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Since 1997, EVS has worked with many partners to build shared content and services, so that information can be effectively exchanged, interpreted and analyzed while minimizing overall effort and cost. Much of this content has been created and published using NCI Thesaurus and NCI Metathesaurus, as outlined in the following sections and described in more detail in the individual user profiles later, where other shared development efforts are also described.

NCI Thesaurus (NCIt)

NCI Thesaurus (NCIt) is NCI's core reference terminology. Over the last 16 years, it has also been adopted by FDA, CDISC, NCPDP and other partners as a shared standards development and coding environment, allowing participants to compare and harmonize with each other's content while taking advantage of full-text definitions, codes, and other features.

About 125,000 out of the 178,080 current NCIt concepts have terms from both EVS and from one or more of these other sources. The chart below gives a detailed breakdown of the main areas of overlapping tagged content. Note that some partners have used NCI terms rather than tagging their own, so these figures understate the true extent of cross-source sharing.

NCIt concepts with terms from tagged outside sources (24.03D: March 2024)

NCIt concepts with tagged synonyms from each outside source (24.03D: March 2024)

NCIt Concepts







NCI Metathesaurus (NCIm)

NCI Metathesaurus (NCIm) was started in the late 1990s to gather up, translate between, and publish the many terminologies used by NCI, including some created in part or whole within NCI. Development of NCI Thesaurus started within NCIm as NewPDQ, an effort to extend and restructure the PDQ Terminology long used to code cancer clinical trial, research and public information resources. NCIm continues to provide a vital environment for EVS collaboration with NCI and other partners to develop, map and publish terminologies of shared interest, and responds to the requirements of a broad range of stakeholders within the cancer research and biomedical community.

NCIt tagged content from outside sources is imported into NCIm with separate source tags. NCIt-derived sources are grouped separately below. The NCIm tags are mostly identical or very similar to those in NCIt; exceptions are CADSR, converted to NCI; HL7, converted to NCI-HL7; and CTRM, which is not imported.

NCIm sources and the number of concepts to which each contributes (202402: February 2024)

NCIm concepts

Source Label - NCIt-derived

Source Name

1177ACC-AHAAmerican College of Cardiology/American Heart Association Clinical Data Terminology, 2023_12D
334BioCBioCarta online maps of molecular pathways, adapted for NCI use, 2023_12D
27BRIDGBiomedical Research Integrated Domain Group Model, 2023_12D
1148BRIDG_3_0_3Biomedical Research Integrated Domain Group Model, 3.0.3, 2023_12D
1658BRIDG_5_3Biomedical Research Integrated Domain Group Model, 5.3, 2023_12D
19304caDSRCancer Data Standards Registry and Repository, 2023_12D
407CARELEXContent Archive Resource Exchange Lexicon, 2023_12D
53CBDDChemical Biology and Drug Development Vocabulary, 2023_12D
265CCPSChildhood Cancer Predisposition Study, 2023_12D
922CDCU.S. Centers for Disease Control and Prevention, 2023_12D
29019CDISCClinical Data Interchange Standards Consortium, 2023_12D
800CDISC-GLOSSClinical Data Interchange Standards Consortium Glossary Terms, 2023_12D


CELLOSAURUSCellosaurus, 2023_12D
3680CPTACClinical Proteomic Tumor Analysis Consortium, 2023_12D
406CRCHCancer Research Center of Hawaii Nutrition Terminology, 2023_12D
775CTCAECommon Terminology Criteria for Adverse Events, 2023_12D
5599CTCAE_3Common Terminology Criteria for Adverse Events 3.0, 2023_12D
4022CTCAE_5Common Terminology Criteria for Adverse Events 5.0, 2023_12D
276CTDCClinical Trial Data Commons, 2023_12D
372CTEP-SDCCancer Therapy Evaluation Program - Simple Disease Classification, 2023_12D
28023CTRPClinical Trials Reporting Program, 2023_12D
904DCPNCI Division of Cancer Prevention Program, 2023_12D
114DICOMDigital Imaging Communications in Medicine, 2023_12D
627DIPG_DMGDiffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma Terminology, 2023_12D
694DTPNCI Developmental Therapeutics Program, 2023_12D
1070EDQM-HCEuropean Directorate for the Quality of Medicines & Healthcare, 2023_12D
27355FDAU.S. Food and Drug Administration, 2023_12D
207GAIAGlobal Alignment of Immunization Safety Assessment in pregnancy, 2023_12D
6030GDCNCI Genomic Data Commons, 2023_12D
281GENCGeopolitical Entities, Names, and Codes Standard, 2023_12D
1439HemOncHematology-Oncology (HemOnc) Chemotherapy Regimen Vocabulary, 2023_12D
106ICD-10International Classification of Diseases, 10th Edition, 2023_12D
693ICDCNCI Integrated Canine Data Commons, 2023_12D
215ICHInternational Conference on Harmonization, 2023_12D
215INCInternational Neonatal Consortium, 2023_12D
156JAXJackson Laboratories Mouse Terminology, adapted for NCI use, 2023_12D
244KEGGKEGG Pathway Database, 2023_12D
5660mCodeMinimal Common Oncology Data Elements, 2023_12D
183778NCINational Cancer Institute Thesaurus, 2023_12D
5079NCI-GLOSSNCI Dictionary of Cancer Terms, 2023_12D
5860NCI-HGNCNCI HUGO Gene Nomenclature Committee, 2023_12D
129NCI-HL7NCI Health Level 7, 2023_12D
509NCPDPNational Council for Prescription Drug Programs, 2023_12D
5NDCNational Drug Code, 2023_12D
4780NICHDNational Institute of Child Health and Human Development, 2023_12D
825OOROOperational Ontology for Radiation Oncology, 2023_12D
1832PCDCPediatric Cancer Data Commons, 2023_12D
39PI-RADSProstate Imaging Reporting and Data System, 2023_12D
169PIDNational Cancer Institute Nature Pathway Interaction Database, 2023_12D
310RENIRegistry Nomenclature Information System, 2023_12D
659SeroNetSerological Sciences Network Terminology, 2023_12D
236UBERONUBERON Ontology, 2023_12D
1546UCUMUnified Code for Units of Measure, 2023_12D
77WHOWorld Health Organization (WHO) Terminology, 2023_12D
25ZFINZebrafish Model Organism Database, 2023_12D

