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Long NameStaging, Thyroid NCI Standard Template
DefinitionThe collection of CDEs used in the staging module based on AJCC Edition 7.
ContextcaBIG
Protocol Long NameNCI Standard Template Forms
WorkflowRELEASED
TypeCRF
Public ID3461837
Version1.0
Module Long NameModule InstructionsQuestionCDECDE Public IDCDE VersionQuestion InstructionsValue Domain Data TypeValue Domain Unit of MeasureDisplay FormatValid ValueForm Value Meaning TextForm Value Meaning Desc.
Mandatory Thyroid Staging QuestionsThese items must be included when this data is collected for reporting.
Date Current Staging Assessment CompletedCurrent Stage Complete Assessment Date627393.0DATEMM/DD/YYYY
Conditional Thyroid Staging QuestionsThere are business rules to indicate situations under which this element should be used on a case report form.
Clinical T StageThyroid Cancer American Joint Committee on Cancer (AJCC) Edition 7 Clinical Tumor T Stage33714351.0Conditionality Rule: Inclusion based on patient population being studied.CHARACTER
TXThyroid Cancer pTX TNM FindingThyroid cancer in which the primary tumor cannot be assessed. (from AJCC 6th and 7th Eds.)
T0Thyroid Cancer pT0 TNM FindingThyroid cancer with no evidence of primary tumor. (from AJCC 6th and 7th Eds.).
T1Thyroid Cancer pT1 TNM FindingThyroid cancer with a tumor size of 2 cm or less in greatest dimension, and limited to the thyroid gland. (from AJCC 6th and 7th Eds.)
T1aThyroid Cancer pT1a TNM Finding v7Thyroid cancer with a tumor size of 1 cm or less in greatest dimension, limited to the thyroid gland. (from AJCC 7th Ed.)
T1bThyroid Cancer pT1b TNM Finding v7Thyroid cancer with a tumor size of more than 1 cm but not more than 2 cm in greatest dimension, limited to the thyroid gland. (from AJCC 7th Ed.)
T2Thyroid Cancer pT2 TNM FindingThyroid cancer with a tumor size greater than 2 cm but not more than 4 cm in greatest dimension, and limited to the thyroid gland. (from AJCC 6th and 7th Eds.)
T3Thyroid Cancer pT3 TNM FindingThyroid cancer with a tumor size greater than 4 cm in greatest dimension and limited to the thyroid gland, or a tumor of any size with minimal extrathyroid extension (e.g., extension to sternothyroid muscle or perithyroid soft tissues). (from AJCC 6th and 7th Eds.)
T4aThyroid Cancer pT4a TNM Finding v7Thyroid cancer with moderately advanced local disease. Tumor of any size extending beyond the thyroid gland capsule to invade subcutaneous soft tissues, larynx, trachea, esophagus, or recurrent laryngeal nerve. (from AJCC 7th Ed.)
T4bThyroid Cancer pT4b TNM Finding v7Thyroid cancer with very advanced disease. Tumor invades prevertebral fascia or encases carotid artery or mediastinal vessels. (from AJCC 7th Ed.)
Clinical T Stage, AnaplasticThyroid Cancer American Joint Committee on Cancer (AJCC) Edition 7 Anaplastic Clinical Tumor T Stage33714361.0All anaplastic carcinomas are considered T4 tumors. Conditionality Rule: Inclusion based on patient population being studied.CHARACTER
T4aThyroid Cancer pT4a Anaplastic Carcinoma TNM Finding v7Intrathyroidal anaplastic carcinoma. (from AJCC 7th Ed.)
T4bThyroid Cancer pT4b Anaplastic Carcinoma TNM Finding v7Anaplastic carcinoma with gross extrathyroid extension. (from AJCC 7th Ed.)
