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SYNOPSIS: Dr. Hall will begin this talk by discussing cutting-edge conceptual and empirical work that highlight trends in team science and offer insights into what makes for successful collaboration in science. She will highlight a conceptual model for transdisciplinary research, as well as empirical findings produced by the National Cancer Institute’s SciTS (Science of Team Science) team that provide guidelines and strategies for success in team science. She will then highlight the NCI’s Team Science Toolkit website (www.teamsciencetoolkit.cancer.gov), a “one-stop-shop” for resources to help lead, manage, evaluate, facilitate, or support team science. She will feature key resources available through the Toolkit that can be used by investigators, academic institutions, and funders to maximize the success of team science. Finally, Dr. Hall will discuss needed future directions to build the SciTS evidence base, and discuss current projects of the NCI SciTS team in support of these goals, including development of a systems map of the factors influencing success in team science.
BIO:
Kara Hall, Ph.D., is a Health Scientist, Director of the Science of Team Science (SciTS) Team, and Co-Director of the Theories Project in the Science of Research and Technology Branch, Behavioral Research Program, Division of Cancer Control and Population Sciences at NCI. During her career, Dr. Hall has participated in a wide variety of interdisciplinary clinical and research endeavors. Dr. Hall was instrumental in the development of a National Research Council consensus study and serves as member of The National Academies Committee on the Science of Team Science (2012-2014). Dr. Hall also co-chairs a Trans-Agency Subcommittee on Collaboration and Team Science of the Federal Networking and Information Technology Research and Development (NITRD) Program in the National Science and Technology Council in the Executive Office of the President.
SUMMARY:
Topic: Team-Based Science — Strategies for Success, Practical Tools, and Future Directions
Speaker: Kara Hall, Ph.D.
Date: Wednesday, December 10, 2014
Time: 11 AM – 12 PM ET
You are invited to listen to Dr. Hall's presentation in Room 2W908 in the NCI Shady Grove Building on Medical Center Drive or via WebEx.
Presentation: A screen cast of the presentation will be available for viewing after the event on our Speaker Series Videos page and on the NCI CBIIT Speaker Series YouTube Playlist 
. View the presentation slides.
About the NCI CBIIT Speaker Series:
The National Cancer Institute (NCI) Center for Biomedical Informatics and Information Technology (CBIIT) Speaker Series is a bi-weekly knowledge-sharing forum featuring both internal and external speakers on topics of interest to the biomedical informatics and research communities. For additional information, including past speaker series presentations, visit the CBIIT Speaker Series page.
Individuals with disabilities who need reasonable accommodation to participate in this program should contact the Office of Space and Facilities Management (OSFM) at 240-276-5900 or the Federal TTY Relay number 1-800-877-8339.
SYNOPSIS:
“My Life in A Day” is a multipurpose smartphone diary and recall that may be used to collect daily time-use, geospatial, image, and other environmental context data in health research. The smartphone application features a customizable interface that can be tailored to the preferences of individual research participants and a built-in crosswalk that links participant customizations to data standards established by the researcher — in essence, allowing participants the flexibility of free-text response and researchers the ease of discrete response options. “My Life in a Day” was developed as a lightweight tool to collect free-living behavior data for a broad variety of research questions and designs, including clinical monitoring, behavioral interventions, and surveillance studies. “My Life in a Day” was created by Dr. James McClain and Dr. Heather Bowles.
BIOs:
Heather Bowles, Ph.D. is a Physical Activity Epidemiologist with the Risk Factor Monitoring and Methods Branch in NCI's Applied Research Program. Before coming to the National Cancer Institute, Dr. Bowles held a research academic appointment in Australia at the Centre for Physical Activity and Health, University of Sydney. Dr. Bowles earned her Ph.D. in Epidemiology from the University of South Carolina and her M.S. in Kinesiology from the University of North Texas.
James McClain, Ph.D., M.P.H., is also a Physical Activity Epidemiologist with the Risk Factor Monitoring and Methods Branch in NCI's Applied Research Program. He first joined the National Cancer Institute as a Cancer Prevention Fellow in 2007. Dr. McClain earned a B.S. and M.S. in Exercise Physiology from Iowa State University, a Ph.D. in Physical Activity, Nutrition, and Wellness from Arizona State University, and an M.P.H. from Johns Hopkins Bloomberg School of Public Health.
SUMMARY:
Topic: Impetus for and Development of a Lightweight, Versatile Smartphone Diary for Research
Speakers: Dr. Heather Bowles and Dr. James McClain
Date: Wednesday, November 12, 2014
Time: 11 AM – 12 PM ET
You are invited to listen to Dr. Bowles' and Dr. McClain's presentation in Room 2W908 in the NCI Shady Grove Building on Medical Center Drive or via WebEx.
Presentation: A screen cast of the presentation will be available for viewing after the event on the NCI CBIIT Speaker Series YouTube Playlist .
