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Long NameStaging, Nasopharyngeal NCI Standard Template
DefinitionThe collection of CDEs used in the nasopharyngeal staging module based on AJCC Edition 7.
ContextcaBIG
Protocol Long NameNCI Standard Template Forms
WorkflowReleased
TypeCRF
Public ID3915165
Version1.0
Module Long NameModule InstructionsQuestionCDECDE Public IDCDE VersionValue Domain Data TypeValue Domain Unit of MeasureDisplay FormatValid ValueForm Value Meaning TextForm Value Meaning Desc.
Mandatory Nasopharyngeal Staging QuestionsThese items must be included when this data is collected for reporting.
Date Current Staging Assessment CompletedCurrent Stage Complete Assessment Date627393.0DATEMM/DD/YYYY
Conditional Nasopharyngeal Staging QuestionsThere are business rules to indicate situations under which this element should be used on a case report form.
Clinical T StageNasopharyngeal Cancer American Joint Committee on Cancer (AJCC) Edition 7 Clinical Tumor T Stage39151561.0CHARACTER
T0Nasopharyngeal Cancer pT0 TNM FindingNasopharyngeal cancer with no evidence of a primary tumor. (from AJCC 6th and 7th Eds.)
T1Nasopharyngeal Cancer pT1 TNM Finding v7Nasopharyngeal cancer with tumor confined to the nasopharynx, or tumor extending to oropharynx and/or nasal cavity without parapharyngeal extension. Parapharyngeal extension denotes posterolateral infiltration of tumor. (from AJCC 7th Ed.)
T2Nasopharyngeal Cancer pT2 TNM Finding v7Nasopharyngeal cancer with parapharyngeal extension. Parapharyngeal extension denotes posterolateral infiltration of tumor. (from AJCC 7th Ed.)
T3Nasopharyngeal Cancer pT3 TNM Finding v7Nasopharyngeal cancer with tumor involving bony structures of skull base and/or paranasal sinuses. (from AJCC 7th Ed.)
T4Nasopharyngeal Cancer pT4 TNM Finding v7Nasopharyngeal cancer with intracranial extension and/or involvement of cranial nerves, hypopharynx, orbit, or with extension to the infratemporal fossa/masticator space. (from AJCC 7th Ed.)
TisNasopharyngeal Cancer pTis TNM FindingNasopharyngeal cancer with a finding of carcinoma in situ. (from AJCC 6th and 7th Eds.)
TXNasopharyngeal Cancer pTX TNM FindingNasopharyngeal cancer in which the primary tumor cannot be assessed. (from AJCC 6th and 7th Eds.)
Clinical N StageNasopharyngeal Cancer American Joint Committee on Cancer (AJCC) Edition 7 Clinical Regional Lymph Node N Stage39151571.0CHARACTER
N0Nasopharyngeal Cancer pN0 TNM FindingNasopharyngeal cancer with no metastasis to regional lymph nodes. (from AJCC 6th and 7th Eds.)
N1Nasopharyngeal Cancer pN1 TNM Finding v7Nasopharyngeal cancer with unilateral metastasis in cervical lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa, and/or unilateral or bilateral, retropharyngeal lymph nodes, 6 cm or less in greatest dimension. Midline nodes are considered ipsilateral nodes. (from AJCC 7th Ed.)
N2Nasopharyngeal Cancer pN2 TNM Finding v7Nasopharyngeal cancer with bilateral metastasis in cervical lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa. Midline nodes are considered ipsilateral nodes. (from AJCC 7th Ed.)
N3Nasopharyngeal Cancer pN3 TNM Finding v7Nasopharyngeal cancer with metastasis in a lymph node (s) more than 6 cm in greatest dimension and/or to supraclavicular fossa. Supraclavicular zone or fossa is relevant to the staging of nasopharyngeal carcinoma and is the triangular region originally described by Ho. It is defined by three points: (1) the superior margin of the sternal end of the clavicle, (2) the superior margin of the lateral end of the clavicle, (3) the point where the neck meets the shoulder. This would include caudal portions of levels IV and VB. All cases with lymph nodes (whole or part) in the fossa are considered N3b. (from AJCC 7th Ed.)