Clinical N StageThyroid Cancer American Joint Committee on Cancer (AJCC) Edition 7 Clinical Regional Lymph Node N Stage33714401.0Conditionality Rule: Inclusion based on patient population being studied.CHARACTER
NXThyroid Cancer pNX TNM FindingThyroid cancer in which regional lymph nodes cannot be assessed. (from AJCC 6th and 7th Eds.)
N0Thyroid Cancer pN0 TNM FindingThyroid cancer with no regional lymph node metastasis. (from AJCC 6th and 7th Eds.)
N1Thyroid Cancer pN1 TNM FindingThyroid cancer with metastasis to regional lymph nodes. (from AJCC 6th and 7th Eds.)
N1aThyroid Cancer pN1a TNM FindingThyroid cancer with metastasis to pretracheal, paratracheal or prelaryngeal/Delphian lymph nodes (Level VI lymph nodes). (from AJCC 6th and 7th Eds.)
N1bThyroid Cancer pN1b TNM Finding v7Thyroid cancer with metastasis to unilateral, bilateral or contralateral cervical (Levels I, II, III, IV, or V) or retropharyngeal or superior mediastinal lymph nodes (Level VII). (from AJCC 7th Ed.)
Clinical M StageThyroid Cancer American Joint Committee on Cancer (AJCC) Edition 7 Clinical Distant Metastasis M Stage33714411.0Conditionality Rule: Inclusion based on patient population being studied.CHARACTER
M0Thyroid Cancer cM0 TNM Finding v7Thyroid cancer without evidence of distant metastasis. (from AJCC 7th Ed.)
M1Thyroid Cancer cM1 TNM Finding v7Thyroid cancer with distant metastasis. (from AJCC 7th Ed.)
Pathologic T StageThyroid Cancer American Joint Committee on Cancer (AJCC) Edition 7 Pathologic Tumor T Stage33714421.0Conditionality Rule: Inclusion based on patient population being studied.CHARACTER
TXThyroid Cancer pTX TNM FindingThyroid cancer in which the primary tumor cannot be assessed. (from AJCC 6th and 7th Eds.)
T0Thyroid Cancer pT0 TNM FindingThyroid cancer with no evidence of primary tumor. (from AJCC 6th and 7th Eds.).
T1Thyroid Cancer pT1 TNM FindingThyroid cancer with a tumor size of 2 cm or less in greatest dimension, and limited to the thyroid gland. (from AJCC 6th and 7th Eds.)
T1aThyroid Cancer pT1a TNM Finding v7Thyroid cancer with a tumor size of 1 cm or less in greatest dimension, limited to the thyroid gland. (from AJCC 7th Ed.)
T1bThyroid Cancer pT1b TNM Finding v7Thyroid cancer with a tumor size of more than 1 cm but not more than 2 cm in greatest dimension, limited to the thyroid gland. (from AJCC 7th Ed.)
T2Thyroid Cancer pT2 TNM FindingThyroid cancer with a tumor size greater than 2 cm but not more than 4 cm in greatest dimension, and limited to the thyroid gland. (from AJCC 6th and 7th Eds.)
T3Thyroid Cancer pT3 TNM FindingThyroid cancer with a tumor size greater than 4 cm in greatest dimension and limited to the thyroid gland, or a tumor of any size with minimal extrathyroid extension (e.g., extension to sternothyroid muscle or perithyroid soft tissues). (from AJCC 6th and 7th Eds.)
T4aThyroid Cancer pT4a TNM Finding v7Thyroid cancer with moderately advanced local disease. Tumor of any size extending beyond the thyroid gland capsule to invade subcutaneous soft tissues, larynx, trachea, esophagus, or recurrent laryngeal nerve. (from AJCC 7th Ed.)
T4bThyroid Cancer pT4b TNM Finding v7Thyroid cancer with very advanced disease. Tumor invades prevertebral fascia or encases carotid artery or mediastinal vessels. (from AJCC 7th Ed.)