About the NCI CBIIT Speaker Series:
The National Cancer Institute (NCI) Center for Biomedical Informatics and Information Technology (CBIIT) Speaker Series is a bi-weekly knowledge-sharing forum featuring both internal and external speakers on topics of interest to the biomedical informatics and research communities. For additional information, including past speaker series presentations, visit the CBIIT Speaker Series page.
Individuals with disabilities who need reasonable accommodation to participate in this program should contact the Office of Space and Facilities Management (OSFM) at 240-276-5900 or the Federal TTY Relay number 1-800-877-8339.
SYNOPSIS: The Office of Research Information Services (ORIS) was created within the Office of the Chief Information Officer to address the need to manage the digital output of all of the research activities of the institution. ORIS has built a first pilot system of SIdora, a general information architecture and software environment based on Islandora and Fedora that is designed to be used by Smithsonian researchers to capture and organize the digital "evidence" as they create it in their research process, and use it directly in their analysis and dissemination activities. The goal is to actively support the research process as it unfolds, leaving behind a coherent expression of the digital content for a complete research project that can permanently stand alongside related publications. The SIdora architecture, which is designed to manage research output as if it were part of a network of information, will be presented and the first version of the software will be demonstrated for managing the excavation evidence of a complete archaeological site in Panama, and for an international study of mammal populations. The demonstration will show how the system enables researchers to manage and describe their own data, use it with Taverna workflows for analysis, and to expose sets of durable resources to be cited in publications.
BIO:
Thornton (Thorny) Staples is the Director of the Office of Research Information Services at the Smithsonian Institution, Office of the Chief Information Officer (CIO). He has previously been Director of the Fedora Project; Director of Community Strategy and Alliances for DuraSpace; CIO of the Smithsonian American Art Museum; Director of Digital Library Research and Development at the University of Virginia; Special Projects Coordinator for Academic Computing at the University of Virginia; and Project Director at the Institute for Advanced Technology in the Humanities at the University of Virginia, which was responsible for the creation of the Rossetti Archive and The Valley of the Shadow. He has also been involved with the development of information architecture for large, complex digital academic and cultural history projects in Europe, Australia and the United States.
SUMMARY:
Topic: SIdora, A Software Environment for Supporting Research at the Smithsonian
Speaker: Thornton Staples
Date: Wednesday, October 29, 2014
Time: 11 AM – 12 PM EDT
You are invited to listen to Mr. Staples' presentation in Room 2W908 in the NCI Shady Grove Building on Medical Center Drive or via WebEx.
Presentation: A screen cast of the presentation will be available for viewing after the event on the NCI CBIIT Speaker Series YouTube Playlist .
About the NCI CBIIT Speaker Series:
The National Cancer Institute (NCI) Center for Biomedical Informatics and Information Technology (CBIIT) Speaker Series is a bi-weekly knowledge-sharing forum featuring both internal and external speakers on topics of interest to the biomedical informatics and research communities. For additional information, including past speaker series presentations, visit the CBIIT Speaker Series page.
Individuals with disabilities who need reasonable accommodation to participate in this program should contact the Office of Space and Facilities Management (OSFM) at 240-276-5900 or the Federal TTY Relay number 1-800-877-8339.
SYNOPSIS: Modern day research could use a hard refresh. In recent years, we've seen an explosion of activity and push for more "open science," from increased access to content and data to new tools and technology to help us address bottlenecks slowing down discovery. But for all of that development, the system is still moving slowly, gaps in training and skills still exist, and we're not moving forward in a coordinated fashion. This talk will look at how we can better work together to advance the mission of more open, collaborative, web-enabled science, and how, together, we can influence the culture of science by demonstrating new and open ways to conduct research on the web.
BIO:
Kaitlin Thaney is the director of the Mozilla Science Lab, an open science initiative of the Mozilla Foundation focused on innovation, best practice, and skills training for research. Prior to Mozilla, Ms. Thaney served as the Manager of External Partnerships at Digital Science, a technology company that works to make research more efficient through better use of technology. Ms. Thaney also advises the UK government on infrastructure for data intensive science and business, serves as a Director for DataKind UK, and is the founding co-chair for the Strata Conference series in London on big data. Prior to Mozilla and Digitial Science, she managed the science program at Creative Commons, worked with MIT and Microsoft, and wrote for the Boston Globe.
SUMMARY:
Topic: Making the Web Work for Science
Speaker: Kaitlin Thaney
Date: Wednesday, October 15, 2014
Time: 11 AM – 12 PM EDT
You are invited to listen to Ms. Thaney's presentation in Room 2W910-912 in the NCI Shady Grove Building on Medical Center Drive or via WebEx.
Presentation: A screen cast of the presentation will be available for viewing after the event on the NCI CBIIT Speaker Series YouTube Playlist .
About the NCI CBIIT Speaker Series:
The National Cancer Institute (NCI) Center for Biomedical Informatics and Information Technology (CBIIT) Speaker Series is a bi-weekly knowledge-sharing forum featuring both internal and external speakers on topics of interest to the biomedical informatics and research communities. For additional information, including past speaker series presentations, visit the CBIIT Speaker Series page.