N3aNasopharyngeal Cancer pN3a TNM FindingNasopharyngeal cancer with metastasis to one or more lymph nodes greater than 6 cm in greatest dimension. (from AJCC 6th and 7th Eds.)
N3bNasopharyngeal Cancer pN3b TNM Finding v7Nasopharyngeal cancer with extension to the supraclavicular fossa. Supraclavicular zone or fossa is relevant to the staging of nasopharyngeal carcinoma and is the triangular region originally described by Ho. It is defined by three points: (1) the superior margin of the sternal end of the clavicle, (2) the superior margin of the lateral end of the clavicle, (3) the point where the neck meets the shoulder. This would include caudal portions of levels IV and VB. All cases with lymph nodes (whole or part) in the fossa are considered N3b. (from AJCC 7th Ed.)
NXNasopharyngeal Cancer pNX TNM FindingNasopharyngeal cancer in which the regional lymph nodes cannot be assessed. (from AJCC 6th and 7th Eds.)
Clinical M StageNasopharyngeal Cancer American Joint Committee on Cancer (AJCC) Edition 7 Clinical Distant Metastasis M Stage39151581.0CHARACTER
M0Nasopharyngeal Cancer cM0 TNM Finding v7Nasopharyngeal cancer without evidence of distant metastasis. (from AJCC 7th Ed.)
M1Nasopharyngeal Cancer cM1 TNM Finding v7Nasopharyngeal cancer with distant metastasis. (from AJCC 7th Ed.)
Pathologic T StageNasopharyngeal Cancer American Joint Committee On Cancer (AJCC) Edition 7 Pathologic Tumor T Stage39151591.0CHARACTER
T0Nasopharyngeal Cancer pT0 TNM FindingNasopharyngeal cancer with no evidence of a primary tumor. (from AJCC 6th and 7th Eds.)
T1Nasopharyngeal Cancer pT1 TNM Finding v7Nasopharyngeal cancer with tumor confined to the nasopharynx, or tumor extending to oropharynx and/or nasal cavity without parapharyngeal extension. Parapharyngeal extension denotes posterolateral infiltration of tumor. (from AJCC 7th Ed.)
T2Nasopharyngeal Cancer pT2 TNM Finding v7Nasopharyngeal cancer with parapharyngeal extension. Parapharyngeal extension denotes posterolateral infiltration of tumor. (from AJCC 7th Ed.)
T3Nasopharyngeal Cancer pT3 TNM Finding v7Nasopharyngeal cancer with tumor involving bony structures of skull base and/or paranasal sinuses. (from AJCC 7th Ed.)
T4Nasopharyngeal Cancer pT4 TNM Finding v7Nasopharyngeal cancer with intracranial extension and/or involvement of cranial nerves, hypopharynx, orbit, or with extension to the infratemporal fossa/masticator space. (from AJCC 7th Ed.)
TisNasopharyngeal Cancer pTis TNM FindingNasopharyngeal cancer with a finding of carcinoma in situ. (from AJCC 6th and 7th Eds.)
TXNasopharyngeal Cancer pTX TNM FindingNasopharyngeal cancer in which the primary tumor cannot be assessed. (from AJCC 6th and 7th Eds.)
Pathologic N StageNasopharyngeal Cancer American Joint Committee on Cancer (AJCC) Edition 7 Pathologic Regional Lymph Node N Stage39151601.0CHARACTER
N0Nasopharyngeal Cancer pN0 TNM FindingNasopharyngeal cancer with no metastasis to regional lymph nodes. (from AJCC 6th and 7th Eds.)
