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Long NameAdverse Event/Serious Adverse Event CTCAE v4 NCI Standard Template
DefinitionThe collection of CDEs used in the Adverse Events/Serious Adverse Events module.
ContextcaBIG
Protocol Long NameNCI Standard Template Forms
WorkflowRELEASED
TypeCRF
Public ID3265657
Version1.0
Module Long NameModule InstructionsQuestionCDECDE Public IDCDE VersionQuestion InstructionsValue Domain Data TypeValue Domain Unit of MeasureDisplay FormatValid ValueForm Value Meaning TextForm Value Meaning Desc.
Mandatory Adverse Event QuestionsMust be included when this data is collected for reporting.
Adverse Event Term (v4.0)Common Terminology Criteria for Adverse Events Version 4.0 Low Level Term Name31253021.1Code used to identify the adverse event using a standard mechanism that facilitates analysis. CTEP's code list and associated Category/Term is currently a standard.CHARACTER
Abdominal distensionAbdominal distensionA disorder characterized by swelling of the abdomen.
Abdominal infectionAbdominal infectionA disorder characterized by an infectious process involving the abdominal cavity.
Abdominal painAbdominal painA disorder characterized by a sensation of marked discomfort in the abdominal region.
Abdominal soft tissue necrosisAbdominal soft tissue necrosisA disorder characterized by a necrotic process occurring in the soft tissues of the abdominal wall.
Abducens nerve disorderAbducens nerve disorderA disorder characterized by involvement of the abducens nerve (sixth cranial nerve).
Accessory nerve disorderAccessory nerve disorderA disorder characterized by involvement of the accessory nerve (eleventh cranial nerve).
AcidosisAcidosisA disorder characterized by abnormally high acidity (high hydrogen-ion concentration) of the blood and other body tissues.
Acoustic nerve disorder NOSAcoustic nerve disorder NOSA disorder characterized by involvement of the acoustic nerve (eighth cranial nerve).
Activated partial thromboplastin time prolongedActivated partial thromboplastin time prolongedAn abnormal laboratory test result in which the partial thromboplastin time is found to be greater than the control value. As a possible indicator of coagulopathy, a prolonged partial thromboplastin time (PTT) may occur in a variety of diseases and disorders, both primary and related to treatment.
Acute coronary syndromeAcute coronary syndromeA disorder characterized by signs and symptoms related to acute ischemia of the myocardium secondary to coronary artery disease. The clinical presentation covers a spectrum of heart diseases from unstable angina to myocardial infarction.
Acute kidney injuryAcute kidney injuryA disorder characterized by the acute loss of renal function and is traditionally classified as pre-renal (low blood flow into kidney), renal (kidney damage) and post-renal causes (ureteral or bladder outflow obstruction).
Adrenal insufficiencyAdrenal insufficiencyA disorder that occurs when the adrenal cortex does not produce enough of the hormone cortisol and in some cases, the hormone aldosterone. It may be due to a disorder of the adrenal cortex as in Addison's disease or primary adrenal insufficiency.
Adult respiratory distress syndromeAdult respiratory distress syndromeA disorder characterized by progressive and life-threatening pulmonary distress in the absence of an underlying pulmonary condition, usually following major trauma or surgery.
AgitationAgitationA disorder characterized by a state of restlessness associated with unpleasant feelings of irritability and tension.
AkathisiaAkathisiaA disorder characterized by an uncomfortable feeling of inner restlessness and inability to stay still; this is a side effect of some psychotropic drugs.
Alanine aminotransferase increasedAlanine aminotransferase increasedA finding based on laboratory test results that indicate an increase in the level of alanine aminotransferase (ALT or SGPT) in the blood specimen.
Alcohol intoleranceAlcohol intoleranceA disorder characterized by an increase in sensitivity to the adverse effects of alcohol, which can include nasal congestion, skin flushes, heart dysrhythmias, nausea, vomiting, indigestion and headaches.
Alkaline phosphatase increasedAlkaline phosphatase increasedA finding based on laboratory test results that indicate an increase in the level of alkaline phosphatase in a blood specimen.
AlkalosisAlkalosisA disorder characterized by abnormally high alkalinity (low hydrogen-ion concentration) of the blood and other body tissues.
Allergic reactionAllergic reactionA disorder characterized by an adverse local or general response from exposure to an allergen.
Allergic rhinitisAllergic rhinitisA disorder characterized by an inflammation of the nasal mucous membranes caused by an IgE-mediated response to external allergens. The inflammation may also involve the mucous membranes of the sinuses, eyes, middle ear, and pharynx. Symptoms include sneezing, nasal congestion, rhinorrhea and itching.
AlopeciaAlopeciaA disorder characterized by a decrease in density of hair compared to normal for a given individual at a given age and body location.
AmnesiaAmnesiaA disorder characterized by systematic and extensive loss of memory.
Anal fistulaAnal fistulaA disorder characterized by an abnormal communication between the opening in the anal canal to the perianal skin.
Anal hemorrhageAnal hemorrhageA disorder characterized by bleeding from the anal region.
Anal mucositisAnal mucositisA disorder characterized by inflammation of the mucous membrane of the anus.
Anal necrosisAnal necrosisA disorder characterized by a necrotic process occurring in the anal region.
Anal painAnal painA disorder characterized by a sensation of marked discomfort in the anal region.
Anal stenosisAnal stenosisA disorder characterized by a narrowing of the lumen of the anal canal.
Anal ulcerAnal ulcerA disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the anal canal.
AnaphylaxisAnaphylaxisA disorder characterized by an acute inflammatory reaction resulting from the release of histamine and histamine-like substances from mast cells, causing a hypersensitivity immune response. Clinically, it presents with breathing difficulty, dizziness, hypotension, cyanosis and loss of consciousness and may lead to death.
AnemiaAnemiaA disorder characterized by an reduction in the amount of hemoglobin in 100 ml of blood. Signs and symptoms of anemia may include pallor of the skin and mucous membranes, shortness of breath, palpitations of the heart, soft systolic murmurs, lethargy, and fatigability.
Ankle fractureAnkle fractureA finding of damage to the ankle joint characterized by a break in the continuity of the ankle bone. Symptoms include marked discomfort, swelling and difficulty moving the affected leg and foot.
Anorectal infectionAnorectal infectionA disorder characterized by an infectious process involving the anal area and the rectum.
AnorexiaAnorexiaA disorder characterized by a loss of appetite.
AnorgasmiaAnorgasmiaA disorder characterized by an inability to achieve orgasm.
AnxietyAnxietyA disorder characterized by apprehension of danger and dread accompanied by restlessness, tension, tachycardia, and dyspnea unattached to a clearly identifiable stimulus.
Aortic injuryAortic injuryA finding of damage to the aorta.
Aortic valve diseaseAortic valve diseaseA disorder characterized by a defect in aortic valve function or structure.
AphoniaAphoniaA disorder characterized by the inability to speak. It may result from injuries to the vocal cords or may be functional (psychogenic).
ApneaApneaA disorder characterized by cessation of breathing.
AppendicitisAppendicitisA disorder characterized by acute inflammation to the vermiform appendix caused by a pathogenic agent.
Appendicitis perforatedAppendicitis perforatedA disorder characterized by acute inflammation to the vermiform appendix caused by a pathogenic agent with gangrenous changes resulting in the rupture of the appendiceal wall. The appendiceal wall rupture causes the release of inflammatory and bacterial contents from the appendiceal lumen into the abdominal cavity.
ArachnoiditisArachnoiditisA disorder characterized by inflammation of the arachnoid membrane and adjacent subarachnoid space.
Arterial injuryArterial injuryA finding of damage to an artery.
Arteritis infectiveArteritis infectiveA disorder characterized by an infectious process involving an artery.
ArthralgiaArthralgiaA disorder characterized by a sensation of marked discomfort in a joint.
ArthritisArthritisA disorder characterized by inflammation involving a joint.
AscitesAscitesA disorder characterized by accumulation of serous or hemorrhagic fluid in the peritoneal cavity.
Aspartate aminotransferase increasedAspartate aminotransferase increasedA finding based on laboratory test results that indicate an increase in the level of aspartate aminotransferase (AST or SGOT) in a blood specimen.
AspirationAspirationA disorder characterized by inhalation of solids or liquids into the lungs.
AsystoleAsystoleA disorder characterized by a dysrhythmia without cardiac electrical activity. Typically, this is accompanied by cessation of the pumping function of the heart.
AtaxiaAtaxiaA disorder characterized by lack of coordination of muscle movements resulting in the impairment or inability to perform voluntary activities.
AtelectasisAtelectasisA disorder characterized by the collapse of part or the entire lung.
Atrial fibrillationAtrial fibrillationA disorder characterized by a dysrhythmia without discernible P waves and an irregular ventricular response due to multiple reentry circuits. The rhythm disturbance originates above the ventricles.
Atrial flutterAtrial flutterA disorder characterized by a dysrhythmia with organized rhythmic atrial contractions with a rate of 200-300 beats per minute. The rhythm disturbance originates in the atria.
Atrioventricular block completeAtrioventricular block completeA disorder characterized by a dysrhythmia with complete failure of atrial electrical impulse conduction through the AV node to the ventricles.
Atrioventricular block first degreeAtrioventricular block first degreeA disorder characterized by a dysrhythmia with a delay in the time required for the conduction of an electrical impulse through the atrioventricular (AV) node beyond 0.2 seconds; prolongation of the PR interval greater than 200 milliseconds.
Autoimmune disorderAutoimmune disorderA disorder resulting from loss of function or tissue destruction of an organ or multiple organs, arising from humoral or cellular immune responses of the individual to his own tissue constituents.
Avascular necrosisAvascular necrosisA disorder characterized by necrotic changes in the bone tissue due to interruption of blood supply. Most often affecting the epiphysis of the long bones, the necrotic changes result in the collapse and the destruction of the bone structure.
AzoospermiaAzoospermiaA disorder characterized by laboratory test results that indicate complete absence of spermatozoa in the semen.
Back painBack painA disorder characterized by marked discomfort sensation in the back region.
Bile duct stenosisBile duct stenosisA disorder characterized by a narrowing of the lumen of the bile duct.
Biliary anastomotic leakBiliary anastomotic leakA finding of leakage of bile due to breakdown of a biliary anastomosis (surgical connection of two separate anatomic structures).
Biliary fistulaBiliary fistulaA disorder characterized by an abnormal communication between the bile ducts and another organ or anatomic site.
Biliary tract infectionBiliary tract infectionA disorder characterized by an infectious process involving the biliary tract.
Bladder anastomotic leakBladder anastomotic leakA finding of leakage of urine due to breakdown of a bladder anastomosis (surgical connection of two separate anatomic structures).
Bladder infectionBladder infectionA disorder characterized by an infectious process involving the bladder.
Bladder perforationBladder perforationA disorder characterized by a rupture in the bladder wall.
Bladder spasmBladder spasmA disorder characterized by a sudden and involuntary contraction of the bladder wall.
BloatingBloatingA disorder characterized by subject-reported feeling of uncomfortable fullness of the abdomen.
Blood and lymphatic system disorders - Other, SpecifyBlood and lymphatic system disorders - Other, specifyNo Value Exists
Blood antidiuretic hormone abnormalBlood antidiuretic hormone abnormalA finding based on laboratory test results that indicate abnormal levels of antidiuretic hormone in the blood specimen.
Blood bilirubin increasedBlood bilirubin increasedA finding based on laboratory test results that indicate an abnormally high level of bilirubin in the blood. Excess bilirubin is associated with jaundice.
Blood corticotrophin decreasedBlood corticotrophin decreasedA finding based on laboratory test results that indicate an decrease in levels of corticotrophin in a blood specimen.
Blood gonadotrophin abnormalBlood gonadotrophin abnormalA finding based on laboratory test results that indicate abnormal levels of gonadotrophin hormone in a blood specimen.
Blood prolactin abnormalBlood prolactin abnormalA finding based on laboratory test results that indicate abnormal levels of prolactin hormone in a blood specimen.
Blurred visionBlurred visionA disorder characterized by visual perception of unclear or fuzzy images.
Body odorBody odorA disorder characterized by an abnormal body smell resulting from the growth of bacteria on the body.
Bone infectionBone infectionA disorder characterized by an infectious process involving the bones.
Bone marrow hypocellularBone marrow hypocellularA disorder characterized by the inability of the bone marrow to produce hematopoietic elements.
Bone painBone painA disorder characterized by marked discomfort sensation in the bones.
Brachial plexopathyBrachial plexopathyA disorder characterized by regional paresthesia of the brachial plexus, marked discomfort and muscle weakness, and limited movement in the arm or hand.
Breast atrophyBreast atrophyA disorder characterized by underdevelopment of the breast.
Breast infectionBreast infectionA disorder characterized by an infectious process involving the breast.
Breast painBreast painA disorder characterized by marked discomfort sensation in the breast region.
Bronchial fistulaBronchial fistulaA disorder characterized by an abnormal communication between the bronchus and another organ or anatomic site.
Bronchial infectionBronchial infectionA disorder characterized by an infectious process involving the bronchi.
Bronchial obstructionBronchial obstructionA disorder characterized by blockage of a bronchus passage, most often by bronchial secretions and exudates.
Bronchial strictureBronchial strictureA disorder characterized by a narrowing of the bronchial tube.
Bronchopleural fistulaBronchopleural fistulaA disorder characterized by an abnormal communication between a bronchus and the pleural cavity.
Bronchopulmonary hemorrhageBronchopulmonary hemorrhageA disorder characterized by bleeding from the bronchial wall and/or lung parenchyma.
BronchospasmBronchospasmA disorder characterized by a sudden contraction of the smooth muscles of the bronchial wall.
BruisingBruisingA finding of injury of the soft tissues or bone characterized by leakage of blood into surrounding tissues.
Bullous dermatitisBullous dermatitisA disorder characterized by inflammation of the skin characterized by the presence of bullae which are filled with fluid.
BurnBurnA finding of impaired integrity to the anatomic site of an adverse thermal reaction. Burns can be caused by exposure to chemicals, direct heat, electricity, flames and radiation. The extent of damage depends on the length and intensity of exposure and time until provision of treatment.
Buttock painButtock painA disorder characterized by marked discomfort sensation in the buttocks.
Capillary leak syndromeCapillary leak syndromeA disorder characterized by leakage of intravascular fluids into the extravascular space. This syndrome is observed in patients who demonstrate a state of generalized leaky capillaries following shock syndromes, low-flow states, ischemia-reperfusion injuries, toxemias, medications, or poisoning. It can lead to generalized edema and multiple organ failure.
Carbon monoxide diffusing capacity decreasedCarbon monoxide diffusing capacity decreasedA finding based on lung function test results that indicate a decrease in the lung capacity to absorb carbon monoxide.
Cardiac arrestCardiac arrestA disorder characterized by cessation of the pumping function of the heart.
Cardiac disorders - Other, SpecifyCardiac disorders - Other, specifyNo Value Exists
Cardiac troponin I increasedCardiac troponin I increasedA laboratory test result which indicates increased levels of cardiac troponin I in a biological specimen.
Cardiac troponin T increasedCardiac troponin T increasedA laboratory test result which indicates increased levels of cardiac troponin T in a biological specimen.
CataractCataractA disorder characterized by partial or complete opacity of the crystalline lens of one or both eyes. This results in a decrease in visual acuity and eventual blindness if untreated.
Catheter related infectionCatheter related infectionA disorder characterized by an infectious process that arises secondary to catheter use.
CD4 lymphocytes decreasedCD4 lymphocytes decreasedA finding based on laboratory test results that indicate an decrease in levels of CD4 lymphocytes in a blood specimen.
Cecal hemorrhageCecal hemorrhageA disorder characterized by bleeding from the cecum.
Cecal infectionCecal infectionA disorder characterized by an infectious process involving the cecum.
Central nervous system necrosisCentral nervous system necrosisA disorder characterized by a necrotic process occurring in the brain and/or spinal cord.
Cerebrospinal fluid leakageCerebrospinal fluid leakageA disorder characterized by loss of cerebrospinal fluid into the surrounding tissues.
Cervicitis infectionCervicitis infectionA disorder characterized by an infectious process involving the uterine cervix.
CheilitisCheilitisA disorder characterized by inflammation of the lip.
Chest pain - cardiacChest pain - cardiacA disorder characterized by substernal discomfort due to insufficient myocardial oxygenation.
Chest wall painChest wall painA disorder characterized by marked discomfort sensation in the chest wall region.
ChillsChillsA disorder characterized by a sensation of cold that often marks a physiologic response to sweating after a fever.
CholecystitisCholecystitisA disorder characterized by inflammation involving the gallbladder. It may be associated with the presence of gallstones.
Cholesterol highCholesterol highA finding based on laboratory test results that indicate higher than normal levels of cholesterol in a blood specimen.
Chronic kidney diseaseChronic kidney diseaseA disorder characterized by gradual and usually permanent loss of kidney function resulting in renal failure.
ChylothoraxChylothoraxA disorder characterized by milky pleural effusion (abnormal collection of fluid) resulting from accumulation of lymph fluid in the pleural cavity.
Cognitive disturbanceCognitive disturbanceA disorder characterized by a conspicuous change in cognitive function.
ColitisColitisA disorder characterized by inflammation of the colon.
Colonic fistulaColonic fistulaA disorder characterized by an abnormal communication between the large intestine and another organ or anatomic site.
Colonic hemorrhageColonic hemorrhageA disorder characterized by bleeding from the colon.
Colonic obstructionColonic obstructionA disorder characterized by blockage of the normal flow of the intestinal contents in the colon.
Colonic perforationColonic perforationA disorder characterized by a rupture in the colonic wall.
Colonic stenosisColonic stenosisA disorder characterized by a narrowing of the lumen of the colon.
Colonic ulcerColonic ulcerA disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the colon.
Concentration impairmentConcentration impairmentA disorder characterized by a deterioration in the ability to concentrate.
Conduction disorderConduction disorderA disorder characterized by pathological irregularities in the cardiac conduction system.
ConfusionConfusionA disorder characterized by a lack of clear and orderly thought and behavior.
Congenital, familial and genetic disorders - Other, SpecifyCongenital, familial and genetic disorders - Other, specifyNo Value Exists
ConjunctivitisConjunctivitisA disorder characterized by inflammation, swelling and redness to the conjunctiva of the eye.
Conjunctivitis infectiveConjunctivitis infectiveA disorder characterized by an infectious process involving the conjunctiva. Clinical manifestations include pink or red color in the eyes.
ConstipationConstipationA disorder characterized by irregular and infrequent or difficult evacuation of the bowels.
Constrictive pericarditisConstrictive pericarditisA disorder characterized by a thickened and fibrotic pericardial sac; these fibrotic changes impede normal myocardial function by restricting myocardial muscle action.
Corneal infectionCorneal infectionA disorder characterized by an infectious process involving the cornea.
Corneal ulcerCorneal ulcerA disorder characterized by an area of epithelial tissue loss on the surface of the cornea. It is associated with inflammatory cells in the cornea and anterior chamber.
CoughCoughA disorder characterized by sudden, often repetitive, spasmodic contraction of the thoracic cavity, resulting in violent release of air from the lungs and usually accompanied by a distinctive sound.
CPK increasedCPK increasedA finding based on laboratory test results that indicate an increase in levels of creatine phosphokinase in a blood specimen.
Cranial nerve infectionCranial nerve infectionA disorder characterized by an infectious process involving a cranial nerve.
Creatinine increasedCreatinine increasedA finding based on laboratory test results that indicate increased levels of creatinine in a biological specimen.
CushingoidCushingoidA disorder characterized by signs and symptoms that resemble Cushing's disease or syndrome: buffalo hump obesity, striations, adiposity, hypertension, diabetes, and osteoporosis, usually due to exogenous corticosteroids.
Cystitis noninfectiveCystitis noninfectiveA disorder characterized by inflammation of the bladder which is not caused by an infection of the urinary tract.
Cytokine release syndromeCytokine release syndromeA disorder characterized by nausea, headache, tachycardia, hypotension, rash, and shortness of breath; it is caused by the release of cytokines from the cells.
Death neonatalDeath neonatalA disorder characterized by cessation of life occurring during the first 28 days of life.
Death NOSDeath NOSA cessation of life that cannot be attributed to a CTCAE term associated with Grade 5.
DehydrationDehydrationA disorder characterized by excessive loss of water from the body. It is usually caused by severe diarrhea, vomiting or diaphoresis.
Delayed orgasmDelayed orgasmA disorder characterized by sexual dysfunction characterized by a delay in climax.
Delayed pubertyDelayed pubertyA disorder characterized by unusually late sexual maturity.
DeliriumDeliriumA disorder characterized by the acute and sudden development of confusion, illusions, movement changes, inattentiveness, agitation, and hallucinations. Usually, it is a reversible condition.
DelusionsDelusionsA disorder characterized by false personal beliefs held contrary to reality, despite contradictory evidence and common sense.
Dental cariesDental cariesA disorder characterized by the decay of a tooth, in which it becomes softened, discolored and/or porous.
Depressed level of consciousnessDepressed level of consciousnessA disorder characterized by a decrease in ability to perceive and respond.
DepressionDepressionA disorder characterized by melancholic feelings of grief or unhappiness.
Dermatitis radiationDermatitis radiationA finding of cutaneous inflammatory reaction occurring as a result of exposure to biologically effective levels of ionizing radiation.
Device related infectionDevice related infectionA disorder characterized by an infectious process involving the use of a medical device.
DiarrheaDiarrheaA disorder characterized by frequent and watery bowel movements.
Disseminated intravascular coagulationDisseminated intravascular coagulationA disorder characterized by systemic pathological activation of blood clotting mechanisms which results in clot formation throughout the body. There is an increase in the risk of hemorrhage as the body is depleted of platelets and coagulation factors.
DizzinessDizzinessA disorder characterized by a disturbing sensation of lightheadedness, unsteadiness, giddiness, spinning or rocking.
Dry eyeDry eyeA disorder characterized by dryness of the cornea and conjunctiva.
Dry mouthDry mouthA disorder characterized by reduced salivary flow in the oral cavity.
Dry skinDry skinA disorder characterized by flaky and dull skin; the pores are generally fine, the texture is a papery thin texture.
Duodenal fistulaDuodenal fistulaA disorder characterized by an abnormal communication between the duodenum and another organ or anatomic site.
Duodenal hemorrhageDuodenal hemorrhageA disorder characterized by bleeding from the duodenum.
Duodenal infectionDuodenal infectionA disorder characterized by an infectious process involving the duodenum.
Duodenal obstructionDuodenal obstructionA disorder characterized by blockage of the normal flow of stomach contents through the duodenum.
Duodenal perforationDuodenal perforationA disorder characterized by a rupture in the duodenal wall.
Duodenal stenosisDuodenal stenosisA disorder characterized by a narrowing of the lumen of the duodenum.
Duodenal ulcerDuodenal ulcerA disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the duodenal wall.
DysarthriaDysarthriaA disorder characterized by slow and slurred speech resulting from an inability to coordinate the muscles used in speech.
DysesthesiaDysesthesiaA disorder characterized by distortion of sensory perception, resulting in an abnormal and unpleasant sensation.
DysgeusiaDysgeusiaA disorder characterized by abnormal sensual experience with the taste of foodstuffs; it can be related to a decrease in the sense of smell.
DysmenorrheaDysmenorrheaA disorder characterized by abnormally painful abdominal cramps during menses.
DyspareuniaDyspareuniaA disorder characterized by painful or difficult coitus.
DyspepsiaDyspepsiaA disorder characterized by an uncomfortable, often painful feeling in the stomach, resulting from impaired digestion. Symptoms include burning stomach, bloating, heartburn, nausea and vomiting.
DysphagiaDysphagiaA disorder characterized by difficulty in swallowing.
DysphasiaDysphasiaA disorder characterized by impairment of verbal communication skills, often resulting from brain damage.
DyspneaDyspneaA disorder characterized by an uncomfortable sensation of difficulty breathing.
Ear and labyrinth disorders - Other, SpecifyEar and labyrinth disorders - Other, specifyNo Value Exists
Ear painEar painA disorder characterized by a sensation of marked discomfort in the ear.
Edema cerebralEdema cerebralA disorder characterized by swelling due to an excessive accumulation of fluid in the brain.
Edema faceEdema faceA disorder characterized by swelling due to excessive fluid accumulation in facial tissues.
Edema limbsEdema limbsA disorder characterized by swelling due to excessive fluid accumulation in the upper or lower extremities.
Edema trunkEdema trunkA disorder characterized by swelling due to excessive fluid accumulation in the trunk area.
Ejaculation disorderEjaculation disorderA disorder characterized by problems related to ejaculation. This category includes premature, delayed, retrograde and painful ejaculation.
Ejection fraction decreasedEjection fraction decreasedThe percentage computed when the amount of blood ejected during a ventricular contraction of the heart is compared to the amount that was present prior to the contraction.
Electrocardiogram QT corrected interval prolongedElectrocardiogram QT corrected interval prolongedA finding of a cardiac dysrhythmia characterized by an abnormally long corrected QT interval.
Encephalitis infectionEncephalitis infectionA disorder characterized by an infectious process involving the brain tissue.
