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This chapter describes how to manage the samples' information accessible from the Navigation Tree. This section includes the following topics:
You can perform the procedures described in this chapter only if you have curator status. If you have view only permissions, see 4 - Managing Sample Composition Annotations 2.1 DRAFT. |
Sample composition records information associated with the way a sample is made, especially in terms of its different parts, its constituents. Composition for a sample in caNanoLab consists of information categorized by nanomaterial entity, functionalizing entity, and chemical association(s). Files relevant to the sample composition or derivation of its data can also be added.
In the Navigation Tree on the left sidebar, click the Composition button. Five tabs showing composition subcategories display on the page that opens.
Select the Add button on the All tab that corresponds to the category of composition annotations you want to add, or select the specific tab itself where you can also add composition data to the sample. The All tab displays any composition annotations that have already been added to the sample; the composition category tabs also display annotations specific to those categories.
You may have the option to add or delete composition details with Add and Delete buttons. If you do not have certain security privileges, the Add and Delete buttons are hidden, and you have read-only access to the existing items. |
See also:
4 - Managing Sample Composition Annotations 2.1 DRAFT
4 - Managing Sample Composition Annotations 2.1 DRAFT
4 - Managing Sample Composition Annotations 2.1 DRAFT
4 - Managing Sample Composition Annotations 2.1 DRAFT
After you click the Composition button on the Navigation Tree, on the All tab click the Add button associated with Nanomaterial Entity or select the Nanomaterial Entity tab where you can also click the Add button to add composition data. Using the Nanomaterial Entity composition feature, you can enter data or add files pertaining to the nanomaterial component of the sample.
The page that opens is organized into four sections. This page is the same for all nanomaterial composition data, except for slight customizations based what you select in the Nanomaterial Entity field. Instructions for using the page are outlined in the steps below.
The following nanomaterial entity types can be selected in the Nanomaterial Entity Summary. Once selected, a Property section appears on the page. You can describe properties for each type by following these links.
After defining the particle properties, continue the process described in 4 - Managing Sample Composition Annotations 2.1 DRAFT.
A biopolymer nanoparticle is a type of polymer that is produced by living organisms. In the context of nanotechnology, a biopolymer can also be a nanomaterial entity or a functionalizing entity.
To define biopolymer properties, follow these steps:
After defining the particle properties, continue the process described in 4 - Managing Sample Composition Annotations 2.1 DRAFT.
Carbon nanotubes (CNTs) are fullerene-like nanostructures that consist of graphene cylinders. The ends of the construct are closed with pentagonal-shaped rings.
To define carbon nanotube properties, follow these steps:
After defining the particle properties, continue the process described in 4 - Managing Sample Composition Annotations 2.1 DRAFT.
A dendrimer is a polymeric molecule which has a highly-branched, three-dimensional architecture. Dendrimers are synthesized from monomers and new branches are added in discrete steps to form a tree-like architecture. A high level of synthetic control is achieved through iterative reactions and purification at each step to regulate the size, architecture, functionality and monodispersity of the molecules. These polymers have desirable pharmacokinetic properties and a polyvalent array of surface groups that make them potential drug delivery vesicles.
To define dendrimer properties, follow these steps:
After defining the particle properties, continue the process described in 4 - Managing Sample Composition Annotations 2.1 DRAFT.
An emulsion is a suspension of liquid within another liquid or a dispersion consisting of two or more liquid phases. In the context of caNanoLab, an emulsion nanoparticle consists of nanoparticles suspended in an emulsifying liquid.
To define emulsion properties, follow these steps:
After defining the particle properties, continue the process described in4 - Managing Sample Composition Annotations 2.1 DRAFT .
A fullerene is one of three known pure forms of carbon that exhibits a spherical shape with a hollow interior; named after Buckminster Fuller. The number of carbon atoms comprising fullerenes is variable; several stable spherical carbon structures containing 70 or more atoms have been documented.
To define fullerene properties, follow these steps:
After defining the particle properties, continue the process described in 4 - Managing Sample Composition Annotations 2.1 DRAFT .
Liposomes are substances composed of layers of lipid that form hollow microscopic spheres within which drugs or agents could be contained for enhanced safety and efficacy. Based upon its size measured in nanometer range, a liposome can be categorized as a nanoparticle.
To define liposome properties, follow these steps:
After defining the particle properties, continue the process described in 4 - Managing Sample Composition Annotations 2.1 DRAFT.
