The initial query with the DICubed i2b2 prototype will be to find the number of patients between the ages of 40 and 50 years. To perform a query in i2b2, one must select query terms from the "Navigate Terms" tab in the upper left of the screen. Opening the Demographics folder, we see a term for Age, along with folders for Race and Sex. As we hover over of the Age term we see a tooltip with a definition of the term along with its NCIt code. Next, we drag the Age term from the Navigate Terms view and drop it in the Query Tool. We see a window that lets us enter parameters for the age term. We select the between operator, and then set 40 and 50 and our lower and upper bound. After clicking OK, we see that 40 - 50 Years range reflected in the Query Tool. To execute the query, press the Run Query button. We see a variety of query options that are available in the system. Select Number of Patients and click OK to execute the query. The query returns with a patient count of 124 patients between the ages of 40 and 50 years. |
Age40_50_Part2 Description
Next, we stratify the query by gender, vital status, race, data set, anatomic site, organ, and clinical course of disease. We press the Run Query but now we select the breakdown queries. Running the query again returns 124 patients, but let us examine the Query Report more closely. We maximize the report area and chose Query Report. The query definition is shown. We see a table for total patients and then tables and bar charts each breakdown option selected. First, we see gender, then vital status, race, dataset (note that the TCGA-BRCA data did not include age), anatomic set, and course of disease. |
We now modify the query to find patients with invasive lobular breast carcinoma between the ages of 40 and 50. In the Navigate Terms window, open the Primary Diagnosis folder. We see the subset of primary diagnoses applicable to the collection data in the prototype. Drag Invasive Lobular Breast Carcinoma to the Query Tool pane group 2. The prototype will search for patients with Age between 40 and 50 AND with Invasive Lobular Breast Carcinoma. Run the query with the breakdown options as before. We now see only 3 patients fit these criteria. |
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We will now do a new query. This query will be to find the number of triple negative (negative estrogen, progesterone, and HER2/Neu) patients in our system. We open up the receptor status folder. Then open the Estrogen Receptor Status folder and drag the Estrogen Receptor Negative term to the Query Tool. Then open the HER2/Neu status folder and drag the HER2/Neu Negative to Query Tool Group 2. Likewise, open the Progesterone Receptor Status folder and drag the Progesterone Receptor Negative to Group 3 in the Query Tool. We now run the query. We note that we have 78 triple negative patients in the system. Examining the report, we see that the report includes all of the terms and make up the query definition. |