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Date

Attendees

Committee MemberPresentAbsent
Kuffel, Gina (NIH/NCI) [C]
X
Amy Leblanc
X

Otridge, John (NIH/NCI) [C]

X
Kim, Erika (NIH/NCI) [E]

X

Sommers, Connie (NIH/NCI) [E]

X


Debbie Knapp
X
Toby HechtX
Ralph Parchment
X

Goals

  • Discuss updates to ICDC and define emerging strategies and priorities

SharePoint Site

https://nih.sharepoint.com/sites/NCI-CBIIT-FNL-ICDC-ICDCLeadershipGroups

Outstanding Action Items


  • Revisit new steering committee members in September (loop Connie into this discussion) 
  • Toby to invite Greg from CCDI to the next Executive Team Meeting in January
  • Toby to look across the NCI directory to find person that has a combination of canine and pediatric oncology background

Agenda

ItemWhoTalking Points
New Steering Committee Members

Toby

  • New CCDI member to potentially present to Steering Committee, need topics of interest
    • How can we compare pediatric/human data to canine data
    • How can our researchers connect to where related human data are accessible
Post Discussion about FidoCure

All

  • Not clear if we really can have a successful collaboration, however we have let them know if they can find a way to work with us that the ICDC would be interested.
  • Their public data is a candidate for the ICDC
  • They are interested in correlating data with biomarkers and that is an area of interest for the ICDC
  • Work instead with peer reviewed and published scientists that use FidoCure data
  • Their data may not be useful to predict outcomes

New ICDC Working Group: Longitudinal Data Acquisition and Use Working Group (LDAUWG)

Purpose: Formulate scientific questions and use cases that can be used to interrogate longitudinal datasets that would justify the ingestion of such data into the ICDC.

All

  • New ICDC  1-pager
  • First meeting is scheduled for Friday March 1st
DGAB Updates

Kuffel, Gina (NIH/NCI) [C] 

Potential new submission request

  • University of Zurich

    New Approved Study 
  • OSA04: 
    • Osteosarcoma study from Auburn University
    • 7 cases
    • Clinical and Transcriptomic data
    • Status: Kick off call to be planned

ICDC Studies in Active Submission 

COTC021 

  • "Evaluation of Orally Administered mTOR inhibitor Rapamycin in Dogs in the Adjuvant Setting with Osteosarcoma" 
  • Dr. Amy LeBlanc 
  • Status: The study, case and sample records were loaded in early September. Sequencing files and file transfer manifest have been transferred to bucket pending validation.

UBC03 

  • "Transcriptomic analyses of early-stage bladder cancer in Scottish Terriers detected through screening" 
  • Dr. Debbie Knapp 
  • Status: Multiple versions of metadata have been received and the final version is in review. Waiting on the File Transfer Manifest.

OSA02 

  • "Immune Pathways and TP53 missense mutations are associated with longer survival in canine osteosarcoma" 
  • Dr. Dawn Duval 
  • Status: Version 1 of metadata loading files have been received and reviewed. Version 2 is expected soon to address validation errors. 

PRECINCT01 

  • "Inhaled IL-15 Immunotherapy for Treatment of Lung Metastases" 
  • UC Davis 
  • 21 cases 
  • Status: 21 pathology reports and 5 study-level files, including Nanostring-based evaluation of cytokine levels, have been received and indexed by DCF. Adverse event data has been ingested. Application-level testing revealed several software bugs related to download of the clinical data and fixes are pending by the ICDC team.  

PRECINCT02 

        • "Novel treatments for Diffuse large B cell lymphoma (DLBCL) in dogs" 
        • Tufts University 
        • 49 cases 
        • Status: Adverse event data has been received and ingested. Visit, vital signs and physical exam data was received and revealed validation errors. Version 2 of these loading files has been received. Lab exam and extent of disease data to be received.  
ICDC Biospecimen Data

Kuffel, Gina (NIH/NCI) [C] 

Upcoming Steering Committee Meeting

Ralph Parchment

  • April meeting: Monday April 15th
  • The minutes can be reviewed in the meeting invite
Upcoming LDAUWG Meeting


  • May 17th 3:00-3:45 PM

Minutes (Not Verbatim)





Previous ICDC Use Cases from Steering Committee

1. Genomic correlates across platforms (DNA, RNA, protein).

2. Correlating multi-omics data with clinical annotation and phenotypes, particularly outcomes.

3. Comparative analyses of canine and human. Examples include:

1. Search for conserved mutations between canine and human tumors

2. Disease diagnosis (e.g. cancer type) and classification mapping between canines and humans

5. Gene expression changes and mutational profiles associated with therapeutic response and outcome

6. How do sporadic tumors in non-human mammals compare to sporadic human tumors?

7. Correlations and model building from radiomic and pathomic features extracted from medical and histopathologic images with outcomes and genomics, as is currently being widely done with human images

8. Develop biomarkers of response and resistance in humans by analyzing the responses and genomic signatures in dogs.

Action items


  • John to get disease areas from Sam V.
  • Toby to reach out to Adam Resnick to gauge interest in joining the Subcommittee
  • Kuffel, Gina (NIH/NCI) [C]  to work with Ralph to get the letters prepared for the new SC members
  • Kuffel, Gina (NIH/NCI) [C] to build list of studies that used FidoCure data