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Date

Attendees

Committee MemberPresentAbsent
Kuffel, Gina (NIH/NCI) [C]
X

Musk, Philip (NIH/NCI) [C]

X
Warren KibbeX
Kim, Erika (NIH/NCI) [E]

X
Gregory Tawa
X
William Hendriks
X
Matthew Breen
X
Roel VerhaakX



Goals

  • Review, discuss, and prioritize ICDC study submission proposals

Outstanding Action items

  • Matthew & Warren to write an email request to Toby pertaining to formalization of a business plan for ICDC
  • Kuffel, Gina (NIH/NCI) [C] to work with Phil add description for NCATS DPI (supported clinical sequencing)

Agenda

Discussion ItemWhoNotes
Study Queue

Musk, Philip (NIH/NCI) 

  • New Data Submission Request: 
    • Osteosarcoma study from Auburn University
    • 7 cases
    • Clinical and Transcriptomic data
    • Recommended by DGAB to the SAC on 8/30/23
  • COTC021: Evaluation of Orally Administered mTOR inhibitor Rapamycin in Dogs in the Adjuvant Setting with Osteosarcoma
    • This is the parallel arm to COTC022: SOC in dogs with Osteosarcoma that was previously uploaded to the ICDC
    • Clinical data for 152 dogs. mRNAseq for 93 dogs
    • Status: Approved by SAC on 6/30/23, Template-based data loading files have been received
  • UBC03
    • Approved by SAC on 8/13/22
    • "Transcriptomic analyses of early stage bladder cancer in Scottish Terriers detected through screening"
    • Purdue University
    • 19 cases
    • Status: v2 template-based data loading files have been reviewed, v3 files have been received, ready for load
  • OSA02
    • Approved by SAC on 9/22/22
    • "Immune Pathways and TP53 missense mutations are associated with longer survival in canine osteosarcoma"
    • Colorado State University
    • 108 cases
    • Status: Submitters generating template-based loading files, reviewing hospital records to extract staging information and progression/survival data
  • ORGANOIDS01
    • Approved by SAC on 9/22/22
    • “Characterization of healthy and diseased canine tissues and organoids"
    • Iowa State University
    • Status: Loaded into the Dev environment and indexing has been completed by DCF, data preview scheduled for tomorrow morning
  • PRECINCT01 
    • Approved by SAC on 6/28/22
    • "Inhaled IL-15 Immunotherapy for Treatment of Lung Metastases"
    • UC Davis
    • 21 cases
    • Status: Most data not yet available, pathology reports have been indexed by DCF and adverse event metadata coming soon, some files have been transferred, bucket permissions resolved, cytokine data is now available
  • PRECINCT02
    • Approved by SAC on 12/8/22
    • "Novel treatments for Diffuse large B cell lymphoma (DLBCL) in dogs"
    • Tufts University
    • 49 cases
    • Status: Submitter has generated version 3 of template-based data loading files, most clinical data has been received, ready for load
  • PANCAN01
    • Approved by SAC on 11/8/21
    • "Canine tumor mutational burden is correlated with TP53 mutation across tumor types and breeds"
    • University of Georgia
    • 684 cases
    • Status: Submitters generating template-based loading files, data manager PoC has been identified, candidate study has been identified to move forward

Minutes (Not Verbatim)

Gina presented data submission request COTC021

WK - moved this to a vote

All members on the call voted to recommend this study for ingestion.


Action items

  • Full publication details needed from Matthew Breen for UC01