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Date

Attendees

Committee MemberPresentAbsent
Kuffel, Gina (NIH/NCI) [C]
X

Musk, Philip (NIH/NCI) [C]

X
Warren KibbeX
Kim, Erika (NIH/NCI) [E]
X
Gregory Tawa
X
William Hendriks
X
Matthew Breen
X
Roel Verhaak
X



Goals

  • Review, discuss, and prioritize ICDC study submission proposals

Outstanding Action items

  • Full publication details needed from Matthew Breen for UC01
  • Matthew & Warren to write an email request to Toby pertaining to formalization of a business plan for ICDC
  • Kuffel, Gina (NIH/NCI) [C] to work with Phil add description for NCATS DPI (supported clinical sequencing)

Agenda

Discussion ItemWhoNotes
Study Queue

Musk, Philip (NIH/NCI) 

  • OSA04: 
    • Osteosarcoma study from Auburn University
    • 7 cases
    • Clinical and Transcriptomic data
    • Approved by the SAC on 9/20/23
  • COTC021: Evaluation of Orally Administered mTOR inhibitor Rapamycin in Dogs in the Adjuvant Setting with Osteosarcoma
    • This is the parallel arm to COTC022: SOC in dogs with Osteosarcoma that was previously uploaded to the ICDC
    • Clinical data for 152 dogs. mRNAseq for 93 dogs
    • Status: Approved by SAC on 6/30/23, Template-based data loading files have been received
  • UBC03
    • Approved by SAC on 8/13/22
    • "Transcriptomic analyses of early stage bladder cancer in Scottish Terriers detected through screening"
    • Purdue University
    • 19 cases
    • Status: v2 template-based data loading files have been reviewed, v3 files have been received, ready for load
  • OSA02
    • Approved by SAC on 9/22/22
    • "Immune Pathways and TP53 missense mutations are associated with longer survival in canine osteosarcoma"
    • Colorado State University
    • 108 cases
    • Status: Submitters generating template-based loading files, reviewing hospital records to extract staging information and progression/survival data
  • ORGANOIDS01
    • Approved by SAC on 9/22/22
    • “Characterization of healthy and diseased canine tissues and organoids"
    • Iowa State University
    • Status: Released to production on 10/16/23
  • PRECINCT01 
    • Approved by SAC on 6/28/22
    • "Inhaled IL-15 Immunotherapy for Treatment of Lung Metastases"
    • UC Davis
    • 21 cases
    • Status: Most data not yet available, pathology reports have been indexed by DCF and adverse event metadata coming soon, some files have been transferred, bucket permissions resolved, cytokine data is now available
  • PRECINCT02
    • Approved by SAC on 12/8/22
    • "Novel treatments for Diffuse large B cell lymphoma (DLBCL) in dogs"
    • Tufts University
    • 49 cases
    • Status: Submitter has generated version 3 of template-based data loading files, most clinical data has been received, ready for load
  • PANCAN01
    • Approved by SAC on 11/8/21
    • "Canine tumor mutational burden is correlated with TP53 mutation across tumor types and breeds"
    • University of Georgia
    • 684 cases
    • Status: Submitters generating template-based loading files, data manager PoC has been identified, candidate study has been identified to move forward

Minutes (Not Verbatim)



Action items