Individuals with disabilities who need reasonable accommodation to participate in this program should contact the Office of Space and Facilities Management (OSFM) at 240-276-5900 or the Federal TTY Relay number 1-800-877-8339.
SYNOPSIS: Historically, clinical research has suffered from the lack of comprehensive tools to measure patient centered outcomes that are brief, highly accurate, and valid for comparisons across the age spectrum and in both healthy populations and disease groups. To address these gaps, the NIH supported the development of four groundbreaking measurement systems: the Patient Reported Outcomes Measurement Information System® (PROMIS®), the NIH Toolbox for Assessment of Neurological and Behavioral Function (NIH Toolbox), the Quality of Life Outcomes in Neurological Disorders (Neuro-QOL), and the Adult Sickle Cell Quality of Life Measurement Information System (ASCQ-Me). These systems measure a complement of important health outcomes either from the individual participant's or patient’s perspective (e.g., symptoms, function, health-related quality of life), or provide performance measures of function (e.g., sensory, motor, and cognitive health). In August 2014, the NCI awarded a trans-NIH Cooperative Agreement to integrate and support these four systems under one research resource. This presentation will describe the systems and their capabilities, and outline plans for their implementation in the research and clinical communities.
BIO:
Ashley Wilder Smith, Ph.D., M.P.H. is a Behavioral Scientist and Program Director in the Outcomes Research Branch of the Applied Research Program. Her program of research focuses on developing, advancing and promoting investigations related to improving current understanding of patient reported outcomes and quality care for cancer patients, survivors and families.
SUMMARY:
Topic: Person Centered Assessment Resource: An Innovative Health Measurement System
Speaker: Ashley Wilder Smith, Ph.D., M.P.H.
Date: Wednesday, October 1, 2014
Time: 11 AM – 12 PM EDT
You are invited to listen to Dr. Smith's presentation in Room 2W908 in the NCI Shady Grove Building on Medical Center Drive or via WebEx.
Presentation: A screen cast of the presentation will be available for viewing after the event on the NCI CBIIT Speaker Series YouTube Playlist .
About the NCI CBIIT Speaker Series:
The National Cancer Institute (NCI) Center for Biomedical Informatics and Information Technology (CBIIT) Speaker Series is a bi-weekly knowledge-sharing forum featuring both internal and external speakers on topics of interest to the biomedical informatics and research communities. For additional information, including past speaker series presentations, visit the CBIIT Speaker Series page.
Individuals with disabilities who need reasonable accommodation to participate in this program should contact the Office of Space and Facilities Management (OSFM) at 240-276-5900 or the Federal TTY Relay number 1-800-877-8339.
SYNOPSIS: Epigenetic modification such as DNA methylation plays a key role in disease susceptibility and gene regulation. However, the genetic regulation of DNA methylation in human is not fully appreciated. Based on the Environment And Genetics of Lung Etiology (EAGLE) study in the NCI’s Division of Cancer Epidemiology and Genetics (DCEG), we performed a methylation-quantitative trait loci (meQTL) analysis in 210 histologically normal human lung tissues. We identified 34,304 cis- and 585 trans-meQTLs, a genetic-epigenetic interaction of surprising magnitude. These findings are replicated in both breast and kidney tissues and show distinct patterns: cis-meQTLs mostly localize to CpG sites outside of genes, promoters and CpG islands (CGIs), while trans-meQTLs are over-represented in promoter CGIs. meQTL SNPs are enriched in CTCF-binding sites, DNaseI hypersensitivity regions and histone marks. Importantly, four of the five established lung cancer risk loci in European ancestry are cis-meQTLs and, in aggregate, cis-meQTLs are enriched for lung cancer risk in a genome-wide analysis of 11,587 subjects. Thus, inherited genetic variation may affect lung carcinogenesis by regulating the human methylome. We developed a novel statistical algorithm and identified an association hotspot with replication in The Cancer Genome Atlas (TCGA) samples.
BIO:
Jianxin Shi received a Ph.D. in Statistics from Stanford University in 2006. He then pursued a postdoctoral research fellowship at the Stanford University School of Medicine focusing his studies on the genetic mapping of psychiatric disorders from 2006 to 2009. Dr. Shi is currently a tenure track investigator in the Biostatistics Branch of the Division of Cancer Epidemiology and Genetics at the NCI. His research focuses on cancer genetics and genomics.
SUMMARY:
Topic: Characterizing the Genetic Basis of Methylome Diversity in Histologically Normal Human Lung Tissue
Speaker: Jianxin Shi, Ph.D.
Date: Wednesday, September 17, 2014
Time: 11 AM – 12 PM EDT
You are invited to listen to Dr. Shi's presentation in Room 2W908 in the NCI Shady Grove Building on Medical Center Drive or via WebEx.
Presentation: A screen cast of the presentation will be available for viewing after the event on the NCI CBIIT Speaker Series YouTube Playlist .