Encephalomyelitis infectionEncephalomyelitis infectionA disorder characterized by an infectious process involving the brain and spinal cord tissues.
EncephalopathyEncephalopathyA disorder characterized by a pathologic process involving the brain.
Endocarditis infectiveEndocarditis infectiveA disorder characterized by an infectious process involving the endocardial layer of the heart.
Endocrine disorders - Other, SpecifyEndocrine disorders - Other, specifyNo Value Exists
EndophthalmitisEndophthalmitisA disorder characterized by an infectious process involving the internal structures of the eye.
EnterocolitisEnterocolitisA disorder characterized by inflammation of the small and large intestines.
Enterocolitis infectiousEnterocolitis infectiousA disorder characterized by an infectious process involving the small and large intestines.
Enterovesical fistulaEnterovesical fistulaA disorder characterized by an abnormal communication between the urinary bladder and the intestine.
EpistaxisEpistaxisA disorder characterized by bleeding from the nose.
Erectile dysfunctionErectile dysfunctionA disorder characterized by the persistent or recurrent inability to achieve or to maintain an erection during sexual activity.
Erythema multiformeErythema multiformeA disorder characterized by target lesions (a pink-red ring around a pale center).
ErythrodermaErythrodermaA disorder characterized by generalized inflammatory erythema and exfoliation. The inflammatory process involves > 90% of the body surface area.
Esophageal anastomotic leakEsophageal anastomotic leakA finding of leakage due to breakdown of an esophageal anastomosis (surgical connection of two separate anatomic structures).
Esophageal fistulaEsophageal fistulaA disorder characterized by an abnormal communication between the esophagus and another organ or anatomic site.
Esophageal hemorrhageEsophageal hemorrhageA disorder characterized by bleeding from the esophagus.
Esophageal infectionEsophageal infectionA disorder characterized by an infectious process involving the esophagus.
Esophageal necrosisEsophageal necrosisA disorder characterized by a necrotic process occurring in the esophageal wall.
Esophageal obstructionEsophageal obstructionA disorder characterized by blockage of the normal flow of the contents in the esophagus.
Esophageal painEsophageal painA disorder characterized by a sensation of marked discomfort in the esophageal region.
Esophageal perforationEsophageal perforationA disorder characterized by a rupture in the wall of the esophagus.
Esophageal stenosisEsophageal stenosisA disorder characterized by a narrowing of the lumen of the esophagus.
Esophageal ulcerEsophageal ulcerA disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the esophageal wall.
Esophageal varices hemorrhageEsophageal varices hemorrhageA disorder characterized by bleeding from esophageal varices.
EsophagitisEsophagitisA disorder characterized by inflammation of the esophageal wall.
EuphoriaEuphoriaA disorder characterized by an exaggerated feeling of well-being which is disproportionate to events and stimuli.
ExostosisExostosisA disorder characterized by non-neoplastic overgrowth of bone.
External ear inflammationExternal ear inflammationA disorder characterized by inflammation, swelling and redness to the outer ear and ear canal.
External ear painExternal ear painA disorder characterized by a sensation of marked discomfort in the external ear region.
Extraocular muscle paresisExtraocular muscle paresisA disorder characterized by incomplete paralysis of an extraocular muscle.
Extrapyramidal disorderExtrapyramidal disorderA disorder characterized by abnormal, repetitive, involuntary muscle movements, frenzied speech and extreme restlessness.
Eye disorders - Other, SpecifyEye disorders - Other, specifyNo Value Exists
Eye infectionEye infectionA disorder characterized by an infectious process involving the eye.
Eye painEye painA disorder characterized by a sensation of marked discomfort in the eye.
Eyelid function disorderEyelid function disorderA disorder characterized by impaired eyelid function.
Facial muscle weaknessFacial muscle weaknessA disorder characterized by a reduction in the strength of the facial muscles.
Facial nerve disorderFacial nerve disorderA disorder characterized by involvement of the facial nerve (seventh cranial nerve).
Facial painFacial painA disorder characterized by a sensation of marked discomfort in the face.
FallFallA finding of sudden movement downward, usually resulting in injury.
Fallopian tube anastomotic leakFallopian tube anastomotic leakA finding of leakage due to breakdown of a fallopian tube anastomosis (surgical connection of two separate anatomic structures).
Fallopian tube obstructionFallopian tube obstructionA disorder characterized by blockage of the normal flow of the contents in the fallopian tube.
Fallopian tube perforationFallopian tube perforationA finding of rupture of the fallopian tube wall.
Fallopian tube stenosisFallopian tube stenosisA disorder characterized by a narrowing of the fallopian tube lumen.
Fat atrophyFat atrophyA disorder characterized by shrinking of adipose tissue.
FatigueFatigueA disorder characterized by a state of generalized weakness with a pronounced inability to summon sufficient energy to accomplish daily activities.
Febrile neutropeniaFebrile neutropeniaA disorder characterized by a decrease in neutrophils associated with fever.
Fecal incontinenceFecal incontinenceA disorder characterized by inability to control the escape of stool from the rectum.
Female genital tract fistulaFemale genital tract fistulaA disorder characterized by an abnormal communication between a female reproductive system organ and another organ or anatomic site.
Feminization acquiredFeminization acquiredA disorder characterized by the development of secondary female sex characteristics in males due to extrinsic factors.
Fetal deathFetal deathA disorder characterized by death in utero; failure of the product of conception to show evidence of respiration, heartbeat, or definite movement of a voluntary muscle after expulsion from the uterus, without possibility of resuscitation.
Fetal growth retardationFetal growth retardationA disorder characterized by inhibition of fetal growth resulting in the inability of the fetus to achieve its potential weight.
FeverFeverA disorder characterized by elevation of the body's temperature above the upper limit of normal.
Fibrinogen decreasedFibrinogen decreasedA finding based on laboratory test results that indicate an decrease in levels of fibrinogen in a blood specimen.
Fibrosis deep connective tissueFibrosis deep connective tissueA disorder characterized by fibrotic degeneration of the deep connective tissues.
Flank painFlank painA disorder characterized by marked discomfort sensation on the lateral side of the body in the region below the ribs and above the hip.
Flashing lightsFlashing lightsA disorder characterized by a sudden or brief burst of light.
FlatulenceFlatulenceA disorder characterized by a state of excessive gas in the alimentary canal.
FloatersFloatersA disorder characterized by an individual seeing spots before their eyes. The spots are shadows of opaque cell fragments in the vitreous humor or lens.
Flu like symptomsFlu like symptomsA disorder characterized by a group of symptoms similar to those observed in patients with the flu. It includes fever, chills, body aches, malaise, loss of appetite and dry cough.
FlushingFlushingA disorder characterized by episodic reddening of the face.
Forced expiratory volume decreasedForced expiratory volume decreasedA finding based on test results that indicate a relative decrease in the fraction of the forced vital capacity that is exhaled in a specific number of seconds.
FractureFractureA finding of traumatic injury to the bone in which the continuity of the bone is broken.
Gait disturbanceGait disturbanceA disorder characterized by walking difficulties.
Gallbladder fistulaGallbladder fistulaA disorder characterized by an abnormal communication between the gallbladder and another organ or anatomic site.
Gallbladder infectionGallbladder infectionA disorder characterized by an infectious process involving the gallbladder.
Gallbladder necrosisGallbladder necrosisA disorder characterized by a necrotic process occurring in the gallbladder.
Gallbladder obstructionGallbladder obstructionA disorder characterized by blockage of the normal flow of the contents of the gallbladder.
Gallbladder painGallbladder painA disorder characterized by a sensation of marked discomfort in the gallbladder region.
Gallbladder perforationGallbladder perforationA disorder characterized by a rupture in the gallbladder wall.
Gastric anastomotic leakGastric anastomotic leakA finding of leakage due to breakdown of a gastric anastomosis (surgical connection of two separate anatomic structures).
Gastric fistulaGastric fistulaA disorder characterized by an abnormal communication between the stomach and another organ or anatomic site.
Gastric hemorrhageGastric hemorrhageA disorder characterized by bleeding from the gastric wall.
Gastric necrosisGastric necrosisA disorder characterized by a necrotic process occurring in the gastric wall.
Gastric perforationGastric perforationA disorder characterized by a rupture in the stomach wall.
Gastric stenosisGastric stenosisA disorder characterized by a narrowing of the lumen of the stomach.
Gastric ulcerGastric ulcerA disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the stomach.
GastritisGastritisA disorder characterized by inflammation of the stomach.
Gastroesophageal reflux diseaseGastroesophageal reflux diseaseA disorder characterized by reflux of the gastric and/or duodenal contents into the distal esophagus. It is chronic in nature and usually caused by incompetence of the lower esophageal sphincter, and may result in injury to the esophageal mucosal. Symptoms include heartburn and acid indigestion.
Gastrointestinal anastomotic leakGastrointestinal anastomotic leakA finding of leakage due to breakdown of a gastrointestinal anastomosis (surgical connection of two separate anatomic structures).
Gastrointestinal disorders - Other, SpecifyGastrointestinal disorders - Other, specifyNo Value Exists
Gastrointestinal fistulaGastrointestinal fistulaA disorder characterized by an abnormal communication between any part of the gastrointestinal system and another organ or anatomic site.
Gastrointestinal painGastrointestinal painA disorder characterized by a sensation of marked discomfort in the gastrointestinal region.
Gastrointestinal stoma necrosisGastrointestinal stoma necrosisA finding of a necrotic process occurring in the gastrointestinal tract stoma.
GastroparesisGastroparesisA disorder characterized by an incomplete paralysis of the muscles of the stomach wall resulting in delayed emptying of the gastric contents into the small intestine.
General disorders and administration site conditions - Other, SpecifyGeneral disorders and administration site conditions - Other, specifyNo Value Exists
Generalized muscle weaknessGeneralized muscle weaknessA disorder characterized by a reduction in the strength of muscles in multiple anatomic sites.
Genital edemaGenital edemaA disorder characterized by swelling due to an excessive accumulation of fluid in the genitals.
GGT increasedGGT increasedA finding based on laboratory test results that indicate higher than normal levels of the enzyme gamma-glutamyltransferase in the blood specimen. GGT (gamma-glutamyltransferase ) catalyzes the transfer of a gamma glutamyl group from a gamma glutamyl peptide to another peptide, amino acids or water.
Gingival painGingival painA disorder characterized by a sensation of marked discomfort in the gingival region.
GlaucomaGlaucomaA disorder characterized by an increase in pressure in the eyeball due to obstruction of the aqueous humor outflow.
Glossopharyngeal nerve disorderGlossopharyngeal nerve disorderA disorder characterized by involvement of the glossopharyngeal nerve (ninth cranial nerve).
Glucose intoleranceGlucose intoleranceA disorder characterized by an inability to properly metabolize glucose.
Growth acceleratedGrowth acceleratedA disorder characterized by greater growth than expected for age.
Growth hormone abnormalGrowth hormone abnormalA finding based on laboratory test results that indicate abnormal levels of growth hormone in a biological specimen.
Growth suppressionGrowth suppressionA disorder characterized by of stature that is smaller than normal as expected for age.
Gum infectionGum infectionA disorder characterized by an infectious process involving the gums.
GynecomastiaGynecomastiaA disorder characterized by excessive development of the breasts in males.
HallucinationsHallucinationsA disorder characterized by a false sensory perception in the absence of an external stimulus.
Haptoglobin decreasedHaptoglobin decreasedA finding based on laboratory test results that indicate an decrease in levels of haptoglobin in a blood specimen.
Head soft tissue necrosisHead soft tissue necrosisA disorder characterized by a necrotic process occurring in the soft tissues of the head.
HeadacheHeadacheA disorder characterized by a sensation of marked discomfort in various parts of the head, not confined to the area of distribution of any nerve.
Hearing impairedHearing impairedA disorder characterized by partial or complete loss of the ability to detect or understand sounds resulting from damage to ear structures.
Heart failureHeart failureA disorder characterized by the inability of the heart to pump blood at an adequate volume to meet tissue metabolic requirements, or, the ability to do so only at an elevation in the filling pressure.
HematomaHematomaA disorder characterized by a localized collection of blood, usually clotted, in an organ, space, or tissue, due to a break in the wall of a blood vessel.
HematosalpinxHematosalpinxA disorder characterized by the presence of blood in a fallopian tube.
HematuriaHematuriaA disorder characterized by laboratory test results that indicate blood in the urine.
Hemoglobin increasedHemoglobin increasedA finding based on laboratory test results that indicate increased levels of hemoglobin in a biological specimen.
HemoglobinuriaHemoglobinuriaA disorder characterized by laboratory test results that indicate the presence of free hemoglobin in the urine.
HemolysisHemolysisA disorder characterized by laboratory test results that indicate widespread erythrocyte cell membrane destruction.
Hemolytic uremic syndromeHemolytic uremic syndromeA disorder characterized by a form of thrombotic microangiopathy with renal failure, hemolytic anemia, and severe thrombocytopenia.
Hemorrhoidal hemorrhageHemorrhoidal hemorrhageA disorder characterized by bleeding from the hemorrhoids.
HemorrhoidsHemorrhoidsA disorder characterized by the presence of dilated veins in the rectum and surrounding area.
Hepatic failureHepatic failureA disorder characterized by the inability of the liver to metabolize chemicals in the body. Laboratory test results reveal abnormal plasma levels of ammonia, bilirubin, lactic dehydrogenase, and alkaline phosphatase.
Hepatic hemorrhageHepatic hemorrhageA disorder characterized by bleeding from the liver.
Hepatic infectionHepatic infectionA disorder characterized by an infectious process involving the liver.
Hepatic necrosisHepatic necrosisA disorder characterized by a necrotic process occurring in the hepatic parenchyma.
Hepatic painHepatic painA disorder characterized by a sensation of marked discomfort in the liver region.
Hepatitis viralHepatitis viralA disorder characterized by a viral pathologic process involving the liver parenchyma.
Hepatobiliary disorders - Other, SpecifyHepatobiliary disorders - Other, specifyNo Value Exists
HiccupsHiccupsA disorder characterized by repeated gulp sounds that result from an involuntary opening and closing of the glottis. This is attributed to a spasm of the diaphragm.
Hip fractureHip fractureA finding of traumatic injury to the hip in which the continuity of either the femoral head, femoral neck, intertrochanteric or subtrochanteric regions is broken.
HirsutismHirsutismA disorder characterized by the presence of excess hair growth in women in anatomic sites where growth is considered to be a secondary male characteristic and under androgen control (beard, moustache, chest, abdomen)
HoarsenessHoarsenessA disorder characterized by harsh and raspy voice arising from or spreading to the larynx.
Hot flashesHot flashesA disorder characterized by an uncomfortable and temporary sensation of intense body warmth, flushing, sometimes accompanied by sweating upon cooling.
HydrocephalusHydrocephalusA disorder characterized by an abnormal increase of cerebrospinal fluid in the ventricles of the brain.
HypercalcemiaHypercalcemiaA disorder characterized by laboratory test results that indicate an elevation in the concentration of calcium in blood.
HyperglycemiaHyperglycemiaA disorder characterized by laboratory test results that indicate an elevation in the concentration of blood sugar. It is usually an indication of diabetes mellitus or glucose intolerance.
HyperhidrosisHyperhidrosisA disorder characterized by excessive perspiration.
HyperkalemiaHyperkalemiaA disorder characterized by laboratory test results that indicate an elevation in the concentration of potassium in the blood; associated with kidney failure or sometimes with the use of diuretic drugs.
HypermagnesemiaHypermagnesemiaA disorder characterized by laboratory test results that indicate an elevation in the concentration of magnesium in the blood.
HypernatremiaHypernatremiaA disorder characterized by laboratory test results that indicate an elevation in the concentration of sodium in the blood.
HyperparathyroidismHyperparathyroidismA disorder characterized by an increase in production of parathyroid hormone by the parathyroid glands. This results in hypercalcemia (abnormally high levels of calcium in the blood).
HypersomniaHypersomniaA disorder characterized by characterized by excessive sleepiness during the daytime.
HypertensionHypertensionA disorder characterized by a pathological increase in blood pressure; a repeatedly elevation in the blood pressure exceeding 140 over 90 mm Hg.
HyperthyroidismHyperthyroidismA disorder characterized by excessive levels of thyroid hormone in the body. Common causes include an overactive thyroid gland or thyroid hormone overdose.
HypertrichosisHypertrichosisA disorder characterized by hair density or length beyond the accepted limits of normal in a particular body region, for a particular age or race.
HypertriglyceridemiaHypertriglyceridemiaA disorder characterized by laboratory test results that indicate an elevation in the concentration of triglyceride concentration in the blood.
HyperuricemiaHyperuricemiaA disorder characterized by laboratory test results that indicate an elevation in the concentration of uric acid.
HypoalbuminemiaHypoalbuminemiaA disorder characterized by laboratory test results that indicate a low concentration of albumin in the blood.
HypocalcemiaHypocalcemiaA disorder characterized by laboratory test results that indicate a low concentration of calcium in the blood.
Hypoglossal nerve disorderHypoglossal nerve disorderA disorder characterized by involvement of the hypoglossal nerve (twelfth cranial nerve).
HypoglycemiaHypoglycemiaA disorder characterized by laboratory test results that indicate a low concentration of glucose in the blood.
HypohidrosisHypohidrosisA disorder characterized by reduced sweating.
HypokalemiaHypokalemiaA disorder characterized by laboratory test results that indicate a low concentration of potassium in the blood.
HypomagnesemiaHypomagnesemiaA disorder characterized by laboratory test results that indicate a low concentration of magnesium in the blood.
HyponatremiaHyponatremiaA disorder characterized by laboratory test results that indicate a low concentration of sodium in the blood.
HypoparathyroidismHypoparathyroidismA disorder characterized by a decrease in production of parathyroid hormone by the parathyroid glands.
HypophosphatemiaHypophosphatemiaA disorder characterized by laboratory test results that indicate a low concentration of phosphates in the blood.
HypotensionHypotensionA disorder characterized by a blood pressure that is below the normal expected for an individual in a given environment.
HypothermiaHypothermiaA disorder characterized by an abnormally low body temperature. Treatment is required when the body temperature is 35C (95F) or below.
HypothyroidismHypothyroidismA disorder characterized by a decrease in production of thyroid hormone by the thyroid gland.
HypoxiaHypoxiaA disorder characterized by a decrease in the level of oxygen in the body.
Ileal fistulaIleal fistulaA disorder characterized by an abnormal communication between the ileum and another organ or anatomic site.
Ileal hemorrhageIleal hemorrhageA disorder characterized by bleeding from the ileal wall.
Ileal obstructionIleal obstructionA disorder characterized by blockage of the normal flow of the intestinal contents in the ileum.
Ileal perforationIleal perforationA disorder characterized by a rupture in the ileal wall.
Ileal stenosisIleal stenosisA disorder characterized by a narrowing of the lumen of the ileum.
Ileal ulcerIleal ulcerA disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the ileum.
IleusIleusA disorder characterized by failure of the ileum to transport intestinal contents.
Immune system disorders - Other, SpecifyImmune system disorders - Other, specifyNo Value Exists
Infections and infestations - Other, SpecifyInfections and infestations - Other, specifyNo Value Exists
Infective myositisInfective myositisA disorder characterized by an infectious process involving the skeletal muscles.
Infusion related reactionInfusion related reactionA disorder characterized by adverse reaction to the infusion of pharmacological or biological substances.
Infusion site extravasationInfusion site extravasationA disorder characterized by leakage of a pharmacologic or a biologic substance from the infusion site into the surrounding tissue. Signs and symptoms include induration, erythema, swelling, burning sensation and marked discomfort at the infusion site.
Injection site reactionInjection site reactionA disorder characterized by an intense adverse reaction (usually immunologic) developing at the site of an injection.
Injury to carotid arteryInjury to carotid arteryA finding of damage to the carotid artery.
Injury to inferior vena cavaInjury to inferior vena cavaA finding of damage to the inferior vena cava.
Injury to jugular veinInjury to jugular veinA finding of damage to the jugular vein.
Injury to superior vena cavaInjury to superior vena cavaA finding of damage to the superior vena cava.
Injury, poisoning and procedural complications - Other, SpecifyInjury, poisoning and procedural complications - Other, specifyNo Value Exists
INR increasedINR increasedA finding based on laboratory test results that indicate an increase in the ratio of the patient's prothrombin time to a control sample in the blood.
InsomniaInsomniaA disorder characterized by difficulty in falling asleep and/or remaining asleep.
Intestinal stoma leakIntestinal stoma leakA finding of leakage of contents from an intestinal stoma (surgically created opening on the surface of the body).
Intestinal stoma obstructionIntestinal stoma obstructionA finding of blockage of the normal flow of the contents of the intestinal stoma.
Intestinal stoma site bleedingIntestinal stoma site bleedingA finding of blood leakage from the intestinal stoma.
Intra-abdominal hemorrhageIntra-abdominal hemorrhageA disorder characterized by bleeding in the abdominal cavity.
Intracranial hemorrhageIntracranial hemorrhageA disorder characterized by bleeding from the cranium.
Intraoperative arterial injuryIntraoperative arterial injuryA finding of damage to an artery during a surgical procedure.
Intraoperative breast injuryIntraoperative breast injuryA finding of damage to the breast parenchyma during a surgical procedure.
Intraoperative cardiac injuryIntraoperative cardiac injuryA finding of damage to the heart during a surgical procedure.
Intraoperative ear injuryIntraoperative ear injuryA finding of damage to the ear during a surgical procedure.
Intraoperative endocrine injuryIntraoperative endocrine injuryA finding of damage to the endocrine gland during a surgical procedure.
Intraoperative gastrointestinal injuryIntraoperative gastrointestinal injuryA finding of damage to the gastrointestinal system during a surgical procedure.
Intraoperative head and neck injuryIntraoperative head and neck injuryA finding of damage to the head and neck during a surgical procedure.
Intraoperative hemorrhageIntraoperative hemorrhageA finding of uncontrolled bleeding during a surgical procedure.
Intraoperative hepatobiliary injuryIntraoperative hepatobiliary injuryA finding of damage to the hepatic parenchyma and/or biliary tract during a surgical procedure.
Intraoperative musculoskeletal injuryIntraoperative musculoskeletal injuryA finding of damage to the musculoskeletal system during a surgical procedure.
Intraoperative neurological injuryIntraoperative neurological injuryA finding of damage to the nervous system during a surgical procedure.
Intraoperative ocular injuryIntraoperative ocular injuryA finding of damage to the eye during a surgical procedure.
Intraoperative renal injuryIntraoperative renal injuryA finding of damage to the kidney during a surgical procedure.
Intraoperative reproductive tract injuryIntraoperative reproductive tract injuryA finding of damage to the reproductive organs during a surgical procedure.
Intraoperative respiratory injuryIntraoperative respiratory injuryA finding of damage to the respiratory system during a surgical procedure.
Intraoperative skin injuryIntraoperative skin injuryA finding of damage to the skin during a surgical procedure.
Intraoperative splenic injuryIntraoperative splenic injuryA finding of damage to the spleen during a surgical procedure.
Intraoperative urinary injuryIntraoperative urinary injuryA finding of damage to the urinary system during a surgical procedure.
Intraoperative venous injuryIntraoperative venous injuryA finding of damage to a vein during a surgical procedure.
Investigations - Other, SpecifyInvestigations - Other, specifyNo Value Exists
Iron overloadIron overloadA disorder characterized by accumulation of iron in the tissues.
Irregular menstruationIrregular menstruationA disorder characterized by irregular cycle or duration of menses.
IrritabilityIrritabilityA disorder characterized by an abnormal responsiveness to stimuli or physiological arousal; may be in response to pain, fright, a drug, an emotional situation or a medical condition.
Ischemia cerebrovascularIschemia cerebrovascularA disorder characterized by a decrease or absence of blood supply to the brain caused by obstruction (thrombosis or embolism) of an artery resulting in neurological damage.
IVth nerve disorderIVth nerve disorderA disorder characterized by involvement of the trochlear nerve (fourth cranial nerve).
Jejunal fistulaJejunal fistulaA disorder characterized by an abnormal communication between the jejunum and another organ or anatomic site.
Jejunal hemorrhageJejunal hemorrhageA disorder characterized by bleeding from the jejunal wall.
Jejunal obstructionJejunal obstructionA disorder characterized by blockage of the normal flow of the intestinal contents in the jejunum.
Jejunal perforationJejunal perforationA disorder characterized by a rupture in the jejunal wall.
Jejunal stenosisJejunal stenosisA disorder characterized by a narrowing of the lumen of the jejunum.
Jejunal ulcerJejunal ulcerA disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the jejunum.
Joint effusionJoint effusionA disorder characterized by excessive fluid in a joint, usually as a result of joint inflammation.
Joint infectionJoint infectionA disorder characterized by an infectious process involving a joint.
Joint range of motion decreasedJoint range of motion decreasedA disorder characterized by a decrease in joint flexibility of any joint.
Joint range of motion decreased cervical spineJoint range of motion decreased cervical spineA disorder characterized by a decrease in flexibility of a cervical spine joint.
Joint range of motion decreased lumbar spineJoint range of motion decreased lumbar spineA disorder characterized by a decrease in flexibility of a lumbar spine joint.
