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Date

Attendees

  • Todd, Toby, Debbie, Amy, John, Ralph, Erika, Connie

  • Regrets: 


Goals

Discussion items

ItemWhoNotes
SC Meeting NotesRalph
  • Agenda for upcoming meeting on the 16th?
ICDC Next PhaseToby
  • ICDC will be 3 years on TO, 2 more to go
  • What's going to happen after the 5 years are up?
    • Another Task Order?
    • What specific tasks in years 6-10?
    • Maintenance and data will be the base
    • Are there specific items that haven't been attempted in the first 5 years?
    • Discuss with the Steering committee
    • Probably don't need decisions until next summer (2022)
    • John - Infrastructure is in place, next piece would be comparative analysis?  Are there datasets and/or tools, pipelines, etc. 
    • Toby - Would need some specific case studies.  Here's the hypothesis and this is the data we need.  That would drive the connections.
    • Cloud Resource needs?
    • Cost for data storage will land on ICDC
    • Helping submitters put data into proper format, general submission support
    • Outreach to submitters to get them informed early in their work.  Tools, instructions to help them.
    • Data loading, submission will become more automated
      • Coming primarily from CRDC
    • Toby - Would like a list of needs
      • That is a PM task
    • Ralph - Would ICDC host reference genomes?  Other ground truth data?  Normal tissue data?
      • NCBI has 5 fully annotated dog genomes
      • Elaine and her team are key to this, they have the most experience in normal genomes
  • ICDC was started with the idea of catalyzing the dog community.  Can it expand to provide this standard service?  Be more than just a data commons.
    • Perhaps something like a forum?
  • Amy - There are examples where consensus have been published.  
    • Just a consensus on a reference genome would be a significant event
    • This area (consensus approaches) is a very unmet need
  • Debbie - compiling information and tools would be very helpful.
  • Amy is working with NCATS to build transcriptional tools, one issue was trying to identify fusions, no current consensus.
    • A white paper around this would be useful.
    • ICDC Cookbook?
  • Even if the consensus is that there is no reference genome and it needs to be breed-based, that would be a major advancement
  • Is the Dog 10K project a source?  Elaine would be best for information on this
  • Erika - This conversation happened in the Non-Cancer group
    • VCF files are publicly available
    • ICDC may need some enhancements but could host this
  • Allocation for training?
    • How to use data in ICDC and connect to CRDC
ICDC SiteTodd
  • Target release date:  Week of June 21st
  • Features:
    • Study Accession IDs
    • Study Embargo notification
    • File Download
    • Multiparticipant support
    • Publication listing
  • Data Release
    • UBC01 and UBC02 -Publications accepted, embargo lifting
    • OSA01 - May be wrapped up shortly, no embargo
    • Will coordinate with CBIIT Comms team for an announcement
ICDC TPMToddGina Kuffel will start June 21st
July/August meetingsTodd
  • Keep July meeting, drop August
  • Task order - Really start things moving in July.
  • Deposition of pathology images - June SC meeting
  • FidoCure - Follow up?  They are interested in providing data
    • Revist at SC
    • Fidocure has yet to define what they would submit
    • NCI needed to understand any potential favoritism
    • Toby - No possibility of favoritism, DGAB decides on if it is appropriate, Exec Comm then makes final decision
    • If the consensus is that their approach isn't sufficient, that's a separate question.
    • Wait for publication and then decide?
      • That would be just sharing data that have been published
      • Consensus is that waiting for publication is the preferred approach
      • Concern about lack of followup data, not a lot of detailed information
      • Sequencing data would be useful

Action items

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