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Long NameStaging, Cervix Uteri NCI Standard Template
DefinitionThe collection of CDEs used in the cervical staging module based on AJCC Edition 7 and FIGO standards.
ContextcaBIG
Protocol Long NameNCI Standard Template Forms
WorkflowRELEASED
TypeCRF
Public ID3443295
Version1.0
Module Long NameModule InstructionsQuestionCDECDE Public IDCDE VersionQuestion InstructionsValue Domain Data TypeValue Domain Unit of MeasureDisplay FormatValid ValueForm Value Meaning TextForm Value Meaning Desc.
Mandatory Cervix Uteri Staging QuestionsThese items must be included when this data is collected for reporting.
Date Current Staging Assessment CompletedCurrent Stage Complete Assessment Date627393.0DATEMM/DD/YYYY
Conditional Cervix Uteri Staging QuestionsThere are business rules to indicate situations under which this element should be used on a case report form.
Clinical T StageCervical Cancer American Joint Committee on Cancer (AJCC) Edition 7 Clinical Tumor T Stage34313071.0Conditionality Rule: Inclusion based on patient population being studied.CHARACTER
T0Cervical Cancer cT0 TNM Finding v7Cervical cancer with no evidence of primary tumor. (from AJCC 7th Ed.)
T1Cervical Cancer cT1 TNM Finding v7Cervical cancer confined to uterus (extension to corpus should be disregarded). (from AJCC 7th Ed.)
T1aCervical Cancer pT1a TNM Finding v7Invasive cervical cancer diagnosed only by microscopy. Stromal invasion with a maximum depth of 5.0 mm measured from the base of the epithelium and a horizontal spread of 7.0 mm or less. Vascular space involvement, venous or lymphatic, does not affect classification. (from AJCC 7th Ed.)
T1a1Cervical Cancer pT1a1 TNM Finding v7Invasive cervical cancer with measured stromal invasion 3.0 mm or less in depth and 7.0 mm or less in horizontal spread. (from AJCC 7th Ed.)
T1a2Cervical Cancer pT1a2 TNM Finding v7Invasive cervical cancer with measured stromal invasion more than 3.0 mm and not more than 5.0 mm with a horizontal spread 7.0 mm or less. (from AJCC 7th Ed.)
T1bCervical Cancer cT1b TNM Finding v7Cervical cancer with clinically visible lesion confined to the cervix. (from AJCC 7th Ed.)
T1b1Cervical Cancer cT1b1 TNM Finding v7Cervical cancer with clinically visible lesion 4.0 cm or less in greatest dimension confined to the cervix. (from AJCC 7th Ed.)
T1b2Cervical Cancer cT1b2 TNM Finding v7Invasive cervical cancer with clinically visible lesion more than 4.0 cm in greatest dimension confined to the cervix. (from AJCC 7th Ed.)
T2Cervical Cancer cT2 TNM Finding v7Cervical cancer invades beyond uterus but not to pelvic wall or to lower third of vagina. (from AJCC 7th Ed.)
T2aCervical Cancer cT2a TNM Finding v7Cervical cancer invades beyond uterus but not to pelvic wall or to lower third of vagina. There is no parametrial invasion. (from AJCC 7th Ed.)
T2a1Cervical Cancer cT2a1 TNM Finding v7Cervical cancer invades beyond uterus but not to pelvic wall or to lower third of vagina. There is no parametrial invasion. Clinically visible lesions 4.0 cm or less in greatest dimension are present. (from AJCC 7th Ed.)
T2a2Cervical Cancer cT2a2 TNM Finding v7Cervical cancer invades beyond uterus but not to pelvic wall or to lower third of vagina. There is no parametrial invasion. Clinically visible lesions more than 4.0 cm in greatest dimension are present. (from AJCC 7th Ed.)
T2bCervical Cancer cT2b TNM Finding v7Cervical cancer invades beyond uterus but not to pelvic wall or to lower third of vagina. Parametrial invasion is present. (from AJCC 7th Ed.)
T3Cervical Cancer cT3 TNM Finding v7Cervical cancer extends to pelvic wall and/or involves lower third of vagina, and/or causes hydronephrosis or nonfunctioning kidney. (from AJCC 7th Ed.)
T3aCervical Cancer cT3a TNM Finding v7Cervical cancer involves lower third of vagina, without extension to pelvic wall. (from AJCC 7th Ed.)