KeratitisKeratitisA disorder characterized by inflammation to the cornea of the eye.
Kidney anastomotic leakKidney anastomotic leakA finding of leakage of urine due to breakdown of a kidney anastomosis (surgical connection of two separate anatomic structures).
Kidney infectionKidney infectionA disorder characterized by an infectious process involving the kidney.
KyphosisKyphosisA disorder characterized by an abnormal increase in the curvature of the thoracic portion of the spine.
Lactation disorderLactation disorderA disorder characterized by disturbances of milk secretion. It is not necessarily related to pregnancy that is observed in females and can be observed in males.
Large intestinal anastomotic leakLarge intestinal anastomotic leakA finding of leakage due to breakdown of an anastomosis (surgical connection of two separate anatomic structures) in the large intestine.
Laryngeal edemaLaryngeal edemaA disorder characterized by swelling due to an excessive accumulation of fluid in the larynx.
Laryngeal fistulaLaryngeal fistulaA disorder characterized by an abnormal communication between the larynx and another organ or anatomic site.
Laryngeal hemorrhageLaryngeal hemorrhageA disorder characterized by bleeding from the larynx.
Laryngeal inflammationLaryngeal inflammationA disorder characterized by an inflammation involving the larynx.
Laryngeal mucositisLaryngeal mucositisA disorder characterized by an inflammation involving the mucous membrane of the larynx.
Laryngeal obstructionLaryngeal obstructionA disorder characterized by blockage of the laryngeal airway.
Laryngeal stenosisLaryngeal stenosisA disorder characterized by a narrowing of the laryngeal airway.
LaryngitisLaryngitisA disorder characterized by an inflammatory process involving the larynx.
Laryngopharyngeal dysesthesiaLaryngopharyngeal dysesthesiaA disorder characterized by an uncomfortable persistent sensation in the area of the laryngopharynx.
LaryngospasmLaryngospasmA disorder characterized by paroxysmal spasmodic muscular contraction of the vocal cords.
Left ventricular systolic dysfunctionLeft ventricular systolic dysfunctionA disorder characterized by failure of the left ventricle to produce adequate output despite an increase in distending pressure and in end-diastolic volume. Clinical manifestations mayinclude dyspnea, orthopnea, and other signs and symptoms of pulmonary congestion and edema.
LethargyLethargyA disorder characterized by a decrease in consciousness characterized by mental and physical inertness.
Leukemia secondary to oncology chemotherapyLeukemia secondary to oncology chemotherapyA disorder characterized by leukemia arising as a result of the mutagenic effect of chemotherapy agents.
LeukocytosisLeukocytosisA disorder characterized by laboratory test results that indicate an increased number of white blood cells in the blood.
LeukoencephalopathyLeukoencephalopathyA disorder characterized by diffuse reactive astrocytosis with multiple areas of necrotic foci without inflammation.
Libido decreasedLibido decreasedA disorder characterized by a decrease in sexual desire.
Libido increasedLibido increasedA disorder characterized by an increase in sexual desire.
Lip infectionLip infectionA disorder characterized by an infectious process involving the lips.
Lip painLip painA disorder characterized by a sensation of marked discomfort of the lip.
Lipase increasedLipase increasedA finding based on laboratory test results that indicate an increase in the level of lipase in a biological specimen.
LipohypertrophyLipohypertrophyA disorder characterized by hypertrophy of the subcutaneous adipose tissue at the site of multiple subcutaneous injections of insulin.
Localized edemaLocalized edemaA disorder characterized by swelling due to excessive fluid accumulation at a specific anatomic site.
LordosisLordosisA disorder characterized by an abnormal increase in the curvature of the lumbar portion of the spine.
Lower gastrointestinal hemorrhageLower gastrointestinal hemorrhageA disorder characterized by bleeding from the lower gastrointestinal tract (small intestine, large intestine, and anus).
Lung infectionLung infectionA disorder characterized by an infectious process involving the lungs.
Lymph gland infectionLymph gland infectionA disorder characterized by an infectious process involving the lymph nodes.
Lymph leakageLymph leakageA disorder characterized by the loss of lymph fluid into the surrounding tissue or body cavity.
Lymph node painLymph node painA disorder characterized by a sensation of marked discomfort in a lymph node.
LymphedemaLymphedemaA disorder characterized by excessive fluid collection in tissues that causes swelling.
LymphoceleLymphoceleA disorder characterized by a cystic lesion containing lymph.
Lymphocyte count decreasedLymphocyte count decreasedA finding based on laboratory test results that indicate a decrease in number of lymphocytes in a blood specimen.
Lymphocyte count increasedLymphocyte count increasedA finding based on laboratory test results that indicate an abnormal increase in the number of lymphocytes in the blood, effusions or bone marrow.
MalabsorptionMalabsorptionA disorder characterized by inadequate absorption of nutrients in the small intestine. Symptoms include abdominal marked discomfort, bloating and diarrhea.
MalaiseMalaiseA disorder characterized by a feeling of general discomfort or uneasiness, an out-of-sorts feeling.
ManiaManiaA disorder characterized by excitement of psychotic proportions manifested by mental and physical hyperactivity, disorganization of behavior and elevation of mood.
Mediastinal hemorrhageMediastinal hemorrhageA disorder characterized by bleeding from the mediastinum.
Mediastinal infectionMediastinal infectionA disorder characterized by an infectious process involving the mediastinum.
Memory impairmentMemory impairmentA disorder characterized by a deterioration in memory function.
MeningismusMeningismusA disorder characterized by neck stiffness, headache, and photophobia resulting from irritation of the cerebral meninges.
MeningitisMeningitisA disorder characterized by acute inflammation of the meninges of the brain and/or spinal cord.
MenopauseMenopauseA disorder characterized by the permanent cessation of menses, usually defined by 12 consecutive months of amenorrhea in a woman over 45 years of age.
MenorrhagiaMenorrhagiaA disorder characterized by abnormally heavy vaginal bleeding during menses.
Metabolism and nutrition disorders - Other, SpecifyMetabolism and nutrition disorders - Other, specifyNo Value Exists
Middle ear inflammationMiddle ear inflammationA disorder characterized by inflammation (physiologic response to irritation), swelling and redness to the middle ear.
Mitral valve diseaseMitral valve diseaseA disorder characterized by a defect in mitral valve function or structure.
Mobitz (type) II atrioventricular blockMobitz (type) II atrioventricular blockA disorder characterized by a dysrhythmia with relatively constant PR interval prior to the block of an atrial impulse. This is the result of intermittent failure of atrial electrical impulse conduction through the atrioventricular (AV) node to the ventricles.
Mobitz type IMobitz type IA disorder characterized by a dysrhythmia with a progressively lengthening PR interval prior to the blocking of an atrial impulse. This is the result of intermittent failure of atrial electrical impulse conduction through the atrioventricular (AV) node to the ventricles.
Movements involuntaryMovements involuntaryA disorder characterized by uncontrolled and purposeless movements.
Mucosal infectionMucosal infectionA disorder characterized by an infectious process involving a mucosal surface.
Mucositis oralMucositis oralA disorder characterized by inflammation of the oral mucosal.
Multi-organ failureMulti-organ failureA disorder characterized by progressive deterioration of the lungs, liver, kidney and clotting mechanisms.
Muscle weakness left-sidedMuscle weakness left-sidedA disorder characterized by a reduction in the strength of the muscles on the left side of the body.
Muscle weakness lower limbMuscle weakness lower limbA disorder characterized by a reduction in the strength of the lower limb muscles.
Muscle weakness right-sidedMuscle weakness right-sidedA disorder characterized by a reduction in the strength of the muscles on the right side of the body.
Muscle weakness trunkMuscle weakness trunkA disorder characterized by a reduction in the strength of the trunk muscles.
Muscle weakness upper limbMuscle weakness upper limbA disorder characterized by a reduction in the strength of the upper limb muscles.
Musculoskeletal and connective tissue disorders - Other, SpecifyMusculoskeletal and connective tissue disorder - Other, specifyNo Value Exists
Musculoskeletal deformityMusculoskeletal deformityA disorder characterized by of a malformation of the musculoskeletal system.
MyalgiaMyalgiaA disorder characterized by marked discomfort sensation originating from a muscle or group of muscles.
MyelitisMyelitisA disorder characterized by inflammation involving the spinal cord. Symptoms include weakness, paresthesia, sensory loss, marked discomfort and incontinence.
Myelodysplastic syndromeMyelodysplastic syndromeA disorder characterized by insufficiently healthy hematapoietic cell production by the bone marrow.
Myocardial infarctionMyocardial infarctionA disorder characterized by gross necrosis of the myocardium; this is due to an interruption of blood supply to the area.
MyocarditisMyocarditisA disorder characterized by inflammation of the muscle tissue of the heart.
MyositisMyositisA disorder characterized by inflammation involving the skeletal muscles.
Nail discolorationNail discolorationA disorder characterized by a change in the color of the nail plate.
Nail infectionNail infectionA disorder characterized by an infectious process involving the nail.
Nail lossNail lossA disorder characterized by loss of all or a portion of the nail.
Nail ridgingNail ridgingA disorder characterized by vertical or horizontal ridges on the nails.
Nasal congestionNasal congestionA disorder characterized by obstruction of the nasal passage due to mucosal edema.
NauseaNauseaA disorder characterized by a queasy sensation and/or the urge to vomit.
Neck edemaNeck edemaA disorder characterized by swelling due to an accumulation of excessive fluid in the neck.
Neck painNeck painA disorder characterized by marked discomfort sensation in the neck area.
Neck soft tissue necrosisNeck soft tissue necrosisA disorder characterized by a necrotic process occurring in the soft tissues of the neck.
Neoplasms benign, malignant and unspecified (incl cysts and polyps) - Other, SpecifyNeoplasms benign, malignant and unspecified (incl cysts and polyps) - Other, specifyNo Value Exists
Nervous system disorders - Other, SpecifyNervous system disorders - Other, specifyNo Value Exists
NeuralgiaNeuralgiaA disorder characterized by intense painful sensation along a nerve or group of nerves.
Neutrophil count decreasedNeutrophil count decreasedA finding based on laboratory test results that indicate a decrease in number of neutrophils in a blood specimen.
Night blindnessNight blindnessA disorder characterized by an inability to see clearly in dim light.
Nipple deformityNipple deformityA disorder characterized by a malformation of the nipple.
Non-cardiac chest painNon-cardiac chest painA disorder characterized by discomfort in the chest unrelated to a heart disorder.
NystagmusNystagmusA disorder characterized by involuntary movements of the eyeballs.
ObesityObesityA disorder characterized by having a high amount of body fat.
Obstruction gastricObstruction gastricA disorder characterized by blockage of the normal flow of the contents in the stomach.
Oculomotor nerve disorderOculomotor nerve disorderA disorder characterized by involvement of the oculomotor nerve (third cranial nerve).
Olfactory nerve disorderOlfactory nerve disorderA disorder characterized by involvement of the olfactory nerve (first cranial nerve).
OligospermiaOligospermiaA disorder characterized by a decrease in the number of spermatozoa in the semen.
Optic nerve disorderOptic nerve disorderA disorder characterized by involvement of the optic nerve (second cranial nerve).
Oral cavity fistulaOral cavity fistulaA disorder characterized by an abnormal communication between the oral cavity and another organ or anatomic site.
Oral dysesthesiaOral dysesthesiaA disorder characterized by a burning or tingling sensation on the lips, tongue or entire mouth.
Oral hemorrhageOral hemorrhageA disorder characterized by bleeding from the mouth.
Oral painOral painA disorder characterized by a sensation of marked discomfort in the mouth, tongue or lips.
Osteonecrosis of jawOsteonecrosis of jawA disorder characterized by a necrotic process occurring in the bone of the mandible.
OsteoporosisOsteoporosisA disorder characterized by reduced bone mass, with a decrease in cortical thickness and in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence.
Otitis externaOtitis externaA disorder characterized by an infectious process involving the outer ear and ear canal. Contributory factors include excessive water exposure (swimmer's ear infection) and cuts in the ear canal. Symptoms include fullness, itching, swelling and marked discomfort in the ear and ear drainage.
Otitis mediaOtitis mediaA disorder characterized by an infectious process involving the middle ear.
Ovarian hemorrhageOvarian hemorrhageA disorder characterized by bleeding from the ovary.
Ovarian infectionOvarian infectionA disorder characterized by an infectious process involving the ovary.
Ovarian ruptureOvarian ruptureA disorder characterized by tearing or disruption of the ovarian tissue.
Ovulation painOvulation painA disorder characterized by marked discomfort sensation in one side of the abdomen between menstrual cycles, around the time of the discharge of the ovum from the ovarian follicle.
PainPainA disorder characterized by the sensation of marked discomfort, distress or agony.
Pain in extremityPain in extremityA disorder characterized by marked discomfort sensation in the upper or lower extremities.
Pain of skinPain of skinA disorder characterized by marked discomfort sensation in the skin.
Palmar-plantar erythrodysesthesia syndromePalmar-plantar erythrodysesthesia syndromeA disorder characterized by redness, marked discomfort, swelling, and tingling in the palms of the hands or the soles of the feet.
PalpitationsPalpitationsA disorder characterized by an unpleasant sensation of irregular and/or forceful beating of the heart.
Pancreas infectionPancreas infectionA disorder characterized by an infectious process involving the pancreas.
Pancreatic anastomotic leakPancreatic anastomotic leakA finding of leakage due to breakdown of a pancreatic anastomosis (surgical connection of two separate anatomic structures).
Pancreatic duct stenosisPancreatic duct stenosisA disorder characterized by a narrowing of the lumen of the pancreatic duct.
Pancreatic enzymes decreasedPancreatic enzymes decreasedA finding based on laboratory test results that indicate an decrease in levels of pancreatic enzymes in a biological specimen.
Pancreatic fistulaPancreatic fistulaA disorder characterized by an abnormal communication between the pancreas and another organ or anatomic site.
Pancreatic hemorrhagePancreatic hemorrhageA disorder characterized by bleeding from the pancreas.
Pancreatic necrosisPancreatic necrosisA disorder characterized by a necrotic process occurring in the pancreas.
PancreatitisPancreatitisA disorder characterized by inflammation of the pancreas.
PapilledemaPapilledemaA disorder characterized by swelling around the optic disc.
Papulopustular rashPapulopustular rashA disorder characterized by an eruption consisting of papules (a small, raised pimple) and pustules (a small pus filled blister), typically appearing in face, scalp, and upper chest and back Unlike acne, this rash does not present with whiteheads or blackheads, and can be symptomatic, with itchy or tender lesions.
ParesthesiaParesthesiaA disorder characterized by functional disturbances of sensory neurons resulting in abnormal cutaneous sensations of tingling, numbness, pressure, cold, and warmth that are experienced in the absence of a stimulus.
ParonychiaParonychiaA disorder characterized by an infectious process involving the soft tissues around the nail.
Paroxysmal atrial tachycardiaParoxysmal atrial tachycardiaA disorder characterized by a dysrhythmia with abrupt onset and sudden termination of atrial contractions with a rate of 150-250 beats per minute. The rhythm disturbance originates in the atria.
Pelvic floor muscle weaknessPelvic floor muscle weaknessA disorder characterized by a reduction in the strength of the muscles of the pelvic floor.
Pelvic infectionPelvic infectionA disorder characterized by an infectious process involving the pelvic cavity.
Pelvic painPelvic painA disorder characterized by marked discomfort sensation in the pelvis.
Pelvic soft tissue necrosisPelvic soft tissue necrosisA disorder characterized by a necrotic process occurring in the soft tissues of the pelvis.
Penile infectionPenile infectionA disorder characterized by an infectious process involving the penis.
Penile painPenile painA disorder characterized by marked discomfort sensation in the penis.
Perforation bile ductPerforation bile ductA disorder characterized by a rupture in the wall of the extrahepatic or intrahepatic bile duct.
Pericardial effusionPericardial effusionA disorder characterized by fluid collection within the pericardial sac, usually due to inflammation.
Pericardial tamponadePericardial tamponadeA disorder characterized by an increase in intrapericardial pressure due to the collection of blood or fluid in the pericardium.
PericarditisPericarditisA disorder characterized by irritation to the layers of the pericardium (the protective sac around the heart).
Perineal painPerineal painA disorder characterized by a sensation of marked discomfort in the area between the genital organs and the anus.
Periodontal diseasePeriodontal diseaseA disorder in the gingival tissue around the teeth.
Periorbital edemaPeriorbital edemaA disorder characterized by swelling due to an excessive accumulation of fluid around the orbits of the face.
Periorbital infectionPeriorbital infectionA disorder characterized by an infectious process involving the orbit of the eye.
Peripheral ischemiaPeripheral ischemiaA disorder characterized by impaired circulation to an extremity.
Peripheral motor neuropathyPeripheral motor neuropathyA disorder characterized by inflammation or degeneration of the peripheral motor nerves.
Peripheral nerve infectionPeripheral nerve infectionA disorder characterized by an infectious process involving the peripheral nerves.
Peripheral sensory neuropathyPeripheral sensory neuropathyA disorder characterized by inflammation or degeneration of the peripheral sensory nerves.
Peritoneal infectionPeritoneal infectionA disorder characterized by an infectious process involving the peritoneum.
Peritoneal necrosisPeritoneal necrosisA disorder characterized by a necrotic process occurring in the peritoneum.
Personality changePersonality changeA disorder characterized by a conspicuous change in a person's behavior and thinking.
Phantom painPhantom painA disorder characterized by marked discomfort related to a limb or an organ that is removed from or is not physically part of the body.
Pharyngeal anastomotic leakPharyngeal anastomotic leakA finding of leakage due to breakdown of a pharyngeal anastomosis (surgical connection of two separate anatomic structures).
Pharyngeal fistulaPharyngeal fistulaA disorder characterized by an abnormal communication between the pharynx and another organ or anatomic site.
Pharyngeal hemorrhagePharyngeal hemorrhageA disorder characterized by bleeding from the pharynx.
Pharyngeal mucositisPharyngeal mucositisA disorder characterized by an inflammation involving the mucous membrane of the pharynx.
Pharyngeal necrosisPharyngeal necrosisA disorder characterized by a necrotic process occurring in the pharynx.
Pharyngeal stenosisPharyngeal stenosisA disorder characterized by a narrowing of the pharyngeal airway.
PharyngitisPharyngitisA disorder characterized by inflammation of the throat.
Pharyngolaryngeal painPharyngolaryngeal painA disorder characterized by marked discomfort sensation in the pharyngolaryngeal region.
PhlebitisPhlebitisA disorder characterized by inflammation of the wall of a vein.
Phlebitis infectivePhlebitis infectiveA disorder characterized by an infectious process involving the vein. Clinical manifestations include erythema, marked discomfort, swelling, and induration along the course of the infected vein.
PhotophobiaPhotophobiaA disorder characterized by fear and avoidance of light.
PhotosensitivityPhotosensitivityA disorder characterized by an increase in sensitivity of the skin to light.
Platelet count decreasedPlatelet count decreasedA finding based on laboratory test results that indicate a decrease in number of platelets in a blood specimen.
Pleural effusionPleural effusionA disorder characterized by an increase in amounts of fluid within the pleural cavity. Symptoms include shortness of breath, cough and marked chest discomfort.
Pleural hemorrhagePleural hemorrhageA disorder characterized by bleeding from the pleural cavity.
Pleural infectionPleural infectionA disorder characterized by an infectious process involving the pleura.
Pleuritic painPleuritic painA disorder characterized by marked discomfort sensation in the pleura.
PneumonitisPneumonitisA disorder characterized by inflammation focally or diffusely affecting the lung parenchyma.
PneumothoraxPneumothoraxA disorder characterized by abnormal presence of air in the pleural cavity resulting in the collapse of the lung.
Portal hypertensionPortal hypertensionA disorder characterized by an increase in blood pressure in the portal venous system.
Portal vein thrombosisPortal vein thrombosisA disorder characterized by the formation of a thrombus (blood clot) in the portal vein.
Postnasal dripPostnasal dripA disorder characterized by excessive mucous secretion in the back of the nasal cavity or throat, causing sore throat and/or coughing.
Postoperative hemorrhagePostoperative hemorrhageA finding of bleeding occurring after a surgical procedure.
Postoperative thoracic procedure complicationPostoperative thoracic procedure complicationA finding of a previously undocumented problem that occurs after a thoracic procedure.
Precocious pubertyPrecocious pubertyA disorder characterized by unusually early development of secondary sexual features; the onset of sexual maturation begins usually before age 8 for girls and before age 9 for boys.
Pregnancy, puerperium and perinatal conditions - Other, SpecifyPregnancy, puerperium and perinatal conditions - Other, specifyNo Value Exists
Premature deliveryPremature deliveryA disorder characterized by delivery of a viable infant before the normal end of gestation. Typically, viability is achievable between the twentieth and thirty-seventh week of gestation.
Premature menopausePremature menopauseA disorder characterized by ovarian failure before the age of 40. Symptoms include hot flashes, night sweats, mood swings and a decrease in sex drive.
PresyncopePresyncopeA disorder characterized by an episode of lightheadedness and dizziness which may precede an episode of syncope.
ProctitisProctitisA disorder characterized by inflammation of the rectum.
Productive coughProductive coughA disorder characterized by expectorated secretions upon coughing.
Prolapse of intestinal stomaProlapse of intestinal stomaA finding of protrusion of the intestinal stoma (surgically created opening on the surface of the body) above the abdominal surface.
Prolapse of urostomyProlapse of urostomyA finding of displacement of the urostomy.
Prostate infectionProstate infectionA disorder characterized by an infectious process involving the prostate gland.
Prostatic hemorrhageProstatic hemorrhageA disorder characterized by bleeding from the prostate gland.
Prostatic obstructionProstatic obstructionA disorder characterized by compression of the urethra secondary to enlargement of the prostate gland. This results in voiding difficulties (straining to void, slow urine stream, and incomplete emptying of the bladder).
Prostatic painProstatic painA disorder characterized by a sensation of marked discomfort in the prostate gland.
ProteinuriaProteinuriaA disorder characterized by laboratory test results that indicate the presence of excessive protein in the urine. It is predominantly albumin, but also globulin.
PruritusPruritusA disorder characterized by an intense itching sensation.
Psychiatric disorders - Other, SpecifyPsychiatric disorders - Other, specifyNo Value Exists
PsychosisPsychosisA disorder characterized by personality change, impaired functioning, and loss of touch with reality. It may be a manifestation of schizophrenia, bipolar disorder or brain tumor.
Pulmonary edemaPulmonary edemaA disorder characterized by accumulation of fluid in the lung tissues that causes a disturbance of the gas exchange that may lead to respiratory failure.
Pulmonary fibrosisPulmonary fibrosisA disorder characterized by the replacement of the lung tissue by connective tissue, leading to progressive dyspnea, respiratory failure or right heart failure.
Pulmonary fistulaPulmonary fistulaA disorder characterized by an abnormal communication between the lung and another organ or anatomic site.
Pulmonary hypertensionPulmonary hypertensionA disorder characterized by an increase in pressure within the pulmonary circulation due to lung or heart disorder.
Pulmonary valve diseasePulmonary valve diseaseA disorder characterized by a defect in pulmonary valve function or structure.
PurpuraPurpuraA disorder characterized by hemorrhagic areas of the skin and mucous membrane. Newer lesions appear reddish in color. Older lesions are usually a darker purple color and eventually become a brownish-yellow color.
Pyramidal tract syndromePyramidal tract syndromeA disorder characterized by dysfunction of the corticospinal (pyramidal) tracts of the spinal cord. Symptoms include an increase in the muscle tone in the lower extremities, hyperreflexia, positive Babinski and a decrease in fine motor coordination.
Radiation recall reaction (dermatologic)Radiation recall reaction (dermatologic)A finding of acute skin inflammatory reaction caused by drugs, especially chemotherapeutic agents, for weeks or months following radiotherapy. The inflammatory reaction is confined to the previously irradiated skin and the symptoms disappear after the removal of the pharmaceutical agent.
RadiculitisRadiculitisA disorder characterized by inflammation involving a nerve root. Patients experience marked discomfort radiating along a nerve path because of spinal pressure on the connecting nerve root.
Rash acneiformRash acneiformA disorder characterized by an eruption of papules and pustules, typically appearing in face, scalp, upper chest and back.
Rash maculo-papularRash maculo-papularA disorder characterized by the presence of macules (flat) and papules (elevated). Also known as morbillform rash, it is one of the most common cutaneous adverse events, frequently affecting the upper trunk, spreading centripetally and associated with pruritus.
Rash pustularRash pustularA disorder characterized by a circumscribed and elevated skin lesion filled with pus.
Rectal anastomotic leakRectal anastomotic leakA finding of leakage due to breakdown of a rectal anastomosis (surgical connection of two separate anatomic structures).
Rectal fistulaRectal fistulaA disorder characterized by an abnormal communication between the rectum and another organ or anatomic site.
Rectal hemorrhageRectal hemorrhageA disorder characterized by bleeding from the rectal wall and discharged from the anus.
Rectal mucositisRectal mucositisA disorder characterized by inflammation of the mucous membrane of the rectum.
Rectal necrosisRectal necrosisA disorder characterized by a necrotic process occurring in the rectal wall.
