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The Cancer and Aging Interest Group (CAIG) organizes activities designed to promote interest, information exchange and interactions among NIH scientists interested in understanding aging, cancer and related co-morbidities.

Topics of interest include, but are not limited to:

  • Recent science advances in understanding the mechanisms associated with aging, which facilitate cancer development.
  • Clinical trials of novel drugs and anti-aging agents, which may play a role in the prediction or prevention of tumor formation.
  • Public health, drug development, and new diagnosis methods.
  • Oncology and co-morbidities, risk stratification, gerontology and geriatric medicine, internal medicine, neurodegenerative diseases and potential trade-off, respiratory medicine, epidemiology, rehabilitation, critical care medicine, physiology, and psychology.


Interactions among scientists are facilitated via webinars and quarterly meetings on current topics as well as an annual CAIG   workshop.

The CAIG is open to NIH intramural and extramural scientists, as well as to academia.


Luigi Ferrucci M.D., Ph.D., National Institute on Aging


Gabriela Riscuta M.D., C.N.S., National Cancer Institute

Konstantin Salnikow Ph.D., National Cancer Institute

Useful Links:

Click here to subscribe to CAIG listserv

National Institute on Aging:

For information on Clinical Trials, please visit:

For information on the Baltimore Longitudinal Study of Aging (BLSA), please visit:

If interested in participating in a clinical trial, please contact the NIA recruitment line at 410-350-3941 or email

NIH corner (restricted access for NIH people using their PIV card and password).




Age-Dependent Changes in Cancer Biology

 October 26-27, 2020

Virtual Conference

The purpose of this conference is to increase awareness of the impact of aging, in cancer risk, with special considerations of cancer in the elderly.  The invited experts will provide input regarding existing gaps in knowledge, discuss the overlap and divergent paths of cancer and aging biology, and facilitate the prioritization of the scientific areas for further research efforts.

This conference is organized in collaboration with the National Cancer Institute, the National Institute on Aging, and the National Institute of Environmental Health Sciences.  This conference was originally schedule for April 2-3, 2020 but was postponed due to the ongoing COVID-19 pandemic.

Draft Agenda

Day 1, October 26, 2020

10:00 am – 10:05 am

Introduction and Overview

Gabriela Riscuta, M.D., C.N.S., NCI

10:05 am -10:20 am

Opening Remarks: Ned Sharpless, M.D., NCI

10:20 am - 10:35 am

Opening Remarks: Richard Hodes, M.D., NIA

10:35 am -11:05 am

Keynote Speaker: Luigi Ferrucci, M.D., Ph.D., NIA/IRP

11:05 am - 11:45 am

Session I : Understanding the Molecular Biology of Cancer in Elderly

Moderator: Max Guo, Ph.D., NIA

11:05 am -11:25 am

Anticancer mechanisms in long-lived mammals   

Vera Gorbunova, Ph.D., University of Rochester (DAB/NIA)

11:25 am -11:45 am

Connecting cancer to aging – an evolutionary perspective

James V. Degregori, Ph.D., University of Colorado (DAB/NIA)

11:45 am -12:05 pm

Panel Discussion

12: 05 pm - 12:25 pm


12: 25 pm - 1:05 pm

12:25 pm-12:45 pm

12: 45 pm -1:05 pm

Session II : Cellular Senescence in Cancer and Aging

Moderator: Basil Eldadah, M.D., Ph.D., NIA/ERP

Mechanisms of immunosenescence and Immune response to vaccines in elderly  

Nan-Ping Weng, M.D., Ph.D., Laboratory of Molecular Biology and Immunology (LMBI), NIA/IRP

Cellular senescence in aging and cancer

Darren Baker, Ph.D., Mayo Clinic

1:05 pm – 1:25 pm

Panel Discussion

1:25 pm - 2:05 pm

1: 25 pm - 1: 45 pm

1:45 pm – 2:05 pm


Session III : Implication of Oxidative Stress Towards Cancer Biology

Moderator: Konstantin Salnikow, Ph.D., NCI

Gender effects in cancer and aging 

Vadim Gladyshev, Ph.D., Brigham and Women’s Hospital, Harvard Medical School

Dysregulation of iron metabolism in cancer and aging  

Suzy Torti, Ph.D., University of Connecticut

2:05 pm - 2:25 pm

Panel Discussion

2: 25 pm - 2:30 pm

Coffee break

2:30 pm – 3:10 pm

2:30 pm - 2:50 pm

2:50 pm - 3:10 pm

Session IV : Senescence, Immune Response and Cancer in the Elderly

Moderators: Matt Young, Ph.D., and Anil Wali, Ph.D., NCI

Telomere and genome integrity in cancer and aging  

Patricia Opresko, Ph.D., University of Pittsburgh (NCI)

