2024-6-21 Executive Team Meeting Notes

Date

21 Jun 2024

Attendees

Committee Member	Present	Absent
Kuffel, Gina (NIH/NCI) [C]	X
Amy Leblanc		X
Otridge, John (NIH/NCI) [C]	X
Kim, Erika (NIH/NCI) [E]		X
Sommers, Connie (NIH/NCI) [E]	X
Debbie Knapp	X
Toby Hecht	X
Ralph Parchment	X

Goals

Discuss updates to ICDC and define emerging strategies and priorities

SharePoint Site

https://nih.sharepoint.com/sites/NCI-CBIIT-FNL-ICDC-ICDCLeadershipGroups

Outstanding Action Items

Kuffel, Gina (NIH/NCI) [C] to send out message to SC members about upcoming talk from Lee Helman and Julia Labadie
Toby to reach out to Adam Resnick to gauge interest in joining the Subcommittee
Kuffel, Gina (NIH/NCI) [C] to work with Ralph to get the letters prepared for the new SC members
Kuffel, Gina (NIH/NCI) [C] to build list of studies that used FidoCure data
Revisit new steering committee members in September (loop Connie into this discussion)
Toby to look across the NCI directory to find person that has a combination of canine and pediatric oncology background

Agenda

Item	Who	Talking Points
ICDC Common Data Element (CDE) Mapping Exercise	Kuffel, Gina (NIH/NCI) [C]	ICDC Model Properties 2024-05-31 - working copy.xlsx
Recent & Upcoming Presentations	Kuffel, Gina (NIH/NCI) [C]	4/15/24: CRDC Component Report Out featuring the ICDC CRDC Component Report Out_ICDC_April 2024.pptx 5/15/24: The Golden Retriever Lifetime Study featuring Julia Labadie Julia Labadie_MAF_20240515.pptx 5/22/24:Dogs and Cancer Part 1: Canine cancer genomics resources and research featuring Cheryl London, Gina Kuffel and Elaine Ostrander https://www.cancergenomicscloud.org/webinars/2024-05-22-webinar 6/20/24: Legacy of the domestic dog: informing biological discovery through large-scale genomics featuring Elaine Ostrander 6/26/24: Dogs and Cancer Part 2: Emerging methods and technologies in comparative oncology featuring Shaying Zhou and Heather Gardner https://www.cancergenomicscloud.org/webinars/june-webinar 7/12/24: ICDC updates to the Phamacodynamic Meeting
Steering Committee Updates	Ralph	On 5/15/24: Dr. Julia Labadie, a Principal Investigator at the Morris Animal Foundation (MAF), presented an overview of the Golden Retriever Lifetime Study (GRLS). This landmark longitudinal study, spanning over a decade, has collected biological specimens and health data from over 3,000 Golden Retrievers throughout their lives. 6/5/24: Dr. Lee Helman provided valuable insights into the Childhood Cancer Data Initiative (CCDI) and the possibility of leveraging canine models of human disease. This presentation holds immense potential for identifying synergies and collaborative opportunities between the ICDC and the CCDI. New CCDI member to potentially present to Steering Committee, need topics of interest How can we compare pediatric/human data to canine data How can our researchers connect to where related human data are accessible New Members Adam Resnick Anne Avery Potential New Members Marc Ernstoff July meeting: July 24th 11:30-1 PM Jim Dattilo will present on his REDCap clinical data evaluation forms that align with the ICDC data model Adam Resnick will present on his CGC public project
Longitudinal Data Acquisition and Use Working Group (LDAUWG) Updates	All	Purpose: Formulate scientific questions and use cases that can be used to interrogate longitudinal datasets that would justify the ingestion of such data into the ICDC. Working Group Charter 1-pager Last meeting was Friday May 17, 2024 Possible collaboration with the Morris Animal Foundation Next meeting is July 12, 2024 at 3 PM.
Data Governance Advisory Board (DGAB) Updates	Kuffel, Gina (NIH/NCI) [C]	ICDC Incoming Data Submission Requests UC02 - 2020 Ostrander Urothelial Carcinoma study Attempting to get bam files transferred into bucket ICDC Studies Recently Approved STS01 Soft tissue sarcoma study from Colorado State University 29 cases Genomics, Transcriptomics, Immunology Status: SAC has approved this submission, template-based loading files for metadata received, kickoff call to be scheduled ICDC Studies in Active Submission OSA04 Osteosarcoma study from Auburn University 7 cases Clinical and Transcriptomic data Status: Version 1 of the metadata has been received and loaded to Dev environment. COTC021 "Evaluation of Orally Administered mTOR inhibitor Rapamycin in Dogs in the Adjuvant Setting with Osteosarcoma" 152 cases Dr. Amy LeBlanc Status: Since study, case and sample records were loaded in early September a reconciliation was performed to ensure accuracy. Sequencing files and file transfer manifest have been transferred to bucket pending validation. 2 study-level files need to be added to the bucket. COTC022 "A Contemporaneous Controlled Study of the Standard of Care (SOC) in Dogs with Appendicular Osteosarcoma" 157 cases Status: Sample and file records have been received. The study has been loaded onto the QA environment and is currently in testing. UBC03 "Transcriptomic analyses of early-stage bladder cancer in Scottish Terriers detected through screening" Dr. Debbie Knapp Status: All data loading template files, object files, and file transfer manifest have been received, validation is pending. OSA02 "Immune Pathways and TP53 missense mutations are associated with longer survival in canine osteosarcoma" 117 cases Dr. Dawn Duval Status: Template data loading files have been received. The study has been loaded onto the Dev tier. Files from the submitter bucket are being transferred into the ICDC production bucket. PRECINCT01 "Inhaled IL-15 Immunotherapy for Treatment of Lung Metastases" UC Davis 21 cases Status: 21 pathology reports and 5 study-level files, including Nanostring-based evaluation of cytokine levels, have been received and indexed by DCF. Adverse event data has been ingested. Application-level testing revealed several software bugs related to download of the clinical data and fixes are pending by the ICDC team. PRECINCT02 "Novel treatments for Diffuse large B cell lymphoma (DLBCL) in dogs" Tufts University 49 cases Status: Adverse event data has been received and ingested. Visit, vital signs and physical exam data was received and revealed validation errors. Version 2 of these loading files has been received. Lab exam and extent of disease data to be received.
ICDC Biospecimen Data	Kuffel, Gina (NIH/NCI) [C]	Collect biospecimen data so that we can build a page in the ICDC application ICDC Biospecimen Data
Next Executive Team Meeting		Friday August 2, 2024 at 12 PM David Shiffley will be presenting about building a non-profit/open-source data warehouse to help veterinary researchers better utilize their own data plus connect with partner researcher's data from around the globe. This database would be designed to push and pull data from the ICDC automatically, ideally creating a central point for all canine cancer related data.

