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Date

Attendees

Committee MemberPresentAbsent
Kuffel, Gina (NIH/NCI) [C]
X

Unknown User (leblancak)


X

Otridge, John (NIH/NCI) [C]

X
Kim, Erika (NIH/NCI) [E]
X

Sommers, Connie (NIH/NCI) [E]


X
Debbie KnappX
Toby HechtX

Unknown User (parchmentr)



Goals

  • Discuss updates to ICDC and define emerging strategies and priorities

SharePoint Site

https://nih.sharepoint.com/sites/NCI-CBIIT-FNL-ICDC-ICDCLeadershipGroups

Outstanding Action Items


Agenda

ItemWhoTalking Points
DGAB Updates

Kuffel, Gina (NIH/NCI) [C]

  • DGAB has recommended a subset of the Iowa State study
  • Data Release: TCL01: A multi-omics analysis of canine cancer cell lines
    • {
              "study_code": "TCL01",
              "files": 95,
              "total_size_MB": 620328.707788,
              "cases": 45,
              "samples": 46
            }
  • UBC03:
    • "Transcriptomic analyses of early stage bladder cancer in Scottish Terriers detected through screening"
    • 19 cases
  • PRECINCT01: 
    • Inhaled IL-15 Immunotherapy for Treatment of Lung Metastases
    • Data includes program, study, and and complete case records.
    • No sample records or files derived from samples yet.
  • PRECINCT02:
    • Novel treatments for Diffuse large B cell lymphoma (DLBCL) in dogs
    • 47 subjects
    • 2 TB of data
BPSC Updates

Kuffel, Gina (NIH/NCI) [C] 

November Steering Committee Updates

Unknown User (parchmentr)

  • Minutes have been posted
  • Invite has gone out for January
  • Send agenda items for January to Ralph
ICDC Next Phase Planning

Unknown User (hechtt)

Minutes (Not Verbatim)



Previous ICDC Use Cases from Steering Committee

1. Genomic correlates across platforms (DNA, RNA, protein).

2. Correlating multi-omics data with clinical annotation and phenotypes, particularly outcomes.

3. Comparative analyses of canine and human. Examples include:

1. Search for conserved mutations between canine and human tumors

2. Disease diagnosis (e.g. cancer type) and classification mapping between canines and humans

5. Gene expression changes and mutational profiles associated with therapeutic response and outcome

6. How do sporadic tumors in non-human mammals compare to sporadic human tumors?

7. Correlations and model building from radiomic and pathomic features extracted from medical and histopathologic images with outcomes and genomics, as is currently being widely done with human images

8. Develop biomarkers of response and resistance in humans by analyzing the responses and genomic signatures in dogs.

Previous Meeting Minutes (Not Verbatim)

TH - Circulating tumor DNA is a strong candidate for the next phase of the ICDC.

CS - There is a grant under the mammalian models from Cheryl London and co. 


Action items