About the NCI CBIIT Speaker Series:
The National Cancer Institute (NCI) Center for Biomedical Informatics and Information Technology (CBIIT) Speaker Series is a bi-weekly knowledge-sharing forum featuring both internal and external speakers on topics of interest to the biomedical informatics and research communities. For additional information, including past speaker series presentations, visit the CBIIT Speaker Series page.
Individuals with disabilities who need reasonable accommodation to participate in this program should contact the Office of Space and Facilities Management (OSFM) at 240-276-5900 or the Federal TTY Relay number 1-800-877-8339.
SYNOPSIS: The NIH Biomedical Translational Research Information System (BTRIS) comprises a repository of clinical research data and a set of tools for NIH investigators to access those data. BTRIS data sources include the NIH Clinical Center’s past (1976-2004) and current (2004-present) electronic health record systems and a number of NIH institute systems, including two NCI systems (LabMatrix and C3D). Tools include a reporting facility for obtaining identifiable protocol-specific data from active clinical protocols and a query facility for obtaining de-identified data sets from across all active and terminated protocols. The presentation will describe the system architecture (including the BTRIS data model and ontology), the reporting and querying tools, and policy issues related to use and re-use of the data.
BIO:
James Cimino, M.D., is a board certified internist who completed a National Library of Medicine (NLM) informatics fellowship at the Massachusetts General Hospital and Harvard University. Following his fellowship, he accepted an academic position at Columbia University College of Physicians and Surgeons and the Presbyterian Hospital in New York City.
Dr. Cimino joined the NIH in 2008, where he now serves as the Chief of the Laboratory for Informatics Development and a Tenured Investigator at the NIH Clinical Center and the NLM. His principal project involves the development of the Biomedical Translational Research Information System (BTRIS), an NIH-wide clinical research data resource. Additionally, he conducts clinical informatics research, directs the NLM's postdoctoral training program in clinical informatics, serves as an internal medicine consultant in the Clinical Center, and teaches as an Adjunct Professor at both Columbia and Georgetown universities. Dr. Cimino is also co-editor of a leading textbook on Biomedical Informatics and an Associate Editor of the Journal of Biomedical Informatics.
SUMMARY:
Topic: The NIH Biomedical Translational Research Information System (BTRIS)
Speaker: James J. Cimino, M.D.
Date: Wednesday, September 3, 2014
Time: 11 AM – 12 PM EDT
Presentation: A screen cast of the presentation will be available for viewing after the event on the NCI CBIIT Speaker Series YouTube Playlist .
About the NCI CBIIT Speaker Series:
The National Cancer Institute (NCI) Center for Biomedical Informatics and Information Technology (CBIIT) Speaker Series is a bi-weekly knowledge-sharing forum featuring both internal and external speakers on topics of interest to the biomedical informatics and research communities. For additional information, including past speaker series presentations, visit the CBIIT Speaker Series page.
Individuals with disabilities who need reasonable accommodation to participate in this program should contact the Office of Space and Facilities Management (OSFM) at 240-276-5900 or the Federal TTY Relay number 1-800-877-8339.
SYNOPSIS: The Roswell Park Cancer Institute's Gynecologic Oncology Group (GOG) is a non-profit international organization with the purpose of promoting excellence in the quality and integrity of clinical and basic scientific research in the field of gynecologic malignancies. Approximately 45 individual clinical trials are active at any one time within GOG for patients with a variety of gynecologic malignancies, including cancers that arise from the ovaries, uterus, and cervix. The GOG has recently joined with the National Surgical Adjuvant Breast and Bowel Project and the Radiation Therapy Oncology Group to form NRG Oncology.
The GOG developed a Web-based data entry system utilizing Cardiff TELEForms, JavaScript, ASP, and ASP.NET/C#. The eCRFs are designed in TELEForms and displayed via secured session SSL Web browsing session to the user in PDF format. The questions residing on the PDF forms are CDE compliant questions and the underlying logic is based upon the valid/permissible values contained within the CDE database. The years of experience using the CDE browser positioned GOG to easily adapt to the use of CDEs within the GOG’s instance of RAVE and carry this knowledge through to the NRG. During the transition to RAVE, the IT staff worked closely with the NCI, CTEP, and CTSU staff to develop methods for the Lead Protocol Organizations (LPOs) to capture NCI eCRF standard within their local terms and derive those values to the NCI standard fields or the reverse. This enables the data reported back to CTEP to be provided in caDSR values while allowing the LPOs to continue leveraging existing processes.
BIO:
Bill Elgie is the Director of Information Technology at the NRG-Buffalo and Gynecologic Oncology Group (GOG) SDMC Offices located within the Roswell Park Cancer Institute. His 30 year career in the information technology field includes over 20 years of directorship and management of computer professionals in the areas involving cancer and AIDS clinical trials research. Prior to joining GOG, Mr. Elgie was the Director of Technical Operations at the Frontier Science and Technology Research Foundation, Inc. in Amherst, New York. He received a B.A. in Computer Science in 1984 and an M.B.A. in 1994, both from Canisius College.
