This section describes how to review or ascribe characterizations to samples that have been submitted to caNanoLab. This section includes the following topics:
You can perform the procedures described in this section only if you have curator status. If you have view only permissions, see Viewing Characterizations Summary. |
Sample characterization, describing distinctive characteristics or essential features of the sample determined through analytical methods, records information associated with sample synthesis and properties. Samples can be characterized in caNanoLab by physical or chemical characteristics, or by data derived under in vitro and in vivo conditions.
To access characterization functions in the Navigation Tree
The All tab displays characterizations already added to the sample. The remaining tabs show annotations specific to those categories.
Based on your security privileges, you may have read-only access to existing items or the ability to Add and Delete function details. |
On the All tab, with the appropriate security privileges, click Add next to the category of characterization annotations you want to add, such as Physico-chemical Characterization. You can also select the corresponding tab where you can add characterizations to the sample.
The page that opens after you click an Add button to add a characterization is very similar for all characterization types. The page differs only in the Properties section if there are special properties driven by the selection of characterization names. They also differ in the drop-down values for the column name in the Finding section driven by the characterization name and assay type selections.
The following links provide additional details.
See also Viewing Characterizations Summary.
Physico-chemical characterization allows you to enter physical or chemical characterizations for the nanomaterial component of the sample.
To continue defining Physico-Chemical Characterization fields
After defining the summary, continue to add a Physico-Chemical Characterization.
The [Characterization] Properties section opens only for the characterizations listed in the table below. To define properties for the characterizations, complete the fields as described in the following table.
Characterization | Property Fields | Field Options |
---|---|---|
Physical State | Type | Select the appropriate type from among the following options: |
Shape Properties | Type (required) | Select from the drop-down list the appropriate shape type: |
Shape Properties | Aspect Ratio | Enter the shape aspect ratio. |
Shape Properties | Minimum,/Maximum Dimensions | Enter the minimum and maximum dimensions of the sample, as well as the units of measurement. |
Solubility Properties | Solvent | Select from the options or enter the name.
|
Solubility Properties | Critical Concentration | Enter appropriate values for the critical concentration, then select the appropriate units for those values. |
Solubility Properties | Is Soluble? | Select Yes or No as to whether the solvent is soluble. |
Surface Properties | Is Hydrophobic? | Indicate with Yes or No whether the surface is hydrophobic. |
After defining the [characterization] properties, continue to add a Physico-Chemical Characterization.
In the Design and Methods sections, complete the fields as described in the following table.
Design and Methods Field | Description |
---|---|
Description | Enter design and methods information not covered by other fields on the form. |
Technique and Instrument | |
Technique* | |
Abbreviation | |
Description | Enter an appropriate description for the characterization design and methods. |
Instrument |
Once you enter the data, click Save to save the information to the sample or Cancel to close the mini-window without saving data.
Continue to add a Physico-Chemical Characterization.
In the Finding sections, you can add one or more publications relevant to the sample as well as data derived for the sample. You can add as many files and derived data as you wish, or you can add derived data without adding files.
Click Add to expand the section, then add data and conditions and add a file.
In the Data and Conditions segment of the window, you can create a matrix where you can enter data values and/or other information, such as laboratory conditions like pH or temperature that are part of your findings.
To define the data and condition matrix, follow these steps.
Column Type "Datum" is selected with this characterization | Autopopulated Column Name Option[s] |
---|---|
Molecular Weight | |
Purity | |
Relaxivity | |
Size | |
Surface |
After adding data and conditions to the sample, continue to add a Physico-Chemical Characterization.
After adding one or more files, add data and conditions or if you have no derived data to add, add a Physico-Chemical Characterization.
In vitro characterization allows you to add characterizations for the nanomaterial component of the sample that were derived from analytical techniques performed under in vitro conditions.
To continue defining this characterization
After defining the summary, add an In Vitro Characterization.
Specify one of the following in vitro Assay Type options or select [Other] to open a window where you can add a new assay type.
Characterization Selection | Assay Type Corresponding to Characterization |
---|---|
Blood Contact | |
Cytotoxicity | |
Immune Cell Function | |
Oxidative stress | |
Sterility | |
Targeting | |
Transfection | Click [Other] to add an assay type. |
The [Characterization] Properties section opens only when you select the following characterizations in the Summary section. To define properties for each unique characterization, enter information for the following fields.