T3bCervical Cancer cT3b TNM Finding v7Cervical cancer extends to pelvic wall and/or causes hydronephrosis or nonfunctioning kidney. (from AJCC 7th Ed.)
T4Cervical Cancer cT4 TNM Finding v7Cervical cancer invades mucosa of bladder or rectum, and/or extends beyond true pelvis (bullous edema is not sufficient to classify a tumor as T4). (from AJCC 7th Ed.)
TisCervical Cancer cTis TNM Finding v7Cervical cancer with a finding of carcinoma in situ. (from AJCC 7th Ed.)
TXCervical Cancer cTX TNM Finding v7Cervical cancer in which primary tumor cannot be assessed. (from AJCC 7th Ed.)
Clinical N StageCervical Cancer American Joint Committee on Cancer (AJCC) Edition 7 Clinical Regional Lymph Node N Stage34313081.0Conditionality Rule: Inclusion based on patient population being studied.CHARACTER
N0Cervical Cancer cN0 TNM Finding v7Cervical cancer with no regional lymph node metastasis. (from AJCC 7th Ed.)
N1Cervical Cancer cN1 TNM Finding v7Cervical cancer with regional lymph node metastasis. (from AJCC 7th Ed.)
NXCervical Cancer cNX TNM Finding v7Cervical cancer in which regional lymph nodes cannot be assessed. (from AJCC 7th Ed.)
Clinical M StageCervical Cancer American Joint Committee on Cancer (AJCC) Edition 7 Clinical Distant Metastasis M Stage34313091.0Conditionality Rule: Inclusion based on patient population being studied.CHARACTER
M0Cervical Cancer cM0 TNM Finding v7Cervical cancer in which there is no evidence of distant metastasis. (from AJCC 7th Ed.)
M1Cervical Cancer cM1 TNM Finding v7Cervical cancer with distant metastasis (including peritoneal spread, involvement of supraclavicular, mediastinal, or paraaortic lymph nodes, lung, liver, or bone). (from AJCC 7th Ed.)
Pathologic T StageCervical Cancer American Joint Committee on Cancer (AJCC) Edition 7 Pathologic Tumor T Stage34313101.0Conditionality Rule: Inclusion based on patient population being studied.CHARACTER
T0Cervical Cancer pT0 TNM Finding v7Cervical cancer with no evidence of primary tumor. (from AJCC 7th Ed.)
T1Cervical Cancer pT1 TNM Finding v7Cervical cancer confined to uterus (extension to corpus should be disregarded). (from AJCC 7th Ed.)
T1aCervical Cancer pT1a TNM Finding v7Invasive cervical cancer diagnosed only by microscopy. Stromal invasion with a maximum depth of 5.0 mm measured from the base of the epithelium and a horizontal spread of 7.0 mm or less. Vascular space involvement, venous or lymphatic, does not affect classification. (from AJCC 7th Ed.)
T1a1Cervical Cancer pT1a1 TNM Finding v7Invasive cervical cancer with measured stromal invasion 3.0 mm or less in depth and 7.0 mm or less in horizontal spread. (from AJCC 7th Ed.)
T1a2Cervical Cancer pT1a2 TNM Finding v7Invasive cervical cancer with measured stromal invasion more than 3.0 mm and not more than 5.0 mm with a horizontal spread 7.0 mm or less. (from AJCC 7th Ed.)
T1bCervical Cancer pT1b TNM Finding v7Cervical cancer with microscopic lesion greater than T1a/IA2. (from AJCC 7th Ed.)
T1b1Cervical Cancer pT1b1 TNM Finding v7Cervical cancer with clinically visible lesion 4.0 cm or less in greatest dimension confined to the cervix. (from AJCC 7th Ed.)
T1b2Cervical Cancer pT1b2 TNM Finding v7Invasive cervical cancer with clinically visible lesion more than 4.0 cm in greatest dimension confined to the cervix. (from AJCC 7th Ed.)
T2Cervical Cancer pT2 TNM Finding v7Cervical cancer invades beyond uterus but not to pelvic wall or to lower third of vagina. (from AJCC 7th Ed.)
T2aCervical Cancer pT2a TNM Finding v7Cervical cancer invades beyond uterus but not to pelvic wall or to lower third of vagina. There is no parametrial invasion. (from AJCC 7th Ed.)
T2a1Cervical Cancer pT2a1 TNM Finding v7Cervical cancer invades beyond uterus but not to pelvic wall or to lower third of vagina. There is no parametrial invasion. Clinically visible lesions 4.0 cm or less in greatest dimension are present. (from AJCC 7th Ed.)
