| Number | Source | Requirement | Date Completed |
|---|---|---|---|
| 1 | SOW | The Contractor shall develop and implement a prototype of the Integrated Canine Data Commons (ICDC) for housing the results of canine tumor sequences and outcomes of canine clinical trials from the Comparative Oncology Trials Consortium and the NCI-sponsored Canine Immunotherapy Trials Network. | |
| 2 | SOW | Building the storage for the datasets to be entered into the system (database, files system, etc). | |
| 3 | SOW | Building the capabilities for end users to search the data in the system. This includes deciding what to allow to become searchable (data, metadata), indexing that data, etc. | |
| 4 | SOW | Building a system that allows end users to submit their data for public display. | |
| 5 | SOW | Providing a means to help users with issues they might have, for example, helpdesk, tutorials, documentation. | |
| 6 | SOW | Deciding exactly what types of datasets, data types, and file formats could be submitted to the system. (This is a Steering Committee Goal). | |
| 7 | COR - 1/14/19 | Should be able to look for all “oral” ”melanomas” from a particular breed from a particular source. | |
| 8 | COR - 1/14/19 | What technology was used for analyses? Reference genome used? | |
| 9 | COR - 1/14/19 | Be able to perform meta-analysis of data in the system aggregated from many studies (e.g. for biomarker/prognostic factor analysis). | |
| 10 | COR - 1/14/19 | Include data visualization of aggregated data and live viewing of results when you added or delete data. | |
| 11 | COR - 1/14/19 | The system should be limited to oncology studies – not cardiology/dermatology or anything like that. | |
| 12 | COR - 1/14/19 | The system should be able to support all canine cancer studies. | |
| 13 | COR - 1/14/19 | Only Completed/Stopped studies are allowed in the system. | |
| 14 | COR - 1/14/19 | Look up data on specific treatments. | |
| 15 | COR - 1/14/19 | Could include literature mined data from another source. | |
| 16 | COR - 1/14/19 | Have a library of data models available in the system for users to choose from when designing a study or uploading a study. | |
| 17 | SC Presentation - 2/20/19 | Full genotype and phenotype characterization of the major canine tumors (and normal tissues) including tumor mutational burden (TMB) and neoantigens (seen by T cells in the context of canine MHC antigens) | |
| 18 | SC Presentation - 2/20/19 | Description of the tumor microenvironment (TME) including numbers and types of subsets of immune (and other) cells | |
| 19 | SC Presentation - 2/20/19 | Clinical data from COTC and other canine cancer trials (including images) | |
| 20 | SC Presentation - 2/20/19 | Treatment naïve, post-treatment, and relapse data | |
| 21 | SC Presentation - 2/20/19 | Including all the clinical data elements for canines | |
| 22 | SC Presentation - 2/20/19 | Obtain canine-specific design criteria and data models from the SC | |
| 23 | SC Presentation - 2/20/19 | Adapt the infrastructure from the Cancer Research Data Commons (CRDC), customize for canine with input from the SC, and prepare tools for cloud analysis | |
| 24 | SC Presentation - 2/20/19 | Test and validate this “1st Prototype” with an existing canine dataset(s) for performance that is inter-operable with the CRDC | |
| 25 | SC Presentation - 2/20/19 | Load datasets from the supplements and other sites (after publication) and verify performance | |
| 26 | SC Presentation - 2/20/19 | Refine and update; validate all systems; launch public accessible ICDC; add data, maintenance. | |
| 27 | Team Standup | When loading records, need to have a progress bar to indicate loading progress and more importantly to prevent hitting the submit button again. The system currently allows the user to click the submit button while processing which causes duplicate records to be added to the system. | |
| 28 | Team | GUI design should be responsive to mobile and desktop. | |
| 29 | Team | GUI should be configurable for easy customization in future. | |
| 30 | PM discussion of 5/17/19 |
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