Rectal obstructionRectal obstructionA disorder characterized by blockage of the normal flow of the intestinal contents in the rectum.
Rectal painRectal painA disorder characterized by a sensation of marked discomfort in the rectal region.
Rectal perforationRectal perforationA disorder characterized by a rupture in the rectal wall.
Rectal stenosisRectal stenosisA disorder characterized by a narrowing of the lumen of the rectum.
Rectal ulcerRectal ulcerA disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the rectum.
Recurrent laryngeal nerve palsyRecurrent laryngeal nerve palsyA disorder characterized by paralysis of the recurrent laryngeal nerve.
Renal and urinary disorders - Other, SpecifyRenal and urinary disorders - Other, specifyNo Value Exists
Renal calculiRenal calculiA disorder characterized by the formation of crystals in the pelvis of the kidney.
Renal colicRenal colicA disorder characterized by paroxysmal and severe flank marked discomfort radiating to the inguinal area. Often, the cause is the passage of kidney stones.
Renal hemorrhageRenal hemorrhageA disorder characterized by bleeding from the kidney.
Reproductive system and breast disorders - Other, SpecifyReproductive system and breast disorders - Other, specifyNo Value Exists
Respiratory failureRespiratory failureA disorder characterized by impaired gas exchange by the respiratory system resulting in hypoxemia and a decrease in oxygenation of the tissues that may be associated with an increase in arterial levels of carbon dioxide.
Respiratory, thoracic and mediastinal disorders - Other, SpecifyRespiratory, thoracic and mediastinal disorders - Other, specifyNo Value Exists
RestlessnessRestlessnessA disorder characterized by an inability to rest, relax or be still.
Restrictive cardiomyopathyRestrictive cardiomyopathyA disorder characterized by an inability of the ventricles to fill with blood because the myocardium (heart muscle) stiffens and loses its flexibility.
Retinal detachmentRetinal detachmentA disorder characterized by the separation of the inner retina layers from the underlying pigment epithelium.
Retinal tearRetinal tearA disorder characterized by a small laceration of the retina, this occurs when the vitreous separates from the retina. Symptoms include flashes and floaters.
Retinal vascular disorderRetinal vascular disorderA disorder characterized by pathological retinal blood vessels that adversely affects vision.
Retinoic acid syndromeRetinoic acid syndromeA disorder characterized by weight gain, dyspnea, pleural and pericardial effusions, leukocytosis and/or renal failure originally described in patients treated with all-trans retinoic acid.
RetinopathyRetinopathyA disorder involving the retina.
Retroperitoneal hemorrhageRetroperitoneal hemorrhageA disorder characterized by bleeding from the retroperitoneal area.
Reversible posterior leukoencephalopathy syndromeReversible posterior leukoencephalopathy syndromeA disorder characterized by headaches, mental status changes, visual disturbances, and seizures associated with imaging findings of posterior leukoencephalopathy. It has been observed in association with hypertensive encephalopathy, eclampsia, and immunosuppressive and cytotoxic drug treatment. It is an acute or subacute reversible condition.
Rhinitis infectiveRhinitis infectiveA disorder characterized by an infectious process involving the nasal mucosal.
Right ventricular dysfunctionRight ventricular dysfunctionA disorder characterized by impairment of right ventricular function associated with low ejection fraction and a decrease in motility of the right ventricular wall.
Salivary duct inflammationSalivary duct inflammationA disorder characterized by inflammation of the salivary duct.
Salivary gland fistulaSalivary gland fistulaA disorder characterized by an abnormal communication between a salivary gland and another organ or anatomic site.
Salivary gland infectionSalivary gland infectionA disorder characterized by an infectious process involving the salivary gland.
Scalp painScalp painA disorder characterized by marked discomfort sensation in the skin covering the top and the back of the head.
Scleral disorderScleral disorderA disorder characterized by involvement of the sclera of the eye.
ScoliosisScoliosisA disorder characterized by a malformed, lateral curvature of the spine.
Scrotal infectionScrotal infectionA disorder characterized by an infectious process involving the scrotum.
Scrotal painScrotal painA disorder characterized by marked discomfort sensation in the scrotal area.
SeizureSeizureA disorder characterized by a sudden, involuntary skeletal muscular contractions of cerebral or brain stem origin.
SepsisSepsisA disorder characterized by the presence of pathogenic microorganisms in the blood stream that cause a rapidly progressing systemic reaction that may lead to shock.
SeromaSeromaA finding of tumor-like collection of serum in the tissues.
Serum amylase increasedSerum amylase increasedA finding based on laboratory test results that indicate an increase in the levels of amylase in a serum specimen.
Serum sicknessSerum sicknessA disorder characterized by a delayed-type hypersensitivity reaction to foreign proteins derived from an animal serum. It occurs approximately six to twenty-one days following the administration of the foreign antigen. Symptoms include fever, arthralgias, myalgias, skin eruptions, lymphadenopathy, chest marked discomfort and dyspnea.
Sick sinus syndromeSick sinus syndromeA disorder characterized by a dysrhythmia with alternating periods of bradycardia and atrial tachycardia accompanied by syncope, fatigue and dizziness.
Sinus bradycardiaSinus bradycardiaA disorder characterized by a dysrhythmia with a heart rate less than 60 beats per minute that originates in the sinus node.
Sinus disorderSinus disorderA disorder characterized by involvement of the paranasal sinuses.
Sinus painSinus painA disorder characterized by marked discomfort in the face, between the eyes, or upper teeth originating from the sinuses.
Sinus tachycardiaSinus tachycardiaA disorder characterized by a dysrhythmia with a heart rate greater than 100 beats per minute that originates in the sinus node.
SinusitisSinusitisA disorder characterized by an infectious process involving the mucous membranes of the paranasal sinuses.
Skin and subcutaneous tissue disorders - Other, SpecifySkin and subcutaneous tissue disorders - Other, specifyNo Value Exists
Skin atrophySkin atrophyA disorder characterized by the degeneration and thinning of the epidermis and dermis.
Skin hyperpigmentationSkin hyperpigmentationA disorder characterized by darkening of the skin due to excessive melanin deposition.
Skin hypopigmentationSkin hypopigmentationA disorder characterized by loss of skin pigment.
Skin indurationSkin indurationA disorder characterized by an area of hardness in the skin.
Skin infectionSkin infectionA disorder characterized by an infectious process involving the skin.
Skin ulcerationSkin ulcerationA disorder characterized by circumscribed, inflammatory and necrotic erosive lesion on the skin.
Sleep apneaSleep apneaA disorder characterized by cessation of breathing for short periods during sleep.
Small intestinal anastomotic leakSmall intestinal anastomotic leakA finding of leakage due to breakdown of an anastomosis (surgical connection of two separate anatomic structures) in the small bowel.
Small intestinal mucositisSmall intestinal mucositisA disorder characterized by inflammation of the mucous membrane of the small intestine.
Small intestinal obstructionSmall intestinal obstructionA disorder characterized by blockage of the normal flow of the intestinal contents.
Small intestinal perforationSmall intestinal perforationA disorder characterized by a rupture in the small intestine wall.
Small intestinal stenosisSmall intestinal stenosisA disorder characterized by a narrowing of the lumen of the small intestine.
Small intestine infectionSmall intestine infectionA disorder characterized by an infectious process involving the small intestine.
Small intestine ulcerSmall intestine ulcerA disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the small intestine.
SneezingSneezingA disorder characterized by the involuntary expulsion of air from the nose.
Social circumstances - Other, SpecifySocial circumstances - Other, specifyNo Value Exists
Soft tissue infectionSoft tissue infectionA disorder characterized by an infectious process involving soft tissues.
Soft tissue necrosis lower limbSoft tissue necrosis lower limbA disorder characterized by a necrotic process occurring in the soft tissues of the lower extremity.
Soft tissue necrosis upper limbSoft tissue necrosis upper limbA disorder characterized by a necrotic process occurring in the soft tissues of the upper extremity.
SomnolenceSomnolenceA disorder characterized by characterized by excessive sleepiness and drowsiness.
Sore throatSore throatA disorder characterized by of marked discomfort in the throat
SpasticitySpasticityA disorder characterized by increased involuntary muscle tone that affects the regions interfering with voluntary movement. It results in gait, movement, and speech disturbances.
Spermatic cord anastomotic leakSpermatic cord anastomotic leakA finding of leakage due to breakdown of a spermatic cord anastomosis (surgical connection of two separate anatomic structures).
Spermatic cord hemorrhageSpermatic cord hemorrhageA disorder characterized by bleeding from the spermatic cord.
Spermatic cord obstructionSpermatic cord obstructionA disorder characterized by blockage of the normal flow of the contents of the spermatic cord.
Spinal fractureSpinal fractureA finding of traumatic injury to the spine in which the continuity of a vertebral bone is broken.
Spleen disorderSpleen disorderA disorder of the spleen.
Splenic infectionSplenic infectionA disorder characterized by an infectious process involving the spleen.
Stenosis of gastrointestinal stomaStenosis of gastrointestinal stomaA finding of narrowing of the gastrointestinal stoma (surgically created opening on the surface of the body).
Stevens-Johnson syndromeStevens-Johnson syndromeA disorder characterized by less than 10% total body skin area separation of dermis. The syndrome is thought to be a hypersensitivity complex affecting the skin and the mucous membranes.
Stoma site infectionStoma site infectionA disorder characterized by an infectious process involving a stoma (surgically created opening on the surface of the body).
Stomach painStomach painA disorder characterized by a sensation of marked discomfort in the stomach.
Stomal ulcerStomal ulcerA disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the jejunal mucosal surface close to the anastomosis site following a gastroenterostomy procedure.
StridorStridorA disorder characterized by a high pitched breathing sound due to laryngeal or upper airway obstruction.
StrokeStrokeA disorder characterized by a sudden loss of sensory function due to an intracranial vascular event.
Sudden death NOSSudden death NOSAn unexpected cessation of life that cannot be attributed to a CTCAE term associated with Grade 5.
Suicidal ideationSuicidal ideationA disorder characterized by thoughts of taking one's own life.
Suicide attemptSuicide attemptA disorder characterized by self-inflicted harm in an attempt to end one's own life.
Superficial soft tissue fibrosisSuperficial soft tissue fibrosisA disorder characterized by fibrotic degeneration of the superficial soft tissues.
Superficial thrombophlebitisSuperficial thrombophlebitisA disorder characterized by a blood clot and inflammation involving a superficial vein of the extremities.
Superior vena cava syndromeSuperior vena cava syndromeA disorder characterized by obstruction of the blood flow in the superior vena cava. Signs and symptoms include swelling and cyanosis of the face, neck, and upper arms, cough, orthopnea and headache.
Supraventricular tachycardiaSupraventricular tachycardiaA disorder characterized by a dysrhythmia with a heart rate greater than 100 beats per minute that originates above the ventricles.
Surgical and medical procedures - Other, SpecifySurgical and medical procedures - Other, specifyNo Value Exists
SyncopeSyncopeA disorder characterized by spontaneous loss of consciousness caused by insufficient blood supply to the brain.
TelangiectasiaTelangiectasiaA disorder characterized by local dilatation of small vessels resulting in red discoloration of the skin or mucous membranes.
Testicular disorderTesticular disorderA disorder characterized by involvement of the testis.
Testicular hemorrhageTesticular hemorrhageA disorder characterized by bleeding from the testis.
Testicular painTesticular painA disorder characterized by a sensation of marked discomfort in the testis.
Thromboembolic eventThromboembolic eventA disorder characterized by occlusion of a vessel by a thrombus that has migrated from a distal site via the blood stream.
Thrombotic thrombocytopenic purpuraThrombotic thrombocytopenic purpuraA disorder characterized by the presence of microangiopathic hemolytic anemia, thrombocytopenic purpura, fever, renal abnormalities and neurological abnormalities such as seizures, hemiplegia, and visual disturbances. It is an acute or subacute condition.
TinnitusTinnitusA disorder characterized by noise in the ears, such as ringing, buzzing, roaring or clicking.
Tooth development disorderTooth development disorderA disorder characterized by a pathological process of the teeth occurring during tooth development.
Tooth discolorationTooth discolorationA disorder characterized by a change in tooth hue or tint.
Tooth infectionTooth infectionA disorder characterized by an infectious process involving a tooth.
ToothacheToothacheA disorder characterized by a sensation of marked discomfort in the tooth.
Toxic epidermal necrolysisToxic epidermal necrolysisA disorder characterized by greater than 30% total body skin area separation of dermis. The syndrome is thought to be a hypersensitivity complex affecting the skin and the mucous membranes.
Tracheal fistulaTracheal fistulaA disorder characterized by an abnormal communication between the trachea and another organ or anatomic site.
Tracheal hemorrhageTracheal hemorrhageA finding of bleeding from the trachea.
Tracheal mucositisTracheal mucositisA disorder characterized by an inflammation involving the mucous membrane of the trachea.
Tracheal obstructionTracheal obstructionA finding of blockage of the lumen of the trachea.
Tracheal stenosisTracheal stenosisA disorder characterized by a narrowing of the trachea.
TracheitisTracheitisA disorder characterized by an infectious process involving the trachea.
Tracheostomy site bleedingTracheostomy site bleedingA finding of blood leakage from the tracheostomy site.
Transient ischemic attacksTransient ischemic attacksA disorder characterized by a brief attack (less than 24 hours) of cerebral dysfunction of vascular origin, with no persistent neurological deficit.
Treatment related secondary malignancyTreatment related secondary malignancyA disorder characterized by development of a malignancy most probably as a result of treatment for a previously existing malignancy.
TremorTremorA disorder characterized by the uncontrolled shaking movement of the whole body or individual parts.
Tricuspid valve diseaseTricuspid valve diseaseA disorder characterized by a defect in tricuspid valve function or structure.
Trigeminal nerve disorderTrigeminal nerve disorderA disorder characterized by involvement of the trigeminal nerve (fifth cranial nerve).
TrismusTrismusA disorder characterized by lack of ability to open the mouth fully due to a decrease in the range of motion of the muscles of mastication.
Tumor lysis syndromeTumor lysis syndromeA disorder characterized by metabolic abnormalities that result from a spontaneous or therapy-related cytolysis of tumor cells.
Tumor painTumor painA disorder characterized by marked discomfort from a neoplasm that may be pressing on a nerve, blocking blood vessels, inflamed or fractured from metastasis.
TyphlitisTyphlitisA disorder characterized by inflammation of the cecum.
Unequal limb lengthUnequal limb lengthA disorder characterized by of a discrepancy between the lengths of the lower or upper extremities.
Unintended pregnancyUnintended pregnancyA disorder characterized by an unexpected pregnancy at the time of conception.
Upper gastrointestinal hemorrhageUpper gastrointestinal hemorrhageA disorder characterized by bleeding from the upper gastrointestinal tract (oral cavity, pharynx, esophagus, and stomach).
Upper respiratory infectionUpper respiratory infectionA disorder characterized by an infectious process involving the upper respiratory tract (nose, paranasal sinuses, pharynx, larynx, or trachea).
Ureteric anastomotic leakUreteric anastomotic leakA finding of leakage due to breakdown of a ureteral anastomosis (surgical connection of two separate anatomic structures).
Urethral anastomotic leakUrethral anastomotic leakA finding of leakage due to breakdown of a urethral anastomosis (surgical connection of two separate anatomic structures).
Urethral infectionUrethral infectionA disorder characterized by an infectious process involving the urethra.
Urinary fistulaUrinary fistulaA disorder characterized by an abnormal communication between any part of the urinary system and another organ or anatomic site.
Urinary frequencyUrinary frequencyA disorder characterized by urination at short intervals.
Urinary incontinenceUrinary incontinenceA disorder characterized by inability to control the flow of urine from the bladder.
Urinary retentionUrinary retentionA disorder characterized by accumulation of urine within the bladder because of the inability to urinate.
Urinary tract infectionUrinary tract infectionA disorder characterized by an infectious process involving the urinary tract, most commonly the bladder and the urethra.
Urinary tract obstructionUrinary tract obstructionA disorder characterized by blockage of the normal flow of contents of the urinary tract.
Urinary tract painUrinary tract painA disorder characterized by a sensation of marked discomfort in the urinary tract.
Urinary urgencyUrinary urgencyA disorder characterized by a sudden compelling urge to urinate.
Urine discolorationUrine discolorationA disorder characterized by a change in the color of the urine.
Urine output decreasedUrine output decreasedA finding based on test results that indicate urine production is less relative to previous output.
Urostomy leakUrostomy leakA finding of leakage of contents from a urostomy.
Urostomy obstructionUrostomy obstructionA finding of blockage of the urostomy.
Urostomy site bleedingUrostomy site bleedingA finding of bleeding from the urostomy site.
Urostomy stenosisUrostomy stenosisA finding of narrowing of the opening of a urostomy.
UrticariaUrticariaA disorder characterized by an itchy skin eruption characterized by wheals with pale interiors and well-defined red margins.
Uterine anastomotic leakUterine anastomotic leakA finding of leakage due to breakdown of a uterine anastomosis (surgical connection of two separate anatomic structures).
Uterine fistulaUterine fistulaA disorder characterized by an abnormal communication between the uterus and another organ or anatomic site.
Uterine hemorrhageUterine hemorrhageA disorder characterized by bleeding from the uterus.
Uterine infectionUterine infectionA disorder characterized by an infectious process involving the endometrium. It may extend to the myometrium and parametrial tissues.
Uterine obstructionUterine obstructionA disorder characterized by blockage of the uterine outlet.
Uterine painUterine painA disorder characterized by a sensation of marked discomfort in the uterus.
Uterine perforationUterine perforationA disorder characterized by a rupture in the uterine wall.
UveitisUveitisA disorder characterized by inflammation to the uvea of the eye.
Vaginal anastomotic leakVaginal anastomotic leakA finding of leakage due to breakdown of a vaginal anastomosis (surgical connection of two separate anatomic structures).
Vaginal dischargeVaginal dischargeA disorder characterized by vaginal secretions. Mucus produced by the cervical glands is discharged from the vagina naturally, especially during the childbearing years.
Vaginal drynessVaginal drynessA disorder characterized by an uncomfortable feeling of itching and burning in the vagina.
Vaginal fistulaVaginal fistulaA disorder characterized by an abnormal communication between the vagina and another organ or anatomic site.
Vaginal hemorrhageVaginal hemorrhageA disorder characterized by bleeding from the vagina.
Vaginal infectionVaginal infectionA disorder characterized by an infectious process involving the vagina.
Vaginal inflammationVaginal inflammationA disorder characterized by inflammation involving the vagina. Symptoms may include redness, edema, marked discomfort and an increase in vaginal discharge.
Vaginal obstructionVaginal obstructionA disorder characterized by blockage of vaginal canal.
Vaginal painVaginal painA disorder characterized by a sensation of marked discomfort in the vagina.
Vaginal perforationVaginal perforationA disorder characterized by a rupture in the vaginal wall.
Vaginal strictureVaginal strictureA disorder characterized by a narrowing of the vaginal canal.
VaginismusVaginismusA disorder characterized by involuntary spasms of the pelvic floor muscles, resulting in pathologic tightness of the vaginal wall during penetration such as during sexual intercourse.
Vagus nerve disorderVagus nerve disorderA disorder characterized by involvement of the vagus nerve (tenth cranial nerve).
Vas deferens anastomotic leakVas deferens anastomotic leakA finding of leakage due to breakdown of a vas deferens anastomosis (surgical connection of two separate anatomic structures).
Vascular access complicationVascular access complicationA finding of a previously undocumented problem related to the vascular access site.
Vascular disorders - Other, SpecifyVascular disorders - Other, specifyNo Value Exists
VasculitisVasculitisA disorder characterized by inflammation involving the wall of a vessel.
Vasovagal reactionVasovagal reactionA disorder characterized by a sudden drop of the blood pressure, bradycardia, and peripheral vasodilation that may lead to loss of consciousness. It results from an increase in the stimulation of the vagus nerve.
Venous injuryVenous injuryA finding of damage to a vein.
Ventricular arrhythmiaVentricular arrhythmiaA disorder characterized by a dysrhythmia that originates in the ventricles.
Ventricular fibrillationVentricular fibrillationA disorder characterized by a dysrhythmia without discernible QRS complexes due to rapid repetitive excitation of myocardial fibers without coordinated contraction of the ventricles.
Ventricular tachycardiaVentricular tachycardiaA disorder characterized by a dysrhythmia with a heart rate greater than 100 beats per minute that originates distal to the bundle of His.
VertigoVertigoA disorder characterized by a sensation as if the external world were revolving around the patient (objective vertigo) or as if he himself were revolving in space (subjective vertigo).
Vestibular disorderVestibular disorderA disorder characterized by dizziness, imbalance, nausea, and vision problems.
VirilizationVirilizationA disorder characterized by inappropriate masculinization occurring in a female or prepubertal male.
Visceral arterial ischemiaVisceral arterial ischemiaA disorder characterized by a decrease in blood supply due to narrowing or blockage of a visceral (mesenteric) artery.
Vital capacity abnormalVital capacity abnormalA finding based on pulmonary function test results that indicate an abnormal vital capacity (amount of exhaled after a maximum inhalation) when compared to the predicted value.
Vitreous hemorrhageVitreous hemorrhageA disorder characterized by blood extravasation into the vitreous humor.
Voice alterationVoice alterationA disorder characterized by a change in the sound and/or speed of the voice.
VomitingVomitingA disorder characterized by the reflexive act of ejecting the contents of the stomach through the mouth.
Vulval infectionVulval infectionA disorder characterized by an infectious process involving the vulva.
Watering eyesWatering eyesA disorder of excessive tearing in the eyes; it can be caused by overproduction of tears or impaired drainage of the tear duct.
Weight gainWeight gainA finding characterized by an increase in overall body weight; for pediatrics, greater than the baseline growth curve.
Weight lossWeight lossA finding characterized by a decrease in overall body weight; for pediatrics, less than the baseline growth curve.
WheezingWheezingA disorder characterized by a high-pitched, whistling sound during breathing. It results from the narrowing or obstruction of the respiratory airways.
White blood cell decreasedWhite blood cell decreasedA finding based on laboratory test results that indicate an decrease in number of white blood cells in a blood specimen.
Wolff-Parkinson-White syndromeWolff-Parkinson-White syndromeA disorder characterized by the presence of an accessory conductive pathway between the atria and the ventricles that causes premature ventricular activation.
Wound complicationWound complicationA finding of development of a new problem at the site of an existing wound.
Wound dehiscenceWound dehiscenceA finding of separation of the approximated margins of a surgical wound.
Wound infectionWound infectionA disorder characterized by an infectious process involving the wound.
Wrist fractureWrist fractureA finding of traumatic injury to the wrist joint in which the continuity of a wrist bone is broken.
Describe 'Other' Adverse EventAdverse Event Verbatim Term Text21881321.0Verbatim AE Description used to 'reinforce' selected AE Type Code.ALPHANUMERIC
Adverse Event GradeAdverse Event Severity Grade29445151.0A coded value to identify the severity of the AE.CHARACTER
1Mild Adverse EventAn adverse event that is asymptomatic; or involves mild or minor symptoms; or is of marginal clinical relevance; or consists of clinical or diagnostic observations alone; or for which intervention is not indicated; or for which only non-prescription intervention is indicated.
2Moderate Adverse EventAn adverse event for which only minimal, local, or noninvasive intervention (e.g. packing, cautery) is indicated; or that limits instrumental activities of daily living (ADLs, e.g., shopping, laundry, transportation, or ability to conduct finances).
3Severe Adverse EventAn adverse event that is medically significant but not life-threatening; or for which inpatient care or prolongation of hospitalization are indicated; or that is an important medical event that does not result in hospitalization, but may jeopardize the patient or may require intervention either to prevent hospitalization, to prevent the AE from becoming life-threatening or causing death; or that is disabling; or that results in persistent or significant disability, incapcity, or limitation of self care activities of daily living (ADLs, e.g., getting in and our of bed, dressing, eating, getting around inside, bathing, or using the toilet).
4Life Threatening Adverse EventAn adverse event that has life-threatening consequences; for which urgent intervention is indicated; that puts the patient at risk of death at the time of the event if immediate intervention is not undertaken; or that causes blindness or deafness.
5Death Related to Adverse EventThe termination of life associated with an adverse event.
Conditional Adverse Event QuestionsThere are business rules to indicate situations under which this data element should be used in a CRF.
AE Start DateAdverse Event Onset Date27449931.0Date on which the AE was first evident. Conditionality Rule: Condition is that this is based on the needs of the Sponsor. CTEP does not currently collect Adverse Event onset dates for routine AEs reported via reporting systems.Date Alpha DVGMM/DD/YYYY
UnknownUnknownNot known, not observed, not recorded, or refused.
Was patient hospitalized for toxicity?Patient Toxicity Hospitalization Indicator25523981.0Normally required only if AE is deemed 'serious'. Conditionality Rule: Conditional based on the reporting of this variable through other means, such as caAERS, AdEERS. If those systems are not in use, this variable needs to be collected. CHARACTER
YesYesThe affirmative response to a question or activity.
NoNoThe non-affirmative response to a question.