Inter-relationship between microbiota diversity, obesity and race in endometrial cancer

Victoria Lin Bae-Jump, M.D., Ph.D., University of North Carolina, Chapel Hill

3: 10 pm - 3: 30 pm

Panel Discussion

3: 30 pm - 4: 30 pm

3: 30 pm - 3:50 pm

3:50 pm - 4:10 pm

Session V : Environmental Factors: the Overlap of Carcinogens/Gerontogens

Moderator: Les Reinlib, Ph.D., NIEHS

Environmental genomics of breast and prostate cancer  

Susan Neuhausen, Ph.D., City of Hope ( NIEHS)

Breast Cancer in young & older women

Lead, Carolina Breast Cancer Study; co-I, African American Breast Cancer Epidemiology and Risk (AMBER); Cancer Genome Atlas Melissa Troester, UNC CH (NIEHS)

4:10 pm - 4:30 pm

Panel Discussion

 4:30 pm Adjourn

Day 2, October 27, 2020

10:00 am - 10: 10 am

Goals and Objectives

Konstantin Salnikow Ph.D. NCI

10:10 am - 10:40 am

Keynote: Epigenetic linkage of aging, cancer and nutrition

Trygve Tollefsbol, Ph.D., University of Alabama (DCP/NCI)

10:40 am - 11:50 am

10:40 am - 11:00 am

11:00 am - 11:20 am

11:20 am - 11:50 am

Session VI : Potential Impact of Nutrition on Cancer Prevention

Moderator: Gabriela Riscuta, M.D., C.N.S., and Pat Prasanna, Ph.D., NCI

Senolytic bioactive food components and their biological pathway for action  

Simmin Meydani, D.V.M., Ph.D., Tufts University  (DCP/NCI) 

Cancer prevention in elderly and particularities for mechanisms of action  

Chengguo Xing, Ph.D., University of Florida (DCP/NCI)

The mechanisms of fasting and advanced glycation end products in cancer prevention in elderly

Sebastian Brandhorst, Ph.D., University of Southern California (DCP/NCI)

11:50 am -12:10 pm

Panel Discussion

12:10 pm - 12:30 pm

Lunch  Break

12:30 pm - 1:00 pm

Keynote speaker:  Melanoma metastasis to lymph nodes; mechanisms and contributing factors.Sean Morrison, Ph.D., UT Southwestern

1:00 pm - 2:00 pm

Session VII : Cancer Therapeutics and Treatment Optimization for the Elderly

Moderators: Weiwei Chen, Ph.D., and Christina Liu, Ph.D., PE, NCI

1:00 pm - 1:20 pm


Age against the machine: How the aging microenvironment governs tumor progression and response to therapy

Ashani Weeraratna Ph.D., Johns Hopkins University (DCTD/NCI)

1:20 pm - 1:40 pm

VLA4-nanoparticles hijack cell adhesion mediated drug resistance  to target refractory myeloma cells and prolong survival

Greg Lanza M.D., Ph.D., Washington University at St. Louis (DCTD/NCI)

1:40 pm - 2:00 pm

Treatment Optimization for the elderly with comorbidities 

Heidi Klepin, M.D., Wake Forest School of Medicine (DCTD/NCI)

2:00 pm - 2: 20 pm

Panel Discussion

2:20 pm - 2:30 pm

Wrap Up and Adjourn

Planning Committee:

Luigi Ferrucci, M.D., Ph.D., (NIH/NIA/IRP) Chair

Gabriela Riscuta, M.D., C.N.S. (NIH/NCI/DCP); co-chair

Konstantin Salnikow, Ph.D., (NIH/NCI/DCB); co-chair

Nelson Aguila, D.V.M., (NIH/NCI)

Weiwei Chen, Ph.D., (NIH/NCI)

Basil Eldadah, M.D., Ph.D., (NIH/NIA/ERP)

Max Guo, Ph.D., (NIH/NIA/ERP)

Christina Liu, Ph.D., (NIH/NCI)

Pat Prasanna, Ph.D., (NIH/NCI/DCTD)

Leslie Reinlib, Ph.D., (NIH/NIEHS)

Sudhir Srivastava, Ph.D., M.P.H., (NIH/NCI/DCP)

Anil Wali, Ph.D., (NIH/NCI)

Matthew Young, Ph.D., (NIH/NCI/DCP)


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