SUMMARY:
Topic: Evolution of Gynecologic Oncology Group (GOG) Use of caDSR From eCRFs to Rave
Speaker: Bill Elgie
Date: Wednesday, July 23, 2014
Time: 11 AM – 12 PM EDT
You are invited to listen to Mr. Elgie's presentation in Room 2W908 in the NCI Shady Grove Building on Medical Center Drive or via WebEx.
Presentation: A screen cast of the presentation will be available for viewing after the event here on the NCI CBIIT Speaker Series YouTube Playlist . The presentation slides are also attached.
About the NCI CBIIT Speaker Series:
The National Cancer Institute (NCI) Center for Biomedical Informatics and Information Technology (CBIIT) Speaker Series is a bi-weekly knowledge-sharing forum featuring both internal and external speakers on topics of interest to the biomedical informatics and research communities. For additional information, including past speaker series presentations, visit the CBIIT Speaker Series page.
Individuals with disabilities who need reasonable accommodation to participate in this program should contact the Office of Space and Facilities Management (OSFM) at 240-276-5900 or the Federal TTY Relay number 1-800-877-8339.
SYNOPSIS: In support of government initiatives in 3D printing, the NIH is making high-quality, scientifically accurate 3D printable files available through an online, open access portal. Few such files can be found on the Web, and most users lack the necessary 3D modeling skills to design custom scientific 3D models. The NIH 3D Print Exchange allows users to discover, share, and create bioscientific and biomedical 3D models that are ready to download and print in 3D. The site already includes hundreds of 3D models, and users are empowered to create their own 3D models through open source, web-based tools and video tutorials, and to share tips and tricks with the community in a discussion forum. Physicians and patients can also use the Exchange to visualize disease processes and treatments through 3D prints of medical imaging data. Students, teachers, and parents will find accompanying worksheets and lesson plans for use in STEM education. In the coming months, the Exchange will announce a nationwide challenge, calling on students to create their own 3D bioscientific models, to encourage use of 3D prints and 3D modeling techniques in the classroom.
BIO:
Darrell Hurt, Ph.D., heads the Computational Biology Section of the Bioinformatics and Computational Biosciences Branch in the Office of Cyber Infrastructure and Computational Biology at the National Institute of Allergy and Infectious Diseases (NIAID). Dr. Hurt focuses on computational structural biology, including protein folding, docking, and molecular dynamics. He also provides special expertise in 3D printing, visualization, and modeling. Before working at NIAID, Dr. Hurt did postdoctoral work in lipid signaling and cell trafficking using X-ray crystallography with Dr. James Hurley at National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). His educational background includes a B.S. in Chemistry with honors from Brigham Young University and a combined M.S./Ph.D. in Chemistry from Cornell University under the mentorship of Dr. Jon Clardy. His doctoral work was recognized with the Pauling Award from the American Crystallographic Association, and he is the author of several scientific research articles.
SUMMARY:
Topic: The NIH 3D Print Exchange
Speaker: Darrell Hurt, Ph.D., Section Head, Computational Biology, Bioinformatics and Computational Biosciences Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Date: Wednesday, July 9, 2014
Time: 11 AM – 12 PM EDT
You are invited to listen to Dr. Hurt's presentation in Room 2W908 in the NCI Shady Grove Building on Medical Center Drive or via WebEx.
Presentation: A screen cast of the presentation will be available for viewing after the event on the NCI CBIIT Speaker Series YouTube Playlist .
About the NCI CBIIT Speaker Series:
The National Cancer Institute (NCI) Center for Biomedical Informatics and Information Technology (CBIIT) Speaker Series is a bi-weekly knowledge-sharing forum featuring both internal and external speakers on topics of interest to the biomedical informatics and research communities. For additional information, including past speaker series presentations, visit the CBIIT Speaker Series page.
Individuals with disabilities who need reasonable accommodation to participate in this program should contact the Office of Space and Facilities Management (OSFM) at 240-276-5900 or the Federal TTY Relay number 1-800-877-8339.
SYNOPSIS: RAPID Stage is a real time surveillance system which will allow FDA to collect adverse events (AE) on emergency use of any FDA approved medical product during emergent health situations through mobile devices, or EHR information transmission systems. FDA will use cloud based, integrated tools and decision strategies to analyze, validate received and visualized AE reporting on regulatory dashboard and transmit public health information directly to healthcare professionals and organizations within 24 hours.
BIO:
Dr. Henry Francis is the Director of the Data Mining and Informatics Evaluation and Research Group in the Office of Translational Sciences, Center for Drug Evaluation and Research (CDER) at the Food and Drug Administration (FDA). In that capacity he directs a transdisciplinary group of senior scientists to test, create, and operate data analysis programs facilitating the efficient use of scientific methods to evaluate complex data information in order to make regulatory decisions for drug approval and drug safety. Dr. Francis’ specific interest is in the development of data mining techniques to enhance pharmacovigliance capabilities in national medication use and health care databases.