Cycle #Treatment Cycle Number27449481.0A repeating period of activity involving treatment and rest. Several cycles can make up a course. Conditionality Rule: Studies use cycles. NUMBER
Optional Adverse Event QuestionsNo requirement for inclusion of this element on the CRF; if the design and scientific questions posed in the study dictate the need to collect this type of data, this is the element to include on the CRF.
To what is the AE attributed?Adverse Event Cancer Treatment Related Type21798921.0List of other therapies (surgery, radiation, etc), disease, concomitant meds, other. Select MOST likely.CHARACTER
Biological TherapyBiological TherapyBiological therapy is a form of treatment that implies the administration of substances which produce a biological reaction in the organism enhancing or restoring the host immune response, modifying the behavior of cancer cells, blocking the pathways of cell neoplastic transformation and tumor ability to metastasize, or facilitating the repairment of cells damaged by aggressive forms of cancer treatment. It includes the use of sera, antitoxins, vaccines, genes, cells, tissues, and organs
ChemotherapyCHEMOTHERAPYCHEMOTHERAPY
Combined modalitycombined modalitycombined modality
Concomitant medicationConcomitant AgentA pharmaceutical agent other than agent(s) tested in a given protocol that is administered to or used by a subject either prior to or during the study. Supportive care and essential ancillary medications required by a treatment regimen should be clearly identified. A protocol complete instructions including appropriate indication, dosage, administration route, schedule, restrictions to use, and any other relevant data should be explicitly stated. Concept also refers to substance(s) used prior or during the study that are not specified by the protocol.
DeviceMedical_DeviceMedical device - any machinery designed to aid diagnostic and medical therapies. Medical device has to be designed with rigorous safety standards. There are several basic types of medical devices: life support equipment used to maintain a patient's body functions; therapeutic equipment; monitors and detectors to measure the indexes of a patient's state; imagine machines and laboratory equipment used with diagnostic and status monitoring purposes. In insurance parlance, the term is usually synonymous with assistive device, although it may include medical supplies.
Diseasediseasedisease
Endocrine TherapyEndocrine TherapyVarious treatment modalities that produce the desired therapeutic effect by means of change of hormone/hormones level. The treatment may include administration of hormones or hormone analogs to the patient, or decreasing the level of hormones in the body by using hormone antagonists, or hormone ablation therapy. The concept covers but not limited to: intermittent or permanent hormone suppression or ablation in treatment of hormone-dependent tumors, hormone replacement therapy of any kind, hormonal component of gender reassignment therapy, hormonal contraception, surgical and radiation castration.
ImmunotherapyImmunotherapy(IM-yoo-no-THER-a-pee) Treatment to stimulate or restore the ability of the immune system to fight infections and other diseases. Also used to lessen side effects that may be caused by some cancer treatments.
Investigational agentInvestigational AgentIn the process of being studied; experimental. (NCI): An active power or cause (as principle, substance, physical or biological factor, etc.) that produces a specific effect. (NCI)
OtherOtherNot otherwise specified.
Radiation therapyRadiation Therapyuse PHOTOTHERAPY, LASER THERAPY, or ULTRAVIOLET THERAPY for therapeutic radiation with visible, laser, or ultraviolet light, respectively.
SurgerySurgeryA specialty in which manual or operative procedures are used in the treatment of disease, injuries, or deformities.
Other Attribution, SpecifyAdverse Event Suspected Other Attribution Text Name22013481.0If 'other' selected in data element above, must provide a description of the presumed cause.CHARACTER
AE Stop DateAdverse Event Resolved Alpha DVG Date21898431.0Date on which the AE resolved.Alpha DVGDD/MON/YYYY
UnknownUnknown DateStart date for an occurrence or event is unknown.
OngoingEvent/Occurrence is OngoingNo stop date, event or occurrence is ongoing.
MedDRA System Organ Class (SOC)MedDRA System Organ Class Term Name29438641.0CHARACTER
Blood and lymphatic system disordersHematopoietic and Lymphoid System DisorderAny deviation from the normal structure or function of the blood or lymphatic system that is manifested by a characteristic set of symptoms and signs.
Cardiac disordersCardiac disordersAny deviation from the normal structure or function of the cardiac system that is manifested by a characteristic set of symptoms and signs.
Congenital, familial and genetic disordersCongenital, Familial and Genetic Disorder ClassA class of disorders that encompasses conditions resulting from a congenital, familial hereditary trait or genetic abnormality as is manifested by a characterstic set of symptoms and signs.
Ear and labyrinth disordersEar and Labyrinth Disorder ClassAny deviation from the normal structure or function of the ear or labyrinth that is manifested by a characteristic set of symptoms and signs.
Endocrine disordersEndocrine DisorderAny deviation from the normal structure or function of the endocrine system that is manifested by a characteristic set of symptoms and signs.
Eye disordersEye DisorderAny deviation from the normal structure or function of the eye that is manifested by a characteristic set of symptoms and signs.
Gastrointestinal disordersGastrointestinal DisorderDiseases of the digestive tract (oral cavity to anus) and associated organs (salivary glands, liver, pancreas).
General disorders and administration site conditionsGeneral Disorders and Administration Site Conditions ClassA class of disorders that encompasses conditions of a general kind that result from a disease, the treatment of disease or administration of treatment at a particular site and are manifested by a characteristic set of symptoms and signs.
Hepatobiliary disordersLiver and Biliary Tract DisorderAny deviation from the normal structure or function of the liver or biliary tract that is manifested by a characteristic set of symptoms and signs.
Immune system disordersImmune System DisorderA disorder resulting from an abnormality in the immune system. -- 2003
Infections and infestationsInfection and infestationA disorder resulting from the presence and activity of a microbial, viral, or parasitic agent. It can be transmitted by direct or indirect contact. -- 2003
Injury, poisoning and procedural complicationsInjury, Poisoning and Procedural Complication ClassA class of disorders that encompasses conditions resulting from an injury, poisoning or procedure.
InvestigationsInvestigationThe act or process of a systematic and thorough examination; research, study; the process of inquiring into or following up, intended to develop facts.
Metabolism and nutrition disordersMetabolism and Nutrition Disorder ClassA class of disorders that encompasses conditions occurring as a result of metabolic dysfunction or deviation from the normal nutritional requirements.
Musculoskeletal and connective tissue disordersConnective and Soft Tissue DisorderAny deviation from the normal structure or function of the musculoskeletal or connective tissue that is manifested by a characteristic set of symptoms and signs.
Neoplasms benign, malignant and unspecified (incl cysts and polyps)NeoplasmAn abnormal tissue growth resulted from uncontrolled cell proliferation. Benign neoplastic cells resemble normal cells without exhibiting significant cytologic atypia, while malignant ones exhibit overt signs such as dysplastic features, atypical mitotic figures, necrosis, nuclear pleomorphism, and anaplasia. Representative examples of benign neoplasms include papillomas, cystadenomas, and lipomas; malignant neoplasms include carcinomas, sarcomas, lymphomas, and leukemias.
Nervous system disordersNervous System DisorderAny deviation from the normal structure or function of the nervous system that is manifested by a characteristic set of symptoms and signs.
Pregnancy, puerperium and perinatal conditionsPregnancy, Puerperium and Perinatal Condition ClassA class of conditions associated with pregnancy, puerperium and perinatal status.
Psychiatric disordersPsychiatric DisorderAny deviation from the normal structure or function of the brain and a psychiatric condition, that results in an impairment of an individual's normal cognitive, emotional, or behavioral functioning, and is caused by physiological or psychosocial factors.
Renal and urinary disordersUrinary Tract DisorderDisorders of any part of the urologic system.
Reproductive system and breast disordersReproductive System and Breast Disorder ClassAny deviation from the normal structure or function of the reproductive system or breast that is manifested by a characteristic set of symptoms and signs.
Respiratory, thoracic and mediastinal disordersRespiratory and Thoracic DisorderAny deviation from the normal structure or function of the respiratory system including the thorax and mediastinum that is manifested by a characteristic set of symptoms and signs.
Skin and subcutaneous tissue disordersSkin DisorderAny deviation from the normal structure or function of the skin or subcutaneous tissue that is manifested by a characteristic set of symptoms and signs.
Social circumstancesSocial CircumstancesA set of concepts that results from or is influenced by criteria or activities associated with the social environment of a person.
Surgical and medical proceduresIntervention or ProcedureAn activity that produces an effect, or that is intended to alter the course of a disease in a patient or population. This is a general term that encompasses the medical, social, behavioral, and environmnetal acts that can have preventive, therapeutic, or palliative effects.
Vascular disordersVascular DisorderAny deviation from the normal structure or function of the vascular system that is manifested by a characteristic set of symptoms and signs.
MedDRA AE Code (CTCAE v4.0)Common Terminology Criteria for Adverse Events Version 4.0 Mapped Low Level Term MedDRA Code31333531.0Code used to identify the adverse event using a standard mechanism that facilitates analysis. CTEP's code list and associated Category/Term is currently a standard.CHARACTER
10000060Abdominal distensionA disorder characterized by swelling of the abdomen.
10000081Abdominal painA disorder characterized by a sensation of marked discomfort in the abdominal region.
10000486AcidosisA disorder characterized by abnormally high acidity (high hydrogen-ion concentration) of the blood and other body tissues.
10000521Acoustic nerve disorder NOSA disorder characterized by involvement of the acoustic nerve (eighth cranial nerve).
10000636Activated partial thromboplastin time prolongedAn abnormal laboratory test result in which the partial thromboplastin time is found to be greater than the control value. As a possible indicator of coagulopathy, a prolonged partial thromboplastin time (PTT) may occur in a variety of diseases and disorders, both primary and related to treatment.
10001367Adrenal insufficiencyA disorder that occurs when the adrenal cortex does not produce enough of the hormone cortisol and in some cases, the hormone aldosterone. It may be due to a disorder of the adrenal cortex as in Addison's disease or primary adrenal insufficiency.
10001409Adult respiratory distress syndromeA disorder characterized by progressive and life-threatening pulmonary distress in the absence of an underlying pulmonary condition, usually following major trauma or surgery.
10001497AgitationA disorder characterized by a state of restlessness associated with unpleasant feelings of irritability and tension.
10001540AkathisiaA disorder characterized by an uncomfortable feeling of inner restlessness and inability to stay still; this is a side effect of some psychotropic drugs.
10001551Alanine aminotransferase increasedA finding based on laboratory test results that indicate an increase in the level of alanine aminotransferase (ALT or SGPT) in the blood specimen.
10001598Alcohol intoleranceA disorder characterized by an increase in sensitivity to the adverse effects of alcohol, which can include nasal congestion, skin flushes, heart dysrhythmias, nausea, vomiting, indigestion and headaches.
10001675Alkaline phosphatase increasedA finding based on laboratory test results that indicate an increase in the level of alkaline phosphatase in a blood specimen.
10001680AlkalosisA disorder characterized by abnormally high alkalinity (low hydrogen-ion concentration) of the blood and other body tissues.
10001718Allergic reactionA disorder characterized by an adverse local or general response from exposure to an allergen.
10001723Allergic rhinitisA disorder characterized by an inflammation of the nasal mucous membranes caused by an IgE-mediated response to external allergens. The inflammation may also involve the mucous membranes of the sinuses, eyes, middle ear, and pharynx. Symptoms include sneezing, nasal congestion, rhinorrhea and itching.
10001760AlopeciaA disorder characterized by a decrease in density of hair compared to normal for a given individual at a given age and body location.
10001949AmnesiaA disorder characterized by systematic and extensive loss of memory.
10002156Anal fistulaA disorder characterized by an abnormal communication between the opening in the anal canal to the perianal skin.
10002167Anal painA disorder characterized by a sensation of marked discomfort in the anal region.
10002176Anal stenosisA disorder characterized by a narrowing of the lumen of the anal canal.
10002180Anal ulcerA disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the anal canal.
10002218AnaphylaxisA disorder characterized by an acute inflammatory reaction resulting from the release of histamine and histamine-like substances from mast cells, causing a hypersensitivity immune response. Clinically, it presents with breathing difficulty, dizziness, hypotension, cyanosis and loss of consciousness and may lead to death.
10002272AnemiaA disorder characterized by an reduction in the amount of hemoglobin in 100 ml of blood. Signs and symptoms of anemia may include pallor of the skin and mucous membranes, shortness of breath, palpitations of the heart, soft systolic murmurs, lethargy, and fatigability.
10002544Ankle fractureA finding of damage to the ankle joint characterized by a break in the continuity of the ankle bone. Symptoms include marked discomfort, swelling and difficulty moving the affected leg and foot.
10002646AnorexiaA disorder characterized by a loss of appetite.
10002652AnorgasmiaA disorder characterized by an inability to achieve orgasm.
10002855AnxietyA disorder characterized by apprehension of danger and dread accompanied by restlessness, tension, tachycardia, and dyspnea unattached to a clearly identifiable stimulus.
10002899Aortic injuryA finding of damage to the aorta.
10002953AphoniaA disorder characterized by the inability to speak. It may result from injuries to the vocal cords or may be functional (psychogenic).
10002972ApneaA disorder characterized by cessation of breathing.
10003011AppendicitisA disorder characterized by acute inflammation to the vermiform appendix caused by a pathogenic agent.
10003012Appendicitis perforatedA disorder characterized by acute inflammation to the vermiform appendix caused by a pathogenic agent with gangrenous changes resulting in the rupture of the appendiceal wall. The appendiceal wall rupture causes the release of inflammatory and bacterial contents from the appendiceal lumen into the abdominal cavity.
10003074ArachnoiditisA disorder characterized by inflammation of the arachnoid membrane and adjacent subarachnoid space.
10003162Arterial injuryA finding of damage to an artery.
10003239ArthralgiaA disorder characterized by a sensation of marked discomfort in a joint.
10003246ArthritisA disorder characterized by inflammation involving a joint.
10003445AscitesA disorder characterized by accumulation of serous or hemorrhagic fluid in the peritoneal cavity.
10003481Aspartate aminotransferase increasedA finding based on laboratory test results that indicate an increase in the level of aspartate aminotransferase (AST or SGOT) in a blood specimen.
10003504AspirationA disorder characterized by inhalation of solids or liquids into the lungs.
10003586AsystoleA disorder characterized by a dysrhythmia without cardiac electrical activity. Typically, this is accompanied by cessation of the pumping function of the heart.
10003591AtaxiaA disorder characterized by lack of coordination of muscle movements resulting in the impairment or inability to perform voluntary activities.
10003598AtelectasisA disorder characterized by the collapse of part or the entire lung.
10003658Atrial fibrillationA disorder characterized by a dysrhythmia without discernible P waves and an irregular ventricular response due to multiple reentry circuits. The rhythm disturbance originates above the ventricles.
10003662Atrial flutterA disorder characterized by a dysrhythmia with organized rhythmic atrial contractions with a rate of 200-300 beats per minute. The rhythm disturbance originates in the atria.
10003673Atrioventricular block completeA disorder characterized by a dysrhythmia with complete failure of atrial electrical impulse conduction through the AV node to the ventricles.
10003674Atrioventricular block first degreeA disorder characterized by a dysrhythmia with a delay in the time required for the conduction of an electrical impulse through the atrioventricular (AV) node beyond 0.2 seconds; prolongation of the PR interval greater than 200 milliseconds.
10003883AzoospermiaA disorder characterized by laboratory test results that indicate complete absence of spermatozoa in the semen.
10003988Back painA disorder characterized by marked discomfort sensation in the back region.
10004665Biliary fistulaA disorder characterized by an abnormal communication between the bile ducts and another organ or anatomic site.
10005047Bladder infectionA disorder characterized by an infectious process involving the bladder.
10005265BloatingA disorder characterized by subject-reported feeling of uncomfortable fullness of the abdomen.
10005329Blood and lymphatic system disorders - Other, specifyNo Value Exists
10005332Blood antidiuretic hormone abnormalA finding based on laboratory test results that indicate abnormal levels of antidiuretic hormone in the blood specimen.
10005364Blood bilirubin increasedA finding based on laboratory test results that indicate an abnormally high level of bilirubin in the blood. Excess bilirubin is associated with jaundice.
10005452Blood corticotrophin decreasedA finding based on laboratory test results that indicate an decrease in levels of corticotrophin in a blood specimen.
10005561Blood gonadotrophin abnormalA finding based on laboratory test results that indicate abnormal levels of gonadotrophin hormone in a blood specimen.
10005778Blood prolactin abnormalA finding based on laboratory test results that indicate abnormal levels of prolactin hormone in a blood specimen.
10005886Blurred visionA disorder characterized by visual perception of unclear or fuzzy images.
10005901Body odorA disorder characterized by an abnormal body smell resulting from the growth of bacteria on the body.
10006002Bone painA disorder characterized by marked discomfort sensation in the bones.
10006179Breast atrophyA disorder characterized by underdevelopment of the breast.
10006259Breast infectionA disorder characterized by an infectious process involving the breast.
10006298Breast painA disorder characterized by marked discomfort sensation in the breast region.
10006437Bronchial fistulaA disorder characterized by an abnormal communication between the bronchus and another organ or anatomic site.
10006440Bronchial obstructionA disorder characterized by blockage of a bronchus passage, most often by bronchial secretions and exudates.
10006482BronchospasmA disorder characterized by a sudden contraction of the smooth muscles of the bronchial wall.
10006504BruisingA finding of injury of the soft tissues or bone characterized by leakage of blood into surrounding tissues.
10006556Bullous dermatitisA disorder characterized by inflammation of the skin characterized by the presence of bullae which are filled with fluid.
10006634BurnA finding of impaired integrity to the anatomic site of an adverse thermal reaction. Burns can be caused by exposure to chemicals, direct heat, electricity, flames and radiation. The extent of damage depends on the length and intensity of exposure and time until provision of treatment.
10007196Capillary leak syndromeA disorder characterized by leakage of intravascular fluids into the extravascular space. This syndrome is observed in patients who demonstrate a state of generalized leaky capillaries following shock syndromes, low-flow states, ischemia-reperfusion injuries, toxemias, medications, or poisoning. It can lead to generalized edema and multiple organ failure.
10007515Cardiac arrestA disorder characterized by cessation of the pumping function of the heart.
10007541Cardiac disorders - Other, specifyNo Value Exists
10007612Cardiac troponin I increasedA laboratory test result which indicates increased levels of cardiac troponin I in a biological specimen.
10007613Cardiac troponin T increasedA laboratory test result which indicates increased levels of cardiac troponin T in a biological specimen.
10007739CataractA disorder characterized by partial or complete opacity of the crystalline lens of one or both eyes. This results in a decrease in visual acuity and eventual blindness if untreated.
10007810Catheter related infectionA disorder characterized by an infectious process that arises secondary to catheter use.
10007839CD4 lymphocytes decreasedA finding based on laboratory test results that indicate an decrease in levels of CD4 lymphocytes in a blood specimen.
10008164Cerebrospinal fluid leakageA disorder characterized by loss of cerebrospinal fluid into the surrounding tissues.
10008330Cervicitis infectionA disorder characterized by an infectious process involving the uterine cervix.
10008417CheilitisA disorder characterized by inflammation of the lip.
10008481Chest pain - cardiacA disorder characterized by substernal discomfort due to insufficient myocardial oxygenation.
10008496Chest wall painA disorder characterized by marked discomfort sensation in the chest wall region.
10008531ChillsA disorder characterized by a sensation of cold that often marks a physiologic response to sweating after a fever.
10008612CholecystitisA disorder characterized by inflammation involving the gallbladder. It may be associated with the presence of gallstones.
10008661Cholesterol highA finding based on laboratory test results that indicate higher than normal levels of cholesterol in a blood specimen.
10009845Cognitive disturbanceA disorder characterized by a conspicuous change in cognitive function.
10009887ColitisA disorder characterized by inflammation of the colon.
10009995Colonic fistulaA disorder characterized by an abnormal communication between the large intestine and another organ or anatomic site.
10009998Colonic hemorrhageA disorder characterized by bleeding from the colon.
10010000Colonic obstructionA disorder characterized by blockage of the normal flow of the intestinal contents in the colon.
10010001Colonic perforationA disorder characterized by a rupture in the colonic wall.
10010004Colonic stenosisA disorder characterized by a narrowing of the lumen of the colon.
10010006Colonic ulcerA disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the colon.
10010250Concentration impairmentA disorder characterized by a deterioration in the ability to concentrate.
10010276Conduction disorderA disorder characterized by pathological irregularities in the cardiac conduction system.
10010300ConfusionA disorder characterized by a lack of clear and orderly thought and behavior.
10010331Congenital, familial and genetic disorders - Other, specifyNo Value Exists
10010741ConjunctivitisA disorder characterized by inflammation, swelling and redness to the conjunctiva of the eye.
10010742Conjunctivitis infectiveA disorder characterized by an infectious process involving the conjunctiva. Clinical manifestations include pink or red color in the eyes.
10010774ConstipationA disorder characterized by irregular and infrequent or difficult evacuation of the bowels.
10010783Constrictive pericarditisA disorder characterized by a thickened and fibrotic pericardial sac; these fibrotic changes impede normal myocardial function by restricting myocardial muscle action.
10011224CoughA disorder characterized by sudden, often repetitive, spasmodic contraction of the thoracic cavity, resulting in violent release of air from the lungs and usually accompanied by a distinctive sound.
10011268CPK increasedA finding based on laboratory test results that indicate an increase in levels of creatine phosphokinase in a blood specimen.
10011368Creatinine increasedA finding based on laboratory test results that indicate increased levels of creatinine in a biological specimen.
10011655CushingoidA disorder characterized by signs and symptoms that resemble Cushing's disease or syndrome: buffalo hump obesity, striations, adiposity, hypertension, diabetes, and osteoporosis, usually due to exogenous corticosteroids.
10011912Death neonatalA disorder characterized by cessation of life occurring during the first 28 days of life.
10011914Death NOSA cessation of life that cannot be attributed to a CTCAE term associated with Grade 5.
10012174DehydrationA disorder characterized by excessive loss of water from the body. It is usually caused by severe diarrhea, vomiting or diaphoresis.
10012205Delayed pubertyA disorder characterized by unusually late sexual maturity.
10012218DeliriumA disorder characterized by the acute and sudden development of confusion, illusions, movement changes, inattentiveness, agitation, and hallucinations. Usually, it is a reversible condition.
10012260DelusionsA disorder characterized by false personal beliefs held contrary to reality, despite contradictory evidence and common sense.
10012318Dental cariesA disorder characterized by the decay of a tooth, in which it becomes softened, discolored and/or porous.
10012373Depressed level of consciousnessA disorder characterized by a decrease in ability to perceive and respond.
10012378DepressionA disorder characterized by melancholic feelings of grief or unhappiness.
10012727DiarrheaA disorder characterized by frequent and watery bowel movements.
10013442Disseminated intravascular coagulationA disorder characterized by systemic pathological activation of blood clotting mechanisms which results in clot formation throughout the body. There is an increase in the risk of hemorrhage as the body is depleted of platelets and coagulation factors.
10013573DizzinessA disorder characterized by a disturbing sensation of lightheadedness, unsteadiness, giddiness, spinning or rocking.
10013774Dry eyeA disorder characterized by dryness of the cornea and conjunctiva.
10013781Dry mouthA disorder characterized by reduced salivary flow in the oral cavity.
10013786Dry skinA disorder characterized by flaky and dull skin; the pores are generally fine, the texture is a papery thin texture.
10013828Duodenal fistulaA disorder characterized by an abnormal communication between the duodenum and another organ or anatomic site.
10013830Duodenal obstructionA disorder characterized by blockage of the normal flow of stomach contents through the duodenum.
10013832Duodenal perforationA disorder characterized by a rupture in the duodenal wall.
10013836Duodenal ulcerA disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the duodenal wall.
10013887DysarthriaA disorder characterized by slow and slurred speech resulting from an inability to coordinate the muscles used in speech.
10013911DysgeusiaA disorder characterized by abnormal sensual experience with the taste of foodstuffs; it can be related to a decrease in the sense of smell.
10013934DysmenorrheaA disorder characterized by abnormally painful abdominal cramps during menses.
10013941DyspareuniaA disorder characterized by painful or difficult coitus.
10013946DyspepsiaA disorder characterized by an uncomfortable, often painful feeling in the stomach, resulting from impaired digestion. Symptoms include burning stomach, bloating, heartburn, nausea and vomiting.
10013950DysphagiaA disorder characterized by difficulty in swallowing.
10013951DysphasiaA disorder characterized by impairment of verbal communication skills, often resulting from brain damage.
10013963DyspneaA disorder characterized by an uncomfortable sensation of difficulty breathing.
10013993Ear and labyrinth disorders - Other, specifyNo Value Exists
10014020Ear painA disorder characterized by a sensation of marked discomfort in the ear.
10014217Edema cerebralA disorder characterized by swelling due to an excessive accumulation of fluid in the brain.
10014222Edema faceA disorder characterized by swelling due to excessive fluid accumulation in facial tissues.
10014326Ejaculation disorderA disorder characterized by problems related to ejaculation. This category includes premature, delayed, retrograde and painful ejaculation.
10014383Electrocardiogram QT corrected interval prolongedA finding of a cardiac dysrhythmia characterized by an abnormally long corrected QT interval.
10014594Encephalitis infectionA disorder characterized by an infectious process involving the brain tissue.
