mostly identical or very similar to those in NCIt; exceptions are CADSR, converted to NCI; HL7, converted to NCI-HL7; and CTRM, which is not imported.

NCIm sources and the number of concepts to which each contributes (202105: May 2021)

NCIm concepts

Source Label - NCIt-derived

Source Name

713ACC-AHAAmerican College of Cardiology/American Heart Association Clinical Data Terminology, 2021_01D
334BioCBioCarta online maps of molecular pathways, adapted for NCI use, 2021_01D
27BRIDGBiomedical Research Integrated Domain Group Model, 2021_01D
1148BRIDG_3_0_3Biomedical Research Integrated Domain Group Model, 3.0.3, 2021_01D
1658BRIDG_5_3Biomedical Research Integrated Domain Group Model, 5.3, 2021_01D
17254caDSRCancer Data Standards Registry and Repository, 2021_01D
407CARELEXContent Archive Resource Exchange Lexicon, 2021_01D
49CBDDChemical Biology and Drug Development Vocabulary, 2021_01D
923CDCU.S. Centers for Disease Control and Prevention, 2021_01D
23324CDISCClinical Data Interchange Standards Consortium, 2021_01D
770CDISC-GLOSSClinical Data Interchange Standards Consortium Glossary Terms, 2021_01D
2000CELLOSAURUSCellosaurus, 2021_01D
3688CPTACClinical Proteomic Tumor Analysis Consortium, 2021_01D
406CRCHCancer Research Center of Hawaii Nutrition Terminology, 2021_01D
775CTCAECommon Terminology Criteria for Adverse Events, 2021_01D
5599CTCAE_3Common Terminology Criteria for Adverse Events 3.0, 2021_01D
4022CTCAE_5Common Terminology Criteria for Adverse Events 5.0, 2021_01D
276CTDCClinical Trial Data Commons, 2021_01D
318CTEPCancer Therapy Evaluation Program, 2004
373CTEP-SDCCancer Therapy Evaluation Program - Simple Disease Classification, 2021_01D
23675CTRPClinical Trials Reporting Program, 2021_01D
903DCPNCI Division of Cancer Prevention Program, 2021_01D
114DICOMDigital Imaging Communications in Medicine, 2021_01D
694DTPNCI Developmental Therapeutics Program, 2021_01D
1026EDQM-HCEuropean Directorate for the Quality of Medicines & Healthcare, 2021_01D
24499FDAU.S. Food and Drug Administration, 2021_01D
207GAIAGlobal Alignment of Immunization Safety Assessment in pregnancy, 2021_01D
5055GDCNCI Genomic Data Commons, 2021_01D
281GENCGeopolitical Entities, Names, and Codes Standard, 2021_01D
632ICDCNCI Integrated Canine Data Commons, 2021_01D
215ICHInternational Conference on Harmonization, 2021_01D
215INCInternational Neonatal Consortium, 2021_01D
156JAXJackson Laboratories Mouse Terminology, adapted for NCI use, 2021_01D
244KEGGKEGG Pathway Database, 2021_01D
158661NCINational Cancer Institute Thesaurus, 2021_01D
5077NCI-GLOSSNCI Dictionary of Cancer Terms, 2021_01D
5158NCI-HGNCNCI HUGO Gene Nomenclature Committee, 2021_01D
129NCI-HL7NCI Health Level 7, 2021_01D
509NCPDPNational Council for Prescription Drug Programs, 2021_01D
5NDCNational Drug Code, 2021_01D
4781NICHDNational Institute of Child Health and Human Development, 2021_01D
879PCDCPediatric Cancer Data Commons, 2021_01D
39PI-RADSProstate Imaging Reporting and Data System, 2021_01D
169PIDNational Cancer Institute Nature Pathway Interaction Database, 2021_01D
310RENIRegistry Nomenclature Information System, 2021_01D
1437UCUMUnified Code for Units of Measure, 2021_01D
25ZFINZebrafish Model Organism Database, 2021_01D