From October 2007 until March 2013, Dr. Francis was the deputy director of the Office of Surveillance and Epidemiology in the CDER. As a clinician, Dr. Francis was an assistant professor of medicine at the Johns Hopkins University School of Medicine’s Division of Infectious diseases.
He completed his Internal Medicine residency training at the Long Beach Veterans Administration Hospital in Long Beach, California, and his infectious diseases specialty training at the Johns Hopkins Hospital Division of Infectious Diseases. He has published over 60 papers and has contributed book chapters on U.S. and international public health issues.
SUMMARY:
Topic: Real-time Applications for Programmable Interactive Devices (RAPID) System for National Emergencies
Speaker: Henry ("Skip") Francis, M.D., Director for Data Mining and Informatics Evaluation and Research, Office of Translational Sciences, Center for Drug Evaluation and Research (CDER), Food and Drug Administration (FDA)
Date: Wednesday, June 11, 2014
Time: 11 AM – 12 PM EDT
You are invited to listen to Dr. Francis' presentation in Room 2W908 in the NCI Shady Grove Building on Medical Center Drive or via WebEx.
Presentation: A screen cast of the presentation will be available for viewing after the event here on the NCI CBIIT Speaker Series YouTube Playlist .
About the NCI CBIIT Speaker Series:
The National Cancer Institute (NCI) Center for Biomedical Informatics and Information Technology (CBIIT) Speaker Series is a bi-weekly knowledge-sharing forum featuring both internal and external speakers on topics of interest to the biomedical informatics and research communities. For additional information, including past speaker series presentations, visit the CBIIT Speaker Series page.
Individuals with disabilities who need reasonable accommodation to participate in this program should contact the Office of Space and Facilities Management (OSFM) at 240-276-5900 or the Federal TTY Relay number 1-800-877-8339.
SYNOPSIS: OMIM is a timely, comprehensive knowledge base of genes and genetic disorders. Comprised of over 22,000 entries describing about 14,500 genes and 7500 phenotypes, including single gene Mendelian disorders, traits (such as hair color), and more common disorders for which there is a significant genetic component. OMIM's free-text, structured entries allow rapid overview of knowledge regarding specific genes and disorders as well as a nuanced discussion of increasingly complex topics. During this presentation Dr. Hamosh will show the types of information (including structured data) available in OMIM regarding genes and disorders, the ability to access data from the front end as well as for batch queries through our API. This interactive session will engender discussion of ways to optimize the resource for your use.
BIO:
Dr. Ada Hamosh, the Dr. Frank V. Sutland Professor of Pediatric Genetics, is the Clinical Director of the McKusick-Nathans Institute of Genetic Medicine at the Johns Hopkins University School of Medicine, the Scientific Director of Online Mendelian Genetics in Man (OMIM®), and the Co-Chair of the Phenotype Review Committee of the combined Baylor-Hopkins Centers for Mendelian Genomics (CMG), a National Human Genome Research Institute-funded project to identify the genes responsible for known and novel Mendelian disorders. Over the past year, Dr. Hamosh and colleagues have developed PhenoDB , a Web-based tool for the collection, storage, and analysis of standardized phenotype and genotype data for use in the CMG project that is freely available to all for clinical and research use.
Dr. Hamosh has authored over 70 papers and serves on several international committees representing genome-phenome relationships, as well as phenotype ontologies, including the International Rare Disease Research Consortium, the Human Variome Project, the ClinGen Project, Global Alliance for Genomic Health, and the Human Genome Organization.
SUMMARY:
Topic: OMIM, Online Mendelian Inheritance in Man, A Knowledgebase of Genes and Genetic Disorders
Speaker: Ada Hamosh, M.P.H., M.D., Johns Hopkins University School of Medicine
Date: Wednesday, May 28, 2014
Time: 11 AM – 12 PM EDT
You are invited to listen to Dr. Hamosh's presentation in Room 2W908 in the NCI Shady Grove Building on Medical Center Drive or via WebEx.
Presentation: A screen cast of the presentation will be available for viewing after the event here on our Speaker Series Videos page and on the NCI CBIIT Speaker Series YouTube Playlist . The presentation slides are also attached.
About the NCI CBIIT Speaker Series:
The National Cancer Institute (NCI) Center for Biomedical Informatics and Information Technology (CBIIT) Speaker Series is a bi-weekly knowledge-sharing forum featuring both internal and external speakers on topics of interest to the biomedical informatics and research communities. For additional information, including past speaker series presentations, visit the CBIIT Speaker Series page.
Questions? Please email us at NCICBIITcomms@mail.nih.gov.
Individuals with disabilities who need reasonable accommodation to participate in this program should contact the Office of Space and Facilities Management (OSFM) at 240-276-5900 or the Federal TTY Relay number 1-800-877-8339.
