2024-4-1 DGAB Meeting notes

• Potential new submission request
  • University of Zurich
• OSA04: 
  • Osteosarcoma study from Auburn University
  • 7 cases
  • Clinical and Transcriptomic data
  • Status: Kick off call to be planned

ICDC Studies in Active Submission 

COTC021 

• "Evaluation of Orally Administered mTOR inhibitor Rapamycin in Dogs in the Adjuvant Setting with Osteosarcoma" 
• Dr. Amy LeBlanc 
• Status: The study, case and sample records were loaded in early September. Sequencing files and file transfer manifest have been transferred to bucket pending validation.

UBC03 

• "Transcriptomic analyses of early-stage bladder cancer in Scottish Terriers detected through screening" 
• Dr. Debbie Knapp 
• Status: Multiple versions of metadata have been received and the final version is in review. Waiting on the File Transfer Manifest.

OSA02 

• "Immune Pathways and TP53 missense mutations are associated with longer survival in canine osteosarcoma" 
• Dr. Dawn Duval 
• Status: Version 1 of metadata loading files have been received and reviewed. Version 2 is expected soon to address validation errors. 

PRECINCT01 

• "Inhaled IL-15 Immunotherapy for Treatment of Lung Metastases" 
• UC Davis 
• 21 cases 
• Status: 21 pathology reports and 5 study-level files, including Nanostring-based evaluation of cytokine levels, have been received and indexed by DCF. Adverse event data has been ingested. Application-level testing revealed several software bugs related to download of the clinical data and fixes are pending by the ICDC team.  

PRECINCT02 

• "Novel treatments for Diffuse large B cell lymphoma (DLBCL) in dogs" 
• Tufts University 
• 49 cases 
• Status: Adverse event data has been received and ingested. Visit, vital signs and physical exam data was received and revealed validation errors. Version 2 of these loading files has been received. Lab exam and extent of disease data to be received.