10014621Encephalomyelitis infectionA disorder characterized by an infectious process involving the brain and spinal cord tissues.
10014625EncephalopathyA disorder characterized by a pathologic process involving the brain.
10014678Endocarditis infectiveA disorder characterized by an infectious process involving the endocardial layer of the heart.
10014698Endocrine disorders - Other, specifyNo Value Exists
10014801EndophthalmitisA disorder characterized by an infectious process involving the internal structures of the eye.
10014893EnterocolitisA disorder characterized by inflammation of the small and large intestines.
10015090EpistaxisA disorder characterized by bleeding from the nose.
10015218Erythema multiformeA disorder characterized by target lesions (a pink-red ring around a pale center).
10015277ErythrodermaA disorder characterized by generalized inflammatory erythema and exfoliation. The inflammatory process involves > 90% of the body surface area.
10015384Esophageal hemorrhageA disorder characterized by bleeding from the esophagus.
10015387Esophageal obstructionA disorder characterized by blockage of the normal flow of the contents in the esophagus.
10015388Esophageal painA disorder characterized by a sensation of marked discomfort in the esophageal region.
10015448Esophageal stenosisA disorder characterized by a narrowing of the lumen of the esophagus.
10015451Esophageal ulcerA disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the esophageal wall.
10015453Esophageal varices hemorrhageA disorder characterized by bleeding from esophageal varices.
10015461EsophagitisA disorder characterized by inflammation of the esophageal wall.
10015533EuphoriaA disorder characterized by an exaggerated feeling of well-being which is disproportionate to events and stimuli.
10015688ExostosisA disorder characterized by non-neoplastic overgrowth of bone.
10015829Extraocular muscle paresisA disorder characterized by incomplete paralysis of an extraocular muscle.
10015832Extrapyramidal disorderA disorder characterized by abnormal, repetitive, involuntary muscle movements, frenzied speech and extreme restlessness.
10015919Eye disorders - Other, specifyNo Value Exists
10015929Eye infectionA disorder characterized by an infectious process involving the eye.
10015958Eye painA disorder characterized by a sensation of marked discomfort in the eye.
10016059Facial painA disorder characterized by a sensation of marked discomfort in the face.
10016173FallA finding of sudden movement downward, usually resulting in injury.
10016241Fat atrophyA disorder characterized by shrinking of adipose tissue.
10016256FatigueA disorder characterized by a state of generalized weakness with a pronounced inability to summon sufficient energy to accomplish daily activities.
10016288Febrile neutropeniaA disorder characterized by a decrease in neutrophils associated with fever.
10016296Fecal incontinenceA disorder characterized by inability to control the escape of stool from the rectum.
10016479Fetal deathA disorder characterized by death in utero; failure of the product of conception to show evidence of respiration, heartbeat, or definite movement of a voluntary muscle after expulsion from the uterus, without possibility of resuscitation.
10016558FeverA disorder characterized by elevation of the body's temperature above the upper limit of normal.
10016596Fibrinogen decreasedA finding based on laboratory test results that indicate an decrease in levels of fibrinogen in a blood specimen.
10016750Flank painA disorder characterized by marked discomfort sensation on the lateral side of the body in the region below the ribs and above the hip.
10016757Flashing lightsA disorder characterized by a sudden or brief burst of light.
10016766FlatulenceA disorder characterized by a state of excessive gas in the alimentary canal.
10016778FloatersA disorder characterized by an individual seeing spots before their eyes. The spots are shadows of opaque cell fragments in the vitreous humor or lens.
10016791Flu like symptomsA disorder characterized by a group of symptoms similar to those observed in patients with the flu. It includes fever, chills, body aches, malaise, loss of appetite and dry cough.
10016825FlushingA disorder characterized by episodic reddening of the face.
10016987Forced expiratory volume decreasedA finding based on test results that indicate a relative decrease in the fraction of the forced vital capacity that is exhaled in a specific number of seconds.
10017076FractureA finding of traumatic injury to the bone in which the continuity of the bone is broken.
10017577Gait disturbanceA disorder characterized by walking difficulties.
10017631Gallbladder fistulaA disorder characterized by an abnormal communication between the gallbladder and another organ or anatomic site.
10017636Gallbladder obstructionA disorder characterized by blockage of the normal flow of the contents of the gallbladder.
10017638Gallbladder painA disorder characterized by a sensation of marked discomfort in the gallbladder region.
10017639Gallbladder perforationA disorder characterized by a rupture in the gallbladder wall.
10017789Gastric hemorrhageA disorder characterized by bleeding from the gastric wall.
10017815Gastric perforationA disorder characterized by a rupture in the stomach wall.
10017822Gastric ulcerA disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the stomach.
10017853GastritisA disorder characterized by inflammation of the stomach.
10017877Gastrointestinal fistulaA disorder characterized by an abnormal communication between any part of the gastrointestinal system and another organ or anatomic site.
10017947Gastrointestinal disorders - Other, specifyNo Value Exists
10017999Gastrointestinal painA disorder characterized by a sensation of marked discomfort in the gastrointestinal region.
10018043GastroparesisA disorder characterized by an incomplete paralysis of the muscles of the stomach wall resulting in delayed emptying of the gastric contents into the small intestine.
10018065General disorders and administration site conditions - Other, specifyNo Value Exists
10018146Genital edemaA disorder characterized by swelling due to an excessive accumulation of fluid in the genitals.
10018286Gingival painA disorder characterized by a sensation of marked discomfort in the gingival region.
10018304GlaucomaA disorder characterized by an increase in pressure in the eyeball due to obstruction of the aqueous humor outflow.
10018746Growth acceleratedA disorder characterized by greater growth than expected for age.
10018748Growth hormone abnormalA finding based on laboratory test results that indicate abnormal levels of growth hormone in a biological specimen.
10018761Growth suppressionA disorder characterized by of stature that is smaller than normal as expected for age.
10018784Gum infectionA disorder characterized by an infectious process involving the gums.
10018801GynecomastiaA disorder characterized by excessive development of the breasts in males.
10019077HallucinationsA disorder characterized by a false sensory perception in the absence of an external stimulus.
10019150Haptoglobin decreasedA finding based on laboratory test results that indicate an decrease in levels of haptoglobin in a blood specimen.
10019211HeadacheA disorder characterized by a sensation of marked discomfort in various parts of the head, not confined to the area of distribution of any nerve.
10019245Hearing impairedA disorder characterized by partial or complete loss of the ability to detect or understand sounds resulting from damage to ear structures.
10019279Heart failureA disorder characterized by the inability of the heart to pump blood at an adequate volume to meet tissue metabolic requirements, or, the ability to do so only at an elevation in the filling pressure.
10019428HematomaA disorder characterized by a localized collection of blood, usually clotted, in an organ, space, or tissue, due to a break in the wall of a blood vessel.
10019450HematuriaA disorder characterized by laboratory test results that indicate blood in the urine.
10019489HemoglobinuriaA disorder characterized by laboratory test results that indicate the presence of free hemoglobin in the urine.
10019491HemolysisA disorder characterized by laboratory test results that indicate widespread erythrocyte cell membrane destruction.
10019515Hemolytic uremic syndromeA disorder characterized by a form of thrombotic microangiopathy with renal failure, hemolytic anemia, and severe thrombocytopenia.
10019611HemorrhoidsA disorder characterized by the presence of dilated veins in the rectum and surrounding area.
10019663Hepatic failureA disorder characterized by the inability of the liver to metabolize chemicals in the body. Laboratory test results reveal abnormal plasma levels of ammonia, bilirubin, lactic dehydrogenase, and alkaline phosphatase.
10019678Hepatic hemorrhageA disorder characterized by bleeding from the liver.
10019692Hepatic necrosisA disorder characterized by a necrotic process occurring in the hepatic parenchyma.
10019705Hepatic painA disorder characterized by a sensation of marked discomfort in the liver region.
10019799Hepatitis viralA disorder characterized by a viral pathologic process involving the liver parenchyma.
10019805Hepatobiliary disorders - Other, specifyNo Value Exists
10020039HiccupsA disorder characterized by repeated gulp sounds that result from an involuntary opening and closing of the glottis. This is attributed to a spasm of the diaphragm.
10020100Hip fractureA finding of traumatic injury to the hip in which the continuity of either the femoral head, femoral neck, intertrochanteric or subtrochanteric regions is broken.
10020112HirsutismA disorder characterized by the presence of excess hair growth in women in anatomic sites where growth is considered to be a secondary male characteristic and under androgen control (beard, moustache, chest, abdomen)
10020201HoarsenessA disorder characterized by harsh and raspy voice arising from or spreading to the larynx.
10020407Hot flashesA disorder characterized by an uncomfortable and temporary sensation of intense body warmth, flushing, sometimes accompanied by sweating upon cooling.
10020508HydrocephalusA disorder characterized by an abnormal increase of cerebrospinal fluid in the ventricles of the brain.
10020587HypercalcemiaA disorder characterized by laboratory test results that indicate an elevation in the concentration of calcium in blood.
10020639HyperglycemiaA disorder characterized by laboratory test results that indicate an elevation in the concentration of blood sugar. It is usually an indication of diabetes mellitus or glucose intolerance.
10020642HyperhidrosisA disorder characterized by excessive perspiration.
10020647HyperkalemiaA disorder characterized by laboratory test results that indicate an elevation in the concentration of potassium in the blood; associated with kidney failure or sometimes with the use of diuretic drugs.
10020670HypermagnesemiaA disorder characterized by laboratory test results that indicate an elevation in the concentration of magnesium in the blood.
10020680HypernatremiaA disorder characterized by laboratory test results that indicate an elevation in the concentration of sodium in the blood.
10020705HyperparathyroidismA disorder characterized by an increase in production of parathyroid hormone by the parathyroid glands. This results in hypercalcemia (abnormally high levels of calcium in the blood).
10020765HypersomniaA disorder characterized by characterized by excessive sleepiness during the daytime.
10020772HypertensionA disorder characterized by a pathological increase in blood pressure; a repeatedly elevation in the blood pressure exceeding 140 over 90 mm Hg.
10020850HyperthyroidismA disorder characterized by excessive levels of thyroid hormone in the body. Common causes include an overactive thyroid gland or thyroid hormone overdose.
10020864HypertrichosisA disorder characterized by hair density or length beyond the accepted limits of normal in a particular body region, for a particular age or race.
10020870HypertriglyceridemiaA disorder characterized by laboratory test results that indicate an elevation in the concentration of triglyceride concentration in the blood.
10020907HyperuricemiaA disorder characterized by laboratory test results that indicate an elevation in the concentration of uric acid.
10020943HypoalbuminemiaA disorder characterized by laboratory test results that indicate a low concentration of albumin in the blood.
10020949HypocalcemiaA disorder characterized by laboratory test results that indicate a low concentration of calcium in the blood.
10021005HypoglycemiaA disorder characterized by laboratory test results that indicate a low concentration of glucose in the blood.
10021013HypohidrosisA disorder characterized by reduced sweating.
10021018HypokalemiaA disorder characterized by laboratory test results that indicate a low concentration of potassium in the blood.
10021028HypomagnesemiaA disorder characterized by laboratory test results that indicate a low concentration of magnesium in the blood.
10021038HyponatremiaA disorder characterized by laboratory test results that indicate a low concentration of sodium in the blood.
10021041HypoparathyroidismA disorder characterized by a decrease in production of parathyroid hormone by the parathyroid glands.
10021059HypophosphatemiaA disorder characterized by laboratory test results that indicate a low concentration of phosphates in the blood.
10021097HypotensionA disorder characterized by a blood pressure that is below the normal expected for an individual in a given environment.
10021113HypothermiaA disorder characterized by an abnormally low body temperature. Treatment is required when the body temperature is 35C (95F) or below.
10021114HypothyroidismA disorder characterized by a decrease in production of thyroid hormone by the thyroid gland.
10021143HypoxiaA disorder characterized by a decrease in the level of oxygen in the body.
10021305Ileal perforationA disorder characterized by a rupture in the ileal wall.
10021307Ileal stenosisA disorder characterized by a narrowing of the lumen of the ileum.
10021309Ileal ulcerA disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the ileum.
10021328IleusA disorder characterized by failure of the ileum to transport intestinal contents.
10021428Immune system disorders - Other, specifyNo Value Exists
10021881Infections and infestations - Other, specifyNo Value Exists
10021918Infective myositisA disorder characterized by an infectious process involving the skeletal muscles.
10022095Injection site reactionA disorder characterized by an intense adverse reaction (usually immunologic) developing at the site of an injection.
10022117Injury, poisoning and procedural complications - Other, specifyNo Value Exists
10022161Injury to carotid arteryA finding of damage to the carotid artery.
10022213Injury to inferior vena cavaA finding of damage to the inferior vena cava.
10022356Injury to superior vena cavaA finding of damage to the superior vena cava.
10022402INR increasedA finding based on laboratory test results that indicate an increase in the ratio of the patient's prothrombin time to a control sample in the blood.
10022437InsomniaA disorder characterized by difficulty in falling asleep and/or remaining asleep.
10022763Intracranial hemorrhageA disorder characterized by bleeding from the cranium.
10022891Investigations - Other, specifyNo Value Exists
10022992Irregular menstruationA disorder characterized by irregular cycle or duration of menses.
10022998IrritabilityA disorder characterized by an abnormal responsiveness to stimuli or physiological arousal; may be in response to pain, fright, a drug, an emotional situation or a medical condition.
10023030Ischemia cerebrovascularA disorder characterized by a decrease or absence of blood supply to the brain caused by obstruction (thrombosis or embolism) of an artery resulting in neurological damage.
10023174Jejunal perforationA disorder characterized by a rupture in the jejunal wall.
10023176Jejunal stenosisA disorder characterized by a narrowing of the lumen of the jejunum.
10023177Jejunal ulcerA disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the jejunum.
10023215Joint effusionA disorder characterized by excessive fluid in a joint, usually as a result of joint inflammation.
10023216Joint infectionA disorder characterized by an infectious process involving a joint.
10023332KeratitisA disorder characterized by inflammation to the cornea of the eye.
10023424Kidney infectionA disorder characterized by an infectious process involving the kidney.
10023509KyphosisA disorder characterized by an abnormal increase in the curvature of the thoracic portion of the spine.
10023838Laryngeal edemaA disorder characterized by swelling due to an excessive accumulation of fluid in the larynx.
10023862Laryngeal stenosisA disorder characterized by a narrowing of the laryngeal airway.
10023874LaryngitisA disorder characterized by an inflammatory process involving the larynx.
10023891LaryngospasmA disorder characterized by paroxysmal spasmodic muscular contraction of the vocal cords.
10024264LethargyA disorder characterized by a decrease in consciousness characterized by mental and physical inertness.
10024378LeukocytosisA disorder characterized by laboratory test results that indicate an increased number of white blood cells in the blood.
10024382LeukoencephalopathyA disorder characterized by diffuse reactive astrocytosis with multiple areas of necrotic foci without inflammation.
10024419Libido decreasedA disorder characterized by a decrease in sexual desire.
10024421Libido increasedA disorder characterized by an increase in sexual desire.
10024561Lip painA disorder characterized by a sensation of marked discomfort of the lip.
10024574Lipase increasedA finding based on laboratory test results that indicate an increase in the level of lipase in a biological specimen.
10024842LordosisA disorder characterized by an abnormal increase in the curvature of the lumbar portion of the spine.
10025182Lymph node painA disorder characterized by a sensation of marked discomfort in a lymph node.
10025233LymphedemaA disorder characterized by excessive fluid collection in tissues that causes swelling.
10025256Lymphocyte count decreasedA finding based on laboratory test results that indicate a decrease in number of lymphocytes in a blood specimen.
10025258Lymphocyte count increasedA finding based on laboratory test results that indicate an abnormal increase in the number of lymphocytes in the blood, effusions or bone marrow.
10025476MalabsorptionA disorder characterized by inadequate absorption of nutrients in the small intestine. Symptoms include abdominal marked discomfort, bloating and diarrhea.
10025482MalaiseA disorder characterized by a feeling of general discomfort or uneasiness, an out-of-sorts feeling.
10026749ManiaA disorder characterized by excitement of psychotic proportions manifested by mental and physical hyperactivity, disorganization of behavior and elevation of mood.
10027175Memory impairmentA disorder characterized by a deterioration in memory function.
10027198MeningismusA disorder characterized by neck stiffness, headache, and photophobia resulting from irritation of the cerebral meninges.
10027199MeningitisA disorder characterized by acute inflammation of the meninges of the brain and/or spinal cord.
10027308MenopauseA disorder characterized by the permanent cessation of menses, usually defined by 12 consecutive months of amenorrhea in a woman over 45 years of age.
10027313MenorrhagiaA disorder characterized by abnormally heavy vaginal bleeding during menses.
10027433Metabolism and nutrition disorders - Other, specifyNo Value Exists
10027786Mobitz (type) II atrioventricular blockA disorder characterized by a dysrhythmia with relatively constant PR interval prior to the block of an atrial impulse. This is the result of intermittent failure of atrial electrical impulse conduction through the atrioventricular (AV) node to the ventricles.
10027787Mobitz type IA disorder characterized by a dysrhythmia with a progressively lengthening PR interval prior to the blocking of an atrial impulse. This is the result of intermittent failure of atrial electrical impulse conduction through the atrioventricular (AV) node to the ventricles.
10028041Movements involuntaryA disorder characterized by uncontrolled and purposeless movements.
10028130Mucositis oralA disorder characterized by inflammation of the oral mucosal.
10028154Multi-organ failureA disorder characterized by progressive deterioration of the lungs, liver, kidney and clotting mechanisms.
10028395Musculoskeletal and connective tissue disorder - Other, specifyNo Value Exists
10028411MyalgiaA disorder characterized by marked discomfort sensation originating from a muscle or group of muscles.
10028524MyelitisA disorder characterized by inflammation involving the spinal cord. Symptoms include weakness, paresthesia, sensory loss, marked discomfort and incontinence.
10028533Myelodysplastic syndromeA disorder characterized by insufficiently healthy hematapoietic cell production by the bone marrow.
10028596Myocardial infarctionA disorder characterized by gross necrosis of the myocardium; this is due to an interruption of blood supply to the area.
10028606MyocarditisA disorder characterized by inflammation of the muscle tissue of the heart.
10028653MyositisA disorder characterized by inflammation involving the skeletal muscles.
10028691Nail discolorationA disorder characterized by a change in the color of the nail plate.
10028735Nasal congestionA disorder characterized by obstruction of the nasal passage due to mucosal edema.
10028813NauseaA disorder characterized by a queasy sensation and/or the urge to vomit.
10028836Neck painA disorder characterized by marked discomfort sensation in the neck area.
10029104Neoplasms benign, malignant and unspecified (incl cysts and polyps) - Other, specifyNo Value Exists
10029205Nervous system disorders - Other, specifyNo Value Exists
10029223NeuralgiaA disorder characterized by intense painful sensation along a nerve or group of nerves.
10029366Neutrophil count decreasedA finding based on laboratory test results that indicate a decrease in number of neutrophils in a blood specimen.
10029404Night blindnessA disorder characterized by an inability to see clearly in dim light.
10029864NystagmusA disorder characterized by involuntary movements of the eyeballs.
10029883ObesityA disorder characterized by having a high amount of body fat.
10029957Obstruction gastricA disorder characterized by blockage of the normal flow of the contents in the stomach.
10030300OligospermiaA disorder characterized by a decrease in the number of spermatozoa in the semen.
10030980Oral hemorrhageA disorder characterized by bleeding from the mouth.
10031009Oral painA disorder characterized by a sensation of marked discomfort in the mouth, tongue or lips.
10031282OsteoporosisA disorder characterized by reduced bone mass, with a decrease in cortical thickness and in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence.
10033072Otitis externaA disorder characterized by an infectious process involving the outer ear and ear canal. Contributory factors include excessive water exposure (swimmer's ear infection) and cuts in the ear canal. Symptoms include fullness, itching, swelling and marked discomfort in the ear and ear drainage.
10033078Otitis mediaA disorder characterized by an infectious process involving the middle ear.
10033279Ovarian ruptureA disorder characterized by tearing or disruption of the ovarian tissue.
10033314Ovulation painA disorder characterized by marked discomfort sensation in one side of the abdomen between menstrual cycles, around the time of the discharge of the ovum from the ovarian follicle.
10033371PainA disorder characterized by the sensation of marked discomfort, distress or agony.
10033425Pain in extremityA disorder characterized by marked discomfort sensation in the upper or lower extremities.
10033474Pain of skinA disorder characterized by marked discomfort sensation in the skin.
10033557PalpitationsA disorder characterized by an unpleasant sensation of irregular and/or forceful beating of the heart.
10033626Pancreatic hemorrhageA disorder characterized by bleeding from the pancreas.
10033645PancreatitisA disorder characterized by inflammation of the pancreas.
10033703PapilledemaA disorder characterized by swelling around the optic disc.
10033987ParesthesiaA disorder characterized by functional disturbances of sensory neurons resulting in abnormal cutaneous sensations of tingling, numbness, pressure, cold, and warmth that are experienced in the absence of a stimulus.
10034016ParonychiaA disorder characterized by an infectious process involving the soft tissues around the nail.
10034040Paroxysmal atrial tachycardiaA disorder characterized by a dysrhythmia with abrupt onset and sudden termination of atrial contractions with a rate of 150-250 beats per minute. The rhythm disturbance originates in the atria.
10034263Pelvic painA disorder characterized by marked discomfort sensation in the pelvis.
10034310Penile painA disorder characterized by marked discomfort sensation in the penis.
10034405Perforation bile ductA disorder characterized by a rupture in the wall of the extrahepatic or intrahepatic bile duct.
10034474Pericardial effusionA disorder characterized by fluid collection within the pericardial sac, usually due to inflammation.
10034484PericarditisA disorder characterized by irritation to the layers of the pericardium (the protective sac around the heart).
10034536Periodontal diseaseA disorder in the gingival tissue around the teeth.
10034578Peripheral ischemiaA disorder characterized by impaired circulation to an extremity.
10034580Peripheral motor neuropathyA disorder characterized by inflammation or degeneration of the peripheral motor nerves.
10034620Peripheral sensory neuropathyA disorder characterized by inflammation or degeneration of the peripheral sensory nerves.
10034719Personality changeA disorder characterized by a conspicuous change in a person's behavior and thinking.
10034825Pharyngeal fistulaA disorder characterized by an abnormal communication between the pharynx and another organ or anatomic site.
10034835PharyngitisA disorder characterized by inflammation of the throat.
10034844Pharyngolaryngeal painA disorder characterized by marked discomfort sensation in the pharyngolaryngeal region.
10034879PhlebitisA disorder characterized by inflammation of the wall of a vein.
10034960PhotophobiaA disorder characterized by fear and avoidance of light.
10034966PhotosensitivityA disorder characterized by an increase in sensitivity of the skin to light.
10035528Platelet count decreasedA finding based on laboratory test results that indicate a decrease in number of platelets in a blood specimen.
10035598Pleural effusionA disorder characterized by an increase in amounts of fluid within the pleural cavity. Symptoms include shortness of breath, cough and marked chest discomfort.
10035623Pleuritic painA disorder characterized by marked discomfort sensation in the pleura.
10035742PneumonitisA disorder characterized by inflammation focally or diffusely affecting the lung parenchyma.
10035759PneumothoraxA disorder characterized by abnormal presence of air in the pleural cavity resulting in the collapse of the lung.
10036200Portal hypertensionA disorder characterized by an increase in blood pressure in the portal venous system.
10036206Portal vein thrombosisA disorder characterized by the formation of a thrombus (blood clot) in the portal vein.
10036402Postnasal dripA disorder characterized by excessive mucous secretion in the back of the nasal cavity or throat, causing sore throat and/or coughing.
10036585Pregnancy, puerperium and perinatal conditions - Other, specifyNo Value Exists
10036595Premature deliveryA disorder characterized by delivery of a viable infant before the normal end of gestation. Typically, viability is achievable between the twentieth and thirty-seventh week of gestation.
10036601Premature menopauseA disorder characterized by ovarian failure before the age of 40. Symptoms include hot flashes, night sweats, mood swings and a decrease in sex drive.
10036653PresyncopeA disorder characterized by an episode of lightheadedness and dizziness which may precede an episode of syncope.
10036774ProctitisA disorder characterized by inflammation of the rectum.
10036790Productive coughA disorder characterized by expectorated secretions upon coughing.
10036968Prostatic painA disorder characterized by a sensation of marked discomfort in the prostate gland.
10037032ProteinuriaA disorder characterized by laboratory test results that indicate the presence of excessive protein in the urine. It is predominantly albumin, but also globulin.
10037087PruritusA disorder characterized by an intense itching sensation.
10037175Psychiatric disorders - Other, specifyNo Value Exists
10037234PsychosisA disorder characterized by personality change, impaired functioning, and loss of touch with reality. It may be a manifestation of schizophrenia, bipolar disorder or brain tumor.
10037375Pulmonary edemaA disorder characterized by accumulation of fluid in the lung tissues that causes a disturbance of the gas exchange that may lead to respiratory failure.
10037383Pulmonary fibrosisA disorder characterized by the replacement of the lung tissue by connective tissue, leading to progressive dyspnea, respiratory failure or right heart failure.