N1Nasopharyngeal Cancer pN1 TNM Finding v7Nasopharyngeal cancer with unilateral metastasis in cervical lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa, and/or unilateral or bilateral, retropharyngeal lymph nodes, 6 cm or less in greatest dimension. Midline nodes are considered ipsilateral nodes. (from AJCC 7th Ed.)
N2Nasopharyngeal Cancer pN2 TNM Finding v7Nasopharyngeal cancer with bilateral metastasis in cervical lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa. Midline nodes are considered ipsilateral nodes. (from AJCC 7th Ed.)
N3Nasopharyngeal Cancer pN3 TNM Finding v7Nasopharyngeal cancer with metastasis in a lymph node (s) more than 6 cm in greatest dimension and/or to supraclavicular fossa. Supraclavicular zone or fossa is relevant to the staging of nasopharyngeal carcinoma and is the triangular region originally described by Ho. It is defined by three points: (1) the superior margin of the sternal end of the clavicle, (2) the superior margin of the lateral end of the clavicle, (3) the point where the neck meets the shoulder. This would include caudal portions of levels IV and VB. All cases with lymph nodes (whole or part) in the fossa are considered N3b. (from AJCC 7th Ed.)
N3aNasopharyngeal Cancer pN3a TNM FindingNasopharyngeal cancer with metastasis to one or more lymph nodes greater than 6 cm in greatest dimension. (from AJCC 6th and 7th Eds.)
N3bNasopharyngeal Cancer pN3b TNM Finding v7Nasopharyngeal cancer with extension to the supraclavicular fossa. Supraclavicular zone or fossa is relevant to the staging of nasopharyngeal carcinoma and is the triangular region originally described by Ho. It is defined by three points: (1) the superior margin of the sternal end of the clavicle, (2) the superior margin of the lateral end of the clavicle, (3) the point where the neck meets the shoulder. This would include caudal portions of levels IV and VB. All cases with lymph nodes (whole or part) in the fossa are considered N3b. (from AJCC 7th Ed.)
NXNasopharyngeal Cancer pNX TNM FindingNasopharyngeal cancer in which the regional lymph nodes cannot be assessed. (from AJCC 6th and 7th Eds.)
Pathologic M StageNasopharyngeal Cancer American Joint Committee on Cancer (AJCC) Edition 7 Pathologic Distant Metastasis M Stage39151611.0CHARACTER
M1Nasopharyngeal Cancer pM1 TNM FindingNasopharyngeal cancer with distant metastasis. (from AJCC 6th and 7th Eds.)
Disease StageNasopharyngeal Cancer American Joint Committee on Cancer (AJCC) Edition 7 Group Stage39151621.0CHARACTER
0Stage 0 Nasopharyngeal CarcinomaAbnormal cells are found in the lining of the nasopharynx (the upper part of the throat behind the nose). These abnormal cells may become cancer and spread into nearby normal tissue.
IStage I Nasopharyngeal CarcinomaStage I includes: T1, N0, M0. T1: Nasopharyngeal cancer with tumor confined to the nasopharynx, or tumor extending to oropharynx and/or nasal cavity without parapharyngeal extension. Parapharyngeal extension denotes posterolateral infiltration of tumor. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)
IIStage II Nasopharyngeal CarcinomaStage II includes: (T1, N1, M0); (T2, N0, M0); (T2, N1, M0). T1: Nasopharyngeal cancer with tumor confined to the nasopharynx, or tumor extending to oropharynx and/or nasal cavity without parapharyngeal extension. Parapharyngeal extension denotes posterolateral infiltration of tumor. T2: Nasopharyngeal cancer with parapharyngeal extension. Parapharyngeal extension denotes posterolateral infiltration of tumor. N0: No regional lymph node metastasis. N1: Nasopharyngeal cancer with unilateral metastasis in cervical lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa, and/or unilateral or bilateral, retropharyngeal lymph nodes, 6 cm or less in greatest dimension. Midline nodes are considered ipsilateral nodes. M0: No distant metastasis. (AJCC 7th ed.)