T2a2Cervical Cancer pT2a2 TNM Finding v7Cervical cancer invades beyond uterus but not to pelvic wall or to lower third of vagina. There is no parametrial invasion. Clinically visible lesions more than 4.0 cm in greatest dimension are present. (from AJCC 7th Ed.)
T2bCervical Cancer pT2b TNM Finding v7Cervical cancer invades beyond uterus but not to pelvic wall or to lower third of vagina. Parametrial invasion is present. (from AJCC 7th Ed.)
T3Cervical Cancer pT3 TNM Finding v7Cervical cancer extends to pelvic wall and/or involves lower third of vagina, and/or causes hydronephrosis or nonfunctioning kidney. (from AJCC 7th Ed.)
T3aCervical Cancer pT3a TNM Finding v7Cervical cancer involves lower third of vagina, without extension to pelvic wall. (from AJCC 7th Ed.)
T3bCervical Cancer pT3b TNM Finding v7Cervical cancer extends to pelvic wall and/or causes hydronephrosis or nonfunctioning kidney. (from AJCC 7th Ed.)
T4Cervical Cancer pT4 TNM Finding v7Cervical cancer invades mucosa of bladder or rectum, and/or extends beyond true pelvis (bullous edema is not sufficient to classify a tumor as T4). (from AJCC 7th Ed.)
TisCervical Cancer pTis TNM Finding v7Cervical cancer with a finding of carcinoma in situ (preinvasive carcinoma). Note: FIGO no longer includes Stage 0 (Tis) (from AJCC 7th Ed.)
TXCervical Cancer pTX TNM Finding v7Cervical cancer in which primary tumor cannot be assessed. (from AJCC 7th Ed.)
Pathologic N StageCervical Cancer American Joint Committee on Cancer (AJCC) Edition 7 Pathologic Regional Lymph Node N Stage34313111.0Conditionality Rule: Inclusion based on patient population being studied.CHARACTER
N0Cervical Cancer pN0 TNM Finding v7Cervical cancer with no regional lymph node metastasis. (from AJCC 7th Ed.)
N1Cervical Cancer pN1 TNM Finding v7Cervical cancer with regional lymph node metastasis. (from AJCC 7th Ed.)
NXCervical Cancer pNX TNM Finding v7Cervical cancer in which regional lymph nodes cannot be assessed. (from AJCC 7th Ed.)
Pathologic M StageCervical Cancer American Joint Committee on Cancer (AJCC) Edition 7 Pathologic Distant Metastasis M Stage34313121.0Conditionality Rule: Inclusion based on patient population being studied.CHARACTER
M1Cervical Cancer pM1 TNM Finding v7Cervical cancer with distant metastasis (including peritoneal spread, involvement of supraclavicular, mediastinal, or paraaortic lymph nodes, lung, liver, or bone). (from AJCC 7th Ed.)
Disease StageCervical Cancer American Joint Committee on Cancer (AJCC) Edition 7 Group Stage34313131.0Conditionality Rule: Inclusion based on patient population being studied.CHARACTER
0Stage 0 Cervical CancerStage 0 includes: (Tis, N0, M0). Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis. FIGO no longer includes stage 0. (AJCC 7th ed.)
