The Cancer Genomics Hub (CGHub) is a secure repository for storing, catalogueing, and accessing cancer genome sequences, alignments, and mutation information from The Cancer Genome Atlas (TCGA) consortium project and other cancer related projects.

The mission of CGHub is to facilitate the work of scientific researchers. CGHub is designed to be a fully automated resource, appearing to users as an extension of their home institute computing resource. User scripts employ the CGHub Application Programming Interface (API) to retrieve the CGHub catalog (index) of files; to select files for download based on metadata attributes such as cancer type, sequence type, source sequencing center or date range; then to initiate download, and finally to confirm success. CGHub is managed by the University of California, Santa Cruz (UCSC), under a subcontract from SAIC-Frederick.

For more information about CGHub, visit the About CGHub webpage.

For customer support related issues or to sign up for the “CGHub Announce” email list, email CGHub Support at: support@cghub.ucsc.edu. The CGHub Announce list is a very low volume email feed, where you can stay up-to-date with any scheduled service related outage and the latest news releases for CGHub. For additional news and updates on CGHub, visit the CGHub News page.

The CGHub Help page displays all of the available documentation for CGHub, such as the CGHub User's Guide , and Technical Manual Pages for GeneTorrent. The help page also displays Troubleshooting and Frequently Asked Questions (FAQ) links.

To download or upload TCGA data (BAM files)  from CGHub, you must be granted authorization from the Data Access Committee (DAC). Visit the “new user ” area for helpful information on the steps you must complete to gain access to the BAM files stored at CGHub. To see a list of controlled access and public access datasets hosted at CGHub, see the CGHub “data sets” page.

Once you have been granted authorization to download or upload data, you must install CGHub’s GeneTorrent software. GeneTorrent is the software for downloading data, and cgsubmit is the software used to upload data. Both can be found on the downloads page.  

In addition, CGHub offers various ways to search their publicly available metadata.

If you have additional questions about CGHub, contact CGHub Support at: support@cghub.ucsc.edu.