10037400Pulmonary hypertensionA disorder characterized by an increase in pressure within the pulmonary circulation due to lung or heart disorder.
10037549PurpuraA disorder characterized by hemorrhagic areas of the skin and mucous membrane. Newer lesions appear reddish in color. Older lesions are usually a darker purple color and eventually become a brownish-yellow color.
10037767Radiation recall reaction (dermatologic)A finding of acute skin inflammatory reaction caused by drugs, especially chemotherapeutic agents, for weeks or months following radiotherapy. The inflammatory reaction is confined to the previously irradiated skin and the symptoms disappear after the removal of the pharmaceutical agent.
10037847Rash acneiformA disorder characterized by an eruption of papules and pustules, typically appearing in face, scalp, upper chest and back.
10037868Rash maculo-papularA disorder characterized by the presence of macules (flat) and papules (elevated). Also known as morbillform rash, it is one of the most common cutaneous adverse events, frequently affecting the upper trunk, spreading centripetally and associated with pruritus.
10037888Rash pustularA disorder characterized by a circumscribed and elevated skin lesion filled with pus.
10038062Rectal fistulaA disorder characterized by an abnormal communication between the rectum and another organ or anatomic site.
10038064Rectal hemorrhageA disorder characterized by bleeding from the rectal wall and discharged from the anus.
10038072Rectal painA disorder characterized by a sensation of marked discomfort in the rectal region.
10038073Rectal perforationA disorder characterized by a rupture in the rectal wall.
10038079Rectal stenosisA disorder characterized by a narrowing of the lumen of the rectum.
10038080Rectal ulcerA disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the rectum.
10038130Recurrent laryngeal nerve palsyA disorder characterized by paralysis of the recurrent laryngeal nerve.
10038359Renal and urinary disorders - Other, specifyNo Value Exists
10038385Renal calculiA disorder characterized by the formation of crystals in the pelvis of the kidney.
10038419Renal colicA disorder characterized by paroxysmal and severe flank marked discomfort radiating to the inguinal area. Often, the cause is the passage of kidney stones.
10038463Renal hemorrhageA disorder characterized by bleeding from the kidney.
10038604Reproductive system and breast disorders - Other, specifyNo Value Exists
10038695Respiratory failureA disorder characterized by impaired gas exchange by the respiratory system resulting in hypoxemia and a decrease in oxygenation of the tissues that may be associated with an increase in arterial levels of carbon dioxide.
10038738Respiratory, thoracic and mediastinal disorders - Other, specifyNo Value Exists
10038743RestlessnessA disorder characterized by an inability to rest, relax or be still.
10038748Restrictive cardiomyopathyA disorder characterized by an inability of the ventricles to fill with blood because the myocardium (heart muscle) stiffens and loses its flexibility.
10038848Retinal detachmentA disorder characterized by the separation of the inner retina layers from the underlying pigment epithelium.
10038897Retinal tearA disorder characterized by a small laceration of the retina, this occurs when the vitreous separates from the retina. Symptoms include flashes and floaters.
10038901Retinal vascular disorderA disorder characterized by pathological retinal blood vessels that adversely affects vision.
10038921Retinoic acid syndromeA disorder characterized by weight gain, dyspnea, pleural and pericardial effusions, leukocytosis and/or renal failure originally described in patients treated with all-trans retinoic acid.
10038923RetinopathyA disorder involving the retina.
10038981Retroperitoneal hemorrhageA disorder characterized by bleeding from the retroperitoneal area.
10039411Salivary gland fistulaA disorder characterized by an abnormal communication between a salivary gland and another organ or anatomic site.
10039413Salivary gland infectionA disorder characterized by an infectious process involving the salivary gland.
10039722ScoliosisA disorder characterized by a malformed, lateral curvature of the spine.
10039757Scrotal painA disorder characterized by marked discomfort sensation in the scrotal area.
10039906SeizureA disorder characterized by a sudden, involuntary skeletal muscular contractions of cerebral or brain stem origin.
10040047SepsisA disorder characterized by the presence of pathogenic microorganisms in the blood stream that cause a rapidly progressing systemic reaction that may lead to shock.
10040102SeromaA finding of tumor-like collection of serum in the tissues.
10040139Serum amylase increasedA finding based on laboratory test results that indicate an increase in the levels of amylase in a serum specimen.
10040400Serum sicknessA disorder characterized by a delayed-type hypersensitivity reaction to foreign proteins derived from an animal serum. It occurs approximately six to twenty-one days following the administration of the foreign antigen. Symptoms include fever, arthralgias, myalgias, skin eruptions, lymphadenopathy, chest marked discomfort and dyspnea.
10040639Sick sinus syndromeA disorder characterized by a dysrhythmia with alternating periods of bradycardia and atrial tachycardia accompanied by syncope, fatigue and dizziness.
10040741Sinus bradycardiaA disorder characterized by a dysrhythmia with a heart rate less than 60 beats per minute that originates in the sinus node.
10040747Sinus painA disorder characterized by marked discomfort in the face, between the eyes, or upper teeth originating from the sinuses.
10040752Sinus tachycardiaA disorder characterized by a dysrhythmia with a heart rate greater than 100 beats per minute that originates in the sinus node.
10040753SinusitisA disorder characterized by an infectious process involving the mucous membranes of the paranasal sinuses.
10040785Skin and subcutaneous tissue disorders - Other, specifyNo Value Exists
10040799Skin atrophyA disorder characterized by the degeneration and thinning of the epidermis and dermis.
10040865Skin hyperpigmentationA disorder characterized by darkening of the skin due to excessive melanin deposition.
10040868Skin hypopigmentationA disorder characterized by loss of skin pigment.
10040872Skin infectionA disorder characterized by an infectious process involving the skin.
10040947Skin ulcerationA disorder characterized by circumscribed, inflammatory and necrotic erosive lesion on the skin.
10040975Sleep apneaA disorder characterized by cessation of breathing for short periods during sleep.
10041101Small intestinal obstructionA disorder characterized by blockage of the normal flow of the intestinal contents.
10041103Small intestinal perforationA disorder characterized by a rupture in the small intestine wall.
10041133Small intestine ulcerA disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the mucosal surface of the small intestine.
10041232SneezingA disorder characterized by the involuntary expulsion of air from the nose.
10041244Social circumstances - Other, specifyNo Value Exists
10041349SomnolenceA disorder characterized by characterized by excessive sleepiness and drowsiness.
10041367Sore throatA disorder characterized by of marked discomfort in the throat
10041416SpasticityA disorder characterized by increased involuntary muscle tone that affects the regions interfering with voluntary movement. It results in gait, movement, and speech disturbances.
10041569Spinal fractureA finding of traumatic injury to the spine in which the continuity of a vertebral bone is broken.
10041633Spleen disorderA disorder of the spleen.
10042033Stevens-Johnson syndromeA disorder characterized by less than 10% total body skin area separation of dermis. The syndrome is thought to be a hypersensitivity complex affecting the skin and the mucous membranes.
10042112Stomach painA disorder characterized by a sensation of marked discomfort in the stomach.
10042127Stomal ulcerA disorder characterized by a circumscribed, inflammatory and necrotic erosive lesion on the jejunal mucosal surface close to the anastomosis site following a gastroenterostomy procedure.
10042241StridorA disorder characterized by a high pitched breathing sound due to laryngeal or upper airway obstruction.
10042244StrokeA disorder characterized by a sudden loss of sensory function due to an intracranial vascular event.
10042435Sudden death NOSAn unexpected cessation of life that cannot be attributed to a CTCAE term associated with Grade 5.
10042458Suicidal ideationA disorder characterized by thoughts of taking one's own life.
10042464Suicide attemptA disorder characterized by self-inflicted harm in an attempt to end one's own life.
10042554Superficial thrombophlebitisA disorder characterized by a blood clot and inflammation involving a superficial vein of the extremities.
10042569Superior vena cava syndromeA disorder characterized by obstruction of the blood flow in the superior vena cava. Signs and symptoms include swelling and cyanosis of the face, neck, and upper arms, cough, orthopnea and headache.
10042604Supraventricular tachycardiaA disorder characterized by a dysrhythmia with a heart rate greater than 100 beats per minute that originates above the ventricles.
10042613Surgical and medical procedures - Other, specifyNo Value Exists
10042772SyncopeA disorder characterized by spontaneous loss of consciousness caused by insufficient blood supply to the brain.
10043189TelangiectasiaA disorder characterized by local dilatation of small vessels resulting in red discoloration of the skin or mucous membranes.
10043306Testicular disorderA disorder characterized by involvement of the testis.
10043345Testicular painA disorder characterized by a sensation of marked discomfort in the testis.
10043565Thromboembolic eventA disorder characterized by occlusion of a vessel by a thrombus that has migrated from a distal site via the blood stream.
10043648Thrombotic thrombocytopenic purpuraA disorder characterized by the presence of microangiopathic hemolytic anemia, thrombocytopenic purpura, fever, renal abnormalities and neurological abnormalities such as seizures, hemiplegia, and visual disturbances. It is an acute or subacute condition.
10043882TinnitusA disorder characterized by noise in the ears, such as ringing, buzzing, roaring or clicking.
10044030Tooth development disorderA disorder characterized by a pathological process of the teeth occurring during tooth development.
10044031Tooth discolorationA disorder characterized by a change in tooth hue or tint.
10044055ToothacheA disorder characterized by a sensation of marked discomfort in the tooth.
10044223Toxic epidermal necrolysisA disorder characterized by greater than 30% total body skin area separation of dermis. The syndrome is thought to be a hypersensitivity complex affecting the skin and the mucous membranes.
10044291Tracheal obstructionA finding of blockage of the lumen of the trachea.
10044302TracheitisA disorder characterized by an infectious process involving the trachea.
10044391Transient ischemic attacksA disorder characterized by a brief attack (less than 24 hours) of cerebral dysfunction of vascular origin, with no persistent neurological deficit.
10044565TremorA disorder characterized by the uncontrolled shaking movement of the whole body or individual parts.
10044684TrismusA disorder characterized by lack of ability to open the mouth fully due to a decrease in the range of motion of the muscles of mastication.
10045152Tumor lysis syndromeA disorder characterized by metabolic abnormalities that result from a spontaneous or therapy-related cytolysis of tumor cells.
10045158Tumor painA disorder characterized by marked discomfort from a neoplasm that may be pressing on a nerve, blocking blood vessels, inflamed or fractured from metastasis.
10045271TyphlitisA disorder characterized by inflammation of the cecum.
10045542Unintended pregnancyA disorder characterized by an unexpected pregnancy at the time of conception.
10046300Upper respiratory infectionA disorder characterized by an infectious process involving the upper respiratory tract (nose, paranasal sinuses, pharynx, larynx, or trachea).
10046539Urinary frequencyA disorder characterized by urination at short intervals.
10046543Urinary incontinenceA disorder characterized by inability to control the flow of urine from the bladder.
10046555Urinary retentionA disorder characterized by accumulation of urine within the bladder because of the inability to urinate.
10046571Urinary tract infectionA disorder characterized by an infectious process involving the urinary tract, most commonly the bladder and the urethra.
10046593Urinary urgencyA disorder characterized by a sudden compelling urge to urinate.
10046628Urine discolorationA disorder characterized by a change in the color of the urine.
10046735UrticariaA disorder characterized by an itchy skin eruption characterized by wheals with pale interiors and well-defined red margins.
10046789Uterine hemorrhageA disorder characterized by bleeding from the uterus.
10046809Uterine painA disorder characterized by a sensation of marked discomfort in the uterus.
10046810Uterine perforationA disorder characterized by a rupture in the uterine wall.
10046851UveitisA disorder characterized by inflammation to the uvea of the eye.
10046901Vaginal dischargeA disorder characterized by vaginal secretions. Mucus produced by the cervical glands is discharged from the vagina naturally, especially during the childbearing years.
10046904Vaginal drynessA disorder characterized by an uncomfortable feeling of itching and burning in the vagina.
10046912Vaginal hemorrhageA disorder characterized by bleeding from the vagina.
10046914Vaginal infectionA disorder characterized by an infectious process involving the vagina.
10046916Vaginal inflammationA disorder characterized by inflammation involving the vagina. Symptoms may include redness, edema, marked discomfort and an increase in vaginal discharge.
10046937Vaginal painA disorder characterized by a sensation of marked discomfort in the vagina.
10046947VaginismusA disorder characterized by involuntary spasms of the pelvic floor muscles, resulting in pathologic tightness of the vaginal wall during penetration such as during sexual intercourse.
10047065Vascular disorders - Other, specifyNo Value Exists
10047115VasculitisA disorder characterized by inflammation involving the wall of a vessel.
10047166Vasovagal reactionA disorder characterized by a sudden drop of the blood pressure, bradycardia, and peripheral vasodilation that may lead to loss of consciousness. It results from an increase in the stimulation of the vagus nerve.
10047228Venous injuryA finding of damage to a vein.
10047281Ventricular arrhythmiaA disorder characterized by a dysrhythmia that originates in the ventricles.
10047290Ventricular fibrillationA disorder characterized by a dysrhythmia without discernible QRS complexes due to rapid repetitive excitation of myocardial fibers without coordinated contraction of the ventricles.
10047302Ventricular tachycardiaA disorder characterized by a dysrhythmia with a heart rate greater than 100 beats per minute that originates distal to the bundle of His.
10047340VertigoA disorder characterized by a sensation as if the external world were revolving around the patient (objective vertigo) or as if he himself were revolving in space (subjective vertigo).
10047386Vestibular disorderA disorder characterized by dizziness, imbalance, nausea, and vision problems.
10047488VirilizationA disorder characterized by inappropriate masculinization occurring in a female or prepubertal male.
10047580Vital capacity abnormalA finding based on pulmonary function test results that indicate an abnormal vital capacity (amount of exhaled after a maximum inhalation) when compared to the predicted value.
10047656Vitreous hemorrhageA disorder characterized by blood extravasation into the vitreous humor.
10047681Voice alterationA disorder characterized by a change in the sound and/or speed of the voice.
10047700VomitingA disorder characterized by the reflexive act of ejecting the contents of the stomach through the mouth.
10047848Watering eyesA disorder of excessive tearing in the eyes; it can be caused by overproduction of tears or impaired drainage of the tear duct.
10047896Weight gainA finding characterized by an increase in overall body weight; for pediatrics, greater than the baseline growth curve.
10047900Weight lossA finding characterized by a decrease in overall body weight; for pediatrics, less than the baseline growth curve.
10047924WheezingA disorder characterized by a high-pitched, whistling sound during breathing. It results from the narrowing or obstruction of the respiratory airways.
10048015Wolff-Parkinson-White syndromeA disorder characterized by the presence of an accessory conductive pathway between the atria and the ventricles that causes premature ventricular activation.
10048031Wound dehiscenceA finding of separation of the approximated margins of a surgical wound.
10048038Wound infectionA disorder characterized by an infectious process involving the wound.
10048049Wrist fractureA finding of traumatic injury to the wrist joint in which the continuity of a wrist bone is broken.
10048293Leukemia secondary to oncology chemotherapyA disorder characterized by leukemia arising as a result of the mutagenic effect of chemotherapy agents.
10048492Corneal ulcerA disorder characterized by an area of epithelial tissue loss on the surface of the cornea. It is associated with inflammatory cells in the cornea and anterior chamber.
10048580Bone marrow hypocellularA disorder characterized by the inability of the bone marrow to produce hematopoietic elements.
10048642LymphoceleA disorder characterized by a cystic lesion containing lymph.
10048677Buttock painA disorder characterized by marked discomfort sensation in the buttocks.
10048706Joint range of motion decreasedA disorder characterized by a decrease in joint flexibility of any joint.
10048762Tooth infectionA disorder characterized by an infectious process involving a tooth.
10048994Bladder spasmA disorder characterized by a sudden and involuntary contraction of the bladder wall.
10049120Scalp painA disorder characterized by marked discomfort sensation in the skin covering the top and the back of the head.
10049182White blood cell decreasedA finding based on laboratory test results that indicate an decrease in number of white blood cells in a blood specimen.
10049192Pancreatic fistulaA disorder characterized by an abnormal communication between the pancreas and another organ or anatomic site.
10049281Nail lossA disorder characterized by loss of all or a portion of the nail.
10049468Intestinal stoma site bleedingA finding of blood leakage from the intestinal stoma.
10049737Treatment related secondary malignancyA disorder characterized by development of a malignancy most probably as a result of treatment for a previously existing malignancy.
10050028Pharyngeal stenosisA disorder characterized by a narrowing of the pharyngeal airway.
10050068Edema limbsA disorder characterized by swelling due to excessive fluid accumulation in the upper or lower extremities.
10050094Duodenal stenosisA disorder characterized by a narrowing of the lumen of the duodenum.
10050457Pancreatic anastomotic leakA finding of leakage due to breakdown of a pancreatic anastomosis (surgical connection of two separate anatomic structures).
10050458Biliary anastomotic leakA finding of leakage of bile due to breakdown of a biliary anastomosis (surgical connection of two separate anatomic structures).
10050528Ejection fraction decreasedThe percentage computed when the amount of blood ejected during a ventricular contraction of the heart is compared to the amount that was present prior to the contraction.
10050662Prostate infectionA disorder characterized by an infectious process involving the prostate gland.
10050816Tracheal stenosisA disorder characterized by a narrowing of the trachea.
10050823Lymph gland infectionA disorder characterized by an infectious process involving the lymph nodes.
10051228ChylothoraxA disorder characterized by milky pleural effusion (abnormal collection of fluid) resulting from accumulation of lymph fluid in the pleural cavity.
10051272Facial muscle weaknessA disorder characterized by a reduction in the strength of the facial muscles.
10051341Bile duct stenosisA disorder characterized by a narrowing of the lumen of the bile duct.
10051472Periorbital infectionA disorder characterized by an infectious process involving the orbit of the eye.
10051592Acute coronary syndromeA disorder characterized by signs and symptoms related to acute ischemia of the myocardium secondary to coronary artery disease. The clinical presentation covers a spectrum of heart diseases from unstable angina to myocardial infarction.
10051741Pancreas infectionA disorder characterized by an infectious process involving the pancreas.
10051746Lower gastrointestinal hemorrhageA disorder characterized by bleeding from the lower gastrointestinal tract (small intestine, large intestine, and anus).
10051792Infusion related reactionA disorder characterized by adverse reaction to the infusion of pharmacological or biological substances.
10051837Skin indurationA disorder characterized by an area of hardness in the skin.
10051886Gastric necrosisA disorder characterized by a necrotic process occurring in the gastric wall.
10052015Cytokine release syndromeA disorder characterized by nausea, headache, tachycardia, hypotension, rash, and shortness of breath; it is caused by the release of cytokines from the cells.
10052298Urethral infectionA disorder characterized by an infectious process involving the urethra.
10052426Glucose intoleranceA disorder characterized by an inability to properly metabolize glucose.
10053481Bronchopleural fistulaA disorder characterized by an abnormal communication between a bronchus and the pleural cavity.
10053496Vaginal strictureA disorder characterized by a narrowing of the vaginal canal.
10053565Pericardial tamponadeA disorder characterized by an increase in intrapericardial pressure due to the collection of blood or fluid in the pericardium.
10053661Oculomotor nerve disorderA disorder characterized by involvement of the oculomotor nerve (third cranial nerve).
10053662Abducens nerve disorderA disorder characterized by involvement of the abducens nerve (sixth cranial nerve).
10053692Wound complicationA finding of development of a new problem at the site of an existing wound.
10054382Feminization acquiredA disorder characterized by the development of secondary female sex characteristics in males due to extrinsic factors.
10054482Neck edemaA disorder characterized by swelling due to an accumulation of excessive fluid in the neck.
10054520Oral dysesthesiaA disorder characterized by a burning or tingling sensation on the lips, tongue or entire mouth.
10054524Palmar-plantar erythrodysesthesia syndromeA disorder characterized by redness, marked discomfort, swelling, and tingling in the palms of the hands or the soles of the feet.
10054541Periorbital edemaA disorder characterized by swelling due to an excessive accumulation of fluid around the orbits of the face.
10054692Visceral arterial ischemiaA disorder characterized by a decrease in blood supply due to narrowing or blockage of a visceral (mesenteric) artery.
10054746Fetal growth retardationA disorder characterized by inhibition of fetal growth resulting in the inability of the fetus to achieve its potential weight.
10055005Ovarian infectionA disorder characterized by an infectious process involving the ovary.
10055026Prostatic obstructionA disorder characterized by compression of the urethra secondary to enlargement of the prostate gland. This results in voiding difficulties (straining to void, slow urine stream, and incomplete emptying of the bladder).
10055078Bronchial infectionA disorder characterized by an infectious process involving the bronchi.
10055226Anal hemorrhageA disorder characterized by bleeding from the anal region.
10055242Duodenal hemorrhageA disorder characterized by bleeding from the duodenum.
10055287Ileal hemorrhageA disorder characterized by bleeding from the ileal wall.
10055291Intra-abdominal hemorrhageA disorder characterized by bleeding in the abdominal cavity.
10055298Intraoperative hemorrhageA finding of uncontrolled bleeding during a surgical procedure.
10055300Jejunal hemorrhageA disorder characterized by bleeding from the jejunal wall.
10055315Pharyngeal hemorrhageA disorder characterized by bleeding from the pharynx.
10055319Pleural hemorrhageA disorder characterized by bleeding from the pleural cavity.
10055322Postoperative hemorrhageA finding of bleeding occurring after a surgical procedure.
10055325Prostatic hemorrhageA disorder characterized by bleeding from the prostate gland.
10055347Testicular hemorrhageA disorder characterized by bleeding from the testis.
10055356Upper gastrointestinal hemorrhageA disorder characterized by bleeding from the upper gastrointestinal tract (oral cavity, pharynx, esophagus, and stomach).
10055472Esophageal perforationA disorder characterized by a rupture in the wall of the esophagus.
10055599Hemoglobin increasedA finding based on laboratory test results that indicate increased levels of hemoglobin in a biological specimen.
10056238Phantom painA disorder characterized by marked discomfort related to a limb or an organ that is removed from or is not physically part of the body.
10056356Mediastinal hemorrhageA disorder characterized by bleeding from the mediastinum.
10056388Olfactory nerve disorderA disorder characterized by involvement of the olfactory nerve (first cranial nerve).
10056519Abdominal infectionA disorder characterized by an infectious process involving the abdominal cavity.
10056522Hepatic infectionA disorder characterized by an infectious process involving the liver.
10056627Phlebitis infectiveA disorder characterized by an infectious process involving the vein. Clinical manifestations include erythema, marked discomfort, swelling, and induration along the course of the infected vein.
10056681Salivary duct inflammationA disorder characterized by inflammation of the salivary duct.
10056745Postoperative thoracic procedure complicationA finding of a previously undocumented problem that occurs after a thoracic procedure.
10056910GGT increasedA finding based on laboratory test results that indicate higher than normal levels of the enzyme gamma-glutamyltransferase in the blood specimen. GGT (gamma-glutamyltransferase ) catalyzes the transfer of a gamma glutamyl group from a gamma glutamyl peptide to another peptide, amino acids or water.
10057066Delayed orgasmA disorder characterized by sexual dysfunction characterized by a delay in climax.
10057262Peritoneal infectionA disorder characterized by an infectious process involving the peritoneum.
10057483Mediastinal infectionA disorder characterized by an infectious process involving the mediastinum.
10058084Precocious pubertyA disorder characterized by unusually early development of secondary sexual features; the onset of sexual maturation begins usually before age 8 for girls and before age 9 for boys.
10058096Pancreatic necrosisA disorder characterized by a necrotic process occurring in the pancreas.
10058597Right ventricular dysfunctionA disorder characterized by impairment of right ventricular function associated with low ejection fraction and a decrease in motility of the right ventricular wall.
10058674Pelvic infectionA disorder characterized by an infectious process involving the pelvic cavity.
10058720Edema trunkA disorder characterized by swelling due to excessive fluid accumulation in the trunk area.
10058804Esophageal infectionA disorder characterized by an infectious process involving the esophagus.
10058838Enterocolitis infectiousA disorder characterized by an infectious process involving the small and large intestines.
10059094Intestinal stoma obstructionA finding of blockage of the normal flow of the contents of the intestinal stoma.
10059095Intestinal stoma leakA finding of leakage of contents from an intestinal stoma (surgically created opening on the surface of the body).
10059446Gallbladder necrosisA disorder characterized by a necrotic process occurring in the gallbladder.
10059639Laryngeal obstructionA disorder characterized by blockage of the laryngeal airway.
10059827Rhinitis infectiveA disorder characterized by an infectious process involving the nasal mucosal.
10059895Urine output decreasedA finding based on test results that indicate urine production is less relative to previous output.
10060602HematosalpinxA disorder characterized by the presence of blood in a fallopian tube.
10060640Hemorrhoidal hemorrhageA disorder characterized by bleeding from the hemorrhoids.
10060890Trigeminal nerve disorderA disorder characterized by involvement of the trigeminal nerve (fifth cranial nerve).
10060929Accessory nerve disorderA disorder characterized by involvement of the accessory nerve (eleventh cranial nerve).
