In 2016 the NCI awarded 8 1-year supplements to support research in canine immunotherapy via collaborations between NCI-designated cancer centers and veterinary medical colleges
Goals included:
•Sequence (whole exome and RNAseq) of at least 25 canine tumors and their normal controls in one or more of the following tumors: B-cell lymphoma, glioma, osteosarcoma, melanoma, bladder cancer and mammary cancer
•Determine mutational load
•Characterize potential neoantigens that can bind canine MHC complexes
•Characterize T lymphocyte numbers and subsets and other relevant aspects of the tumor microenvironment in canine tumors
Institution | Project Leader(s) | Canine Cancer(s) |
Baylor/U Florida Vet Med/Texas A&M/Tech U Denmark | Jonathan Levitt, PhD/Alan Herron, DVM | bladder, mammary, melanoma |
U Colorado/Colorado State U Vet | Jill Slansky, PhD/Steven Dow, DVM, PhD | B-cell lymphoma |
DFCI-HCC/Tufts U Vet Med | Katherine Janeway, MD/Cheryl London, DVM | osteosarcoma |
Purdue U/Duke U | Deborah Knapp, DVM/H. Kim Lyerly, MD | bladder |
Roswell Park/Cornell U Vet Med | Richard Koya, MD PhD/Kristy Richards, MD PhD | B-cell lymphoma |
UC Davis/UC Davis Vet Med | Arta Monjazeb, MD PhD | glioma, melanoma, osteosarcoma |
Ohio State U/OSU Vet Med/TGEN | Peter Shields, MD/Jeffrey Trent, PhD | melanoma, osteosarcoma |
MD Anderson/Texas A&M | Amy Heimberger, MD/Jonathan Levine, DVM | glioma |
P30 Grant holder:
Richard C. Koya, MD, PhD (email of 12/11/18):
Associate Director of the Center for Immunotherapy
Director of the Vector Development & Production Facility
Associate Professor of Oncology and Immunology
Roswell Park Comprehensive Cancer Center
Center for Immunotherapy
Elm and Carlton Streets, CCC-419
Buffalo, NY, 14263
Phone: (716) 845-1300, ext. 6582
Email: richard.koya@roswellpark.org
Bioinformatician
Sebastiano Battaglia, PhD
Assistant Professor of Oncology
Center For Immunotherapy
Assistant Member
Dept. of Cancer Genetic and Genomics
Roswell Park Comprehensive Cancer Center
Elm and Carlton sts.
14263, Buffalo, NY, USAA
p: +1 716 845 2300 ext. 5559
e: sebastiano.battaglia@roswellpark.org
P30 Grant holder:
Deborah Knapp (email of 12/11/18):
Dhawan D, Hahn NM, Ramos-Vara JA, Knapp DW. Naturally-occurring canine invasive urothelial carcinoma harbors luminal and basal transcriptional subtypes found in human muscle invasive bladder cancer. PLoS Genet. 2018 Aug 8;14(8):e1007571. doi: 10.1371/journal.pgen.1007571. eCollection 2018 Aug. PMID: 30089113
Dhawan D, Paoloni M, Shukradas S, Choudhury DR, Craig BA, Ramos-Vara JA, Hahn N, Bonney PL, Khanna C, Knapp DW. Comparative Gene Expression Analyses Identify Luminal and Basal Subtypes of Canine Invasive Urothelial Carcinoma That Mimic Patterns in Human Invasive Bladder Cancer. PLoS One. 2015 Sep 9;10(9):e0136688. doi: 10.1371/journal.pone.0136688. eCollection 2015. PMID: 26352142