Pathologic T Stage, AnaplasticThyroid Cancer American Joint Committee on Cancer (AJCC) Edition 7 Anaplastic Pathologic Tumor T Stage33714431.0All anaplastic carcinomas are considered T4 tumors. Conditionality Rule: Inclusion based on patient population being studied.CHARACTER
T4aThyroid Cancer pT4a Anaplastic Carcinoma TNM Finding v7Intrathyroidal anaplastic carcinoma. (from AJCC 7th Ed.)
T4bThyroid Cancer pT4b Anaplastic Carcinoma TNM Finding v7Anaplastic carcinoma with gross extrathyroid extension. (from AJCC 7th Ed.)
Pathologic N StageThyroid Cancer American Joint Committee on Cancer (AJCC) Edition 7 Pathologic Regional Lymph Node N Stage33714441.0Conditionality Rule: Inclusion based on patient population being studied.CHARACTER
NXThyroid Cancer pNX TNM FindingThyroid cancer in which regional lymph nodes cannot be assessed. (from AJCC 6th and 7th Eds.)
N0Thyroid Cancer pN0 TNM FindingThyroid cancer with no regional lymph node metastasis. (from AJCC 6th and 7th Eds.)
N1Thyroid Cancer pN1 TNM FindingThyroid cancer with metastasis to regional lymph nodes. (from AJCC 6th and 7th Eds.)
N1aThyroid Cancer pN1a TNM FindingThyroid cancer with metastasis to pretracheal, paratracheal or prelaryngeal/Delphian lymph nodes (Level VI lymph nodes). (from AJCC 6th and 7th Eds.)
N1bThyroid Cancer pN1b TNM Finding v7Thyroid cancer with metastasis to unilateral, bilateral or contralateral cervical (Levels I, II, III, IV, or V) or retropharyngeal or superior mediastinal lymph nodes (Level VII). (from AJCC 7th Ed.)
Pathologic M StageThyroid Cancer American Joint Committee on Cancer (AJCC) Edition 7 Pathologic Distant Metastasis M Stage33714451.0Conditionality Rule: Inclusion based on patient population being studied.CHARACTER
M1Thyroid Cancer pM1 TNM FindingThyroid cancer with distant metastasis. (from AJCC 6th and 7th Eds.)
Papillary of Follicular Disease Stage, Under 45 YearsPapillary or Follicular (Differentiated) Thyroid Cancer American Joint Committee on Cancer (AJCC) Edition 7 Under 45 Years Group Stage34618301.0Conditionality Rule: Inclusion based on patient population being studied.CHARACTER
IStage I Differentiated Thyroid Gland Carcinoma Under 45 YearsAny T, Any N, M0. M0: No evidence of distant metastasis. (from AJCC 7th Ed.)
IIStage II Differentiated Thyroid Gland Carcinoma Under 45 YearsStage II includes: Any T, Any N, M1. M1: Distant metastasis. (from AJCC 7th Ed.)
Stage unknownStage UnknownA finding indicating that the extent of organ/tissue involvement by a malignant neoplasm is not reported or not assessed.
Papillary of Follicular Disease Stage, 45 Years and OlderPapillary or Follicular (Differentiated) Thyroid Cancer American Joint Committee on Cancer (AJCC) Edition 7 45 Years and Older Group Stage34618311.0Conditionality Rule: Inclusion based on patient population being studied.CHARACTER
IStage I Differentiated Thyroid Gland Carcinoma 45 Years and OlderT1, N0, M0. T1: Tumor size 2 cm or less in greatest dimension, limited to the thyroid gland. N0: No regional lymph node metastasis. M0: No evidence of distant metastasis. (from AJCC 7th Ed.)
IIStage II Differentiated Thyroid Gland Carcinoma 45 Years and OlderStage II includes: T2, N0, M0. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension, limited to the thyroid gland. N0: No regional lymph node metastasis. M0: No evidence of distant metastasis. (from AJCC 7th Ed.)