10061017Bone infectionA disorder characterized by an infectious process involving the bones.
10061103Dermatitis radiationA finding of cutaneous inflammatory reaction occurring as a result of exposure to biologically effective levels of ionizing radiation.
10061145Eyelid function disorderA disorder characterized by impaired eyelid function.
10061149Female genital tract fistulaA disorder characterized by an abnormal communication between a female reproductive system organ and another organ or anatomic site.
10061185Glossopharyngeal nerve disorderA disorder characterized by involvement of the glossopharyngeal nerve (ninth cranial nerve).
10061212Hypoglossal nerve disorderA disorder characterized by involvement of the hypoglossal nerve (twelfth cranial nerve).
10061229Lung infectionA disorder characterized by an infectious process involving the lungs.
10061261Lactation disorderA disorder characterized by disturbances of milk secretion. It is not necessarily related to pregnancy that is observed in females and can be observed in males.
10061304Nail infectionA disorder characterized by an infectious process involving the nail.
10061322Optic nerve disorderA disorder characterized by involvement of the optic nerve (second cranial nerve).
10061339Perineal painA disorder characterized by a sensation of marked discomfort in the area between the genital organs and the anus.
10061351Pleural infectionA disorder characterized by an infectious process involving the pleura.
10061389Tricuspid valve diseaseA disorder characterized by a defect in tricuspid valve function or structure.
10061403Vagus nerve disorderA disorder characterized by involvement of the vagus nerve (tenth cranial nerve).
10061457Facial nerve disorderA disorder characterized by involvement of the facial nerve (seventh cranial nerve).
10061461Erectile dysfunctionA disorder characterized by the persistent or recurrent inability to achieve or to maintain an erection during sexual activity.
10061510Scleral disorderA disorder characterized by involvement of the sclera of the eye.
10061532Mitral valve diseaseA disorder characterized by a defect in mitral valve function or structure.
10061541Pulmonary valve diseaseA disorder characterized by a defect in pulmonary valve function or structure.
10061574Urinary tract obstructionA disorder characterized by blockage of the normal flow of contents of the urinary tract.
10061589Aortic valve diseaseA disorder characterized by a defect in aortic valve function or structure.
10061640Anorectal infectionA disorder characterized by an infectious process involving the anal area and the rectum.
10061664Autoimmune disorderA disorder resulting from loss of function or tissue destruction of an organ or multiple organs, arising from humoral or cellular immune responses of the individual to his own tissue constituents.
10061695Biliary tract infectionA disorder characterized by an infectious process involving the biliary tract.
10061788Corneal infectionA disorder characterized by an infectious process involving the cornea.
10061912Penile infectionA disorder characterized by an infectious process involving the penis.
10061928RadiculitisA disorder characterized by inflammation involving a nerve root. Patients experience marked discomfort radiating along a nerve path because of spinal pressure on the connecting nerve root.
10061970Gastric stenosisA disorder characterized by a narrowing of the lumen of the stomach.
10062112Splenic infectionA disorder characterized by an infectious process involving the spleen.
10062156Scrotal infectionA disorder characterized by an infectious process involving the scrotum.
10062169Vascular access complicationA finding of a previously undocumented problem related to the vascular access site.
10062225Urinary tract painA disorder characterized by a sensation of marked discomfort in the urinary tract.
10062233Uterine infectionA disorder characterized by an infectious process involving the endometrium. It may extend to the myometrium and parametrial tissues.
10062244Sinus disorderA disorder characterized by involvement of the paranasal sinuses.
10062255Soft tissue infectionA disorder characterized by an infectious process involving soft tissues.
10062263Small intestinal stenosisA disorder characterized by a narrowing of the lumen of the small intestine.
10062283Nail ridgingA disorder characterized by vertical or horizontal ridges on the nails.
10062315LipohypertrophyA disorder characterized by hypertrophy of the subcutaneous adipose tissue at the site of multiple subcutaneous injections of insulin.
10062466Localized edemaA disorder characterized by swelling due to excessive fluid accumulation at a specific anatomic site.
10062501Non-cardiac chest painA disorder characterized by discomfort in the chest unrelated to a heart disorder.
10062548Tracheal hemorrhageA finding of bleeding from the trachea.
10062570Enterovesical fistulaA disorder characterized by an abnormal communication between the urinary bladder and the intestine.
10062572Generalized muscle weaknessA disorder characterized by a reduction in the strength of muscles in multiple anatomic sites.
10062632Gallbladder infectionA disorder characterized by an infectious process involving the gallbladder.
10062646Pancreatic enzymes decreasedA finding based on laboratory test results that indicate an decrease in levels of pancreatic enzymes in a biological specimen.
10062667Laryngopharyngeal dysesthesiaA disorder characterized by an uncomfortable persistent sensation in the area of the laryngopharynx.
10062872DysesthesiaA disorder characterized by distortion of sensory perception, resulting in an abnormal and unpleasant sensation.
10063057Cystitis noninfectiveA disorder characterized by inflammation of the bladder which is not caused by an infection of the urinary tract.
10063190Rectal mucositisA disorder characterized by inflammation of the mucous membrane of the rectum.
10063524Bronchial strictureA disorder characterized by a narrowing of the bronchial tube.
10063575Bladder perforationA disorder characterized by a rupture in the bladder wall.
10063636Pyramidal tract syndromeA disorder characterized by dysfunction of the corticospinal (pyramidal) tracts of the spinal cord. Symptoms include an increase in the muscle tone in the lower extremities, hyperreflexia, positive Babinski and a decrease in fine motor coordination.
10063761Reversible posterior leukoencephalopathy syndromeA disorder characterized by headaches, mental status changes, visual disturbances, and seizures associated with imaging findings of posterior leukoencephalopathy. It has been observed in association with hypertensive encephalopathy, eclampsia, and immunosuppressive and cytotoxic drug treatment. It is an acute or subacute reversible condition.
10064026Pelvic floor muscle weaknessA disorder characterized by a reduction in the strength of the muscles of the pelvic floor.
10064505Stoma site infectionA disorder characterized by an infectious process involving a stoma (surgically created opening on the surface of the body).
10064658Osteonecrosis of jawA disorder characterized by a necrotic process occurring in the bone of the mandible.
10064687Device related infectionA disorder characterized by an infectious process involving the use of a medical device.
10064774Infusion site extravasationA disorder characterized by leakage of a pharmacologic or a biologic substance from the infusion site into the surrounding tissue. Signs and symptoms include induration, erythema, swelling, burning sensation and marked discomfort at the infusion site.
10064848Chronic kidney diseaseA disorder characterized by gradual and usually permanent loss of kidney function resulting in renal failure.
10065368Urinary fistulaA disorder characterized by an abnormal communication between any part of the urinary system and another organ or anatomic site.
10065417Brachial plexopathyA disorder characterized by regional paresthesia of the brachial plexus, marked discomfort and muscle weakness, and limited movement in the arm or hand.
10065703Pancreatic duct stenosisA disorder characterized by a narrowing of the lumen of the pancreatic duct.
10065704Peritoneal necrosisA disorder characterized by a necrotic process occurring in the peritoneum.
10065705Pharyngeal anastomotic leakA finding of leakage due to breakdown of a pharyngeal anastomosis (surgical connection of two separate anatomic structures).
10065706Pharyngeal necrosisA disorder characterized by a necrotic process occurring in the pharynx.
10065707Rectal obstructionA disorder characterized by blockage of the normal flow of the intestinal contents in the rectum.
10065709Rectal necrosisA disorder characterized by a necrotic process occurring in the rectal wall.
10065710Small intestinal mucositisA disorder characterized by inflammation of the mucous membrane of the small intestine.
10065712Gastrointestinal stoma necrosisA finding of a necrotic process occurring in the gastrointestinal tract stoma.
10065713Gastric fistulaA disorder characterized by an abnormal communication between the stomach and another organ or anatomic site.
10065719Jejunal fistulaA disorder characterized by an abnormal communication between the jejunum and another organ or anatomic site.
10065720Oral cavity fistulaA disorder characterized by an abnormal communication between the oral cavity and another organ or anatomic site.
10065721Anal mucositisA disorder characterized by inflammation of the mucous membrane of the anus.
10065722Anal necrosisA disorder characterized by a necrotic process occurring in the anal region.
10065727Esophageal necrosisA disorder characterized by a necrotic process occurring in the esophageal wall.
10065728Ileal fistulaA disorder characterized by an abnormal communication between the ileum and another organ or anatomic site.
10065730Ileal obstructionA disorder characterized by blockage of the normal flow of the intestinal contents in the ileum.
10065732Jejunal obstructionA disorder characterized by blockage of the normal flow of the intestinal contents in the jejunum.
10065735Laryngeal inflammationA disorder characterized by an inflammation involving the larynx.
10065738Unequal limb lengthA disorder characterized by of a discrepancy between the lengths of the lower or upper extremities.
10065744Arteritis infectiveA disorder characterized by an infectious process involving an artery.
10065745Prolapse of intestinal stomaA finding of protrusion of the intestinal stoma (surgically created opening on the surface of the body) above the abdominal surface.
10065746Bronchopulmonary hemorrhageA disorder characterized by bleeding from the bronchial wall and/or lung parenchyma.
10065747Cecal hemorrhageA disorder characterized by bleeding from the cecum.
10065748Urostomy site bleedingA finding of bleeding from the urostomy site.
10065749Tracheostomy site bleedingA finding of blood leakage from the tracheostomy site.
10065752Duodenal infectionA disorder characterized by an infectious process involving the duodenum.
10065755Lip infectionA disorder characterized by an infectious process involving the lips.
10065759Laryngeal hemorrhageA disorder characterized by bleeding from the larynx.
10065761Cecal infectionA disorder characterized by an infectious process involving the cecum.
10065762Spermatic cord hemorrhageA disorder characterized by bleeding from the spermatic cord.
10065763Ovarian hemorrhageA disorder characterized by bleeding from the ovary.
10065764Mucosal infectionA disorder characterized by an infectious process involving a mucosal surface.
10065765Cranial nerve infectionA disorder characterized by an infectious process involving a cranial nerve.
10065766Peripheral nerve infectionA disorder characterized by an infectious process involving the peripheral nerves.
10065771Small intestine infectionA disorder characterized by an infectious process involving the small intestine.
10065772Vulval infectionA disorder characterized by an infectious process involving the vulva.
10065773Lymph leakageA disorder characterized by the loss of lymph fluid into the surrounding tissue or body cavity.
10065775Abdominal soft tissue necrosisA disorder characterized by a necrotic process occurring in the soft tissues of the abdominal wall.
10065776Muscle weakness lower limbA disorder characterized by a reduction in the strength of the lower limb muscles.
10065777Soft tissue necrosis lower limbA disorder characterized by a necrotic process occurring in the soft tissues of the lower extremity.
10065778Soft tissue necrosis upper limbA disorder characterized by a necrotic process occurring in the soft tissues of the upper extremity.
10065779Head soft tissue necrosisA disorder characterized by a necrotic process occurring in the soft tissues of the head.
10065780Muscle weakness left-sidedA disorder characterized by a reduction in the strength of the muscles on the left side of the body.
10065781Neck soft tissue necrosisA disorder characterized by a necrotic process occurring in the soft tissues of the neck.
10065783Musculoskeletal deformityA disorder characterized by of a malformation of the musculoskeletal system.
10065784Central nervous system necrosisA disorder characterized by a necrotic process occurring in the brain and/or spinal cord.
10065785External ear painA disorder characterized by a sensation of marked discomfort in the external ear region.
10065786Laryngeal fistulaA disorder characterized by an abnormal communication between the larynx and another organ or anatomic site.
10065787Tracheal fistulaA disorder characterized by an abnormal communication between the trachea and another organ or anatomic site.
10065788Fallopian tube anastomotic leakA finding of leakage due to breakdown of a fallopian tube anastomosis (surgical connection of two separate anatomic structures).
10065789Fallopian tube obstructionA disorder characterized by blockage of the normal flow of the contents in the fallopian tube.
10065790Fallopian tube perforationA finding of rupture of the fallopian tube wall.
10065791Fallopian tube stenosisA disorder characterized by a narrowing of the fallopian tube lumen.
10065793Pelvic soft tissue necrosisA disorder characterized by a necrotic process occurring in the soft tissues of the pelvis.
10065794Muscle weakness right-sidedA disorder characterized by a reduction in the strength of the muscles on the right side of the body.
10065795Muscle weakness trunkA disorder characterized by a reduction in the strength of the trunk muscles.
10065796Joint range of motion decreased cervical spineA disorder characterized by a decrease in flexibility of a cervical spine joint.
10065798Superficial soft tissue fibrosisA disorder characterized by fibrotic degeneration of the superficial soft tissues.
10065799Fibrosis deep connective tissueA disorder characterized by fibrotic degeneration of the deep connective tissues.
10065800Joint range of motion decreased lumbar spineA disorder characterized by a decrease in flexibility of a lumbar spine joint.
10065802Bladder anastomotic leakA finding of leakage of urine due to breakdown of a bladder anastomosis (surgical connection of two separate anatomic structures).
10065803Kidney anastomotic leakA finding of leakage of urine due to breakdown of a kidney anastomosis (surgical connection of two separate anatomic structures).
10065805Spermatic cord obstructionA disorder characterized by blockage of the normal flow of the contents of the spermatic cord.
10065811Uterine fistulaA disorder characterized by an abnormal communication between the uterus and another organ or anatomic site.
10065813Vaginal fistulaA disorder characterized by an abnormal communication between the vagina and another organ or anatomic site.
10065814Ureteric anastomotic leakA finding of leakage due to breakdown of a ureteral anastomosis (surgical connection of two separate anatomic structures).
10065815Urethral anastomotic leakA finding of leakage due to breakdown of a urethral anastomosis (surgical connection of two separate anatomic structures).
10065817Vaginal obstructionA disorder characterized by blockage of vaginal canal.
10065818Vaginal perforationA disorder characterized by a rupture in the vaginal wall.
10065822Prolapse of urostomyA finding of displacement of the urostomy.
10065823Nipple deformityA disorder characterized by a malformation of the nipple.
10065825Intraoperative gastrointestinal injuryA finding of damage to the gastrointestinal system during a surgical procedure.
10065826Intraoperative arterial injuryA finding of damage to an artery during a surgical procedure.
10065827Intraoperative hepatobiliary injuryA finding of damage to the hepatic parenchyma and/or biliary tract during a surgical procedure.
10065828Intraoperative urinary injuryA finding of damage to the urinary system during a surgical procedure.
10065829Intraoperative musculoskeletal injuryA finding of damage to the musculoskeletal system during a surgical procedure.
10065830Intraoperative neurological injuryA finding of damage to the nervous system during a surgical procedure.
10065831Intraoperative breast injuryA finding of damage to the breast parenchyma during a surgical procedure.
10065832Intraoperative respiratory injuryA finding of damage to the respiratory system during a surgical procedure.
10065834Intraoperative endocrine injuryA finding of damage to the endocrine gland during a surgical procedure.
10065836IVth nerve disorderA disorder characterized by involvement of the trochlear nerve (fourth cranial nerve).
10065837External ear inflammationA disorder characterized by inflammation, swelling and redness to the outer ear and ear canal.
10065838Middle ear inflammationA disorder characterized by inflammation (physiologic response to irritation), swelling and redness to the middle ear.
10065840Intraoperative reproductive tract injuryA finding of damage to the reproductive organs during a surgical procedure.
10065841Intraoperative ocular injuryA finding of damage to the eye during a surgical procedure.
10065842Intraoperative head and neck injuryA finding of damage to the head and neck during a surgical procedure.
10065843Intraoperative cardiac injuryA finding of damage to the heart during a surgical procedure.
10065844Intraoperative ear injuryA finding of damage to the ear during a surgical procedure.
10065845Intraoperative renal injuryA finding of damage to the kidney during a surgical procedure.
10065846Intraoperative skin injuryA finding of damage to the skin during a surgical procedure.
10065847Intraoperative splenic injuryA finding of damage to the spleen during a surgical procedure.
10065848Intraoperative venous injuryA finding of damage to a vein during a surgical procedure.
10065849Injury to jugular veinA finding of damage to the jugular vein.
10065851Esophageal fistulaA disorder characterized by an abnormal communication between the esophagus and another organ or anatomic site.
10065873Pulmonary fistulaA disorder characterized by an abnormal communication between the lung and another organ or anatomic site.
10065879Gastrointestinal anastomotic leakA finding of leakage due to breakdown of a gastrointestinal anastomosis (surgical connection of two separate anatomic structures).
10065880Laryngeal mucositisA disorder characterized by an inflammation involving the mucous membrane of the larynx.
10065881Pharyngeal mucositisA disorder characterized by an inflammation involving the mucous membrane of the pharynx.
10065882Urostomy leakA finding of leakage of contents from a urostomy.
10065883Urostomy obstructionA finding of blockage of the urostomy.
10065885Urostomy stenosisA finding of narrowing of the opening of a urostomy.
10065886Uterine anastomotic leakA finding of leakage due to breakdown of a uterine anastomosis (surgical connection of two separate anatomic structures).
10065887Vaginal anastomotic leakA finding of leakage due to breakdown of a vaginal anastomosis (surgical connection of two separate anatomic structures).
10065888Vas deferens anastomotic leakA finding of leakage due to breakdown of a vas deferens anastomosis (surgical connection of two separate anatomic structures).
10065891Large intestinal anastomotic leakA finding of leakage due to breakdown of an anastomosis (surgical connection of two separate anatomic structures) in the large intestine.
10065892Small intestinal anastomotic leakA finding of leakage due to breakdown of an anastomosis (surgical connection of two separate anatomic structures) in the small bowel.
10065893Gastric anastomotic leakA finding of leakage due to breakdown of a gastric anastomosis (surgical connection of two separate anatomic structures).
10065894Rectal anastomotic leakA finding of leakage due to breakdown of a rectal anastomosis (surgical connection of two separate anatomic structures).
10065895Muscle weakness upper limbA disorder characterized by a reduction in the strength of the upper limb muscles.
10065897Spermatic cord anastomotic leakA finding of leakage due to breakdown of a spermatic cord anastomosis (surgical connection of two separate anatomic structures).
10065898Stenosis of gastrointestinal stomaA finding of narrowing of the gastrointestinal stoma (surgically created opening on the surface of the body).
10065900Tracheal mucositisA disorder characterized by an inflammation involving the mucous membrane of the trachea.
10065906Carbon monoxide diffusing capacity decreasedA finding based on lung function test results that indicate a decrease in the lung capacity to absorb carbon monoxide.
10065928Uterine obstructionA disorder characterized by blockage of the uterine outlet.
10065961Esophageal anastomotic leakA finding of leakage due to breakdown of an esophageal anastomosis (surgical connection of two separate anatomic structures).
10065973Iron overloadA disorder characterized by accumulation of iron in the tissues.
10066480Avascular necrosisA disorder characterized by necrotic changes in the bone tissue due to interruption of blood supply. Most often affecting the epiphysis of the long bones, the necrotic changes result in the collapse and the destruction of the bone structure.
10066874Gastroesophageal reflux diseaseA disorder characterized by reflux of the gastric and/or duodenal contents into the distal esophagus. It is chronic in nature and usually caused by incompetence of the lower esophageal sphincter, and may result in injury to the esophageal mucosal. Symptoms include heartburn and acid indigestion.
10069138Papulopustular rashA disorder characterized by an eruption consisting of papules (a small, raised pimple) and pustules (a small pus filled blister), typically appearing in face, scalp, and upper chest and back Unlike acne, this rash does not present with whiteheads or blackheads, and can be symptomatic, with itchy or tender lesions.
10069339Acute kidney injuryA disorder characterized by the acute loss of renal function and is traditionally classified as pre-renal (low blood flow into kidney), renal (kidney damage) and post-renal causes (ureteral or bladder outflow obstruction).
10069501Left ventricular systolic dysfunctionA disorder characterized by failure of the left ventricle to produce adequate output despite an increase in distending pressure and in end-diastolic volume. Clinical manifestations mayinclude dyspnea, orthopnea, and other signs and symptoms of pulmonary congestion and edema.
AE AttributionCTC Adverse Event Attribution Scale12853.0This question is not asked for baseline assessments. Question should be asked (mandatory) for all studies that involve drug therapy.CHARACTER
DefiniteDEFINITENo Value Exists
PossiblePOSSIBLEPOSSIBLE
ProbablePROBABLEPROBABLE
UnlikelyUNLIKELYUNLIKELY
UnrelatedUNRELATEDUNRELATED
Reporting Period End DateAdverse Event Final Assessment Date20068514.0End of the assessment period.DATEMM/DD/YYYY
Were adverse events assessed during most recent periodAdverse Event Most Recent Assessment Ind-321799711.0Indicator to clarify whether any AEs were identified during the reporting period. This is confirmation that the remainder of the form was intentionally left blank.CHARACTER
YesYesThe affirmative response to a question or activity.
NoNoThe non-affirmative response to a question.
UnknownUnknownNot known, not observed, not recorded, or refused.
Expected? (Yes/No)Adverse Event Expected Indicator21836191.0CHARACTER
YesYesThe affirmative response to a question or activity.
NoNoThe non-affirmative response to a question.
Serious?Serious Adverse Event Indicator21999081.0If a 'yes' response is entered, complete the SAE section for this AE.CHARACTER
YesYesThe affirmative response to a question or activity.
NoNoThe non-affirmative response to a question.
Event Onset TimeAdverse Event Onset Time25852341.0Enter the time of day when AE was first evident. Used when Date of Onset is insufficient.TIMETIME (HR(24):MN)
CourseProtocol Course Number Count27321841.0May be used during protocol therapy period to automatically set the evaluation start/end dates to the period of the course of treatment (e.g. user supplies course# and evaluation period derived).NUMBER
AE Evaluation Period Start DateAdverse Event Begin Assessment Date27449431.0Date of the beginning (start) of the assessment period.DATEMM/DD/YYYY
Pre-existing AE?Adverse Event Pre-Existing Indicator27462801.0Should be derivable if you capture AEs for specified periods; not needed if you track an AE until it resolves (including worsening)rather than for a defined assessment period.CHARACTER
YesYesThe affirmative response to a question or activity.
NoNoThe non-affirmative response to a question.
AE Resolved TimeAdverse Event Resolution Time27463011.0Enter the time of day when AE was resolved.TIMETIME (HR(24):MN)
AE Ongoing?Adverse Event Ongoing Event Indicator27463111.0Flag to indicate whether AE has resolved or not. This ensures that leaving 'Stop Date' blank was not done inadvertently.CHARACTER
YesYesThe affirmative response to a question or activity.
NoNoThe non-affirmative response to a question.
Participant Status/OutcomeAdverse Event Outcome Type27465171.0CHARACTER
FatalDeathThe absence of life or state of being dead.
Not Recovered/Not ResolvedNOT RECOVERED OR NOT RESOLVEDOne of the possible results of an adverse event outcome that indicates that the event has not improved or recuperated.
Recovered/ResolvedRecovered or ResolvedOne of the possible results of an adverse event outcome that indicates that the event has improved or recuperated.
Recovered/Resolved with SequelaeRECOVERED OR RESOLVED WITH SEQUELAEOne of the possible results of an adverse event outcome where the subject recuperated but retained pathological conditions resulting from the prior disease or injury.
Recovering/ResolvingRECOVERING OR RESOLVINGOne of the possible results of an adverse event outcome that indicates that the event is improving.
UnknownUnknownNot known, not observed, not recorded, or refused.
Adverse Event Condition PatternAdverse Event Condition Pattern20084181.0This should be derivable from a review of AEs over time.CHARACTER
1single episodesingle episode
2intermittentintermittent
3CONTINUOUSExisting in time or space without stop or interruption.
Did event reappear after study agent was reintroduced?Adverse Event Reappearance Indicator21796151.0Enter response from choice list.ALPHANUMERIC
YesYesThe affirmative response to a question or activity.
NoNoThe non-affirmative response to a question.
N/ANot ApplicableDetermination of a value is not relevant in the current context.
CommentsResearch Comments Text7975.0A general comment that should not be specific to a single AE.CHARACTER
Optional Serious Adverse Event QuestionsThe following additional elements are optional on a SAE form.
Why serious?Serious Adverse Event Description Reason Text21796793.0Select the appropriate response.CHARACTER
1Results in DeathResults in Death
2Is life-threateningIs life-threatening
3Requires inpatient hospitalization or prolongation of existing hospitalizationRequires inpatient hospitalization or prolongation of existing hospitalization
4Results in persistent or significant disability/incapacityResults in persistent or significant disability/incapacity
5Is a congenital anomaly/birth defectIs a congenital anomaly/birth defect
6In the medical judgment of the treating physician and/or investigator, it may jeopardize the participant or require intervention to prevent one of these outcomesIn the medical judgment of the treating physician and/or investigator, it may jeopardize the participant or require intervention to prevent one of these outcomes
7Other, specifyOther, specify
8Meets criteria per protocol but does not meet other criterion (above)Meets criteria per protocol but does not meet other criterion (above)
Dose-Limiting Toxicity?Dose Limiting Toxicity Ind20041063.0Select the appropriate response.CHARACTER
NNoThe non-affirmative response to a question.
YYesThe affirmative response to a question or activity.