After defining the [characterization] properties, add an In Vitro Characterization.
In the Design and Methods sections, complete the fields as described in the following table.
Design and Methods Field | Description |
---|---|
Technique and Instrument | |
Technique* | |
Abbreviation | |
Description | Enter an appropriate description for the characterization design and methods. |
Instrument |
Once you enter the data, click Save to save the information to the sample or Cancel to close the mini-window without saving data.
Continue to adding an In Vitro Characterization.
In the Finding sections, you can add one or more publications relevant to the sample as well as data derived for the sample. You can add as many files and derived data as you wish, or you can add derived data without adding files.
Click Add to expand the section, then add data and conditions and add a file.
In the Data and Conditions segment of the window, you can create a matrix where you can enter data values and/or other information, such as laboratory conditions that are part of your findings.
To define the matrix for the data, follow these steps.
Column Type "Datum" is selected with this characterization | Autopopulated Column Name Option[s] |
---|---|
Enzyme Induction |
After adding data and conditions to the sample, add an In Vitro Characterization.
In vivo characterization allows you to add characterizations for the nanomaterial component of the sample that were derived from analytical techniques performed under in vivo conditions.
To continue defining Summary fields
After defining the summary, continue the process described in Adding an In Vivo Characterization.
In the Design and Methods sections, complete the fields as described in the following table.
Design and Methods Field | Description |
---|---|
Description | Enter information not covered by other fields on the form. |
Technique and Instrument | |
Technique* | |
Abbreviation | |
Description | Enter an appropropriate description for the design and methods. |
Instrument |
Once you specify the data, click Save to save the information to the sample or Cancel to close the mini-window without saving data.
Continue the process described in Adding an In Vivo Characterization.
In the Finding sections, you can add one or more publications relevant to the sample as well as data derived for the sample. You can add as many files and derived data as you wish, or you can add derived data without adding files.
Complete the instructions as described in Adding Data and Conditions and Adding a File.
In the Data and Conditions segment of the window, you can create a matrix where you can enter data values and/or other information that are part of your findings.
To define the matrix for the data
For an in vivo characterization, click [Other] to name the column yourself.
After adding one or more files, continue by Adding Data and Conditions or if you have no derived data to add, return to the steps described in Adding an In Vivo Characterization.
Sample characterization, describing distinctive characteristics or essential features of the sample determined through analytical methods, records information associated with sample synthesis and properties. Samples can be characterized in caNanoLab by physical or chemical characteristics, or by data derived under in vitro and in vivo conditions.
To view a sample characterizations summary
caNanoLab lists characterizations that have been added to a sample under their corresponding Physical, In Vitro and In Vivo Characterization subcategories when you select the Characterization button on the Navigation Tree.
See also Characterization Tasks.
If you have read only permissions, you will be able to view characterization but not perform associated tasks |
From a characterization summary page, and with curator privileges, you can perform these tasks:
To print a characterization
If buttons described in this section do not display, then you can assume that you have read-only access to the data. |
To export a characterization
If buttons described in this section do not display, then you can assume that you have read-only access to the data. |
To edit a characterization
If buttons described in this section do not display, then you can assume that you have read-only access to the data. |
The characterization files and/or derived data for this sample can be copied to other samples from the same primary point of contact.
To copy characterizations, open the sample characterization form that displays the characterization
If buttons described in this section do not display, then you can assume that you have read-only access to the data. |
To delete a characterization for a selected sample
This only deletes the characterization(s) for the selected sample. If the characterization(s) is copied for other samples, the characterization will not be deleted. |
Deleted characterizations are placed in the sample archive for history purposes.
If buttons described in this section do not display, then you can assume that you have read-only access to the data. |
Click the Publications button on the Navigation Tree. A Publication[s] summary page displays those publications associated with the sample, and the publication identifier, title, authors and year, where appropriate. Additionally, each publication category tab displays its corresponding publications.
Either on the Publications All tab or the subcategory tabs, you can
If you work from the Publications menu option, you can associate multiple samples with a publication. Alternatively, if you add publications to an open sample using the Navigation Tree option, you can use the copy feature to associate the publication with other samples in the same way you copy characterizations to multiple samples. See Copying Characterizations.