A metal particle is a nanoparticle composed of electropositive chemical elements characterized by ductility, malleability, luster, and conductance of heat and electricity. They can replace the hydrogen of an acid and form bases with hydroxyl radicals.
There are no unique metal particle properties to be defined. Continue the process described in 4 - Managing Sample Composition Annotations 2.1 DRAFT.
A key feature that distinguishes polymers from other molecules is the repetition of a linked series of many identical, similar, or complementary monomers. A polymer nanoparticle is just that--a polymer measured in nanometer range.
To define polymer properties, follow these steps:
After defining the particle properties, continue the process described in 4 - Managing Sample Composition Annotations 2.1 DRAFT.
A Quantum Dot is a nanometer-sized semiconductor particle, made of cadmium selenide (CdSe), cadmium sulfide (CdS) or cadmium telluride (CdTe) with an inert polymer coating. The semiconductor material used for the core is chosen based upon the emission wavelength range being targeted: CdS for UV-blue, CdSe for the bulk of the visible spectrum, and CdTe for far red and near-infrared. The size of the particle determines the exact color of a given quantum dot. The polymer coating protects cells from cadmium toxicity but also facilitates the attachment of a variety of targeting molecules, including monoclonal antibodies directed to tumor-specific biomarkers. Because of their small size, quantum dots can function as cell- and even molecule-specific markers that will not interfere with the normal cellular functions.
There are no unique quantum dot properties to be defined. Continue the process described in 4 - Managing Sample Composition Annotations 2.1 DRAFT.
This section opens automatically when you open the Nanomaterial Entity section. See 4 - Managing Sample Composition Annotations 2.1 DRAFT.
To define composing elements for the nanomaterial entity, follow these steps:
After defining composing elements, continue the process described in 4 - Managing Sample Composition Annotations 2.1 DRAFT.
To add results in the form of supporting documentation to the nanomaterial entity, follow these steps.
After adding one or more files, return to the steps described in 4 - Managing Sample Composition Annotations 2.1 DRAFT.
After you click the Composition button on the Navigation Tree, on the All tab click the Add button associated with Functionalizing Entity or select the Functionalizing Entity tab where you can also click the Add button to add composition data. Using the Functionalizing Entity composition feature, you can enter data or add files describing the substance, physical or biological factor, etc. of the sample that produces a specific effect or function.
The page that opens is organized into four sections. This page is the same for all functionalizing entity composition data, except for slight variations based what you select in the Functionalizing Entity Type* field. Instructions for using the page are outlined in the steps below.
To continue defining Functionalizing Entity fields, follow these steps.
After defining the Functionalizing Entity, continue the process described in 4 - Managing Sample Composition Annotations 2.1 DRAFT.
The [Funtionalizing Entity Type] Properties section opens for some Functionalizing Entity types as you make that selection. To define properties for each unique functionalizing entity, enter information for the following fields.
Antibody – Select from the following fields:
Biopolymer – Select from the following fields:
Small Molecule: Add an Alternate Name for the Small Molecule.
After defining the Functionalizing Entity properties, continue the process described in 4 - Managing Sample Composition Annotations 2.1 DRAFT.
To define function information for the functionalizing entity, follow these steps.
In the Navigation Tree, a hypertext link for the new Composition characterization is added under Functionalizing Entity.
After defining the function Information, continue the process described in 4 - Managing Sample Composition Annotations 2.1 DRAFT.
To add results in the form of supporting documents to the functionalizing entity, follow these steps:
As appropriate, continue the process described in 4 - Managing Sample Composition Annotations 2.1 DRAFT or Adding Chemical Association Composition Annotations.
Using the [Sample] Composition Chemical Association subcategory, you can enter basic annotation information describing the chemical association(s) of the sample and/or functionalizing entities of the sample.
To enter chemical association information, you must have entered at least two composing elements and/or at least one functionalizing entity for the sample entity. |
To enter chemical association information, follow these steps.
This section of the [Sample] Composition category allows you to add files relevant to the sample independently of the entity or chemical associations that you defined. You can add as many files as you wish.
To add a file, follow these steps.
After adding one or more files, continue the process described in 4 - Managing Sample Composition Annotations 2.1 DRAFT.
You can add as many files as you wish. |
For more information about working with publications, see Managing Publications.
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