2023-1-6 Executive Team Meeting Notes

Date

06 Jan 2023

Attendees

Committee Member	Present	Absent
Kuffel, Gina (NIH/NCI) [C]	X
Unknown User (leblancak)	X
Otridge, John (NIH/NCI) [C]		X
Kim, Erika (NIH/NCI) [E]	X
Sommers, Connie (NIH/NCI) [E]	X
Debbie Knapp	X
Toby Hecht	X
Unknown User (parchmentr)

Goals

Discuss updates to ICDC and define emerging strategies and priorities

SharePoint Site

https://nih.sharepoint.com/sites/NCI-CBIIT-FNL-ICDC-ICDCLeadershipGroups

Outstanding Action Items

Agenda

Item	Who	Talking Points
DGAB Updates	Kuffel, Gina (NIH/NCI) [C]	ICDC Studies in the Queue UBC03 Approved by SAC on 8/13/22 "Transcriptomic analyses of early stage bladder cancer in Scottish Terriers detected through screening" Purdue University 19 cases Status: Submitters generating template-based data loading files OSA02 Approved by SAC on 9/21/22 "Immune Pathways and TP53 missense mutations are associated with longer survival in canine osteosarcoma" Colorado State University 108 cases Status: Submitters generating template-based data loading files ORGANOIDS01 Approved by SAC on12/5/22 “Characterization of healthy and diseased canine tissues and organoids" Iowa State University Status: Submitters generating template-based data loading files UBCO4 Approved by SAC on 12/22/22 "Whole exome sequencing analysis of canine urothelial carcinomas without BRAF V595E mutation" North Carolina State University 36 cases Status: Onboarding kick-off call on 1/5/23 PRECINCT01 Approved by SAC on 6/28/22 "Inhaled IL-15 Immunotherapy for Treatment of Lung Metastases" UC Davis 21 cases Status: Data not yet available PRECINCT02 Approved by SAC on 12/8/22 "Novel treatments for Diffuse large B cell lymphoma (DLBCL) in dogs" Tufts University 47 cases Status: Data not yet available PANCAN01 Approved by SAC on 11/8/21 "Canine tumor mutational burden is correleated with TP53 mutation across tumor types and breeds" University of Georgia 684 cases Status: Submitters generating template-based data loading files UMCVM Approved by SAC on 4/19/21 "Comparative analysis of genome-wide DNA methylation identifies patterns that associate with conserved transcriptional programs in osteosarcoma" University of Minnesota 44 cases Status: On hold until FTE is designated
BPSC Updates	Kuffel, Gina (NIH/NCI) [C]	2022 BPSC Review Article No additional edits are allowed at this time Authors are entering applicable PubMed central IDs Cheryl London is completing references in EndNote
December Steering Committee Updates	Unknown User (parchmentr)	We did not meet in the month of December We will resume in January
ICDC Next Phase Planning	Unknown User (hechtt)	Request for Information (RFI) has been issued RFI has been promoted through the following channels Twitter NCIDataSci Sloan Kerlavage CRDC site CBIIT site 2 focus groups met Ideas from the ICDC brainstorming sessions final.docx

Minutes (Not Verbatim)

Previous ICDC Use Cases from Steering Committee

1. Genomic correlates across platforms (DNA, RNA, protein).

2. Correlating multi-omics data with clinical annotation and phenotypes, particularly outcomes.

3. Comparative analyses of canine and human. Examples include:

1. Search for conserved mutations between canine and human tumors

2. Disease diagnosis (e.g. cancer type) and classification mapping between canines and humans

5. Gene expression changes and mutational profiles associated with therapeutic response and outcome

6. How do sporadic tumors in non-human mammals compare to sporadic human tumors?

7. Correlations and model building from radiomic and pathomic features extracted from medical and histopathologic images with outcomes and genomics, as is currently being widely done with human images

8. Develop biomarkers of response and resistance in humans by analyzing the responses and genomic signatures in dogs.

Previous Meeting Minutes (Not Verbatim)

TH - Circulating tumor DNA is a strong candidate for the next phase of the ICDC.

CS - There is a grant under the mammalian models from Cheryl London and co.

Action items

Content

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