SYNOPSIS: With over one million new biomedical publications indexed in PubMed every year, new biological knowledge is being generated at a breakneck pace. However, the scientific community’s ability to fully utilize that knowledge has not kept pace with the rate of knowledge generation. Developing better tools to efficiently query, summarize, and analyze the sum total of biomedical knowledge is a pressing challenge for the research community.
"Crowdsourcing" is one mechanism for addressing massive challenges by harnessing the collective efforts of large communities. Scientists and biologists are increasingly applying crowdsourcing toward research problems. In this presentation, Dr. Su will present three such efforts that focus on both organizing and generating new biological knowledge on the function of human genes.
BIO:
Andrew Su is an Associate Professor at the Scripps Research Institute in the Departments of Molecular and Experimental Medicine and Integrative Structural and Computational Biology. His research focuses on applying the tools of bioinformatics, statistics, crowdsourcing, and computer science to biomedical discovery. Prior to joining Scripps in July 2011, he was the Associate Director of Bioinformatics at the Genomics Institute of the Novartis Research Foundation in San Diego, California. He also serves as the Gene Wiki Editor at the journal Gene and on the Scientific Advisory Board of the Gene Ontology Consortium. Dr. Su received his Ph.D. in Chemistry from the Scripps Research Institute and a B.A. in Chemistry, Computing and Information Systems, and Integrated Science from Northwestern University.
SUMMARY:
Topic: Crowdsourcing Biology: The Gene Wiki, BioGPS, and Gene Games
Speaker: Andrew Su, Ph.D., Associate Professor, Scripps Research Institute
Date: Wednesday, May 14, 2014
Time: 11 AM – 12 PM EDT
You are invited to listen to Dr. Su's presentation in Room 2W908 in the NCI Shady Grove Building on Medical Center Drive or via WebEx.
Presentation: A screen cast of the presentation will be available for viewing after the event here on the NCI CBIIT Speaker Series YouTube Playlist . The presentation slides are also attached.
About the NCI CBIIT Speaker Series:
The National Cancer Institute (NCI) Center for Biomedical Informatics and Information Technology (CBIIT) Speaker Series is a bi-weekly knowledge-sharing forum featuring both internal and external speakers on topics of interest to the biomedical informatics and research communities. For additional information, including past speaker series presentations, visit the CBIIT Speaker Series page.
Questions? Please email us at NCICBIITcomms@mail.nih.gov.
Individuals with disabilities who need reasonable accommodation to participate in this program should contact the Office of Space and Facilities Management (OSFM) at 240-276-5900 or the Federal TTY Relay number 1-800-877-8339.
SYNOPSIS:This presentation will provide an overview of how CDER’s Computational Science Center (CSC) is integrating bioinformatics and analytics into the regulatory review environment. There are a number of components that work together to enable reviewers to utilize analytical tools to assist them in answering regulatory review questions and making decisions. These components include guidance and rule development, submission and use of standardized data, data validation, analytical tools that support data exploration from the reviewer perspective, and repositories to allow data integration. The CSC is a program that provides services to CDER, and review divisions to implement the components and facilitate analytical tool skill development.
BIO:
Dr. Lilliam Rosario is the Director of the Office of Computational Science (OCS) in the Office of Translational Sciences (OTS), Center for Drug Evaluation and Research (CDER) at the Food and Drug Administration (FDA). The OCS leads and directly supports the modernization of CDER’s scientific computing capabilities by providing services across the spectrum of innovation, supporting the submission and use of high-quality data, and providing access to high-end analytical tools and training, enabling the overall regulatory review process. Dr. Rosario has served as associate director in the FDA’s Office of Science and Innovation, Office of the Chief Scientist. She has also worked in the Office of New Drugs in FDA’s CDER. Dr. Rosario holds a Ph.D. in neuroscience from Rutgers University and a B.A. in chemistry from the University of Puerto Rico.
SUMMARY:
Topic: Modernizing the Review Process Through Innovation
Speaker: Lilliam Rosario, Ph.D.
Date: Wednesday, April 30, 11 a.m.-12 p.m. EDT
You are invited to listen to Dr. Rosario's presentation in Room 2W908 in the NCI Shady Grove Building on Medical Center Drive or via WebEx.
Presentation: A screen cast of the presentation will be available for viewing after the event here on our Speaker Series Videos page and on the NCI’s CBIIT Speaker Series YouTube Playlist . The presentation slides are also attached.
About the NCI CBIIT Speaker Series:
The National Cancer Institute (NCI) Center for Biomedical Informatics and Information Technology (CBIIT) Speaker Series is a bi-weekly knowledge-sharing forum featuring both internal and external speakers on topics of interest to the biomedical informatics and research communities. For additional information, including past speaker series presentations, visit the CBIIT Speaker Series page.
Questions? Please email us at NCICBIITcomms@mail.nih.gov.
Individuals with disabilities who need reasonable accommodation to participate in this program should contact the Office of Space and Facilities Management (OSFM) at 240-276-5900 or the Federal TTY Relay number 1-800-877-8339.