Minutes (Not Verbatim)

RP - Coordinated Leidos subcontracts to provide electronic data capture that they typically would have collected. This would be deployed to the COP sites that want to participate. During follow-up care data points will be collected. COTC sites have the medical expertise to process samples. Might roll this out as a study, may focus on paper data capture. Sequencing may be done by the Broad and Matthew Breen.

TH - These conversations have not materialized for over 2 years. LDAUWG will advise on how to collect, what to collect, and analysis guidance.

RP - The GRLS study is interested in involving us. We willl commit the funds through the PRs. 1 for GRLS and MAF, 1 for Tufts and metadata collection using the Dog Aging templates from Dan Promislow, and 1 for COTC clinical trial sites that want to participate. We can ask through the RFP if any groups want to volunteer for the sequencing effort. As part of the RFP we can include around 6 cancer-free senior individuals.

Notes on FidoCure

Not clear if we really can have a successful collaboration, however we have let them know if they can find a way to work with us that the ICDC would be interested.
Their public data is a candidate for the ICDC
They are interested in correlating data with biomarkers and that is an area of interest for the ICDC
Work instead with peer reviewed and published scientists that use FidoCure data
Their data may not be useful to predict outcomes

Previous ICDC Use Cases from Steering Committee

1. Genomic correlates across platforms (DNA, RNA, protein).

2. Correlating multi-omics data with clinical annotation and phenotypes, particularly outcomes.

3. Comparative analyses of canine and human. Examples include:

1. Search for conserved mutations between canine and human tumors

2. Disease diagnosis (e.g. cancer type) and classification mapping between canines and humans

5. Gene expression changes and mutational profiles associated with therapeutic response and outcome

6. How do sporadic tumors in non-human mammals compare to sporadic human tumors?

7. Correlations and model building from radiomic and pathomic features extracted from medical and histopathologic images with outcomes and genomics, as is currently being widely done with human images

8. Develop biomarkers of response and resistance in humans by analyzing the responses and genomic signatures in dogs.

Action items

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