Summary

The Reference Image Database to Evaluate Therapy Response (RIDER)

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1. Executive Summary

The RIDER database is a targeted data collection for the purpose of generating an initial consensus on how to harmonize data collection and analysis for quantitative imaging methods as applied to measure the response to drug or radiation therapy. The long term goal is to provide a resource to permit harmonized methods for data collection and analysis across different commercial imaging platforms, as required to support multi-site clinical trials, using imaging as a biomarker for therapy response. Thus the database should permit an objective comparison of methods for data collection and analysis as a national and international resource as described in the first RIDER white paper report (2006):

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All the image data are DICOM compliant and the image, annotations and meta data formats meets all the requirements for caBIG and the NBIA.  The data collection has two phases as described below, which have resulted in several distinct image Collections.

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RIDER

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Pilot (2005-2007)

Download on NBIA by searching Collection name: RIDER Pilot

This data collection was originally supported under supplemental funding for the LIDC U01 project and focused on the collection of longitudinal studies using X-ray CT for monitoring the response to therapy. The data came primarily from MDACC and several of the LIDC academic sites. The data is not annotated. However it contains a sub-set of 30 longitudinal cases that are annotated using the RECIST criteria.

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RIDER Contracts: 2007-Beyond

NCI has exercised a series of contracts with specific academic sites for collection of repeat "coffee break" and longitudinal phantom and patient data for a range of imaging modalities (currently CT, PET CT, DCE MRI, DW MRI) and organ sites (currently lung, breast, and neuro). The goals are as follows:

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The RIDER project will be replaced when the QIN initiative is fully implemented as this research network will be tasked to create database resources collected from phase 1-3 clinical trials, where clinical outcomes will be included in the meta data: http://grants.nih.gov/grants/guide/pa-files/PAR-08-225.html

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ACADEMIC SITE COLLECTIONS: Focus on methods for data analysis

MSKCC

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• Images contained in "RIDER Lung CT" Collection in NBIA
• Repeat CT Measurements: Human subjects: Lung
• Download the related lesion notes: MSKCC RepeatCT Lesion notes for RIDER.xls
• Download the related publication: Zhaob-RepeatCT Radiology2009.pdf

UNIVERSITY OF WASHINGTON

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• Images contained in "Phantom" Collection in NBIA
• Repeat measurements: PET/CT phantoms

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• Images contained in "RIDER Lung PET CT" Collection in NBIA
• Longitudinal PET/CT human studies: Lung

DUKE UNIVERSITY

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DUKE UNIVERSITY

• Images contained in "RIDER Neuro MRI" Collection in NBIA
• Repeat human subject studies: Neuro
• Dynamic Contract Enhanced studies: DCE MRI:
• Diffusion weighted imaging: DWI MR
• Diffusion tensor imaging: DT MRI.

UNIVERSITY OF MICHIGAN

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• Images contained in "RIDER Breast MRI" Collection in NBIA
• Repeat measurements: Human subjects: Breast
• DCE MRI
• ISMRM 2009 poster demonstrates how each of the "coffee break" exams were used as an estimate of each patient's null hypothesis, i.e. distribution associated with no change, and thus supports the estimate of the null's 97.5 percentile for subsequent estimation of early response to neoadjuvant chemotherapy on an individual patient basis.

MDACC

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MDACC

• Images contained in "RIDER Phantom MRI" Collection in NBIA
• Repeat measurement: Phantom studies
• DCE MRI
• RIDER_MR_Phantom_Data_Summary.pdf provides a summary of the images in this collection.
• RIDER_PhantomMR_Key.pdf provides a key for understanding their presentation in NBIA.

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ACADEMIC SITE COLLECTIONS: Focus on harmonized methods for data collection

MULTI SITE STUDY (Total of 20 sites): Organized under a contract with the University of Michigan ( Under development: 2009)

• Repeat measurements
• Diffusion Weighted Imaging (DWI)
• Phantom measurements
• Human subjects
• White Paper: http://www.neoplasia.com/pdf/manuscript/v11i02/neo081328.pdf

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SOCIETY DATA COLLECTIONS

RSNA QIBA AND NCI (RIDER and IRAT) (2009-beyond: under development)

• Multi Site DCE MRI phantom studies using a modified ADNI phantom (http://www.loni.ucla.edu/ADNI/ )
• http://www.rsna.org/Research/qiba.cfm

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OTHER FEDERAL AGENCIES

FDA CDRH: Partly funded by NCI and NIBIB

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• NIST has NCI NBIA data and data from other data sources
• See Biochange 2008
• http://www.itl.nist.gov/iad/894.05/biochange2008/Biochange2008-webpage.htm

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Pilot Statistics

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Modalities

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CT, DX

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Number of Patients

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322

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Number of Studies

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1,779

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Number of Series

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4,931

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Number of Images

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Data Access

You can view and download these images on NBIA. You do not need to log in unless you want access to advanced features in the site. Simply follow these steps:

• Navigate to http://imaging.nci.nih.gov
• Click the "Search Images" link in the center of the page
• Scroll down through the search criteria until you see the "Collections" section
• Select the check box for whichever RIDER sub-collection you are interested in
• Press "Submit"

This will return the full list of cases included in the collection. To download the associated DICOM images:

• Press the "Check All" button and then "Add to Basket"
• Press the "View My Basket" button at the bottom of the page (or "View Contents" in the left menu bar)
• Press the "Download Manager" button to open a Java applet and specify where you'd like to save your images