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Annotating a sample is the process of adding biological or related data to nanoparticle entities. In caNanoLab, it involves selecting the sample to annotate, saving the sample composition and function(s), and entering the sample characterizations (physico-chemical, in vitro and in vivo) via the Navigation Tree. Note that annotating a sample with characterizations includes submitting the source of the characterization, the instrument used to perform the characterization, where appropriate, a relevant protocol, the characterization information itself, and applicable information in the form of uploaded files. A single sample can have multiple annotations, either coming from different sources, or the same data source being tested under different conditions (for example, temperature, solvents, instruments).

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Once you open a sample, you can use links in the Navigation Tree in the left sidebar to ascertain if the sample has annotations. The flow chart on the right shows how annotations are organized.

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CreateSample CreateSample

Creating a Sample

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SharingSample SharingSample

Sharing a Sample with a User or Group

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MakingSamplePublic MakingSamplePublic

Making a Sample Public

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1. There are three ways to access the basic sample search: From the home page Browse caNanoLab panel, or if you are logged in, click the Workflow menu option and Search Samples icon, or just click the Samples menu option.
   The Manage Samples page displays.

2. Click Search Existing Samples in the Sample Links panel.

   The following table lists and describes each field. Enter text or select options as appropriate.

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   title "Other" option
   Some fields may contain the [Other] option. Click Other to enter an alternative to the selections listed. At that point, your entry is enclosed in [new entry] brackets, indicating that your entry is temporary. Once you click Submit (or Update), your entry is persisted and the brackets disappear.

   When defining search criteria, there are no required fields. You can add only those parameters that you consider essential to the search.

   Sample Search Options	Description
   Keywords	Enter one or more keywords by which samples could be identified in this search. caNanoLab can search for characterization or publication keywords, as well as text describing characterizations.
   Sample Name	Enter text for the name of a sample. Select Contains (for search using partial text) or Equals (for exact text search).
   Sample Point of Contact	Enter text for the name or organization point of contact. Select Contains (for search using partial text) or Equals (for exact text search).
   Composition	Nanomaterial Entity Select from the scroll list the nanoparticle category to which the nanomaterial entity targeted by the search belongs. Example: Dendrimer Functionalizing Entity Select from the scroll list the functionalizing category to which the sample targeted by the search belongs.* Monomer Polymer Quantum Dot Antibody Biopolymer Small Molecule Function Select from the drop-down list the function type category which best fits the sample targeted by the search: Imaging Function [Other] Targeting Function Therapeutic Function Transfection *You may see terms in caNanoLab that are not defined in the help glossary. These have been added by curators as [other]; they may be reviewed and defined at a later time.
   Characterization Type/Characterization	Click the drop-down list on the left and select the characterization type that applies to the sample to be searched: Physico-Chemical, In Vitro or In Vivo. Your selection determines the sub-categories that display in the Characterization field to the right. Select one or more of the items in the Characterization list.* (CTRL + click to select more than one.) Physico-Chemical Characterizations: Molecular Weight Physical State Purity Relaxivity Shape Size Solubility Surface In Vitro Characterizations: Blood Contact Cytotoxicity Enzyme Induction Immune Cell Function Oxidative Stress Sterility  Targeting Transfection In Vivo Characterizations: Pharmacokinetics Toxicology *You may see terms in caNanoLab that are not defined in the help glossary. These have been added by curators as [other]; they may be reviewed and defined at a later time.

    

   To clear all fields and start again, click Reset.

3. To execute the search, click Search.

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   title No parameters?
   Include Page caNanoLab:No parameter searchcaNanoLab: No parameter search

   For information about the search results, see Sample Search Results.

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A sample search looks for a sample based on annotations that added or characterization or data files uploaded. Sample Search Results display in the browser window in table format. Column headings are appropriate for the sample for which you searched. They are described in the following table. Columns are sortable by clicking the column headings.

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• Copying an Existing Sample
• Updating a Sample
• Managing Samples in caNanoLab#Adding Adding Publications to a Sample
• Managing Samples in caNanoLab#Deleting Deleting a Sample
• Managing Samples in caNanoLab#Data Data Availability Metrics

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The Update Sample page appears when you copy an existing sample or perform a search and click the Edit link in the first column of the the Sample Search Results page. This page also opens when you, as a curator, choose to edit a sample while you are reviewing data prior to public releas

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