NCIm concepts

Source Label - Other

Source Name

15884AODAlcohol and Other Drug Thesaurus, 2000
276AOTAuthorized Osteopathic Thesaurus, 2003
13257CBOClinical Bioinformatics Ontology, 2011_02
544CCSR_ICD10CMClinical Classifications Software Refined for ICD-10-CM, 2023
357CCSR_ICD10PCSClinical Classifications Software Refined for ICD-10-PCS, 2023
962CDCRECRace & Ethnicity - CDC, 1.2
3080COSTARCOSTAR, 1989-1995
16485CSPCRISP Thesaurus, 2006
3839CSTCOSTART, 1995
318CTEPCancer Therapy Evaluation Program, 2004
618CVXVaccines Administered, 2017_02_08, 2023_08_16
11414DRUGBANKDrugBank, 5.0_2023_08_11
7290DXPDXplain, 1994
102551FMAFoundational Model of Anatomy Ontology, 4_15
7482GARDGenetic and Rare Diseases Information Center, 2015_04
71881GOGene Ontology, 2023_05_10
8081HCPCSHealthcare Common Procedure Coding System, 2023
43627HGNCHUGO Gene Nomenclature Committee, 2023_04
9078HL7V3.0HL7 Vocabulary Version 3.0, 2023_02
19235HPOHuman Phenotype Ontology, 2023_07_21
17416ICD10ICD10, 2016
105376ICD10CMInternational Classification of Diseases, 10th Edition, Clinical Modification, 2024
191545ICD10PCSICD-10-PCS, 2024
20886ICD9CMInternational Classification of Diseases, Ninth Revision, Clinical Modification, 2014
2864ICDOInternational Classification of Disease for Oncology, 3_2
748ICPCInternational Classification of Primary Care, 1993
5055ISO3166-2International Organization for Standardization 3166-2, 2012
175623LNCLOINC, 276
41MCMMcMaster University Epidemiology Terms, 1992
332MDBCACMitelman Database of Chromosome Aberrations in Cancer, 2005_12
62093MDRMedical Dictionary for Regulatory Activities Terminology (MedDRA), 26_1
3523MED-RTMedication Reference Terminology, 2023_09_05
2123MEDLINEPLUSMedlinePlus Health Topics, 20221101
900MGEDMGED Ontology, 131
456461MSHMedical Subject Headings, 2024_2023_08_03
218961MTHUMLS Metathesaurus, 2023AB
11MTHCMSFRFMetathesaurus CMS Formulary Reference File, MTHCMSFRF_2020
19007MTHICD9International Classification of Diseases, Ninth Revision, Clinical Modification, Metathesaurus additional entry terms, 2014
1633MTHMSTMetathesaurus Version of Minimal Standard Terminology Digestive Endoscopy, 2001
57391MTHSPLMetathesaurus FDA Structured Product Labels, 2023_08_24
88MVXManufacturers of Vaccines, 2023_09_06
719490NCBINCBI Taxonomy, 2023_04_13
1887NPONPO: NanoParticle Ontology for Cancer Nanotechnology Research, 2011_12_08
103963OMIMOnline Mendelian Inheritance in Man, 2023_08_10
12399PDQPhysician Data Query, 2016_07_31
2039PMAPortfolio Management Application, 2010
270PNDSPerioperative Nursing Data Set, 2021
940QMRQuick Medical Reference (QMR), 1996
45826RADLEXRadLex, 4_1
217864RXNORMRxNorm Vocabulary, 20AA_230905F
361058SNOMEDCT_USUS Edition of SNOMED CT, 2023_09_01
167SOPSource of Payment Typology, 9.2
4811SPNStandard Product Nomenclature, 2003
230SRCMetathesaurus Source Terminology Names
29104UMDUMDNS: product category thesaurus, 2023
5002USPUSP Compendial Nomenclature, 2023_08_17
1605USPMGUSP Medicare Model Guidelines, 2020
61107UWDAUniversity of Washington Digital Anatomist, 1.7.3
38334VANDFVeterans Health Administration National Drug File, 2023_07_31

Overall Counts (February 2024)

ConceptsRelationships Attributes Total Number of Terms


 24,395,137 7,098,885

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