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Date

Attendees

Committee MemberPresentAbsent
Kuffel, Gina (NIH/NCI) [C]
X

Unknown User (leblancak)

X

Otridge, John (NIH/NCI) [C]

X
Kim, Erika (NIH/NCI) [E]

X

Sommers, Connie (NIH/NCI) [E]

X


Debbie Knapp
X
Toby HechtX

Unknown User (parchmentr)


X

Goals

  • Discuss updates to ICDC and define emerging strategies and priorities

SharePoint Site

https://nih.sharepoint.com/sites/NCI-CBIIT-FNL-ICDC-ICDCLeadershipGroups

Outstanding Action Items


Agenda

ItemWhoTalking Points
Discussion of potential submission of FidoCure and Vidium Animal Health data

Sommers, Connie (NIH/NCI) [E] 

  • Previous conversations revealed some issues with analytic techniques
DGAB Updates

Kuffel, Gina (NIH/NCI) [C] 

Recently Approved

  • COTC021
    • "Evaluation of Orally Administered mTOR inhibitor Rapamycin in Dogs in the Adjuvant Setting with Osteosarcoma"
    • 152 cases, 93 files
    • Full clinical dataset is available for both arms of this trial (324 dogs)
    • Scan H & E is available
    • Status: Approved by SAC on 6/30/23

ICDC Studies in Active Submission

  • ORGANOIDS01
    • Approved by SAC on 9/22/22
    • “Characterization of healthy and diseased canine tissues and organoids"
    • Iowa State University
    • Status: Data has been loaded to the Dev tier
BPSC Updates

Kuffel, Gina (NIH/NCI) [C] 

  • 2022 BPSC Review Article

    The manuscript entitled "Leading the Pack: Best Practices in Comparative Canine Cancer Genomics to Inform Human Oncology" has been successfully submitted online and is being delivered to the Editorial Office of Veterinary and Comparative Oncology for consideration.

Upcoming Steering Committee Meeting

Unknown User (parchmentr)

  • Enter date: Wednesday 7/26, no August Meeting
  • Toby is unavailable at 12:30 pm, proposing change to 11 or 11:30 am
  • Proposed Agenda:
Next Software Release

Kuffel, Gina (NIH/NCI) [C] 

  • Target date is July 26, 2023
  • New Features
    • 2 new tabs on the Study Details page, one for supporting data and the other for clinical data observations
    • Full-text search for JBrowse
    • Liftover tracks for gene annotations from human hg38 to canFam genomes
    • Updated UI design for "My Files" Cart Page
    • Button for exporting a file manifest directly to the CGC

Minutes (Not Verbatim)

AL - Jerry Post agreed that it is an exciting time for canine oncology. He thinks it would be a good idea for us to connect more. He expressed some concerns with integrating their data with our committee. They have novel data that would be interesting for the ICDC. Vidium has a publication out and may be more willing to share data.

TH - We should schedule a formal session with both groups to reconnect.

TH - Debbie has been in touch and has a paper that has been accepted that actually uses ICDC data.

TH - Cancer health disparity in acral melanoma in African Americans. Human dog comparative oncology could be important.

AL - Will H. has a paper that performs a broad assessment of canine melanomas in dogs

JO - Did we want to find out if there is publicly available data on this and bring it into the ICDC?






Previous ICDC Use Cases from Steering Committee

1. Genomic correlates across platforms (DNA, RNA, protein).

2. Correlating multi-omics data with clinical annotation and phenotypes, particularly outcomes.

3. Comparative analyses of canine and human. Examples include:

1. Search for conserved mutations between canine and human tumors

2. Disease diagnosis (e.g. cancer type) and classification mapping between canines and humans

5. Gene expression changes and mutational profiles associated with therapeutic response and outcome

6. How do sporadic tumors in non-human mammals compare to sporadic human tumors?

7. Correlations and model building from radiomic and pathomic features extracted from medical and histopathologic images with outcomes and genomics, as is currently being widely done with human images

8. Develop biomarkers of response and resistance in humans by analyzing the responses and genomic signatures in dogs.




Action items

  • Debbie to write invitation for Jaime Modiano
  • Revisit new steering committee members in September 
  • Debbie Knapp to send an email to FidoCure and Vidium to see if these groups are willing to sit down and meet with us.