NCIm concepts

Source Label - Other

Source Name

15881AODAlcohol and Other Drug Thesaurus, 2000
276AOTAuthorized Osteopathic Thesaurus, 2003
13256CBOClinical Bioinformatics Ontology, 2011_02
280CCS_10Clinical Classifications Software for ICD-10-PCS, 2020
537CCSR_10Clinical Classifications Software Refined for ICD-10-CM, 2020
3079COSTARCOSTAR, 1989-1995
16495CSPCRISP Thesaurus, 2006
3844CSTCOSTART, 1995
484CVXVaccines Administered, 2017_02_08, 2020_07_28
8739DRUGBANKDrugBank, 5.0_2016_06_22, 5.0_2020_07_30
7289DXPDXplain, 1994
102564FMAFoundational Model of Anatomy Ontology, 4_15
7498GARDGenetic and Rare Diseases Information Center, 2015_04
70907GOGene Ontology, 2020_05_02
7392HCPCSHealthcare Common Procedure Coding System, 2020
41990HGNCHUGO Gene Nomenclature Committee, 2020_05
9745HL7V3.0HL7 Vocabulary Version 3.0, 2019_12
16693HPOHuman Phenotype Ontology, 2020_06_08
17424ICD10ICD10, 2016
103155ICD10CMInternational Classification of Diseases, 10th Edition, Clinical Modification, 2021
190672ICD10PCSICD-10-PCS, 2021
20940ICD9CMInternational Classification of Diseases, Ninth Revision, Clinical Modification, 2014
2874ICDOInternational Classification of Disease for Oncology, 3_2
748ICPCInternational Classification of Primary Care, 1993
5055ISO3166-2International Organization for Standardization 3166-2, 2012
161239LNCLOINC, 268
41MCMMcMaster University Epidemiology Terms, 1992
332MDBCACMitelman Database of Chromosome Aberrations in Cancer, 2005_12
57970MDRMedical Dictionary for Regulatory Activities Terminology (MedDRA), 23_1
3375MED-RTMedication Reference Terminology, 2020_09_08
2125MEDLINEPLUSMedlinePlus Health Topics, 20191029
900MGEDMGED Ontology, 131
399713MSHMedical Subject Headings, 2021_2020_07_16
206928MTHUMLS Metathesaurus, 2020AB
8MTHCMSFRFMetathesaurus CMS Formulary Reference File, MTHCMSFRF_2014
19016MTHICD9International Classification of Diseases, Ninth Revision, Clinical Modification, Metathesaurus additional entry terms, 2014
1633MTHMSTMetathesaurus Version of Minimal Standard Terminology Digestive Endoscopy, 2001
65727MTHSPLMetathesaurus FDA Structured Product Labels, 2020_08_28
78MVXManufacturers of Vaccines, 2020_09_04
1907788NCBINCBI Taxonomy, 2020_05_21
0NCISEERNCI SEER ICD Neoplasm Code Mappings, 1999
1887NPONPO: NanoParticle Ontology for Cancer Nanotechnology Research, 2011_12_08
93898OMIMOnline Mendelian Inheritance in Man, 2020_07_27
12400PDQPhysician Data Query, 2016_07_31
2039PMAPortfolio Management Application, 2010
260PNDSPerioperative Nursing Data Set, 4_2018
940QMRQuick Medical Reference (QMR), 1996
45724RADLEXRadLex, 4_0
195824RXNORMRxNorm Vocabulary, 20AA_200908F
352065SNOMEDCT_USUS Edition of SNOMED CT, 2020_09_01
169SOPSource of Payment Typology, 9
4810SPNStandard Product Nomenclature, 2003
210SRCMetathesaurus Source Terminology Names
28128UMDUMDNS: product category thesaurus, 2020
4808USPUSP Compendial Nomenclature, 2020_02_06
1605USPMGUSP Medicare Model Guidelines, 2020
61111UWDAUniversity of Washington Digital Anatomist, 1.7.3
35546VANDFVeterans Health Administration National Drug File, 2020_08_03

Overall Counts (May 2021)

ConceptsRelationships Attributes Total Number of Terms


 27,255,262 8,300,055

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