IIIStage III Differentiated Thyroid Gland CarcinomaStage III includes: (T3, N0, M0); (T1, N1a, M0); (T2, N1a, M0); (T3, N1a, M0). T3: Tumor greater than 4 cm in greatest dimension and limited to the thyroid gland, or tumor of any size with minimal extrathyroid extension (e.g., extension to sternothyroid muscle or perithyroid soft tissues). T1: Tumor size 2 cm or less in greatest dimension, limited to the thyroid gland. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension, limited to the thyroid gland. N0: No regional lymph node metastasis. N1a: Metastasis to pretracheal, paratracheal or prelaryngeal/Delphian lymph nodes (Level VI lymph nodes). M0: No distant metastasis. (AJCC 7th ed.)
IVAStage IVA Differentiated Thyroid Gland CarcinomaStage IVA includes: (T4a, N0, M0); (T4a, N1a, M0); (T1, N1b, M0); (T2, N1b, M0); (T3, N1b, M0); (T4a, N1b, M0). T4a: Moderately advanced local disease. Tumor of any size extending beyond the thyroid gland capsule to invade subcutaneous soft tissues, larynx, trachea, esophagus, or recurrent laryngeal nerve. ). T1: Tumor size 2 cm or less in greatest dimension, limited to the thyroid gland. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension, limited to the thyroid gland. T3: Tumor more than 4 cm in greatest dimension and limited to the thyroid gland, or tumor of any size with minimal extrathyroid extension (e.g., extension to sternothyroid muscle or perithyroid soft tissues). N0: No regional lymph node metastasis. N1a: Metastasis to pretracheal, paratracheal or prelaryngeal/Delphian lymph nodes (Level VI lymph nodes). N1b: Metastasis to unilateral, bilateral or contralateral cervical (Levels I, II, III, IV, or V) or retropharyngeal or superior mediastinal lymph nodes (Level VII). M0: No distant metastasis. (AJCC 7th ed.)
IVBStage IVB Differentiated Thyroid Gland CarcinomaStage IVB includes: T4b, Any N, M0. T4b: Very advanced disease. Tumor invades prevertebral fascia or encases carotid artery or mediastinal vessels. M0: No distant metastasis. (AJCC 7th ed.)
IVCStage IVC Differentiated Thyroid Gland CarcinomaStage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 7th ed.)
Stage unknownStage UnknownA finding indicating that the extent of organ/tissue involvement by a malignant neoplasm is not reported or not assessed.
Medullary Disease StageMedullary Thyroid Cancer American Joint Committee on Cancer (AJCC) Edition 7 Group Stage34618321.0Conditionality Rule: Inclusion based on patient population being studied.CHARACTER
IStage I Thyroid Gland Medullary CarcinomaStage I includes: T1, N0, M0. T1: Tumor size 2 cm or less in greatest dimension, limited to the thyroid gland. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)
IIStage II Thyroid Gland Medullary CarcinomaStage II includes: (T2, N0, M0); (T3, N0, M0). T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension, limited to the thyroid gland. T3: Tumor more than 4 cm in greatest dimension and limited to the thyroid gland, or tumor of any size with minimal extrathyroid extension (e.g., extension to sternothyroid muscle or perithyroid soft tissues). N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.)
IIIStage III Thyroid Gland Medullary CarcinomaStage III includes: (T1, N1a, M0); (T2, N1a, M0); (T3, N1a, M0). T1: Tumor size 2 cm or less in greatest dimension, limited to the thyroid gland. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension, limited to the thyroid gland. T3: Tumor more than 4 cm in greatest dimension and limited to the thyroid gland, or tumor of any size with minimal extrathyroid extension (e.g., extension to sternothyroid muscle or perithyroid soft tissues). N1a: Metastasis to pretracheal, paratracheal or prelaryngeal/Delphian lymph nodes (Level VI lymph nodes). M0: No distant metastasis. (AJCC 7th ed.)