IIIStage III Nasopharyngeal CarcinomaStage III includes: (T1, N2, M0); (T2, N2, M0); (T3, N0, M0); (T3, N1, M0); (T3, N2, M0). T1: Nasopharyngeal cancer with tumor confined to the nasopharynx, or tumor extending to oropharynx and/or nasal cavity without parapharyngeal extension. Parapharyngeal extension denotes posterolateral infiltration of tumor. T2: Nasopharyngeal cancer with parapharyngeal extension. Parapharyngeal extension denotes posterolateral infiltration of tumor. T3: Nasopharyngeal cancer with tumor involving bony structures of skull base and/or paranasal sinuses. N0: No regional lymph node metastasis. N1: Nasopharyngeal cancer with unilateral metastasis in cervical lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa, and/or unilateral or bilateral, retropharyngeal lymph nodes, 6 cm or less in greatest dimension. Midline nodes are considered ipsilateral nodes. N2: Nasopharyngeal cancer with bilateral metastasis in cervical lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa. Midline nodes are considered ipsilateral nodes. M0: No distant metastasis. (AJCC 7th ed.)
IVAStage IVA Nasopharyngeal CarcinomaStage IVA includes: (T4, N0, M0); (T4, N1, M0); (T4, N2, M0). T4: Nasopharyngeal cancer with intracranial extension and/or involvement of cranial nerves, hypopharynx, orbit, or with extension to the infratemporal fossa/masticator space. N0: No regional lymph node metastasis. N1: Nasopharyngeal cancer with unilateral metastasis in cervical lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa, and/or unilateral or bilateral, retropharyngeal lymph nodes, 6 cm or less in greatest dimension. Midline nodes are considered ipsilateral nodes. N2: Nasopharyngeal cancer with bilateral metastasis in cervical lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa. Midline nodes are considered ipsilateral nodes. M0: No distant metastasis. (AJCC 7th ed.)
IVBStage IVB Nasopharyngeal CarcinomaStage IVB includes: Any T, N3, M0. N3: Nasopharyngeal cancer with metastasis in a lymph node (s) more than 6 cm in greatest dimension and/or to supraclavicular fossa. Supraclavicular zone or fossa is relevant to the staging of nasopharyngeal carcinoma and is the triangular region originally described by Ho. It is defined by three points: (1) the superior margin of the sternal end of the clavicle, (2) the superior margin of the lateral end of the clavicle, (3) the point where the neck meets the shoulder. This would include caudal portions of levels IV and VB. All cases with lymph nodes (whole or part) in the fossa are considered N3b. M0: No distant metastasis. (AJCC 7th ed.)
IVCStage IVC Nasopharyngeal CarcinomaStage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 7th ed.)
Stage unknownStage UnknownA finding indicating that the extent of organ/tissue involvement by a malignant neoplasm is not reported or not assessed.
Optional Nasopharyngeal Staging QuestionsThere is no requirement for inclusion of these elements on the case report form. If the design and scientific questions posed in the study dictate the need to collect this type of data, these elements should be included.
Staging Time PointDisease Staging Timepoint Name28473521.0CHARACTER
Current DiagnosisCurrent DiagnosisOccurring in or belonging to the present time.: The investigation, analysis and recognition of the presence and nature of disease, condition, or injury from expressed signs and symptoms; also, the scientific determination of any kind; the concise results of such an investigation.
Initial DiagnosisFirst DiagnosisPreceding all others in time or space or degree.: The investigation, analysis and recognition of the presence and nature of disease, condition, or injury from expressed signs and symptoms; also, the scientific determination of any kind; the concise results of such an investigation.
RestagingRestagingRepeat of staging assessment
Study EnrollmentClinical Study EnrollmentResearch conducted with human subjects or on material of human origin in which an investigator directly interacts with human subjects; includes development of new technologies, mechanism of human diseases, therapy, clinical trials, epidemiology, behavior and health services research. : Enrollment; to insert, register, or enter in a list, catalog, or roll. (Merriam-Webster Online)