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Adding Chemical Association Composition Annotations
Adding Nanomaterial Entity Composition Annotations
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- Select the Nanomaterial Entity Type (required) from the drop-down list. Enter a Description for the entity.
- A [Nanomaterial] Properties section appears whose fields are customized according to what you selected for Nanomaterial Entity Type. For specific information about completing the Properties section, see Defining Nanomaterial Entity Properties.
- In the Composing Element section, add information regarding the elements that compose the nanomaterial entity of the sample. For more information, see Defining Nanomaterial Composing Elements.
- In the File section, click Add to expand the page where you can add one or more files whose data is relevant to the nanomaterial entity or the derivation of its data. For more information, see Adding a File.
- In the Copy to Other Samples... section, select one or more samples in the list to which you want this composition data transferred. This option copies files and data to one or more selected samples "owned" by the same point of contact. For more information, see Copying Characterizations.
- When you finish, click Submit to save the data to the sample or click Reset to clear all fields on the form.
Defining Nanomaterial Entity Properties
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After defining the particle properties, continue the process described in Adding Nanomaterial Entity Composition Annotations.
Biopolymer
A biopolymer nanoparticle is a type of polymer that is produced by living organisms. In the context of nanotechnology, a biopolymer can also be a nanomaterial entity or a functionalizing entity.
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After defining the particle properties, continue the process described in Adding Nanomaterial Entity Composition Annotations.
Carbon Nanotube
Carbon nanotubes (CNTs) are fullerene-like nanostructures that consist of graphene cylinders. The ends of the construct are closed with pentagonal-shaped rings.
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After defining the particle properties, continue the process described in Adding Nanomaterial Entity Composition Annotations.
Dendrimer
A dendrimer is a polymeric molecule which has a highly-branched, three-dimensional architecture. Dendrimers are synthesized from monomers and new branches are added in discrete steps to form a tree-like architecture. A high level of synthetic control is achieved through iterative reactions and purification at each step to regulate the size, architecture, functionality and monodispersity of the molecules. These polymers have desirable pharmacokinetic properties and a polyvalent array of surface groups that make them potential drug delivery vesicles.
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After defining the particle properties, continue the process described in Adding Nanomaterial Entity Composition Annotations.
Emulsion
An emulsion is a suspension of liquid within another liquid or a dispersion consisting of two or more liquid phases. In the context of caNanoLab, an emulsion nanoparticle consists of nanoparticles suspended in an emulsifying liquid.
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After defining the particle properties, continue the process described in Adding Nanomaterial Entity Composition Annotations.
Fullerene
A fullerene is one of three known pure forms of carbon that exhibits a spherical shape with a hollow interior; named after Buckminster Fuller. The number of carbon atoms comprising fullerenes is variable; several stable spherical carbon structures containing 70 or more atoms have been documented.
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After defining the particle properties, continue the process described in Adding Nanomaterial Entity Composition Annotations.
Liposome
Liposomes are substances composed of layers of lipid that form hollow microscopic spheres within which drugs or agents could be contained for enhanced safety and efficacy. Based upon its size measured in nanometer range, a liposome can be categorized as a nanoparticle.
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After defining the particle properties, continue the process described in Adding Nanomaterial Entity Composition Annotations.
Metal Particle
A metal particle is a nanoparticle composed of electropositive chemical elements characterized by ductility, malleability, luster, and conductance of heat and electricity. They can replace the hydrogen of an acid and form bases with hydroxyl radicals.
There are no unique metal particle properties to be defined. Continue the process described in Adding Nanomaterial Entity Composition Annotations.
Polymer
A key feature that distinguishes polymers from other molecules is the repetition of a linked series of many identical, similar, or complementary monomers. A polymer nanoparticle is just that--a polymer measured in nanometer range.
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After defining the particle properties, continue the process described in Adding Nanomaterial Entity Composition Annotations.Composition Annotations.
Quantum Dot
A Quantum Dot is a nanometer-sized semiconductor particle, made of cadmium selenide (CdSe), cadmium sulfide (CdS) or cadmium telluride (CdTe) with an inert polymer coating. The semiconductor material used for the core is chosen based upon the emission wavelength range being targeted: CdS for UV-blue, CdSe for the bulk of the visible spectrum, and CdTe for far red and near-infrared. The size of the particle determines the exact color of a given quantum dot. The polymer coating protects cells from cadmium toxicity but also facilitates the attachment of a variety of targeting molecules, including monoclonal antibodies directed to tumor-specific biomarkers. Because of their small size, quantum dots can function as cell- and even molecule-specific markers that will not interfere with the normal cellular functions.
There are no unique quantum dot properties to be defined. Continue the process described in Adding Nanomaterial Entity Composition Annotations.
Defining Nanomaterial Composing Elements
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After defining composing elements, continue the process described in Adding Nanomaterial Entity Composition Annotations.
Adding a File
To add results in the form of supporting documentation to the nanomaterial entity
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After adding one or more files, return to the steps described in Adding Nanomaterial Entity Composition Annotations.
Adding Functionalizing Entity Composition Annotations
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- Select the Functionalizing Entity Type (required). For more information, see Defining a Functionalizing Entity.
A customized [Functionalizing Entity] Properties section based on your selection of the Functionalizing Entity Type appears on the page. For information about defining properties for the composition, see Defining [Functionalizing Entity type] Properties . - In the Function Information section, add information about the functionalizing elements of the sample. For more information, see Defining Function Information.
- In the File section, click Add to expand the page where you can add one or more files whose data is relevant to the functionalizing entity or the derivation of its data. For more information, see Adding a File.
- In the Copy to Other Samples... section, select one or more samples in the list to which you want this composition data transferrred. This option copies files and data to one or more selected samples "owned" by the same point of contact. For more information, see Copying Characterizations.
When you finish, click Save to save the data to the sample or click Reset to clear all fields on the form.
Defining a Functionalizing Entity
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After defining the Functionalizing Entity, continue the process described in Adding Functionalizing Entity Composition Annotations.
Defining [Functionalizing Entity type] Properties
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After defining the Functionalizing Entity properties, continue the process described in Adding Functionalizing Entity Composition Annotations.
Defining Function Information
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After defining the function Information, continue the process described in Adding Functionalizing Entity Composition Annotations.
Adding a File
To add results in the form of supporting documents to the functionalizing entity, follow these steps:
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As appropriate, continue the process described in Adding Functionalizing Entity Composition Annotations or Adding Chemical Association Composition Annotations.
Adding Chemical Association Composition Annotations
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- Once you enter the essential nanomaterial entity and functionalizing entity information under the Composition category, click the Add button corresponding to Chemical Association on the All tab or select the Chemical Association tab itself where you can click the Add button.
- The page that opens is organized into three sections. Select from the drop-down list the Association Type (required). Options include:
Description: Enter any additional information that describes the chemical association of the two elements. - In the Elements Information section, both Element boxes select the nanomaterial or functionalizing entities for which you are defining the chemical association. These have been previously defined for the sample you are annotating. For each selection you make, another drop-down list appears displaying entities relating to your previous selection. Make the appropriate selections in each.The arrow between the Element text boxes symbolizes the association between the two.
- In the File section, click Add to expand the page where you can add one or more files whose data is relevant to the nanomaterial entity or the derivation of its data. For more information, see Adding a File.
Adding Composition Files
This section of the [Sample] Composition category allows you to add files relevant to the sample independently of the entity or chemical associations that you defined. You can add as many files as you wish.
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For more information about working with publications, see Managing Publications.
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