Note: These collections are currently being migrated to The Cancer Imaging Archive (TCIA) and will be available again shortly with the exception of RIDER Pilot, which is being deprecated. |
The Reference Image Database to Evaluate Therapy Response (RIDER) database is a targeted data collection for the purpose of generating an initial consensus on how to harmonize data collection and analysis for quantitative imaging methods as applied to measure the response to drug or radiation therapy. The long term goal is to provide a resource to permit harmonized methods for data collection and analysis across different commercial imaging platforms, as required to support multi-site clinical trials, using imaging as a biomarker for therapy response. Thus the database should permit an objective comparison of methods for data collection and analysis as a national and international resource as described in the first RIDER white paper report (2006):
All the image data are DICOM compliant and the image, annotations and meta data formats meets all the requirements for caBIG and the NBIA. The data collection has two phases as described below, which have resulted in several distinct image Collections.
This data collection was originally supported under supplemental funding for the LIDC U01 project and focused on the collection of longitudinal studies using X-ray CT for monitoring the response to therapy. The data came primarily from MDACC and several of the LIDC academic sites. The data is not annotated.
Pilot Statistics |
|
---|---|
Modalities |
CT, DX |
Number of Patients |
322 |
Number of Studies |
1,779 |
Number of Series |
4,930 |
Number of Images |
384,535 |
NCI has exercised a series of contracts with specific academic sites for collection of repeat "coffee break" and longitudinal phantom and patient data for a range of imaging modalities (currently CT, PET CT, DCE MRI, DW MRI) and organ sites (currently lung, breast, and neuro). The goals are as follows:
The databases are being provided with a timely goal of 18 months time frame, namely from the time the contract was initiated and the published results within less than 2 years. The methods for data collection and analysis including results are described in the new Combined RIDER white Paper Report (Sept 2008):
The RIDER project will be replaced when the QIN initiative is fully implemented as this research network will be tasked to create database resources collected from phase 1-3 clinical trials, where clinical outcomes will be included in the meta data: http://grants.nih.gov/grants/guide/pa-files/PAR-11-150.html
Lung CT Statistics |
|
---|---|
Modalities |
CT |
Number of Patients |
32 |
Number of Studies |
46 |
Number of Series |
64 |
Number of Images |
15,716 |
Collection Statistics |
|
---|---|
Modalities |
CT, PT |
Number of Patients |
20 |
Number of Studies |
20 |
Number of Series |
60 |
Number of Images |
2,231 |
Lung PET CT Statistics |
|
---|---|
Modalities |
CT, PT |
Number of Patients |
244 |
Number of Studies |
275 |
Number of Series |
1349 |
Number of Images |
269,522 |
Neuro MRI Statistics |
|
---|---|
Modalities |
MR |
Number of Patients |
19 |
Number of Studies |
108 |
Number of Series |
368 |
Number of Images |
70,220 |
Breast MRI Statistics |
|
---|---|
Modalities |
MR |
Number of Patients |
5 |
Number of Studies |
10 |
Number of Series |
40 |
Number of Images |
2,400 |
Phantom MRI Statistics |
|
---|---|
Modalities |
MR |
Number of Patients |
10 |
Number of Studies |
13 |
Number of Series |
45 |
Number of Images |
7,061 |
MULTI SITE STUDY (Total of 20 sites): Organized under a contract with the University of Michigan ( Under development: 2009)
RSNA QIBA AND NCI (RIDER and IRAT) (2009-beyond: under development)
FDA CDRH: Partly funded by NCI and NIBIB
NIST