IStage I Cervical CancerStage I includes: I (T1, N0, M0); IA (T1a, N0, M0); IA1 (T1a1, N0, M0); IA2 (T1a2, N0, M0); IB (T1b, N0, M0); IB1(T1b1, N0, M0); IB2 (T1b2, N0, M0). T1: Cervical carcinoma confined to uterus (extension to corpus should be disregarded). T1a: Invasive carcinoma diagnosed only by microscopy. Stromal invasion with a maximum depth of 5.0 mm measured from the base of the epithelium and a horizontal spread of 7.0 mm or less. Vascular space involvement, venous or lymphatic, does not affect classification. T1a1: Measured stromal invasion 3.0 mm or less in depth and 7.0 or less horizontal spread. T1a2: Measured stromal invasion more than 3.0mm and not more than 5.0 mm with a horizontal spread 7.0mm or less. T1b: Clinically visible lesion confined to the cervix or microscopic lesion greater than T1a/IA2. T1b1: Clinically visible lesion 4.0 cm or less in greatest dimension. T1b2: Clinically visible lesion more than 4.0 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)
IAStage IA Cervical CancerStage IA includes: IA (T1a, N0, M0); IA1 (T1a1, N0, M0); IA2 (T1a2, N0, M0). T1a: Invasive carcinoma diagnosed only by microscopy. Stromal invasion with a maximum depth of 5.0 mm measured from the base of the epithelium and a horizontal spread of 7.0 mm or less. Vascular space involvement, venous or lymphatic, does not affect classification. T1a1: Measured stromal invasion 3.0 mm or less in depth and 7.0 or less horizontal spread. T1a2: Measured stromal invasion more than 3.0 mm and not more than 5.0 mm with a horizontal spread 7.0 mm or less. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)
IA1Stage IA1 Cervical CancerStage IA1 includes: T1a1, N0, M0. T1a1: Measured stromal invasion 3.0 mm or less in depth and 7.0 mm or less in horizontal spread. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)
IA2Stage IA2 Cervical CancerStage IA2 includes: T1a2, N0, M0. T1a2: Measured stromal invasion more than 3.0 mm and not more than 5.0 mm with a horizontal spread 7.0 mm or less. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)
IBStage IB Cervical CancerStage IB includes: IB (T1b, N0, M0); IB1(T1b1, N0, M0); IB2 (T1b2, N0, M0). T1b: Clinically visible lesion confined to the cervix or microscopic lesion greater than T1a/IA2. T1b1: Clinically visible lesion 4.0 cm or less in greatest dimension. T1b2: Clinically visible lesion more than 4.0 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)
IB1Stage IB1 Cervical CancerStage IB1 includes: T1b1, N0, M0. T1b1: Clinically visible lesion 4.0 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)
IB2Stage IB2 Cervical CancerStage IB2 includes: T1b2, N0, M0. T1b2: Clinically visible lesion more than 4.0 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)
IIStage II Cervical CancerStage II includes: II (T2, N0, M0); IIA (T2a, N0, M0); IIA1 (T2a1, N0, M0); IIA2 (T2a2, N0, M0); IIB (T2b, N0, M0); T2: Cervical carcinoma invades beyond uterus but no to pelvic wall or to lower third of vagina. T2a: Tumor without parametrial invasion. T2a1: Clinically visible lesion 4.0 cm or less in greatest dimension. T2a2: Clinically visible lesion more than 4.0 cm in greatest dimension. T2b: Tumor with parametrial invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)
IIAStage IIA Cervical CancerStage IIA includes: IIA (T2a, N0, M0); IIA1 (T2a1, N0, M0); IIA2 (T2a2, N0, M0). T2a: Tumor without parametrial invasion. T2a1: Clinically visible lesion 4.0 cm or less in greatest dimension. T2a2: Clinically visible lesion more than 4.0 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)
IIA1Stage IIA1 Cervical CancerStage IIA1 includes: T2a1, N0, M0. Tumor invades beyond uterus but no to pelvic wall or to lower third of vagina. No parametrial invasion. T2a1: Clinically visible lesion 4.0 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)
IIA2Stage IIA2 Cervical CancerStage IIA2 includes: T2a2, N0, M0. Tumor invades beyond uterus but no to pelvic wall or to lower third of vagina. No parametrial invasion. T2a2: Clinically visible lesion more than 4.0 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)
IIBStage IIB Cervical CancerStage IIB includes: T2b, N0, M0. T2b: Tumor with parametrial invasion. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)
IIIStage III Cervical CancerStage III includes: III (T3, N0, M0); IIIA (T3a, N0, M0); IIIB (T1, N1, M0), (T2, N1, M0), (T3a, N1, M0), (T3b, Any N, M0). T3: Tumor extends to pelvic wall and/or involves lower third of vagina, and/or causes hydronephrosis or non-functioning kidney. T3a: Tumor involves lower third of vagina, no extension to pelvic wall. T3b: Tumor extends to pelvic wall and/or causes hydronephrosis or non functioning kidney. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)
IIIAStage IIIA Cervical CancerStage IIIA includes: T3a, N0, M0. T3a: Tumor involves lower third of vagina, no extension to pelvic wall. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)
IIIBStage IIIB Cervical CancerStage IIIB includes: (T3b, Any N, M0); (T1-3, N1, M0). T3: Tumor extends to pelvic wall and/or involves lower third of vagina, and/or causes hydronephrosis or non-functioning kidney. T3b: Tumor extends to pelvic wall and/or causes hydronephrosis or non-functioning kidney. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and7th eds.)
