Chair:
Luigi Ferrucci M.D., Ph.D., National Institute on Aging
Co-chairs:
Gabriela Riscuta M.D., C.N.S., National Cancer Institute
Konstantin Salnikow Ph.D., National Cancer Institute
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If interested in participating in a clinical trial, please contact the NIA recruitment line at 410-350-3941 or email NIAStudiesRecruitment@mail.nih.gov
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Age-Dependent Changes in Cancer Biology
October 26-27, 2020
Virtual Conference
The purpose of this conference is to increase awareness of the impact of aging, in cancer risk, with special considerations of cancer in the elderly. The invited experts will provide input regarding existing gaps in knowledge, discuss the overlap and divergent paths of cancer and aging biology, and facilitate the prioritization of the scientific areas for further research efforts.
This conference is organized in collaboration with the National Cancer Institute, the National Institute on Aging, and the National Institute of Environmental Health Sciences. This conference was originally schedule for April 2-3, 2020 but was postponed due to the ongoing COVID-19 pandemic.
Draft Agenda
Day 1, October 26, 2020
10:00 am – 10:05 am | Introduction and Overview Gabriela Riscuta, M.D., C.N.S., NCI |
10:05 am -10:20 am | Opening Remarks: Ned Sharpless, M.D., NCI |
10:20 am - 10:35 am | Opening Remarks: Richard Hodes, M.D., NIA |
10:35 am -11:05 am | Keynote Speaker: Luigi Ferrucci, M.D., Ph.D., NIA/IRP |
11:05 am - 11:45 am | Session I : Understanding the Molecular Biology of Cancer in Elderly Moderator: Max Guo, Ph.D., NIA |
11:05 am -11:25 am | Anticancer mechanisms in long-lived mammals Vera Gorbunova, Ph.D., University of Rochester (DAB/NIA) |
11:25 am -11:45 am | Connecting cancer to aging – an evolutionary perspective James V. Degregori, Ph.D., University of Colorado (DAB/NIA) |
11:45 am -12:05 pm | Panel Discussion |
12: 05 pm - 12:25 pm | Lunch |
12: 25 pm - 1:05 pm 12:25 pm-12:45 pm 12: 45 pm -1:05 pm | Session II : Cellular Senescence in Cancer and Aging Moderator: Basil Eldadah, M.D., Ph.D., NIA/ERP Mechanisms of immunosenescence and Immune response to vaccines in elderly Nan-Ping Weng, M.D., Ph.D., Laboratory of Molecular Biology and Immunology (LMBI), NIA/IRP Cellular senescence in aging and cancer Darren Baker, Ph.D., Mayo Clinic |
1:05 pm – 1:25 pm | Panel Discussion |
1:25 pm - 2:05 pm 1: 25 pm - 1: 45 pm 1:45 pm – 2:05 pm
| Session III : Implication of Oxidative Stress Towards Cancer Biology Moderator: Konstantin Salnikow, Ph.D., NCI Gender effects in cancer and aging Vadim Gladyshev, Ph.D., Brigham and Women’s Hospital, Harvard Medical School Dysregulation of iron metabolism in cancer and aging Suzy Torti, Ph.D., University of Connecticut |
2:05 pm - 2:25 pm | Panel Discussion |
2: 25 pm - 2:30 pm | Coffee break |
2:30 pm – 3:10 pm 2:30 pm - 2:50 pm 2:50 pm - 3:10 pm | Session IV : Senescence, Immune Response and Cancer in the Elderly Moderators: Matt Young, Ph.D., and Anil Wali, Ph.D., NCI Telomere and genome integrity in cancer and aging Patricia Opresko, Ph.D., University of Pittsburgh (NCI) Inter-relationship between microbiota diversity, obesity and race in endometrial cancer Victoria Lin Bae-Jump, M.D., Ph.D., University of North Carolina, Chapel Hill |
