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Date

Attendees

Committee MemberPresentAbsent
Kuffel, Gina (NIH/NCI) [C]
X
Erika BergerX
Toby HechtX
Connie SommersX
Amy Leblanc
X
Igor KuzminX
Debbie KnappX
Ralph ParchmentX
Roel VerhaakX
Nicola MasonX
Shaying ZhaoX
John OtridgeX



Goals

  • Discuss the next 5 years for ICDC in preparation of the new task order

Viable Options 

ItemWhoNotes
Canine and human sequences of tumors treated with the same therapy (not necessarily the same tumor)



Pre and post-treatment sequences in dogs



Immune subsets before and after treatment



Flow cytometry (raw) data



Nanostring profiling data



Integrating environmental exposures of human cancer patients with canines



Comparison omics data of the same tumor in humans and dogs

Adverse events in humans and dogs treated with the same agent(s)

Cardiac, kidney, and other organ impairments caused by treatment of humans and dogs with cancer



Non-Cancer Diseases



Longitudinal studies of normal dogs over a lifetime of sequencing of their tumors when they arise



Tools & data from Pharma



Epigenomic (methylation) data from dogs before and after treatment



MHCI and MHCII sequences normal sequences, binding motifs, neoepitopes that bind MHC



Metablomic and proteomic data



Imaging data that links out to IDC



Development of tetramers/elispots



Sequences of normal tissues



 Check with clinician/scientists studying a cancer type and ask what they want to get out of dogs that would inspire them to use ICDC in their research



Multiple mammary tumors at different stages from a single dog

Debbie Knapp

  • someone at Purdue that has published on insitu mammary gland study
  • Nicola Mason is also aware of a group that is studying this
Single-cell transcriptomic data



Collaborations with large corporations that don't have the ability to appropriately mine data (ie. Banfield)


  • Epidemiology data such as diagnosis list from non-academic groups and practices
Tumor heterogeneity at the lesion level that can be traced to the medical imaging and aggregated with the respective omics data



Radiation and immunotherapy


  • abscopal effect


Action items