SYNOPSIS: Data drive research, but many studies use inefficient legacy technologies to manage their data. Better tools now exist for collecting, storing, using, and sharing data. For a large-scale new biobanking project within the prospective California Teachers Study cohort, we leveraged cloud computing and a Customer Relationship Management (CRM) system to build a novel data management system that provides real-time, on-demand access to all data, eliminates data silos, and reduces data management costs. We use mobile phones and tablets to ensure study-wide protocol compliance, guarantee high-quality data entry, and increase staff productivity. This presentation will describe why CRM and cloud computing are good for research and how we implemented our innovative system to achieve these results. We encourage other investigators to consider similar approaches and will discuss lessons learned from our experience.
BIO:
James V. Lacey, Jr., earned his M.P.H. and Ph.D. from the University of Michigan School of Public Health in Ann Arbor. From 1998 to 2009, while at the NCI’s Division of Cancer Epidemiology and Genetics (DCEG), he led and collaborated on a wide range of epidemiologic research studies. In 2009, he joined the Department of Population Sciences at City of Hope, a NCI-designated Comprehensive Cancer Center. Dr. Lacey’s research primarily focuses on the clinical epidemiology of female reproductive cancers.
SUMMARY:
Topic: Faster, Safer, Cheaper, Better: How CRM and Cloud Computing Can Help Studies Collect, Store, Use, and Share Data
Speaker: James Lacey, Ph.D., Associate Professor, Division of Cancer Etiology Department of Population Sciences, City of Hope
Date: Wednesday, April 16, 2014
Time: 11 AM – 12 PM EDT
You are invited to listen to Dr. Lacey's presentation in Room 2W908 in the NCI Shady Grove Building on Medical Center Drive or via WebEx.
Presentation: A screen cast of the presentation will be available for viewing after the event here on our Speaker Series Videos page and on the NCI CBIIT Speaker Series YouTube Playlist .
About the NCI CBIIT Speaker Series:
The National Cancer Institute (NCI) Center for Biomedical Informatics and Information Technology (CBIIT) Speaker Series is a bi-weekly knowledge-sharing forum featuring both internal and external speakers on topics of interest to the biomedical informatics and research communities. For additional information, including past speaker series presentations, visit the CBIIT Speaker Series page.
Questions? Please email us at NCICBIITcomms@mail.nih.gov.
Individuals with disabilities who need reasonable accommodation to participate in this program should contact the Office of Space and Facilities Management (OSFM) at 240-276-5900 or the Federal TTY Relay number 1-800-877-8339.
SYNOPSIS: The NCI Mouse Models of Human Cancers Consortium has provided a focus on animal cancer models for the last 15 years. However, the program ends in 2014, and a new entity is needed to extend the outreach and educational aspects of the Consortium to support new directions for translational applications of animal models. Dr. Marks will describe a new NCI program, an open Oncology Models Forum. The Forum will provide the cancer research community with a comprehensive resource for information to guide generating, validating, and credentialing new models, informing their practical uses, advancing modeling techniques, and providing catalogs of available models-related resources, programs, and services. The goal of the Forum program will center on effective, reliable use of mice, mouse models, and human-in-mouse models in translational cancer research. Key to the success of the Forum will be use of the HubZero® platform to enable collaborators from anywhere to work together on common problems that pertain to animal models.
BIO:
Dr. Cheryl Marks is Associate Director of the NCI’s Division of Cancer Biology, and manages the NCI Mouse Models of Human Cancers Consortium. Dr. Marks received her Ph.D. in biochemical genetics from the George Washington University, and post-doctoral training in the National Institute of Neurological Disorders and Stroke (NINDS) intramural program. She joined the NCI as a program director in 1987.
SUMMARY:
Topic: The Oncology Models Forum: An Interactive Platform for Collaborative Translational Research
Speaker: Cheryl Marks, Ph.D., Division Associate Director, NCI Division of Cancer Biology
Date: Wednesday, April 2, 2014
Time: 11 AM – 12 PM EDT
You are invited to listen to Dr. Marks' presentation in Room 2W908 in the NCI Shady Grove Building on Medical Center Drive or via WebEx.
Presentation: A screen cast of the presentation will be available for viewing after the event here on our Speaker Series Videos page and on the NCI CBIIT Speaker Series YouTube Playlist . The presentation slides are also attached.
About the NCI CBIIT Speaker Series:
The National Cancer Institute (NCI) Center for Biomedical Informatics and Information Technology (CBIIT) Speaker Series is a bi-weekly knowledge-sharing forum featuring both internal and external speakers on topics of interest to the biomedical informatics and research communities. For additional information, including past speaker series presentations, visit the CBIIT Speaker Series page.
Questions? Please email us at NCICBIITcomms@mail.nih.gov.
Individuals with disabilities who need reasonable accommodation to participate in this program should contact the Office of Space and Facilities Management (OSFM) at 240-276-5900 or the Federal TTY Relay number 1-800-877-8339.