3: 10 pm - 3: 30 pm | Panel Discussion |
3: 30 pm - 4: 30 pm 3: 30 pm - 3:50 pm 3:50 pm - 4:10 pm | Session V : Environmental Factors: the Overlap of Carcinogens/Gerontogens Moderator: Les Reinlib, Ph.D., NIEHS Environmental genomics of breast and prostate cancer Susan Neuhausen, Ph.D., City of Hope ( NIEHS) Breast Cancer in young & older women Lead, Carolina Breast Cancer Study; co-I, African American Breast Cancer Epidemiology and Risk (AMBER); Cancer Genome Atlas Melissa Troester, UNC CH (NIEHS) |
4:10 pm - 4:30 pm | Panel Discussion |
| 4:30 pm | Adjourn |
Day 2, October 27, 2020
10:00 am - 10: 10 am | Goals and Objectives Konstantin Salnikow Ph.D. NCI |
10:10 am - 10:40 am | Keynote: Epigenetic linkage of aging, cancer and nutrition Trygve Tollefsbol, Ph.D., University of Alabama (DCP/NCI) |
10:40 am - 11:50 am 10:40 am - 11:00 am 11:00 am - 11:20 am 11:20 am - 11:50 am | Session VI : Potential Impact of Nutrition on Cancer Prevention Moderator: Gabriela Riscuta, M.D., C.N.S., and Pat Prasanna, Ph.D., NCI Senolytic bioactive food components and their biological pathway for action Simmin Meydani, D.V.M., Ph.D., Tufts University (DCP/NCI) Cancer prevention in elderly and particularities for mechanisms of action Chengguo Xing, Ph.D., University of Florida (DCP/NCI) The mechanisms of fasting and advanced glycation end products in cancer prevention in elderly Sebastian Brandhorst, Ph.D., University of Southern California (DCP/NCI) |
11:50 am -12:10 pm | Panel Discussion |
12:10 pm - 12:30 pm | Lunch Break |
12:30 pm - 1:00 pm | Keynote speaker: Melanoma metastasis to lymph nodes; mechanisms and contributing factors.Sean Morrison, Ph.D., UT Southwestern |
1:00 pm - 2:00 pm | Session VII : Cancer Therapeutics and Treatment Optimization for the Elderly Moderators: Weiwei Chen, Ph.D., and Christina Liu, Ph.D., PE, NCI |
1:00 pm - 1:20 pm
| Age against the machine: How the aging microenvironment governs tumor progression and response to therapy Ashani Weeraratna Ph.D., Johns Hopkins University (DCTD/NCI) |
1:20 pm - 1:40 pm | VLA4-nanoparticles hijack cell adhesion mediated drug resistance to target refractory myeloma cells and prolong survival Greg Lanza M.D., Ph.D., Washington University at St. Louis (DCTD/NCI) |
1:40 pm - 2:00 pm | Treatment Optimization for the elderly with comorbidities Heidi Klepin, M.D., Wake Forest School of Medicine (DCTD/NCI) |
2:00 pm - 2: 20 pm | Panel Discussion |
2:20 pm - 2:30 pm | Wrap Up and Adjourn |
Planning Committee:
Luigi Ferrucci, M.D., Ph.D., (NIH/NIA/IRP) Chair
Gabriela Riscuta, M.D., C.N.S. (NIH/NCI/DCP); co-chair
Konstantin Salnikow, Ph.D., (NIH/NCI/DCB); co-chair
Nelson Aguila, D.V.M., (NIH/NCI)
Weiwei Chen, Ph.D., (NIH/NCI)
Basil Eldadah, M.D., Ph.D., (NIH/NIA/ERP)
Max Guo, Ph.D., (NIH/NIA/ERP)
Christina Liu, Ph.D., (NIH/NCI)
Pat Prasanna, Ph.D., (NIH/NCI/DCTD)
Leslie Reinlib, Ph.D., (NIH/NIEHS)
Sudhir Srivastava, Ph.D., M.P.H., (NIH/NCI/DCP)
Anil Wali, Ph.D., (NIH/NCI)
Matthew Young, Ph.D., (NIH/NCI/DCP)
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