IVAStage IVA Thyroid Gland Medullary CarcinomaStage IVA includes: (T4a, N0, M0); (T4a, N1a, M0); (T1, N1b, M0); (T2, N1b, M0); (T3, N1b, M0); (T4a, N1b, M0). T4a: Moderately advanced local disease. Tumor of any size extending beyond the thyroid gland capsule to invade subcutaneous soft tissues, larynx, trachea, esophagus, or recurrent laryngeal nerve. ). T1: Tumor size 2 cm or less in greatest dimension, limited to the thyroid gland. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension, limited to the thyroid gland. T3: Tumor more than 4 cm in greatest dimension and limited to the thyroid gland, or tumor of any size with minimal extrathyroid extension (e.g., extension to sternothyroid muscle or perithyroid soft tissues). T4b: Very advanced disease. Tumor invades prevertebral fascia or encases carotid artery or mediastinal vessels. N0: No regional lymph node metastasis. N1a: Metastasis to pretracheal, paratracheal or prelaryngeal/Delphian lymph nodes (Level VI lymph nodes). N1b: Metastasis to unilateral, bilateral or contralateral cervical (Levels I, II, III, IV, or V) or retropharyngeal or superior mediastinal lymph nodes (Level VII). M0: No distant metastasis. (AJCC 7th ed.)
IVBStage IVB Thyroid Gland Medullary CarcinomaStage IVB includes: T4b, Any N, M0. T4b: Very advanced disease. Tumor invades prevertebral fascia or encases carotid artery or mediastinal vessels. M0: No distant metastasis. (AJCC 7th ed.)
IVCStage IVC Thyroid Gland Medullary CarcinomaStage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 7th ed.)
Stage unknownStage UnknownA finding indicating that the extent of organ/tissue involvement by a malignant neoplasm is not reported or not assessed.
Anaplastic Disease StageAnaplastic Thyroid Cancer American Joint Committee on Cancer (AJCC) Edition 7 Group Stage34618331.0All anaplastic carcinomas are considered Stage IV Conditionality Rule: Inclusion based on patient population being studied.CHARACTER
IVAStage IVA Thyroid Gland Undifferentiated (Anaplastic) CarcinomaStage IVA includes: T4a, Any N, M0. T4a: Intrathyroidal anaplastic carcinoma. M0: No distant metastasis. (AJCC 7th ed.)
IVBStage IVB Thyroid Gland Undifferentiated (Anaplastic) CarcinomaStage IVB includes: T4b, Any N, M0. T4b: Anaplastic carcinoma with gross extrathyroid extension. M0: No distant metastasis. (AJCC 7th ed.)
IVCStage IVC Thyroid Gland Undifferentiated (Anaplastic) CarcinomaStage IVC includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 7th ed.)
Stage unknownStage UnknownA finding indicating that the extent of organ/tissue involvement by a malignant neoplasm is not reported or not assessed.
Optional Thyroid Staging QuestionsThere is no requirement for inclusion of these elements on the case report form. If the design and scientific questions posed in the study dictate the need to collect this type of data, these elements should be included.
Staging Time PointDisease Staging Timepoint Name28473521.0CHARACTER
Current DiagnosisCurrent DiagnosisOccurring in or belonging to the present time.: The investigation, analysis and recognition of the presence and nature of disease, condition, or injury from expressed signs and symptoms; also, the scientific determination of any kind; the concise results of such an investigation.
Initial DiagnosisFirst DiagnosisPreceding all others in time or space or degree.: The investigation, analysis and recognition of the presence and nature of disease, condition, or injury from expressed signs and symptoms; also, the scientific determination of any kind; the concise results of such an investigation.
RestagingRestagingRepeat of staging assessment
Study EnrollmentClinical Study EnrollmentResearch conducted with human subjects or on material of human origin in which an investigator directly interacts with human subjects; includes development of new technologies, mechanism of human diseases, therapy, clinical trials, epidemiology, behavior and health services research. : Enrollment; to insert, register, or enter in a list, catalog, or roll. (Merriam-Webster Online)