2024-6-10 DGAB Meeting notes

ICDC Incoming Data Submission Requests

• • UC02 - Urothelial Carcinoma study

ICDC Studies Recently Approved

• STS01
  • Soft tissue sarcoma study from Colorado State University
  • 29 cases
  • Genomics, Transcriptomics, Immunology 
    
  • Status: SAC has approved this submission, template-based loading files for metadata received, kickoff call to be scheduled

ICDC Studies in Active Submission 

OSA04 

• • Osteosarcoma study from Auburn University
  • 7 cases
  • Clinical and Transcriptomic data
  • Status: Version 1 of the metadata has been received and loaded to Dev environment.

COTC021 

• "Evaluation of Orally Administered mTOR inhibitor Rapamycin in Dogs in the Adjuvant Setting with Osteosarcoma" 
• 152 cases
• Dr. Amy LeBlanc 
• Status: Since study, case and sample records were loaded in early September a reconciliation was performed to ensure accuracy. Sequencing files and file transfer manifest have been transferred to bucket pending validation. 2 study-level files need to be added to the bucket.

COTC022

• "A Contemporaneous Controlled Study of the Standard of Care (SOC) in Dogs with Appendicular Osteosarcoma" 
• 157 cases
• Status: Sample and file records have been received. The study has been loaded onto the QA environment and is currently in testing.

UBC03 

• "Transcriptomic analyses of early-stage bladder cancer in Scottish Terriers detected through screening" 
• Dr. Debbie Knapp 
• Status: All data loading template files, object files, and file transfer manifest have been received, validation is pending. 

OSA02 

• "Immune Pathways and TP53 missense mutations are associated with longer survival in canine osteosarcoma" 
• 117 cases
• Dr. Dawn Duval 
• Status: Template data loading files have been received. The study has been loaded onto the Dev tier. Files from the submitter bucket are being transferred into the ICDC production bucket. 

PRECINCT01 

• "Inhaled IL-15 Immunotherapy for Treatment of Lung Metastases" 
• UC Davis 
• 21 cases 
• Status: 21 pathology reports and 5 study-level files, including Nanostring-based evaluation of cytokine levels, have been received and indexed by DCF. Adverse event data has been ingested. Application-level testing revealed several software bugs related to download of the clinical data and fixes are pending by the ICDC team.  

PRECINCT02 

• "Novel treatments for Diffuse large B cell lymphoma (DLBCL) in dogs" 
• Tufts University 
• 49 cases 
• Status: Adverse event data has been received and ingested. Visit, vital signs and physical exam data was received and revealed validation errors. Version 2 of these loading files has been received. Lab exam and extent of disease data to be received.