IVAStage IVA Cervical CancerStage IVA includes: T4, Any N, M0). T4: Tumor invades mucosa of bladder or rectum, and/or extends beyond true pelvis (bullous edema is not sufficient to classify a tumor as T4). M0: No distant metastasis. (AJCC 6th and 7th eds.)
IVBStage IVB Cervical CancerStage IVB includes: Any T, Any N, MI. M1: Distant metastasis. (AJCC 6th and 7th eds.)
Stage unknownStage UnknownA finding indicating that the extent of organ/tissue involvement by a malignant neoplasm is not reported or not assessed.
StageGynecologic Tumor Grouping FIGO 2009 Cervical Carcinoma Stage31169431.0Conditionality Rule: Inclusion based on patient population being studied.CHARACTER
IStage IThe carcinoma is strictly confined to the cervix (extension to the corpus would be disregarded) (according to FIGO 2009 Stage Description)
IAStage IAInvasive carcinoma which can be diagnosed only by microscopy, with deepest invasion =<5 mm and largest extension =>7 mm (according to FIGO 2009 Stage Description)
IA1Stage IA1Measured stromal invasion of =<3.0 mm in depth and extension of =<7.0 mm (according to FIGO 2009 Stage Description)
IA2Stage IA2Measured stromal invasion of >3.0 mm and not >5.0 mm with an extension of not >7.0 mm (according to FIGO 2009 Stage Description)
IBStage IBClinically visible lesions limited to the cervix uteri or pre-clinical cancers greater than stage IA (according to FIGO 2009 Stage Description)
IB1Stage IB1Clinically visible lesion =<4.0 cm in greatest dimension (according to FIGO 2009 Stage Description)
IB2Stage IB2Clinically visible lesion >4.0 cm in greatest dimension (according to FIGO 2009 Stage Description)
IIStage IICervical carcinoma invades beyond the uterus, but not to the pelvic wall or to the lower third of the vagina (according to FIGO 2009 Stage Description)
IIAStage IIAWithout parametrial invasion (according to FIGO 2009 Stage Description)
IIA1Stage IIA1Clinically visible lesion =<4.0 cm in greatest dimension (according to FIGO 2009 Stage Description)
IIA2Stage IIA2Clinically visible lesion >4 cm in greatest dimension (according to FIGO 2009 Stage Description)
IIBStage IIBWith obvious parametrial invasion (according to FIGO 2009 Stage Description)
IIIStage IIIThe tumor extends to the pelvic wall and/or involves lower third of the vagina and/or causes hydronephrosis or non-functioning kidney (according to FIGO 2009 Stage Description)
IIIAStage IIIATumor involves lower third of the vagina, with no extension to the pelvic wall (according to FIGO 2009 Stage Description)
IIIBStage IIIBExtension to the pelvic wall and/or hydronephrosis or non-functioning kidney (according to FIGO 2009 Stage Description)
IVStage IVThe carcinoma has extended beyond the true pelvis or has involved (biopsy proven) the mucosa of the bladder or rectum. A bullous edema, as such, does not permit a case to be allotted to Stage IV (according to FIGO 2009 Stage Description)
IVAStage IVASpread of the growth to adjacent organs (according to FIGO 2009 Stage Description)
IVBStage IVBSpread to distant organs (according to FIGO 2009 Stage Description)
Optional Cervix Uteri Staging QuestionsThere is no requirement for inclusion of these elements on the case report form. If the design and scientific questions posed in the study dictate the need to collect this type of data, these elements should be included.
Staging Time PointDisease Staging Timepoint Name28473521.0CHARACTER
Current DiagnosisCurrent DiagnosisOccurring in or belonging to the present time.: The investigation, analysis and recognition of the presence and nature of disease, condition, or injury from expressed signs and symptoms; also, the scientific determination of any kind; the concise results of such an investigation.
Initial DiagnosisFirst DiagnosisPreceding all others in time or space or degree.: The investigation, analysis and recognition of the presence and nature of disease, condition, or injury from expressed signs and symptoms; also, the scientific determination of any kind; the concise results of such an investigation.
RestagingRestagingRepeat of staging assessment
Study EnrollmentClinical Study EnrollmentResearch conducted with human subjects or on material of human origin in which an investigator directly interacts with human subjects; includes development of new technologies, mechanism of human diseases, therapy, clinical trials, epidemiology, behavior and health services research. : Enrollment; to insert, register, or enter in a list, catalog, or roll. (Merriam-Webster Online)